Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
138 results
Cited 2 times since 2018 (0.4 per year) source: EuropePMC
Anatomical record (Hoboken, N.J. : 2007), Volume 302, Issue 1, 9 2 2018, Pages 83-92 Disruption of RHOA-ROCK Signaling Results in Atrioventricular Block and Disturbed Development of the Putative Atrioventricular Node. Kelder TP, Vicente-Steijn R, Poelmann RE, Schalij MJ, Deruiter MC, Jongbloed MRM, Gittenberger-de Groot AC
The RHOA-ROCK signaling pathway is involved in numerous developmental processes, including cell proliferation, differentiation and migration. RHOA is expressed in the atrioventricular node (AVN) and altered expression of RHOA results in atrioventricular (AV) conduction disorders in mice. The current study aims to detect functional AVN disorders after disturbing RHOA-ROCK signaling in chicken embryos. RHOA-ROCK signaling was inhibited chemically by using the Rho-kinase inhibitor compound Y-27632... Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 9, 27 4 2018, Pages 701-707 Coronary anatomy in Turner syndrome versus patients with isolated bicuspid aortic valves. Koenraadt WMC, Siebelink HJ, Bartelings MM, Schalij MJ, van der Vlugt MJ, van den Bosch AE, Budde RPJ, Roos-Hesselink JW, Duijnhouwer AL, van den Hoven AT, DeRuiter MC, Jongbloed MRM
Objective: Variations in coronary anatomy, like absent left main stem and left dominant coronary system, have been described in patients with Turner syndrome (TS) and in patients with bicuspid aortic valves (BAV). It is unknown whether coronary variations in TS are related to BAV and to specific BAV subtypes. Aim: To compare coronary anatomy in patients with TS with/without BAV versus isolated BAV and to study BAV morphology subtypes in these groups. Methods: Coronary anatomy and BAV morphology... Abstract
Cited 3 times since 2018 (0.5 per year) source: EuropePMC
International journal of cardiology, Volume 274, 12 2 2018, Pages 113-116 Aortic dissection and prophylactic surgery in congenital heart disease. Kuijpers JM, Koolbergen DR, Groenink M, Boekholdt SM, Meijboom FJ, Jongbloed MRM, Hoendermis ES, Duijnhouwer AL, Mulder BJM, Bouma BJ
Background: Proximal aortic dilatation in certain congenital heart diseases (CHD) prompts concerns about dissection and consideration of prophylactic surgery. To evaluate contemporary prophylactic practice, we determined incidence of aortic dissection and prophylactic surgery in aortopathy-associated CHD, compared to Marfan syndrom (MFS) and controls. Methods and results: We followed patients from the CONCOR adult CHD registry (2002-2015), with a native proximal aorta and aortopathy-associated C... Abstract
Cited 2 times since 2018 (0.4 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 4, Issue 10, 29 5 2018, Pages 1308-1318 Noninvasive Identification of Ventricular Tachycardia-Related Anatomical Isthmuses in Repaired Tetralogy of Fallot: What Is the Role of the 12-Lead Ventricular Tachycardia Electrocardiogram. Brouwer C, Kapel GFL, Jongbloed MRM, Schalij MJ, de Riva Silva M, Zeppenfeld K
Objectives: This study sought to evaluate the relation between 12-lead ventricular tachycardia (VT) electrocardiography (ECG) and VT-related anatomical isthmuses (AIs) in repaired tetralogy of Fallot (rTOF). Background: Slow-conducting AIs are the dominant VT substrate in rTOF. Whether an AI is considered critical relies on pace mapping (PM) guided by the VT ECG. Methods: VT ECGs, electroanatomical mapping data and PM results were analyzed in 25 rTOF patients (group 1) (age 57 ± 13 years). Selec... Abstract
Cited 15 times since 2018 (2.6 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 156, Issue 6, 18 3 2018, Pages 2260-2269 Coding of coronary arterial origin and branching in congenital heart disease: The modified Leiden Convention. Gittenberger-de Groot AC, Koenraadt WMC, Bartelings MM, Bökenkamp R, DeRuiter MC, Hazekamp MG, Bogers AJJC, Quaegebeur JM, Schalij MJ, Vliegen HW, Poelmann RE, Jongbloed MRM
