Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
484 results
Cited 31 times since 2010 (2.2 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 3, Issue 4, 17 3 2010, Pages 433-442 Reduced left ventricular torsion early after myocardial infarction is related to left ventricular remodeling. Nucifora G, Marsan NA, Bertini M, Delgado V, Siebelink HM, van Werkhoven JM, Scholte AJ, Schalij MJ, van der Wall EE, Holman ER, Bax JJ
Background: Left ventricular (LV) torsion is emerging as a sensitive parameter of LV systolic myocardial performance. The aim of the present study was to explore the effects of acute myocardial infarction (AMI) on LV torsion and to determine the value of LV torsion early after AMI in predicting LV remodeling at 6-month follow-up. Methods and results: A total of 120 patients with a first ST-segment elevation AMI (mean+/-SD age, 59+/-10 years; 73% male) were included. All patients underwent primar... Abstract
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G28-37 Non-invasive imaging in percutaneous mitral valve procedures. Marsan NA, Bax JJ
Novel percutaneous techniques for the treatment of mitral valve (MV) disease have recently been developed and provide an alternative to surgery in patients with high operative risk. However, the complexity of MV anatomy and the variety of mitral regurgitation mechanisms require sophisticated procedures and accurate patient selection. Non-invasive imaging (echocardiography, multislice computed tomography) provides crucial anatomical details and exact characterisation of the mechanism underlying m... Abstract
Cited 22 times since 2010 (1.5 per year) source: EuropePMC
The American journal of cardiology, Volume 105, Issue 8, 20 3 2010, Pages 1153-1158 Value of tissue Doppler echocardiography in predicting response to cardiac resynchronization therapy in patients with heart failure. Van Bommel RJ, Ypenburg C, Borleffs CJ, Delgado V, Marsan NA, Bertini M, Holman ER, Schalij MJ, Bax JJ
Several studies have demonstrated a relation between left ventricular (LV) dyssynchrony and response to cardiac resynchronization therapy (CRT). Many methods of determining LV dyssynchrony have been proposed, including a value of 65 ms as assessed by tissue Doppler imaging. The aim of the present validation study was to prospectively test the predictive accuracy of the 65-ms cutoff for LV dyssynchrony in a large cohort of patients with heart failure undergoing CRT. The study included 361 patient... Abstract
Cited 85 times since 2010 (6 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 23, Issue 2, 1 1 2010, Pages 109-115 Reference values for right ventricular volumes and ejection fraction with real-time three-dimensional echocardiography: evaluation in a large series of normal subjects. Tamborini G, Marsan NA, Gripari P, Maffessanti F, Brusoni D, Muratori M, Caiani EG, Fiorentini C, Pepi M
Background: The quantification of right ventricular (RV) size and function is of diagnostic and prognostic importance. Recently, new software for the analysis of RV geometry using three-dimensional (3D) echocardiographic images has been validated. The aim of this study was to provide normal reference values for RV volumes and function using this technique. Methods: A total of 245 subjects, including 15 to 20 subjects for each gender and age decile, were studied. Dedicated 3D acquisitions of the... Abstract
Cited 22 times since 2009 (1.5 per year) source: EuropePMC
The American journal of cardiology, Volume 105, Issue 3, 21 3 2009, Pages 306-311 Impact of left ventricular dyssynchrony early on left ventricular function after first acute myocardial infarction. Nucifora G, Bertini M, Marsan NA, Delgado V, Scholte AJ, Ng AC, van Werkhoven JM, Siebelink HM, Holman ER, Schalij MJ, van der Wall EE, Bax JJ
The impact of left ventricular (LV) dyssynchrony after acute myocardial infarction (AMI) on LV ejection fraction (EF) is unknown. One hundred twenty-nine patients with a first ST-elevation AMI (58 + or - 11 years, 78% men) and QRS duration Abstract
Cited 29 times since 2009 (2 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 2, Issue 12, 1 1 2009, Pages 1425-1435 Role of left ventricular twist mechanics in the assessment of cardiac dyssynchrony in heart failure. Bertini M, Sengupta PP, Nucifora G, Delgado V, Ng AC, Marsan NA, Shanks M, van Bommel RJ, Schalij MJ, Narula J, Bax JJ
