Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
112 results
Cited 1 times since 2020 (0.3 per year) source: EuropePMC
Journal of cardiac surgery, Volume 35, Issue 12, 21 3 2020, Pages 3477-3485 Prosthesis-patient mismatch after mitral valve replacement: A pooled meta-analysis of Kaplan-Meier-derived individual patient data. Tomšič A, Arabkhani B, Schoones JW, Etnel JRG, Marsan NA, Klautz RJM, Palmen M
Objective: The hemodynamic effect and early and late survival impact of prosthesis-patient mismatch (PPM) after mitral valve replacement remains insufficiently explored. Methods: Pubmed, Embase, Web of Science, and Cochrane Library databases were searched for English language original publications. The search yielded 791 potentially relevant studies. The final review and analysis included 19 studies compromising 11,675 patients. Results: Prosthetic effective orifice area was calculated with the... Abstract
Cited 6 times since 2020 (1.7 per year) source: EuropePMC
Alcohol and alcoholism (Oxford, Oxfordshire), Volume 55, Issue 6, 1 1 2020, Pages 660-666 L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety. Eriksson CJP, Metsälä M, Möykkynen T, Mäkisalo H, Kärkkäinen O, Palmén M, Salminen JE, Kauhanen J
Aims: Alcohol-related hangover symptoms: nausea, headache, stress and anxiety cause globally considerable amount of health problems and economic losses. Many of these harmful effects are produced by alcohol and its metabolite, acetaldehyde, which also is a common ingredient in alcohol beverages. The aim of the present study is to investigate the effect of the amino acid L-cysteine on the alcohol/acetaldehyde related aftereffects. Methods: Voluntary healthy participants were recruited through adv... Abstract
Alcohol and alcoholism (Oxford, Oxfordshire), Volume 55, Issue 6, 1 1 2020, Pages 705 Corrigendum to: L-Cysteine Containing Vitamin Supplement Which Prevents or Alleviates Alcohol-related Hangover Symptoms: Nausea, Headache, Stress and Anxiety. Eriksson CJP, Metsälä M, Möykkynen T, Mäkisalo H, Kärkkäinen O, Palmén M, Salminen JE, Kauhanen J
Cited 7 times since 2020 (1.9 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 58, Issue 3, 1 1 2020, Pages 544-550 A structured approach to native mitral valve infective endocarditis: Is repair better than replacement? Defauw RJ, Tomšič A, van Brakel TJ, Marsan NA, Klautz RJM, Palmen M
Objectives: Mitral valve repair in native active infective endocarditis is technically challenging. The survival benefit over valve replacement is poorly established and possibly absent because of the high risk of repair failure and reoperation. In this study, we explore the results of our structured approach in these patients. Methods: Between January 2000 and January 2017, 149 patients underwent surgery for native mitral infective endocarditis. Among them, 97 (66%) patients underwent valve rep... Abstract
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue Suppl 1, 1 1 2020, Pages 115-121 The role of long-term mechanical circulatory support in patients with advanced heart failure. Felix SEA, de Jonge N, Caliskan K, Birim O, Damman K, Kuijpers M, Tops LF, Palmen M, Ramjankhan FZ
In patients with end-stage heart failure, advanced therapies such as heart transplantation and long-term mechanical circulatory support (MCS) with a left ventricular assist device (LVAD) have to be considered. LVADs can be implanted as a bridge to transplantation or as an alternative to heart transplantation: destination therapy. In the Netherlands, long-term LVAD therapy is gaining importance as a result of increased prevalence of heart failure together with a low number of heart transplantatio... Abstract
Cited 25 times since 2020 (6.5 per year) source: EuropePMC
Molecular therapy. Nucleic acids, Volume 21, 21 3 2020, Pages 932-953 Adenosine-to-Inosine Editing of Vasoactive MicroRNAs Alters Their Targetome and Function in Ischemia. van der Kwast RVCT, Parma L, van der Bent ML, van Ingen E, Baganha F, Peters HAB, Goossens EAC, Simons KH, Palmen M, de Vries MR, Quax PHA, Nossent AY
Adenosine-to-inosine (A-to-I) editing in the seed sequence of microRNAs can shift the microRNAs' targetomes and thus their function. Using public RNA-sequencing data, we identified 35 vasoactive microRNAs that are A-to-I edited. We quantified A-to-I editing of the primary (pri-)microRNAs in vascular fibroblasts and endothelial cells. Nine pri-microRNAs were indeed edited, and editing consistently increased under ischemia. We determined mature microRNA editing for the highest expressed micro... Abstract
Cited 12 times since 2020 (2.9 per year) source: EuropePMC
