Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
482 results
Cited 79 times since 2009 (5.2 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 2, 18 3 2009, Pages 135-145 Acute effects of right ventricular apical pacing on left ventricular synchrony and mechanics. Delgado V, Tops LF, Trines SA, Zeppenfeld K, Marsan NA, Bertini M, Holman ER, Schalij MJ, Bax JJ
Background: Chronic right ventricular (RV) apical pacing has a detrimental effect on left ventricular (LV) function. However, the acute effects of RV apical pacing on LV mechanics remain unclear. The purpose of the study was to assess the acute impact of RV apical pacing on global LV function, evaluating LV contraction synchrony and LV shortening and twist, using 2D speckle-tracking strain imaging. Methods and results: A group of 25 patients with structural normal hearts referred for electrophys... Abstract
Cited 34 times since 2008 (2.2 per year) source: EuropePMC
The American journal of cardiology, Volume 103, Issue 5, 26 4 2008, Pages 690-694 Comparison of time course of response to cardiac resynchronization therapy in patients with ischemic versus nonischemic cardiomyopathy. Marsan NA, Bleeker GB, van Bommel RJ, Ypenburg C, Delgado V, Borleffs CJ, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
The time course of the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) systolic function and reverse remodeling is still unknown and was the subject of this study. In particular, whether the acute benefit of CRT translates in late response was explored. Furthermore, the time course of response was compared between ischemic and nonischemic patients. A total of 222 consecutive patients with heart failure (135 ischemic) scheduled for CRT were included. Standard echocardi... Abstract
Cited 21 times since 2008 (1.4 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 36, Issue 4, 3 1 2008, Pages 594-601 Agreement and disagreement between contrast-enhanced magnetic resonance imaging and nuclear imaging for assessment of myocardial viability. Roes SD, Kaandorp TA, Marsan NA, Westenberg JJ, Dibbets-Schneider P, Stokkel MP, Lamb HJ, van der Wall EE, de Roos A, Bax JJ
Purpose: The purpose of this study was to compare contrast-enhanced MRI and nuclear imaging with (99m)Tc-tetrofosmin and (18)F-fluorodeoxyglucose ((18)F-FDG) single photon emission computed tomography (SPECT) for assessment of myocardial viability. Methods: Included in the study were 60 patients with severe ischaemic left ventricular (LV) dysfunction who underwent contrast-enhanced MRI, (99m)Tc-tetrofosmin and (18)F-FDG SPECT. Myocardial segments were assigned a wall motion score from 0 (normoki... Abstract
Cited 24 times since 2008 (1.6 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 31, Issue 12, 1 1 2008, Pages 1628-1639 Noninvasive imaging in cardiac resynchronization therapy--Part 2: Follow-up and optimization of settings. Ypenburg C, Van De Veire N, Westenberg JJ, Bleeker GB, Marsan NA, Henneman MM, Van Der Wall EE, Schalij MJ, Abraham TP, Barold SS, Bax JJ
Cardiac resynchronization therapy (CRT) has become a therapeutic option for drug-refractory heart failure. Several noninvasive imaging techniques play an increasingly important role before and after device implantation. This review highlights the acute and long-term CRT benefits after implantation as assessed with echocardiography and nuclear imaging. Furthermore, optimization of CRT settings, in particular atrioventricular and interventricular delay, will be discussed using echocardiography and... Abstract
Cited 44 times since 2008 (2.8 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 31, Issue 11, 1 1 2008, Pages 1475-1499 Noninvasive imaging in cardiac resynchronization therapy--part 1: selection of patients. Ypenburg C, Westenberg JJ, Bleeker GB, VAN de Veire N, Marsan NA, Henneman MM, van der Wall EE, Schalij MJ, Abraham TP, Barold SS, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for patients with advanced heart failure, depressed left ventricular function, and wide QRS complex. However, individual response varies, and a substantial amount of patients do not respond to CRT. Recent studies observed that assessment of inter- and particularly intraventricular dyssynchrony may allow identification of potential responders to CRT. In addition, presence of scar tissue and venous anatomy may play a role in the sel... Abstract
Cited 9 times since 2008 (0.6 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 10 Suppl 3, 1 1 2008, Pages iii73-9 Predicting response to CRT. The value of two- and three-dimensional echocardiography. Marsan NA, Breithardt OA, Delgado V, Bertini M, Tops LF
Recently, it has been suggested that a direct assessment of left ventricular (LV) mechanical dyssynchrony may improve the selection of candidates to cardiac resynchronization therapy (CRT). In fact, when the established clinical and electrocardiographic selection criteria are applied, response to CRT may vary widely and up to one-third of the patients fail to benefit from CRT. Echocardiography has been extensively applied to assess LV dyssynchrony and to predict favourable response to CRT, using... Abstract