Objectives: Variations in coronary anatomy are common and may relate to the position of the coronary ostium relative to the aortic sinus, the angle of coronary take-off, or the course of the coronary arterial branches. Several classification systems have been proposed. However, they all lack a simple rationale that is applicable irrespective of the relative position of the great arteries, as well as in bicuspid aortic valves. We present a modification of a relatively simple system introduced in... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
International journal of cardiology, Volume 273, 24 4 2018, Pages 203-206 ECG derived ventricular gradient exceeds echocardiography in the early detection of pulmonary hypertension in scleroderma patients. Meijer FMM, Kies P, Jongbloed MRM, van Wijngaarden SE, Swenne CA, Man S, Schalij MJ, de Vries-Bouwstra JK, Vliegen HW
Background: Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension (PH) which is a major cause of death in this population. Echocardiographic (TTE) derived pulmonary arterial pressure (PAP) can be unreliable for the early detection of PH. Previous studies demonstrate that the ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) can detect PH in a heterogeneous population suspected of PH. The aim of this study is to assess... Abstract
Cited 36 times since 2018 (6 per year) source: EuropePMC
Circulation, Volume 137, Issue 22, 1 1 2018, Pages 2393-2407 Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical Implications of Adverse Energetics in Patients With a Fontan Circulation. Rijnberg FM, Hazekamp MG, Wentzel JJ, de Koning PJH, Westenberg JJM, Jongbloed MRM, Blom NA, Roest AAW
Visualization and quantification of the adverse effects of distorted blood flow are important emerging fields in cardiology. Abnormal blood flow patterns can be seen in various cardiovascular diseases and are associated with increased energy loss. These adverse energetics can be measured and quantified using 3-dimensional blood flow data, derived from computational fluid dynamics and 4-dimensional flow magnetic resonance imaging, and provide new, promising hemodynamic markers. In patients with p... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 4, Issue 6, 28 4 2018, Pages 781-793 Slow Conducting Electroanatomic Isthmuses: An Important Link Between QRS Duration and Ventricular Tachycardia in Tetralogy of Fallot. Kapel GFL, Brouwer C, Jalal Z, Sacher F, Venlet J, Schalij MJ, Thambo JB, Jongbloed MRM, Blom NA, de Riva M, Zeppenfeld K
Objectives: This study sought to evaluate the influence of slow conducting anatomic isthmuses (SCAI) as dominant ventricular tachycardia (VT) substrate on QRS duration. Background: QRS prolongation has been associated with VT in repaired tetralogy of Fallot. Methods: Seventy-eight repaired tetralogy of Fallot patients (age 37 ± 15 years, 52 male, QRS duration 153 ± 29 ms, 67 right bundle branch blocks [RBBB]) underwent programmed stimulation and electroanatomic activation mapping during sinus rh... Abstract
Cited 6 times since 2018 (1 per year) source: EuropePMC
International journal of cardiology, Volume 252, 1 1 2018, Pages 88-93 Incidence and risk factors of post-operative arrhythmias and sudden cardiac death after atrioventricular septal defect (AVSD) correction: Up to 47years of follow-up. Kharbanda RK, Blom NA, Hazekamp MG, Yildiz P, Mulder BJM, Wolterbeek R, Weijerman ME, Schalij MJ, Jongbloed MRM, Roest AAW
Background: Atrioventricular septal defect (AVSD) has an incidence of 4-5.3 per 10.000 live births and is associated with Down syndrome (DS). Data on arrhythmias and sudden cardiac death (SCD) after AVSD correction is scarce. Aim: To analyse the incidence of post-operative arrhythmias and SCD after AVSD correction and explore risk factors. Methods: This is a retrospective multicenter study including patients after biventricular AVSD correction. Univariate and multivariate analyses were performed... Abstract
Cited 4 times since 2018 (0.6 per year) source: EuropePMC
Pediatric cardiology, Volume 39, Issue 4, 16 3 2018, Pages 690-694 Pulmonary Valve Morphology in Patients with Bicuspid Aortic Valves. Koenraadt WMC, Bartelings MM, Gittenberger-de Groot AC, Bökenkamp R, DeRuiter MC, Schalij MJ, Jongbloed MRM