Cardiovascular research, Volume 116, Issue 5, 1 1 2020, Pages 931-943 Stress-induced remodelling of the mitral valve: a model for leaflet thickening and superimposed tissue formation in mitral valve disease. Kruithof BPT, Paardekooper L, Hiemstra YL, Goumans MJ, Palmen M, Delgado V, Klautz RJM, Ajmone Marsan N
Aims: In mitral valve prolapse (MVP), leaflet thickening has recently been suggested to be due, in addition to a myxomatous degeneration, to the presence of a superimposed tissue (SIT), defined as an additional fibrous layer on top of the original leaflet. The mechanisms of SIT formation are currently unknown. We hypothesized that SIT formation would result from excessive leaflet stress and we used a unique ex vivo model to assess the correlation between leaflet remodelling and the type and loca... Abstract
Cited 3 times since 2020 (0.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 57, Issue 2, 1 1 2020, Pages 293-299 Risk factors and clinical significance of elevated mitral valve gradient following valve repair for degenerative disease. Tomšič A, Hiemstra YL, Arabkhani B, Mertens BJA, van Brakel TJ, Versteegh MIM, Marsan NA, Klautz RJM, Palmen M
Objectives: The risk factors and clinical effect of elevated mitral valve (MV) gradients after valve repair for degenerative valve disease remain insufficiently understood. Methods: Between January 2004 and December 2015, a total of 484 patients underwent valve repair for degenerative disease. A true-sized full annuloplasty ring was implanted in all cases. We analysed the effect of preoperative and intraoperative factors on the postrepair gradient. Additionally, we explored the effect of postrep... Abstract
Cited 6 times since 2020 (1.4 per year) source: EuropePMC
Clinical therapeutics, Volume 42, Issue 2, 11 2 2020, Pages 276-285 Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Ferric Carboxymaltose in Chinese Patients with Iron-deficiency Anemia. Ding Y, Zhu X, Li X, Zhang H, Wu M, Liu J, Palmen M, Roubert B, Li C
Purpose: Iron deficiency (ID) is one of the most commonly known nutritional deficiencies and is considered the primary cause of anemia (iron-deficiency anemia). Ferric carboxymaltose (FCM), an intravenous iron preparation, has been widely used for >10 years for iron-deficiency anemia treatment worldwide because of its many advantages. Methods: This single-center, open-label, single dose escalation study in Chinese subjects was designed to assess the pharmacokinetic/pharmacodynamic parameters... Abstract
Cited 7 times since 2019 (1.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 12, 1 1 2019, Pages 590-593 Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF
Ventricular assist device (VAD) implantation is an established treatment modality for patients with end-stage heart failure, and improves symptoms and survival. In the Netherlands, it is not yet routinely considered in patients with congenital heart disease and failing systemic right ventricle (SRV). Recently, a VAD was implanted in 2 SRV patients, one who underwent a Mustard procedure during infancy for transposition of the great arteries (male, 47 years old) and one with a congenitally correct... Abstract
Journal of cardiothoracic surgery, Volume 14, Issue 1, 21 3 2019, Pages 200 Vasoresponsiveness in patients with heart failure (VASOR): protocol for a prospective observational study. van Vessem ME, Beeres SLMA, de Wilde RBP, de Vries R, Berendsen RR, de Jonge E, Danser AHJ, Klautz RJM, Schalij MJ, Palmen M
Background: Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of vasodilator pathways, inactivation of vasoconstrictor pathways and the resistance to vasopressors. However, the precise etiology remains unclear. The aim of the Vasoresponsiveness in patients with heart failure (VASOR) study is to objectify and characterize the altered vasoresponsiveness in patients with heart failure, before, during... Abstract
Cited 3 times since 2019 (0.6 per year) source: EuropePMC
Journal of cardiothoracic and vascular anesthesia, Volume 33, Issue 12, 14 2 2019, Pages 3273-3280 Vasoplegia After Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation in Patients With Heart Failure. van Vessem ME, Petrus AHJ, Palmen M, Braun J, Schalij MJ, Klautz RJM, Beeres SLMA
Objectives: Patients undergoing heart failure surgery are at risk for developing postoperative vasoplegia. The aim of this study was to determine the incidence, survival, and predictors of vasoplegia in heart failure patients undergoing mitral valve repair for functional mitral regurgitation and to evaluate the effect of ischemic versus non-ischemic etiology. Design: Retrospective. Setting: University medical center, single institutional. Participants: Heart failure patients with functional mitr... Abstract