Cited 115 times since 2008 (7.4 per year) source: EuropePMC
Radiology, Volume 249, Issue 3, 10 2 2008, Pages 792-800 Mitral valve and tricuspid valve blood flow: accurate quantification with 3D velocity-encoded MR imaging with retrospective valve tracking. Westenberg JJ, Roes SD, Ajmone Marsan N, Binnendijk NM, Doornbos J, Bax JJ, Reiber JH, de Roos A, van der Geest RJ
Purpose: To validate flow assessment performed with three-dimensional (3D) three-directional velocity-encoded (VE) magnetic resonance (MR) imaging with retrospective valve tracking and to compare this modality with conventional two-dimensional (2D) one-directional VE MR imaging in healthy subjects and patients with regurgitation. Materials and methods: Patients and volunteers gave informed consent, and local medical ethics committee approval was obtained. Patient data were selected retrospective... Abstract
Cited 29 times since 2008 (1.9 per year) source: EuropePMC
The American journal of cardiology, Volume 102, Issue 10, 6 1 2008, Pages 1366-1372 Comparison between tissue Doppler imaging and velocity-encoded magnetic resonance imaging for measurement of myocardial velocities, assessment of left ventricular dyssynchrony, and estimation of left ventricular filling pressures in patients with ischemic cardiomyopathy. Marsan NA, Westenberg JJ, Tops LF, Ypenburg C, Holman ER, Reiber JH, de Roos A, van der Wall EE, Schalij MJ, Roelandt JR, Bax JJ
Velocity-encoded magnetic resonance imaging (VE-MRI), commonly used to perform flow measurements, can be applied for myocardial velocity analysis, similar to tissue Doppler imaging (TDI). In this study, a comparison between VE-MRI and TDI was performed for the assessment of left ventricular dyssynchrony and left ventricular filling pressures. Ten healthy volunteers and 22 patients with heart failure secondary to ischemic cardiomyopathy underwent both VE-MRI and TDI. Longitudinal myocardial peak... Abstract
Cited 43 times since 2008 (2.7 per year) source: EuropePMC
Heart rhythm, Volume 5, Issue 9, 6 1 2008, Pages 1257-1264 Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, Van de Veire NR, Delgado V, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony... Abstract
Cited 73 times since 2008 (4.6 per year) source: EuropePMC
The American journal of cardiology, Volume 102, Issue 7, 18 3 2008, Pages 847-853 Comparison of left atrial volumes and function by real-time three-dimensional echocardiography in patients having catheter ablation for atrial fibrillation with persistence of sinus rhythm versus recurrent atrial fibrillation three months later. Marsan NA, Tops LF, Holman ER, Van de Veire NR, Zeppenfeld K, Boersma E, van der Wall EE, Schalij MJ, Bax JJ
Real-time 3-dimensional echocardiography (RT3DE) can provide a unique combination of accurate left atrial (LA) volume quantification and rapid, automatic assessment of LA function. The aim of the study was to evaluate the changes in LA volumes and function in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation (RFCA) using RT3DE; 57 consecutive patients referred for RFCA were studied. Paroxysmal AF was present in 43 patients (75%) and persistent AF in 14 (25%). Aft... Abstract
Cited 11 times since 2008 (0.7 per year) source: EuropePMC
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 9, Issue 6, 16 3 2008, Pages 816-818 Safety of contrast-enhanced echocardiography within 24 h after acute myocardial infarction. Nucifora G, Marsan NA, Siebelink HM, van Werkhoven JM, Schuijf JD, Schalij MJ, Poldermans D, Holman ER, Bax JJ
Aims: Contrast-enhanced echocardiography is widely used to enhance left ventricular (LV) endocardial border delineation in stable patients with known or suspected coronary artery disease. In patients with acute myocardial infarction, accurate assessment of LV function and size is important, but data on the safety of contrast-enhanced echocardiography in the early stage of myocardial infarction (within 24 h) are lacking. In the current study, the experience on the safety of contrast-enhanced echo... Abstract
Cited 7 times since 2008 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 102, Issue 6, 18 3 2008, Pages 718-721 Effects of interruption of long-term cardiac resynchronization therapy on left ventricular function and dyssynchrony. Ypenburg C, Van Bommel RJ, Marsan NA, Delgado V, Bleeker GB, van der Wall EE, Schalij MJ, Bax JJ
Interruption of short-term cardiac resynchronization therapy (CRT) has been shown to acutely worsen left ventricular (LV) function, mitral regurgitation, and LV dyssynchrony. The present study aims to assess whether LV reverse remodeling influences interruption of CRT, and, more practically, whether long-term continuous pacing is necessary in patients with reverse LV remodeling. A total of 135 recipients of CRT were selected after showing LV reverse remodeling defined as a decrease in LV end-sys... Abstract