The authors discuss an incremental value of assessing left ventricular (LV) twist mechanics in patients with heart failure (HF) and its potential usefulness in characterizing response to cardiac resynchronization therapy (CRT) and reversal of LV remodeling at 6 months follow-up. They also underscore a critical relationship between LV lead position and changes in LV twist after CRT, and suggest that the reversal of LV remodeling in HF patients following CRT primarily results from restoration of t... Abstract
Cited 140 times since 2009 (9.7 per year) source: EuropePMC
European heart journal, Volume 30, Issue 24, 1 1 2009, Pages 3037-3047 Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Delgado V, Tops LF, van Bommel RJ, van der Kley F, Marsan NA, Klautz RJ, Versteegh MI, Holman ER, Schalij MJ, Bax JJ
Aims: To evaluate myocardial multidirectional strain and strain rate (S-and-SR) in severe aortic stenosis (AS) patients with preserved left ventricular (LV) ejection fraction (EF), using two-dimensional speckle-tracking strain imaging (2D-STI). The long-term effect of aortic valve replacement (AVR) on S-and-SR was also evaluated. Methods and results: Changes in LV radial, circumferential, and longitudinal S-and-SR were evaluated in 73 severe AS patients (65 +/- 13 years; aortic valve area 0.8 +/... Abstract
Cited 22 times since 2009 (1.5 per year) source: EuropePMC
American heart journal, Volume 158, Issue 5, 1 1 2009, Pages 769-776 Cardiac resynchronization therapy in patients with ischemic versus non-ischemic heart failure: Differential effect of optimizing interventricular pacing interval. Marsan NA, Bleeker GB, Van Bommel RJ, Borleffs C, Bertini M, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Whether sequential biventricular pacing provides substantial benefits over conventional simultaneous stimulation remains unclear, particularly regarding the differences between ischemic and non-ischemic patients. The purpose of this study was to evaluate the acute effect of interventricular pacing interval (V-V) optimization on left ventricular (LV) systolic performance and dyssynchrony in ischemic versus non-ischemic patients. Methods: Sixty-nine consecutive patients underwent cardi... Abstract
Cited 87 times since 2009 (6 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 2, Issue 11, 1 1 2009, Pages 1245-1252 Quantification of functional mitral regurgitation by real-time 3D echocardiography: comparison with 3D velocity-encoded cardiac magnetic resonance. Marsan NA, Westenberg JJ, Ypenburg C, Delgado V, van Bommel RJ, Roes SD, Nucifora G, van der Geest RJ, de Roos A, Reiber JC, Schalij MJ, Bax JJ
Objectives: The aim of this study was to evaluate feasibility and accuracy of real-time 3-dimensional (3D) echocardiography for quantification of mitral regurgitation (MR), in a head-to-head comparison with velocity-encoded cardiac magnetic resonance (VE-CMR). Background: Accurate grading of MR severity is crucial for appropriate patient management but remains challenging. VE-CMR with 3D three-directional acquisition has been recently proposed as the reference method. Methods: A total of 64 pati... Abstract
Cited 23 times since 2009 (1.6 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 22, 1 1 2009, Pages 1881-1890 Real-time three dimensional echocardiography: current and future clinical applications. Marsan NA, Tops LF, Nihoyannopoulos P, Holman ER, Bax JJ
Cited 86 times since 2009 (5.9 per year) source: EuropePMC
Investigative radiology, Volume 44, Issue 10, 1 1 2009, Pages 669-675 Flow assessment through four heart valves simultaneously using 3-dimensional 3-directional velocity-encoded magnetic resonance imaging with retrospective valve tracking in healthy volunteers and patients with valvular regurgitation. Roes SD, Hammer S, van der Geest RJ, Marsan NA, Bax JJ, Lamb HJ, Reiber JH, de Roos A, Westenberg JJ
