Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
170 results
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 2, 1 1 2016, Pages 154-155 An anomalous left coronary artery with a malignant course: coronary angiography and myocardial perfusion imaging with computed tomography. de Graaf MA, van Rosendael AR, Kroft LJ, Vliegen HW, Hazekamp MG, Bax JJ, Scholte AJ
Cited 64 times since 2016 (7.7 per year) source: EuropePMC
European heart journal, Volume 37, Issue 43, 18 3 2016, Pages 3285-3290 Genotype impacts survival in Marfan syndrome. Franken R, Groenink M, de Waard V, Feenstra HM, Scholte AJ, van den Berg MP, Pals G, Zwinderman AH, Timmermans J, Mulder BJ
Aims: The aorta in Marfan syndrome (MFS) patients is variably affected. We investigated the assumed genotype-effect on protein production as a risk factor for a severe aortic phenotype in adult MFS patients. Methods and results: We collected clinical and genetic data from all 570 adults with MFS who had been included in the Dutch CONgenital CORvitia registry since the start in 2001. Mean age was 36.5 ± 13.5 years (51.2% male, 28.9% prior aortic surgery, 8.2% prior aortic dissection). Patients we... Abstract
Cited 7 times since 2015 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 117, Issue 6, 30 5 2016, Pages 887-893 Value of Coronary Computed Tomography Angiography in Tailoring Aspirin Therapy for Primary Prevention of Atherosclerotic Events in Patients at High Risk With Diabetes Mellitus. Dimitriu-Leen AC, Scholte AJ, van Rosendael AR, van den Hoogen IJ, Kharagjitsingh AV, Wolterbeek R, Knuuti J, Kroft LJ, Delgado V, Jukema JW, de Graaf MA, Bax JJ
Aspirin use for primary prevention in patients at high risk with diabetes mellitus (DM) is often recommended under the assumption that most patients with DM have coronary artery disease (CAD). However, not all patients may have CAD. The present study evaluated, in 425 patients at high risk with DM (without chest pain syndrome or a history of cardiac disease), the prevalence of CAD on coronary computed tomography angiography (CTA). Moreover, the association between the presence and number of trad... Abstract
Cited 12 times since 2015 (1.4 per year) source: EuropePMC
The American journal of cardiology, Volume 117, Issue 5, 14 2 2015, Pages 768-774 Prognostic Value of Coronary Computed Tomography Imaging in Patients at High Risk Without Symptoms of Coronary Artery Disease. Dedic A, Ten Kate GJ, Roos CJ, Neefjes LA, de Graaf MA, Spronk A, Delgado V, van Lennep JE, Moelker A, Ouhlous M, Scholte AJ, Boersma E, Sijbrands EJ, Nieman K, Bax JJ, de Feijter PJ
At present, traditional risk factors are used to guide cardiovascular management of asymptomatic subjects. Intensified surveillance may be warranted in those identified as high risk of developing cardiovascular disease (CVD). This study aims to determine the prognostic value of coronary computed tomography (CT) angiography (CCTA) next to the coronary artery calcium score (CACS) in patients at high CVD risk without symptoms suspect for coronary artery disease (CAD). A total of 665 patients at hig... Abstract
Cited 9 times since 2015 (1.1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 32, Issue 4, 14 2 2015, Pages 543-552 Enhanced characterization of calcified areas in intravascular ultrasound virtual histology images by quantification of the acoustic shadow: validation against computed tomography coronary angiography. Broersen A, de Graaf MA, Eggermont J, Wolterbeek R, Kitslaar PH, Dijkstra J, Bax JJ, Reiber JH, Scholte AJ
We enhance intravascular ultrasound virtual histology (VH) tissue characterization by fully automatic quantification of the acoustic shadow behind calcified plaque. VH is unable to characterize atherosclerosis located behind calcifications. In this study, the quantified acoustic shadows are considered calcified to approximate the real dense calcium (DC) plaque volume. In total, 57 patients with 108 coronary lesions were included. A novel post-processing step is applied on the VH images to quanti... Abstract
Cited 1 times since 2015 (0.1 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 5, 11 2 2015, Pages 1176-1179 One-stop-shop cardiac CT: Calcium score, angiography, and myocardial perfusion. van Rosendael AR, Dimitriu-Leen AC, Bax JJ, Kroft LJ, Scholte AJHA
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 6, 2 1 2015, Pages 1510-1513 One-stop-shop cardiac CT: 3D fusion of CT coronary anatomy and myocardial perfusion for guiding revascularization in complex multivessel disease. van Rosendael AR, Dimitriu-Leen AC, Montero-Cabezas JM, Bax JJ, Kroft LJ, Scholte AJ
