Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
484 results
Cited 31 times since 2011 (2.3 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 33, Issue 2, 1 1 2011, Pages 312-319 Left ventricular diastolic function assessment from three-dimensional three-directional velocity-encoded MRI with retrospective valve tracking. Brandts A, Bertini M, van Dijk EJ, Delgado V, Marsan NA, van der Geest RJ, Siebelink HM, de Roos A, Bax JJ, Westenberg JJ
Purpose: To compare parameters describing left ventricular (LV) diastolic function obtained with three-dimensional (3D) three-directional velocity-encoded (VE) MRI with retrospective valve tracking and two-dimensional (2D) one-directional VE MRI in patients with ischemic heart failure. Second, to compare classification of LV diastolic function, and in particular for discriminating restrictive filling patterns, with both MRI techniques versus Doppler echocardiography. Materials and methods: The 3... Abstract
Cited 21 times since 2011 (1.6 per year) source: EuropePMC
American heart journal, Volume 161, Issue 3, 31 5 2011, Pages 552-557 Clinical and echocardiographic predictors of nonresponse to cardiac resynchronization therapy. Shanks M, Delgado V, Ng AC, Auger D, Mooyaart EA, Bertini M, Marsan NA, van Bommel RJ, Holman ER, Poldermans D, Schalij MJ, Bax JJ
Background: Lack of response to cardiac resynchronization therapy (CRT) ranges between 30% to 40% of heart failure (HF) patients. The present study aimed to evaluate the clinical and echocardiographic determinants of nonresponse to CRT. Methods: A total of 581 patients (66.4 ± 10.0 years, 77.9% male) with advanced HF scheduled for CRT implantation were included. Clinical and echocardiographic evaluations were performed at baseline and 6 months of follow-up. Nonresponse was defined as no improvem... Abstract
Cited 22 times since 2011 (1.6 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 91, Issue 1, 1 1 2011, Pages 113-121 Three-dimensional echocardiography for the preoperative assessment of patients with left ventricular aneurysm. Marsan NA, Westenberg JJ, Roes SD, van Bommel RJ, Delgado V, van der Geest RJ, de Roos A, Klautz RJ, Reiber JC, Bax JJ
Background: Surgical ventricular reconstruction has been proposed as a treatment option in heart failure patients with left ventricular (LV) aneurysm. The feasibility of this procedure has some limitations, and extensive preoperative evaluation is necessary to give the correct indication. For this purpose, magnetic resonance imaging (MRI) is currently considered the gold standard, providing accurate quantification of LV shape, size, and global and regional function together with the assessment o... Abstract
Cited 91 times since 2011 (6.8 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 57, Issue 3, 1 1 2011, Pages 324-331 Left atrial strain predicts reverse remodeling after catheter ablation for atrial fibrillation. Tops LF, Delgado V, Bertini M, Marsan NA, Den Uijl DW, Trines SA, Zeppenfeld K, Holman E, Schalij MJ, Bax JJ
Objectives: The purpose of this study was to assess left atrial (LA) strain during long-term follow-up after catheter ablation for atrial fibrillation and to find predictors for LA reverse remodeling. Background: The association between LA reverse remodeling and improvement in LA strain after catheter ablation has not been investigated thus far. Methods: In 148 patients undergoing catheter ablation for atrial fibrillation, LA volumes and LA strain were assessed with echocardiography at baseline... Abstract
Cited 7 times since 2010 (0.5 per year) source: EuropePMC
The American journal of cardiology, Volume 107, Issue 5, 22 4 2010, Pages 736-740 Value of the surface electrocardiogram in detecting right ventricular dilatation in the presence of left bundle branch block. Van Bommel RJ, Marsan NA, Delgado V, van Rijnsoever EP, Schalij MJ, Bax JJ, Wellens HJ