Objectives: To validate 3-dimensional (3D) 3-directional velocity-encoded (VE) magnetic resonance imaging (MRI) for flow assessment through all 4 heart valves simultaneously with retrospective valve-tracking during off-line analysis in healthy volunteers and in patients with valvular regurgitation. Material and methods: Three-dimensional 3-directional VE MRI was performed in 22 healthy volunteers and in 29 patients with ischemic cardiomyopathy who were suspected of valvular regurgitation and net... Abstract
Cited 89 times since 2009 (6.1 per year) source: EuropePMC
European journal of heart failure, Volume 11, Issue 10, 1 1 2009, Pages 929-936 Independent relationship of left atrial size and mortality in patients with heart failure: an individual patient meta-analysis of longitudinal data (MeRGE Heart Failure). Rossi A, Temporelli PL, Quintana M, Dini FL, Ghio S, Hillis GS, Klein AL, Marsan NA, Prior DL, Yu CM, Poppe KK, Doughty RN, Whalley GA, MeRGE Heart Failure Collaborators
Aims: Left atrial (LA) size is considered a marker of poor prognosis in heart failure (HF) patients. Prior studies have recruited relatively few subjects limiting their power to adequately analyse the interaction between LA size, left ventricular (LV) systolic and diastolic function, and prognosis. Method and results: The MeRGE collaboration combines prospective data from 18 studies in HF patients. In this analysis of data from 1157 patients, the primary endpoint was death or hospitalization for... Abstract
Cited 45 times since 2009 (3.1 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 54, Issue 14, 1 1 2009, Pages 1317-1325 Effects of cardiac resynchronization therapy on left ventricular twist. Bertini M, Marsan NA, Delgado V, van Bommel RJ, Nucifora G, Borleffs CJ, Boriani G, Biffi M, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Objectives: This study explored the effects of cardiac resynchronization therapy (CRT) on left ventricular (LV) twist, particularly in relation to LV lead position. Background: LV twist is emerging as a comprehensive index of LV function. Methods: Eighty heart failure patients were included. Two-dimensional echocardiography was performed at baseline, immediately after CRT, and at 6-month follow-up. Speckle-tracking analysis was applied to assess LV twist. The LV lead was placed preferably in a (... Abstract
Cited 3 times since 2009 (0.2 per year) source: EuropePMC
Minerva cardioangiologica, Volume 57, Issue 4, 1 1 2009, Pages 415-441 Advanced applications of 3-dimensional echocardiography. Ng AC, Delgado V, Bertini M, Nucifora G, Shanks M, Ajmone Marsan N, Holman E, Van De Veire NR, Leung DY, Bax JJ
Over the last few decades, advancements in ultrasound, electronic and computing technologies have permitted current second generation 3-dimensional (3D) echocardiography to display on-line 3D rendered images of the heart. Since various studies demonstrated its superiority over 2-dimensional echocardiography, there is growing enthusiasm to embrace this new 3D echocardiographic technology. With its increasing widespread clinical availability, 3D echocardiography is getting closer to routine clinic... Abstract
Cited 36 times since 2009 (2.4 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 32, Issue 8, 1 1 2009, Pages 1040-1049 Relevance of echocardiographic evaluation of right ventricular function in patients undergoing cardiac resynchronization therapy. Scuteri L, Rordorf R, Marsan NA, Landolina M, Magrini G, Klersy C, Frattini F, Petracci B, Vicentini A, Campana C, Tavazzi L, Ghio S
Aims: Right ventricular (RV) dysfunction is a marker of poor prognosis in heart failure (HF) patients. It is still unclear whether RV function might influence response to cardiac resynchronization therapy (CRT). Methods: Forty-four consecutive patients with HF, large QRS, and either intraventricular or interventricular dyssynchrony underwent echocardiographic evaluation before, 1 month after, and 6 months after CRT. Response to CRT was considered in case of significant LV reverse remodeling, def... Abstract
Cited 71 times since 2009 (4.8 per year) source: EuropePMC
European heart journal, Volume 30, Issue 19, 4 1 2009, Pages 2360-2367 Magnetic resonance imaging and response to cardiac resynchronization therapy: relative merits of left ventricular dyssynchrony and scar tissue. Marsan NA, Westenberg JJ, Ypenburg C, van Bommel RJ, Roes S, Delgado V, Tops LF, van der Geest RJ, Boersma E, de Roos A, Schalij MJ, Bax JJ