Cited 9 times since 2015 (1.1 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 43, Issue 2, 29 5 2015, Pages 326-332 The impact of acquisition time of planar cardiac (123)I-MIBG imaging on the late heart to mediastinum ratio. Dimitriu-Leen AC, Gimelli A, Al Younis I, Veltman CE, Verberne HJ, Wolterbeek R, Zandbergen-Harlaar S, Bax JJ, Scholte AJHA
Purpose: The aim of this study was to investigate whether performing the late cardiac (123)I-metaiodobenzylguanidine (MIBG) scan earlier than 4 h post-injection (p.i.) has relevant impact on the late heart to mediastinum ratio (H/M ratio) in patients with heart failure (HF). Methods: Forty-nine patients with HF (median left ventricular ejection fraction of 31 %, 51 % ischaemic HF) referred for cardiac (123)I-MIBG scintigraphy were scanned at 15 min (early) p.i. and at 1, 2, 3 and 4 h (late) p.i.... Abstract
Cited 1 times since 2015 (0.1 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 22, Issue 5, 1 1 2015, Pages 866-873 Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT. Kitsiou A, Dorbala S, Scholte AJ
European heart journal. Cardiovascular Imaging, Volume 16, Issue 9, 1 1 2015, Pages 959-965 Highlights of the 12th International Conference on Nuclear Cardiology and Cardiac CT. Kitsiou A, Dorbala S, Scholte AJ
The 12th International Conference on Nuclear Cardiology and Cardiac CT was held from 3 to 5 May 2015 in Madrid, Spain. In this article, the three Congress Program Committee Chairs summarize selected highlights of the presented abstracts. Abstract
Cited 139 times since 2015 (16 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 42, Issue 12, 21 3 2015, Pages 1929-1940 EANM procedural guidelines for radionuclide myocardial perfusion imaging with SPECT and SPECT/CT: 2015 revision. Verberne HJ, Acampa W, Anagnostopoulos C, Ballinger J, Bengel F, De Bondt P, Buechel RR, Cuocolo A, van Eck-Smit BL, Flotats A, Hacker M, Hindorf C, Kaufmann PA, Lindner O, Ljungberg M, Lonsdale M, Manrique A, Minarik D, Scholte AJ, Slart RH, Trägårdh E, de Wit TC, Hesse B, European Association of Nuclear Medicine (EANM)
Since the publication of the European Association of Nuclear Medicine (EANM) procedural guidelines for radionuclide myocardial perfusion imaging (MPI) in 2005, many small and some larger steps of progress have been made, improving MPI procedures. In this paper, the major changes from the updated 2015 procedural guidelines are highlighted, focusing on the important changes related to new instrumentation with improved image information and the possibility to reduce radiation exposure, which is fur... Abstract
Cited 14 times since 2015 (1.6 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 23, Issue 1, 9 2 2015, Pages 24-36 Prognostic value of coronary computed tomography angiography in diabetic patients without chest pain syndrome. van den Hoogen IJ, de Graaf MA, Roos CJ, Leen AC, Kharagjitsingh AV, Wolterbeek R, Kroft LJ, Wouter Jukema J, Bax JJ, Scholte AJ
Aims: Diabetic patients with coronary artery disease (CAD) are often free of chest pain syndrome. A useful modality for non-invasive assessment of CAD is coronary computed tomography angiography (CTA). However, the prognostic value of CAD on coronary CTA in diabetic patients without chest pain syndrome is relatively unknown. Therefore, the aim was to investigate the long-term prognostic value of coronary CTA in a large population diabetic patients without chest pain syndrome. Methods: Between 20... Abstract
Cited 16 times since 2015 (1.8 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 56 Suppl 4, 1 1 2015, Pages 25S-30S 123I-MIBG SPECT for Evaluation of Patients with Heart Failure. Dimitriu-Leen AC, Scholte AJ, Jacobson AF
Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The condition of cardiac sympathetic nerves can be evaluated by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. Most cardiac (123)I-MIBG studies have relied on measurements from anterior planar images of the chest. However, it has become progressively more common to include SPECT imaging in clinical and research protocols. This review examines recent trends in (123)I-MIBG SPECT imaging and evidence that pr... Abstract
Cited 36 times since 2015 (4 per year) source: EuropePMC
International journal of cardiology, Volume 194, 15 3 2015, Pages 7-12 Increased aortic tortuosity indicates a more severe aortic phenotype in adults with Marfan syndrome. Franken R, El Morabit A, de Waard V, Timmermans J, Scholte AJ, van den Berg MP, Marquering H, Planken NR, Zwinderman AH, Mulder BJ, Groenink M
Background: Patients with Marfan syndrome (MFS) have a highly variable occurrence of aortic complications. Aortic tortuosity is often present in MFS and may help to identify patients at risk for aortic complications. Methods: 3D-visualization of the total aorta by MR imaging was performed in 211 adult MFS patients (28% with prior aortic root replacement) and 20 controls. A method to assess aortic tortuosity (aortic tortuosity index: ATI) was developed and reproducibility was tested. The relation... Abstract
