Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
196 results
Cited 46 times since 2014 (4.5 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 4, 25 4 2014, Pages 1583-1590 Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, Gittenberger-de Groot AC, Poelmann RE, Klautz RJ, Lindeman JH, Goumans MJ, Palmen M, Mohamed SA, Sievers HH, Bogers AJ, DeRuiter MC
Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made. Methods: Ascending aortic wall biopsies were divided into 4 groups: bicuspid (n=36) and tricuspid (n=23) without and with dilation. The expression of vascular smo... Abstract
Cited 12 times since 2013 (1.1 per year) source: EuropePMC
European journal of anaesthesiology, Volume 30, Issue 11, 1 1 2013, Pages 685-694 Minimised closed circuit coronary artery bypass grafting in the elderly is associated with lower levels of organ-specific biomarkers: a prospective randomised study. van Boven WJ, Gerritsen WB, Driessen AH, van Dongen EP, Klautz RJ, Aarts LP
Background: Restrictive fluid management may protect organ function and improve postoperative outcome in elderly coronary artery bypass grafting (CABG) patients. Objective: We assessed organ-specific biomarker release to study the contribution of a fluid restrictive closed circuit concept to organ protection in elderly CABG patients. Cardiac, respiratory and abdominal organ injury was measured during and following minimal fluid coronary artery bypass grafting (mCABG), off-pump coronary artery by... Abstract
Cited 4 times since 2013 (0.4 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 20 3 2013 The role of exercise echocardiography in the management of mitral valve disease. Jansen R, Kracht PA, Cramer MJ, Tietge WJ, van Herwerden LA, Klautz RJ, Kluin J, Chamuleau SA
Purpose: Exercise echocardiography can assess the dynamic component of mitral valve (MV) disease and may therefore be helpful for the clinical decision-making by the heart team. The purpose of this study is to determine the role of exercise echocardiography in the management of disproportionately symptomatic or otherwise atypical patients with mitral regurgitation (MR) and stenosis (MS) in clinical practice. Methods: Data of 14 MR and 14 MS patients, including echocardiograms at rest, were prese... Abstract
Cited 14 times since 2013 (1.3 per year) source: Scopus
Interactive cardiovascular and thoracic surgery, Volume 17, Issue 3, 4 1 2013, Pages 523-530 Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery. Kortekaas KA, Lindeman JH, Reinders ME, Palmen M, Klautz RJ, de Groot PG, Roest M
Objectives: Post-cardiac surgery vasoplegia is a common complication of cardiac surgery, characterized by profound loss of systemic vascular resistance. This results in severe hypotension, high cardiac output and metabolic acidosis reflecting inadequate tissue perfusion. The pathophysiological mechanisms underlying this syndrome remain unknown. We hypothesized that this vasoplegia reflects endothelial dysfunction, either as pre-existing condition or as a consequence of the surgical procedure. Me... Abstract
Cited 5 times since 2013 (0.5 per year) source: Scopus
The American journal of cardiology, Volume 112, Issue 5, 24 4 2013, Pages 714-719 Mitral valve geometry and hemodynamics after surgical mitral valve annuloplasty and implications for percutaneous treatment of patients with recurrent mitral regurgitation. Al Amri I, Debonnaire P, Witkowski T, van der Kley F, Palmen M, de Weger A, Klautz RJ, Bax JJ, Schalij MJ, Ajmone Marsan N, Delgado V
The feasibility of transcatheter mitral valve therapy (edge-to-edge or valve-in-ring technique) in patients with significant mitral regurgitation (MR) recurrence after surgical restrictive mitral valve annuloplasty remains unknown. The aim of the present study was to investigate the eligibility for transcatheter mitral valve therapy of high-surgical-risk patients with significant MR recurrence after initial successful restrictive mitral valve annuloplasty. A total of 47 patients (age 67 ± 10 yea... Abstract
Cited 57 times since 2013 (5.2 per year) source: EuropePMC
PloS one, Volume 8, Issue 4, 24 4 2013, Pages e62395 Citation analysis may severely underestimate the impact of clinical research as compared to basic research. van Eck NJ, Waltman L, van Raan AF, Klautz RJ, Peul WC
Background: Citation analysis has become an important tool for research performance assessment in the medical sciences. However, different areas of medical research may have considerably different citation practices, even within the same medical field. Because of this, it is unclear to what extent citation-based bibliometric indicators allow for valid comparisons between research units active in different areas of medical research. Methodology: A visualization methodology is introduced that reve... Abstract
Cited 23 times since 2013 (2.1 per year) source: Scopus
European journal of heart failure, Volume 15, Issue 9, 10 2 2013, Pages 1011-1018 Galectin-3 and left ventricular reverse remodelling after surgical mitral valve repair. Kortekaas KA, Hoogslag GE, de Boer RA, Dokter MM, Versteegh MI, Braun J, Marsan NA, Verwey HF, Delgado V, Schalij MJ, Klautz RJ