Cited 247 times since 2008 (15.4 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 51, Issue 20, 1 1 2008, Pages 1944-1952 Assessment of left ventricular dyssynchrony by speckle tracking strain imaging comparison between longitudinal, circumferential, and radial strain in cardiac resynchronization therapy. Delgado V, Ypenburg C, van Bommel RJ, Tops LF, Mollema SA, Marsan NA, Bleeker GB, Schalij MJ, Bax JJ
Objectives: The objective of this study was to assess the usefulness of each type of strain for left ventricular (LV) dyssynchrony assessment and its predictive value for a positive response after cardiac resynchronization therapy (CRT). Furthermore, changes in extent of LV dyssynchrony for each type of strain were evaluated during follow-up. Background: Different echocardiographic techniques have been proposed for assessment of LV dyssynchrony. The novel 2-dimensional (2D) speckle tracking stra... Abstract
JACC. Cardiovascular imaging, Volume 1, Issue 3, 1 1 2008, Pages 380-389 Imaging highlights from the European Association of Echocardiography and the Society of Cardiovascular Magnetic Resonance. Marsan NA, Arai AE, van Rossum AC, Zamorano JL, Bax JJ
Echocardiography and cardiovascular magnetic resonance represent 2 of the important cardiovascular imaging techniques. This article summarizes the highlights of scientific abstracts of the Euroecho meeting (the annual meeting of the European Association of Echocardiography) and the Society of Cardiovascular Magnetic Resonance (SCMR). Abstract
Cited 53 times since 2008 (3.3 per year) source: EuropePMC
The American journal of cardiology, Volume 101, Issue 7, 6 1 2008, Pages 1023-1029 Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomography and noninvasive assessment of left ventricular dyssynchrony by 3-dimensional tissue synchronization imaging in patients with heart failure scheduled for cardiac resynchronization therapy. Van de Veire NR, Marsan NA, Schuijf JD, Bleeker GB, Wijffels MC, van Erven L, Holman ER, De Sutter J, van der Wall EE, Schalij MJ, Bax JJ
Objectives of this study were to perform a prospective head-to-head comparison between multi-slice computed tomography (MSCT) venography and invasive venography in cardiac resynchronization therapy (CRT) candidates as well as to evaluate the relation between left ventricular (LV) lead position and effect on LV dyssynchrony and immediate response to CRT. Twenty-one consecutive heart failure patients scheduled for CRT implantation were prospectively enrolled to undergo 64-slice MSCT to visualize t... Abstract
Cited 46 times since 2008 (2.8 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 21, Issue 7, 28 4 2008, Pages 801-807 Real-time three-dimensional echocardiography as a novel approach to quantify left ventricular dyssynchrony: a comparison study with phase analysis of gated myocardial perfusion single photon emission computed tomography. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ
Background: Different imaging modalities have been explored for assessment of left ventricular (LV) dyssynchrony. Gated myocardial perfusion single photon emission computed tomography (GMPS) with phase analysis is a reliable technique to quantify LV dyssynchrony and predict response to cardiac resynchronization therapy. Objective: Real-time 3-dimensional echocardiography (RT3DE) is a novel imaging technique that provides a LV systolic dyssynchrony index, based on regional volumetric changes as a... Abstract
Cited 14 times since 2008 (0.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 2, 15 3 2008, Pages 119-124 Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. van Ramshorst J, Atsma DE, Beeres SL, Mollema SA, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Objective: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. Methods: In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infar... Abstract
Cited 76 times since 2007 (4.6 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 19, Issue 4, 20 3 2007, Pages 392-399 Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Ghio S, van de Veire NR, Holman ER, van der Wall EE, Tavazzi L, Schalij MJ, Bax JJ
Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for... Abstract
Cited 23 times since 2007 (1.4 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 12, 1 1 2007, Pages 2001-2010 Nuclear imaging in cardiac resynchronization therapy. Henneman MM, van der Wall EE, Ypenburg C, Bleeker GB, van de Veire NR, Marsan NA, Chen J, Garcia EV, Westenberg JJ, Schalij MJ, Bax JJ
Recently, cardiac resynchronization therapy (CRT) has become implemented in the treatment of patients with severe heart failure. Although the improvement in systolic function after CRT implantation can be considerable, 20%-30% of patients do not respond to CRT. Evidence is accumulating that the presence of left ventricular (LV) dyssynchrony is mandatory for a response to CRT. Since the early 1980s attempts have been made to assess cardiac dyssynchrony with nuclear imaging, and it has been report... Abstract
Cited 48 times since 2007 (2.9 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 35, Issue 1, 12 2 2007, Pages 166-173 Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging. Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ
Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal cou... Abstract