Cited 22 times since 2015 (2.4 per year) source: EuropePMC
Atherosclerosis, Volume 241, Issue 1, 1 1 2015, Pages 55-61 HDL cholesterol, leptin and interleukin-6 predict high risk coronary anatomy assessed by CT angiography in patients with stable chest pain. Caselli C, De Graaf MA, Lorenzoni V, Rovai D, Marinelli M, Del Ry S, Giannessi D, Bax JJ, Neglia D, Scholte AJ
Objectives: Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation could predict high risk coronary anatomy at CTA in patients with stable chest pain. Methods: We evaluated a panel of 17 biomarkers in 429 patients (60.3 ± 0.4 years, 268 males) with... Abstract
Cited 151 times since 2015 (16.5 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 8, Issue 3, 1 1 2015, Pages e002179 Detection of significant coronary artery disease by noninvasive anatomical and functional imaging. Neglia D, Rovai D, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Perrone Filardi P, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Fiechter M, Stehli J, Gaemperli O, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Marinelli M, Puzzuoli S, Mangione M, Marcheschi P, Mariani F, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Kaufmann PA, Underwood SR, Knuuti J, EVINCI Study Investigators
Background: The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy of commonly used imaging techniques for identifying patients with significant CAD. Methods and results: A total of 475 patients with stable chest pain and intermediate likelihood of CAD underwent coronary computed tomographic angiography an... Abstract
Cited 3 times since 2015 (0.3 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 16, Issue 8, 13 2 2015, Pages 863-870 Changes in ischaemia as assessed with single-photon emission computed tomography myocardial perfusion imaging in high-risk patients with diabetes without cardiac symptoms: relation with coronary atherosclerosis on computed tomography coronary angiography. de Graaf MA, Roos CJ, Mansveld JM, Kharagjitsingh AV, Dibbets-Schneider P, Kroft LJ, Jukema JW, Ficaro EP, Bax JJ, Scholte AJ
Aims: The study aims (i) to evaluate changes in myocardial ischaemia on single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) after 2 years in a cohort of high-risk patients with diabetes without cardiac symptoms or known coronary artery disease (CAD) and (ii) to assess the value of baseline computed tomography coronary angiography (CTA)-derived coronary atherosclerosis parameters to predict changes in myocardial ischaemia. Methods and results: The population cons... Abstract
Cited 3 times since 2015 (0.3 per year) source: EuropePMC
Cardiovascular diagnosis and therapy, Volume 5, Issue 1, 1 1 2015, Pages 63-66 Myocardial CT perfusion for the prediction of obstructive coronary artery disease, valuable or not? van Rosendael AR, de Graaf MA, Scholte AJ
Adenosine stress myocardial computed tomography perfusion (CTP) is a relatively new myocardial perfusion imaging technique. Together with coronary CT angiography (CTA) it provides anatomic and functional information of coronary artery disease (CAD). In previous studies, the combination of these techniques demonstrated to be valuable for identifying hemodynamically significant stenoses. George et al., performed a secondary analysis on the CORE320 study and compared the diagnostic performance of C... Abstract
Cited 3 times since 2015 (0.3 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 2, 1 1 2015, Pages 130-132 Cardiac arrest during vigorous exercise: coronary plaque rupture or myocardial ischaemia? van Rosendael AR, de Graaf MA, Scholte AJ
Cited 86 times since 2015 (9.3 per year) source: EuropePMC
Circulation. Cardiovascular genetics, Volume 8, Issue 2, 22 4 2015, Pages 383-388 Beneficial Outcome of Losartan Therapy Depends on Type of FBN1 Mutation in Marfan Syndrome. Franken R, den Hartog AW, Radonic T, Micha D, Maugeri A, van Dijk FS, Meijers-Heijboer HE, Timmermans J, Scholte AJ, van den Berg MP, Groenink M, Mulder BJ, Zwinderman AH, de Waard V, Pals G
Background: It has been shown that losartan reduces aortic dilatation in patients with Marfan syndrome. However, treatment response is highly variable. This study investigates losartan effectiveness in genetically classified subgroups. Methods and results: In this predefined substudy of COMPARE, Marfan patients were randomized to daily receive losartan 100 mg or no losartan. Aortic root dimensions were measured by MRI at baseline and after 3 years. FBN1 mutations were classified based on fibrill... Abstract