Aims: Mitral valve repair in patients with functional mitral regurgitation (FMR) has been associated with beneficial left ventricular (LV) reverse remodelling. Recently, galectin-3 emerged as a marker of myocardial inflammation and fibrosis which may influence LV remodelling after surgery. The aim of the current study was to evaluate the association between pre-operative galectin-3 levels and LV reverse remodelling in heart failure patients with significant FMR who underwent mitral valve repair.... Abstract
Cited 73 times since 2013 (6.6 per year) source: Scopus
Antioxidants & redox signaling, Volume 19, Issue 6, 26 4 2013, Pages 535-545 Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal. de Vries DK, Kortekaas KA, Tsikas D, Wijermars LG, van Noorden CJ, Suchy MT, Cobbaert CM, Klautz RJ, Schaapherder AF, Lindeman JH
Aims: Ischemia/reperfusion (I/R) injury is a common clinical problem. Although the pathophysiological mechanisms underlying I/R injury are unclear, oxidative damage is considered a key factor in the initiation of I/R injury. Findings from preclinical studies consistently show that quenching reactive oxygen and nitrogen species (RONS), thus limiting oxidative damage, alleviates I/R injury. Results from clinical intervention studies on the other hand are largely inconclusive. In this study, we sys... Abstract
Cited 23 times since 2013 (2 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 145, Issue 6, 16 3 2013, Pages 1611-6, 1616.e1-4 Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery. Later AF, Sitniakowsky LS, van Hilten JA, van de Watering L, Brand A, Smit NP, Klautz RJ
Objectives: Anti-inflammatory effects of tranexamic acid and aprotinin, used to abate perioperative blood loss, are reported and might be of substantial clinical relevance. The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved. Methods: Whole-blood messenger ribonucleic acid expression of 114 inflammatory genes was compared pre- and postoperatively in 35 patients randomized to receive either placebo, tranexamic acid, or aprot... Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 94, Issue 6, 1 1 2012, Pages 2122-2125 Implantation of a left ventricular assist device in patients with a complex apical anatomy. Palmen M, Verwey HF, Haeck ML, Holman ER, Schalij MJ, Klautz RJ
Implantation of a left ventricular assist device can be challenging in patients with an altered apical anatomy after cardiac surgery or as the result of the presence of a calcified apical aneurysm. In this paper we present 2 cases with a challenging apical anatomy and introduce a new surgical technique facilitating left ventricular assist device implantation in these patients. Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
Cytokine, Volume 61, Issue 2, 24 4 2012, Pages 438-444 A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery. Later AF, Bruggemans EF, Romijn FP, van Pelt J, Klautz RJ
Purpose: Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels. Additional drug specific immune modulating qualities are often mentioned in the discussion on which antifibrinolytic can best be used. To determine the extent and relevance of these effects, we investigated cytokine and growth factor plasma levels in cardiac surgery patients randomized to receive either tranexamic... Abstract
Cited 12 times since 2012 (1 per year) source: Scopus
European journal of heart failure, Volume 15, Issue 4, 9 2 2012, Pages 400-407 Heart failure determines the myocardial inflammatory response to injury. Kortekaas KA, Lindeman JH, Versteegh MI, van Beelen E, Kleemann R, Klautz RJ
Aims: Systemic complications after cardiac surgery are common in heart failure patients. However, the pathophysiological mechanisms, such as a different local inflammatory response of failing hearts, remain in question. This study examines whether failing hearts respond differently to cardioplegic arrest and reperfusion compared with non-failing hearts (controls). Methods and results: The inflammatory response was evaluated in samples collected simultaneously from the radial artery and coronary... Abstract
Cited 98 times since 2012 (8.3 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 14, Issue 1, 29 5 2012, Pages 69-76 Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair. Witkowski TG, Thomas JD, Debonnaire PJ, Delgado V, Hoke U, Ewe SH, Versteegh MI, Holman ER, Schalij MJ, Bax JJ, Klautz RJ, Marsan NA
Aims: Despite a successful surgical procedure and adherence to current recommendations, postoperative left ventricular (LV) dysfunction after mitral valve repair (MVr) for organic mitral regurgitation (MR) may still occur. New approaches are therefore needed to detect subclinical preoperative LV dysfunction. LV global longitudinal strain (GLS), assessed with speckle-tracking echocardiographic analysis, has been proposed as a novel measure to better depict latent LV dysfunction. The aim of this s... Abstract
Cited 10 times since 2012 (0.8 per year) source: Scopus
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 5, 1 1 2012, Pages 202-207 Preexisting heart failure is an underestimated risk factor in cardiac surgery. Kortekaas KA, Lindeman JH, Versteegh MI, Stijnen T, Dion RA, Klautz RJ