Approximately 20% of patients with heart failure have left bundle branch block (LBBB) on surface electrocardiogram (ECG). In this group of patients, detection of right ventricular (RV) dilatation on standard ECG can be of clinical relevance because RV enlargement is an important prognostic marker. Consequently, the aim of this study was to evaluate diagnostic accuracy for several electrocardiographic criteria in determining significant RV dilatation in these patients. Standard 12-lead ECGs were... Abstract
Cited 167 times since 2010 (12.5 per year) source: EuropePMC
Circulation, Volume 123, Issue 1, 20 3 2010, Pages 70-78 Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial scar to predict long-term survival of ischemic heart failure patients undergoing cardiac resynchronization therapy. Delgado V, van Bommel RJ, Bertini M, Borleffs CJ, Marsan NA, Arnold CT, Nucifora G, van de Veire NR, Ypenburg C, Boersma E, Holman ER, Schalij MJ, Bax JJ
Background: The relative merits of left ventricular (LV) dyssynchrony, LV lead position, and myocardial scar to predict long-term outcome after cardiac resynchronization therapy remain unknown and were evaluated in the present study. Methods and results: In 397 ischemic heart failure patients, 2-dimensional speckle tracking imaging was performed, with comprehensive assessment of LV radial dyssynchrony, identification of the segment with latest mechanical activation, and detection of myocardial s... Abstract
Cited 117 times since 2010 (8.7 per year) source: Scopus
American heart journal, Volume 160, Issue 6, 1 1 2010, Pages 1113-1120 Impact of left ventricular systolic function on clinical and echocardiographic outcomes following transcatheter aortic valve implantation for severe aortic stenosis. Ewe SH, Ajmone Marsan N, Pepi M, Delgado V, Tamborini G, Muratori M, Ng AC, van der Kley F, de Weger A, Schalij MJ, Fusari M, Biglioli P, Bax JJ
Background: This study aimed to evaluate the impact of baseline left ventricular (LV) systolic function on clinical and echocardiographic outcomes following transcatheter aortic valve implantation (TAVI). Survival of patients undergoing TAVI was also compared with that of a population undergoing surgical aortic valve replacement. Methods: One hundred forty-seven consecutive patients (mean age=80±7 years) undergoing TAVI in 2 centers were included. Mean follow-up period was 9.1±5.1 months. Result... Abstract
Cited 29 times since 2010 (2.1 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 96, Issue 21, 1 1 2010, Pages 1737-1743 Left ventricular rotational mechanics in patients with coronary artery disease: differences in subendocardial and subepicardial layers. Bertini M, Delgado V, Nucifora G, Ajmone Marsan N, Ng AC, Shanks M, Antoni ML, van de Veire NR, van Bommel RJ, Rapezzi C, Schalij MJ, Bax JJ
Objective: Subendocardial and subepicardial layers have opposite orientation of the myofibres and they are differently affected by coronary artery disease. This study investigated the differences in subendocardial and subepicardial left ventricular (LV) twist in patients with coronary artery disease. Methods: 214 patients were included in the study: 60 with first ST elevation myocardial infarction (STEMI), 111 with chronic ischaemic heart failure (HF) and 43 normal subjects. Real-time three-dime... Abstract
Cited 5 times since 2010 (0.4 per year) source: EuropePMC
Nature reviews. Cardiology, Volume 7, Issue 11, 1 1 2010, Pages 604-606 Cardiomyopathies: Myocardial fibrosis assessed by CMR to predict events in HCM. Ajmone Marsan N, Bax JJ
Cited 30 times since 2010 (2.2 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6, Issue 5, 1 1 2010, Pages 643-652 Multimodality imaging in transcatheter aortic valve implantation: key steps to assess procedural feasibility. Delgado V, Ewe SH, Ng AC, van der Kley F, Marsan NA, Schuijf JD, Schalij MJ, Bax JJ
Transcatheter aortic valve implantation (TAVI) has been an important breakthrough in the treatment of patients with symptomatic, severe aortic stenosis and contraindications for surgical aortic valve replacement. Accurate aortic root measurements and evaluation of spatial relationships with the coronary ostia are crucial in pre-operative TAVI assessment. In addition, characterisation of the peripheral artery anatomy and aorta is an important key step in the procedural feasibility evaluation. The... Abstract