Aim: To assess the relative value of a novel measure of left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and the extent of scar tissue for prediction of response to cardiac resynchronization therapy (CRT). Methods and results: Thirty-five heart failure patients scheduled for CRT were included. Left ventricular dyssynchrony was defined as the standard deviation of 16 segment time-to-maximum radial wall thickness (SDt-16) obtained from a cine-set of short-axis slice... Abstract
Cited 3 times since 2009 (0.2 per year) source: EuropePMC
The American journal of cardiology, Volume 104, Issue 3, 6 1 2009, Pages 440-446 Usefulness of multimodality imaging for detecting differences in temporal occurrence of left ventricular systolic mechanical events in healthy young adults. Marsan NA, Tops LF, Westenberg JJ, Delgado V, de Roos A, van der Wall EE, Schalij MJ, Bax JJ
Detailed information about the absolute temporal occurrence of myocardial motion and deformation events during the cardiac cycle is still lacking. However, the normal time range of these parameters may be of great importance as a reference for detecting and interpreting mechanical dyssynchrony and for identifying a delayed contraction in case of left ventricular (LV) dysfunction. The aim of this study was to determine in young healthy subjects and for different LV segments the value of (1) time... Abstract
Cited 27 times since 2009 (1.8 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 3, 17 3 2009, Pages 249-257 Long-term improvement in left ventricular strain after successful catheter ablation for atrial fibrillation in patients with preserved left ventricular systolic function. Tops LF, Den Uijl DW, Delgado V, Marsan NA, Zeppenfeld K, Holman E, van der Wall EE, Schalij MJ, Bax JJ
Background: The effect of successful catheter ablation on left ventricular (LV) strain in patients with preserved LV systolic function is unknown. The aim of the present study was to assess the long-term effects of catheter ablation for atrial fibrillation (AF) on LV strain and strain rate in patients with preserved LV ejection fraction. Methods and results: In 78 patients undergoing catheter ablation for AF, speckle tracking strain imaging was performed to assess LV strain in 3 directions (radi... Abstract
Cited 32 times since 2009 (2.1 per year) source: EuropePMC
The American journal of cardiology, Volume 103, Issue 11, 8 2 2009, Pages 1506-1512 Left ventricular rotational mechanics in acute myocardial infarction and in chronic (ischemic and nonischemic) heart failure patients. Bertini M, Nucifora G, Marsan NA, Delgado V, van Bommel RJ, Boriani G, Biffi M, Holman ER, Van der Wall EE, Schalij MJ, Bax JJ
Left ventricular (LV) twist and untwisting rate are emerging as global and thorough parameters for assessment of LV function. This study explored differences of LV twist and untwisting rate in patients with acute myocardial infarction (AMI) and patients with ischemic and nonischemic chronic heart failure (HF). Fifty patients with AMI, 49 with ischemic HF, and 38 with nonischemic HF were studied. As a control group, 28 subjects without evidence of structural heart disease were included. Speckle-t... Abstract
Cited 2 times since 2009 (0.1 per year) source: EuropePMC
American heart journal, Volume 157, Issue 5, 25 4 2009, Pages 882.e1-8 Real-time 3-dimensional echocardiography early after acute myocardial infarction: incremental value of echo-contrast for assessment of left ventricular function. Nucifora G, Marsan NA, Holman ER, Siebelink HM, van Werkhoven JM, Scholte AJ, van der Wall EE, Schalij MJ, Bax JJ
Background: Accurate and reproducible assessment of left ventricular (LV) systolic function is important in patients with acute myocardial infarction (AMI). Real-time 3-dimensional echocardiography (RT3DE) is an accurate technique, but it relies heavily on good image quality. The aim of the present study was to evaluate the incremental value of contrast-enhanced RT3DE. Methods: A total of 140 consecutive patients (58 +/- 11 years, 78% men) with ST-elevation AMI clinically underwent nonenhanced a... Abstract