Background: Heart failure is characterised as a strong risk factor for systemic failure after cardiac surgery. However, the impact has never been substantiated. Methods: Patients with heart failure (n = 48) - scheduled for elective ventricular reconstruction or external constraint device-were compared with a one-to-one matched control group of patients without heart failure undergoing cardiac surgery between 2006 and 2009. Results: As expected, patients with heart failure more frequently experie... Abstract
Cited 21 times since 2012 (1.7 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 4, 1 1 2012, Pages 167-175 Treatment options in end-stage heart failure: where to go from here? Haeck ML, Hoogslag GE, Rodrigo SF, Atsma DE, Klautz RJ, van der Wall EE, Schalij MJ, Verwey HF
Chronic heart failure is a major healthcare problem associated with high morbidity and mortality. Despite significant progress in treatment strategies, the prognosis of heart failure patients remains poor. The golden standard treatment for heart failure is heart transplantation after failure of medical therapy, surgery and/or cardiac resynchronisation therapy. In order to improve patients' outcome and quality of life, new emerging treatment modalities are currently being investigated, inclu... Abstract
Cited 11 times since 2012 (0.9 per year) source: Scopus
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 41, Issue 5, 9 2 2012, Pages e117-25 No prominent role for terminal complement activation in the early myocardial reperfusion phase following cardiac surgery. Kortekaas KA, van der Pol P, Lindeman JH, Baan CC, van Kooten C, Klautz RJ
Objectives: Complement activation is considered an important mediator of myocardial ischaemia/reperfusion (I/R) injury. Although complement inhibitors are highly effective in animals, clinical trials fail to show a substantial benefit in humans. This raises questions on the role of complement activation in human myocardial I/R injury. Methods: Soluble C5b-9, i.e. terminal complement complex, and C5a were assessed in patients with non-ischaemic (n = 10) and ischaemic heart failure (n = 10), and p... Abstract
Cited 8 times since 2012 (0.7 per year) source: EuropePMC
Current opinion in cardiology, Volume 27, Issue 2, 1 1 2012, Pages 111-117 Mitral valve surgery in low ejection fraction, severe ischemic mitral regurgitation patients: should we repair them all? Braun J, Klautz RJ
Purpose of review: The optimal surgical treatment of chronic ischemic mitral regurgitation still is the subject of much debate in the surgical and cardiological communities. Although combined restrictive mitral annuloplasty and revascularization has demonstrated good results with regard to improvement of clinical status, low rates of recurrent mitral regurgitation and sustained left ventricular reverse remodeling, a survival benefit still has not been demonstrated. In addition, not all patients... Abstract
Cited 13 times since 2012 (1.1 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 3, 1 1 2012, Pages 94-101 Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial. Tietge WJ, de Heer LM, van Hessen MW, Jansen R, Bots ML, van Gilst W, Schalij M, Klautz RJ, Van den Brink RB, Van Herwerden LA, Doevendans PA, Chamuleau SA, Kluin J
Background: Asymptomatic severe mitral valve (MV) regurgitation with preserved left ventricular function is a challenging clinical entity as data on the recommended treatment strategy for these patients are scarce and conflicting. For asymptomatic patients, no randomised trial has been performed for objectivising the best treatment strategy. Methods: The Dutch AMR (Asymptomatic Mitral Regurgitation) trial is a multicenter, prospective, randomised trial comparing early MV repair versus watchful w... Abstract
Cited 28 times since 2012 (2.3 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 93, Issue 3, 31 5 2012, Pages 754-760 Changes in left ventricular function after mitral valve repair for severe organic mitral regurgitation. Witkowski TG, Thomas JD, Delgado V, van Rijnsoever E, Ng AC, Hoke U, Ewe SH, Auger D, Yiu KH, Holman ER, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA
Background: Limited data are available on the changes in left ventricular (LV) contractile function at long-term follow-up after mitral valve repair (MVr). Moreover, assessment of LV systolic function in patients undergoing MVr is troublesome with current methods, given that mitral regurgitation is characterized by increased preload and decreased afterload, potentially masking LV dysfunction. The aim of this study was to assess the value of LV global strain (longitudinal and circumferential) mea... Abstract
Cited 6 times since 2012 (0.5 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 41, Issue 1, 1 1 2012, Pages 74-80; discussion 80-1 Management of mitral regurgitation during left ventricular reconstruction for ischemic heart failure. Klein P, Braun J, Holman ER, Versteegh MI, Verwey HF, Dion RA, Bax JJ, Klautz RJ
Objective: Remodeling of the left ventricle (LV) in ischemic cardiomyopathy frequently leads to functional mitral regurgitation (MR). The indication for correcting MR in patients undergoing LV reconstruction (LVR) is unclear. In this study, we evaluated our strategy of correcting MR≥grade 2+ by restrictive mitral annuloplasty (RMA) during LVR. Methods: We studied 92 consecutive patients (76 men, mean age 61±10 years) who underwent LVR for ischemic heart failure (IHF). RMA was performed in all pa... Abstract