Cited 11 times since 2010 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 10, 1 1 2010, Pages 1404-1409 Left ventricular muscle and fluid mechanics in acute myocardial infarction. Nucifora G, Delgado V, Bertini M, Marsan NA, Van de Veire NR, Ng AC, Siebelink HM, Schalij MJ, Holman ER, Sengupta PP, Bax JJ
Left ventricular (LV) diastolic filling is characterized by the formation of intraventricular rotational bodies of fluid (termed "vortex rings") that optimize the efficiency of LV ejection. The aim of the present study was to evaluate the morphology and dynamics of LV diastolic vortex ring formation early after acute myocardial infarction (AMI), in relation to LV diastolic function and infarct size. A total of 94 patients with a first ST-segment elevation AMI (59 ± 11 years; 78% men) w... Abstract
Cited 6 times since 2010 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 8, 1 1 2010, Pages 1146-1151 Effect of cardiac resynchronization therapy in patients with New York Heart Association functional class IV heart failure. van Bommel RJ, van Rijnsoever E, Borleffs CJ, Delgado V, Marsan NA, Bertini M, Schalij MJ, Bax JJ
Cardiac resynchronization therapy (CRT) is considered a class I indication in treatment of patients with New York Heart Association (NYHA) functional class III and IV heart failure. However, only small numbers of patients in large clinical trials have been in NYHA functional class IV. Therefore, little is known about the effects of CRT in this group. Therefore, we evaluated the effects of CRT in patients with NYHA functional class IV heart failure. Of all patients referred for CRT implantation,... Abstract
Cited 22 times since 2010 (1.6 per year) source: EuropePMC
American heart journal, Volume 160, Issue 4, 1 1 2010, Pages 737-743 Prevalence and characteristics of patients with clinical improvement but not significant left ventricular reverse remodeling after cardiac resynchronization therapy. Auger D, van Bommel RJ, Bertini M, Delgado V, Ng AC, Ewe SH, Shanks M, Marsan NA, Mooyaart EA, Witkowski T, Poldermans D, Schalij MJ, Bax JJ
Background: Although most patients who improve in clinical status after cardiac resynchronization therapy (CRT) also show a significant left ventricular (LV) reverse remodeling, some patients do not show echocardiographic improvement. The aim of the present study was to evaluate the degree of agreement between clinical and echocardiographic response to CRT in a large cohort of heart failure patients, and to evaluate the characteristics of patients with clinical response but without echocardiogra... Abstract
Cited 24 times since 2010 (1.8 per year) source: EuropePMC
European heart journal, Volume 31, Issue 24, 23 4 2010, Pages 3054-3062 Association of intraventricular mechanical dyssynchrony with response to cardiac resynchronization therapy in heart failure patients with a narrow QRS complex. van Bommel RJ, Tanaka H, Delgado V, Bertini M, Borleffs CJ, Ajmone Marsan N, Holzmeister J, Ruschitzka F, Schalij MJ, Bax JJ, Gorcsan J
Aims: current criteria for cardiac resynchronization therapy (CRT) are restricted to patients with a wide QRS complex (>120 ms). Overall, only 30% of heart failure patients demonstrate a wide QRS complex, leaving the majority of heart failure patients without this treatment option. However, patients with a narrow QRS complex exhibit left ventricular (LV) mechanical dyssynchrony, as assessed with echocardiography. To further elucidate the possible beneficial effect of CRT in heart failure pati... Abstract
Cited 74 times since 2010 (5.4 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 3, Issue 6, 1 1 2010, Pages 694-700 Quantitative assessment of mitral regurgitation: comparison between three-dimensional transesophageal echocardiography and magnetic resonance imaging. Shanks M, Siebelink HM, Delgado V, van de Veire NR, Ng AC, Sieders A, Schuijf JD, Lamb HJ, Ajmone Marsan N, Westenberg JJ, Kroft LJ, de Roos A, Bax JJ