Cited 17 times since 2019 (3.4 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 13, Issue 2 Pt 2, 12 2 2019, Pages 577-585 Prognostic Value of Global Longitudinal Strain and Etiology After Surgery for Primary Mitral Regurgitation. Hiemstra YL, Tomsic A, van Wijngaarden SE, Palmen M, Klautz RJM, Bax JJ, Delgado V, Ajmone Marsan N
Objectives: This study sought to investigate whether left ventricular (LV) global longitudinal strain (GLS) is associated with long-term outcome after mitral valve (MV) surgery for primary mitral regurgitation (MR) and assess the differences in outcome according to MR etiology: Barlow's disease (BD), fibroelastic deficiency (FED), and forme fruste (FF). Background: Appropriate timing of MV surgery for primary MR is still challenging and may differ according to the etiology. In these patient... Abstract
The Journal of thoracic and cardiovascular surgery, Volume 157, Issue 5, 11 2 2019, Pages e249-e250 The devil is in the details, not the ring. Tomšič A, Palmen M, Klautz RJM
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 54, Issue 6, 1 1 2018, Pages 1147-1148 Off-pump mitral valve repair: is less really more? Tomšic A, Klautz RJM, Palmen M
Cited 7 times since 2018 (1.2 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 107, Issue 4, 6 1 2018, Pages 1195-1201 Outcomes of Valve Repair for Degenerative Disease in Patients With Mitral Annular Calcification. Tomšič A, Hiemstra YL, van Brakel TJ, Versteegh MIM, Marsan NA, Klautz RJM, Palmen M
Background: The risk factors for the development of mitral annular calcification (MAC) in degenerative mitral valve disease and the effect it may have on patient-and valve-related outcomes require further evaluation. Methods: Between January 2002 and December 2015, 627 patients underwent mitral valve operations for degenerative disease. MAC was seen in 75 patients (12%); 73 (97%) underwent valve repair (6 without annuloplasty ring implantation) and 2 (3%) underwent valve replacement after an uns... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
The Journal of cardiovascular surgery, Volume 60, Issue 1, 29 5 2018, Pages 111-118 Excessive leaflet tissue in mitral valve repair for isolated posterior leaflet prolapse-leaflet resection or shortening neochords? A propensity score adjusted comparison. Tomšič A, Hiemstra YL, van Brakel TJ, Versteegh MI, Ajmone Marsan N, Klautz RJ, Palmen M
Background: Chordal replacement techniques are progressively used to treat posterior mitral valve leaflet (PMVL) prolapse while leaflet resection remains commonly in use to address excessive leaflet tissue. For excessive tissue in height, shortening neochords can be used alternatively. Use of chordal replacement techniques has been suggested to result in lower diastolic transvalvular gradients, higher freedom from reoperation and improved left ventricular function. Methods: From 1/2005 to 12/201... Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 106, Issue 5, 14 2 2018, Pages 1371-1378 Vasoplegia After Surgical Left Ventricular Restoration: 2-Year Follow-Up. van Vessem ME, Palmen M, Couperus LE, Stijnen T, Berendsen RR, Aarts LPHJ, de Jonge E, Klautz RJM, Schalij MJ, Beeres SLMA
Background: Vasoplegia is a severe complication that can develop after surgical procedures for heart failure. The current study evaluated the effect of vasoplegia on survival, cardiac function, and renal function 2 years after surgical left ventricular restoration (SVR). Methods: Heart failure patients with a left ventricular ejection fraction (LVEF) of 0.35 or less who underwent SVR in 2006 to 2014 were included. Vasoplegia was defined as the continuous need of vasopressors (norepinephrine ≥0.2... Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 54, Issue 1, 1 1 2018, Pages 199 Mitral valve infective endocarditis: putting the puzzle pieces together. Tomšic A, Klautz RJM, Palmen M
Interactive cardiovascular and thoracic surgery, Volume 27, Issue 1, 1 1 2018, Pages 124-130 Papillary muscle head repositioning for commissural prolapse in degenerative mitral valve disease. Tomšic A, Klautz RJM, van Brakel TJ, Ajmone Marsan N, Versteegh MIM, Palmen M
Objectives: Surgical correction of commissural mitral valve prolapse can be challenging. Several surgical techniques, including commissural closure, leaflet resection with sliding plasty and chordal replacement, remain commonly in use. Conversely, papillary muscle head repositioning remains uncommonly utilized for the treatment of commissural prolapse. Methods: Between January 2003 and December 2015, 518 patients underwent primary mitral valve repair for severe degenerative mitral valve regurgit... Abstract