Background: quantification of mitral regurgitation severity with 2-dimensional (2D) imaging techniques remains challenging. The present study compared the accuracy of 2D transesophageal echocardiography (TEE) and 3-dimensional (3D) TEE for quantification of mitral regurgitation, using MRI as the reference method. Methods and results: two-dimensional and 3D TEE and cardiac MRI were performed in 30 patients with mitral regurgitation. Mitral effective regurgitant orifice area (EROA) and regurgitant... Abstract
Cited 46 times since 2010 (3.3 per year) source: EuropePMC
European heart journal, Volume 31, Issue 22, 7 1 2010, Pages 2783-2790 Morbidity and mortality in heart failure patients treated with cardiac resynchronization therapy: influence of pre-implantation characteristics on long-term outcome. van Bommel RJ, Borleffs CJ, Ypenburg C, Marsan NA, Delgado V, Bertini M, van der Wall EE, Schalij MJ, Bax JJ
Aims: Cardiac resynchronization therapy (CRT) improves cardiac function, heart failure symptoms, and prognosis in selected patients. Many baseline characteristics associated with heart failure may influence prognosis after CRT. The objective of this study was to evaluate the effect of several baseline characteristics in relation to long-term prognosis in heart failure patients treated with CRT. Methods and results: A total of 716 consecutive heart failure patients treated with CRT were included... Abstract
Cited 7 times since 2010 (0.5 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 5, 23 4 2010, Pages 682-687 Effect of cardiac resynchronization therapy on subendo- and subepicardial left ventricular twist mechanics and relation to favorable outcome. Bertini M, Delgado V, Nucifora G, Marsan NA, Ng AC, Shanks M, Van Bommel RJ, Borleffs CJ, Ewe SH, Boriani G, Biffi M, Schalij MJ, Bax JJ
The analysis of left ventricular (LV) mechanics provides novel insights into the effects of cardiac resynchronization therapy (CRT) on LV performance. Currently, advances in speckle-tracking echocardiographic analysis have permitted the characterization of subendocardial and subepicardial LV twist. The aim of this study was to investigate the role of the acute changes in subendocardial and subepicardial LV twist for the prediction of midterm beneficial effects of CRT. A total of 84 patients with... Abstract
European heart journal, Volume 31, Issue 19, 8 2 2010, Pages 2323-2325 Changes in functional mitral regurgitation after cardiac resynchronization therapy. Marsan NA, Bax JJ
Cited 20 times since 2010 (1.4 per year) source: EuropePMC
The American journal of cardiology, Volume 106, Issue 1, 1 1 2010, Pages 73-77 Effect of cardiac resynchronization therapy on cerebral blood flow. van Bommel RJ, Marsan NA, Koppen H, Delgado V, Borleffs CJ, Ypenburg C, Bertini M, Schalij MJ, Bax JJ
Decreased cerebral blood flow is frequently observed in patients with heart failure, and this could be the result of impaired cardiac systolic function. Cardiac resynchronization therapy (CRT) improves cardiac function and heart failure symptoms in selected patients. The effects of CRT on cerebral blood flow have not been previously evaluated. In the present study, left ventricular systolic function and cerebral blood flow were assessed in 35 patients with heart failure, before and 6 months afte... Abstract
Cited 1 times since 2010 (0.1 per year) source: EuropePMC
Minerva cardioangiologica, Volume 58, Issue 3, 1 1 2010, Pages 313-332 Echocardiography and non-invasive imaging in cardiac resynchronization therapy. Delgado V, Mooyaart EA, Ct Ng A, Auger D, Bertini M, van Bommel RJ, Yiu KH, Ewe SH, Witkowski TG, Ajmone Marsan N, Schuijf JD, van der Wall EE, Schalij MJ, Bax JJ
The beneficial effects of cardiac resynchronization therapy (CRT) on morbidity and mortality in advanced heart failure patients have been extensively demonstrated. However, previous single- and multicenter studies demonstrated that approximately 30-40% of CRT patients do not show significant clinical improvement or LV reverse remodeling despite fulfilling current inclusion criteria. In search of novel indices that may help to improve the selection of responders to CRT, non-invasive multimodality... Abstract