The aortic and pulmonary valve share a common developmental origin from the embryonic arterial trunk. Bicuspid aortic valve is the most common congenital anomaly and can occur isolated as well as in association with other congenital heart disease (CHD). Data on pulmonary valve morphology in these cases are scarce. In this study, we aimed to determine pulmonary valve morphology in hearts with BAV associated with CHD. In 83 post-mortem heart specimens with BAV and associated CHD, pulmonary valve m... Abstract
Cited 5 times since 2018 (0.8 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 104, Issue 14, 5 1 2018, Pages 1200-1207 Impact of surgery on presence and dimensions of anatomical isthmuses in tetralogy of Fallot. Kapel GFL, Laranjo S, Blom NA, Hazekamp MG, Schalij MJ, Bartelings MM, Jongbloed MRM, Zeppenfeld K
Objective: In tetralogy of Fallot (TOF), the dominant ventricular tachycardia substrates are slow-conducting anatomical isthmuses. Surgical correction has evolved, which might have influenced isthmus presence and dimensions. Methods: One hundred and forty-two postmortem TOF specimens (84/58 corrected/uncorrected) were studied for isthmus presence. Isthmus 1 is located between the tricuspid annulus and right ventricular (RV) outflow tract (RVOT) patch/RV incision, isthmus 2 between RVOT patch/RV... Abstract
Cited 148 times since 2017 (23.4 per year) source: EuropePMC
Circulation research, Volume 122, Issue 3, 27 4 2017, Pages e5-e16 MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo. Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL
Rationale: There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used in single experimental models. Consequently, data and techniques have been difficult to reproduce across models and laboratories, analysis is time consuming, and only specialist researchers can quantify data. Objective: Here, we describe and validate an automated, open-source software tool (MUSCLEMOTION) ada... Abstract
Cited 5 times since 2017 (0.8 per year) source: EuropePMC
PloS one, Volume 12, Issue 11, 30 5 2017, Pages e0188048 Intracardiac anatomical relationships and potential for streaming in double inlet left ventricles. Meyer SL, Jongbloed MR, Ho SY, Bartelings MM, McCarthy KP, Uemura H, Ebels T
The aim of this study was to gain better understanding of the variable anatomical features of double inlet left ventricle hearts without cavopulmonary connection that would potentially facilitate favorable streaming. Thirty-nine post-mortem specimens of double inlet left ventricle without cavopulmonary connection were investigated. The focus was on anatomical characteristics that could influence the flow and separation of deoxygenated and oxygenated blood in the ventricles. Elements of interest... Abstract
Cited 10 times since 2017 (1.5 per year) source: EuropePMC
Cardiovascular research, Volume 113, Issue 10, 1 1 2017, Pages 1186-1197 RHOA-ROCK signalling is necessary for lateralization and differentiation of the developing sinoatrial node. Vicente-Steijn R, Kelder TP, Tertoolen LG, Wisse LJ, Pijnappels DA, Poelmann RE, Schalij MJ, deRuiter MC, Gittenberger-de Groot AC, Jongbloed MRM
Aims: RHOA-ROCK signalling regulates cell migration, proliferation, differentiation, and transcription. RHOA is expressed in the developing cardiac conduction system in chicken and mice. In early development, the entire sinus venosus myocardium, including both the transient left-sided and the definitive sinoatrial node (SAN), has pacemaker potential. Later, pacemaker potential is restricted to the right-sided SAN. Disruption of RHOA expression in adult mice causes arrhythmias including bradycard... Abstract
Cited 6 times since 2017 (0.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 104, Issue 5, 27 4 2017, Pages 385-393 Coronary anatomy in children with bicuspid aortic valves and associated congenital heart disease. Koenraadt WMC, Bartelings MM, Bökenkamp R, Gittenberger-de Groot AC, DeRuiter MC, Schalij MJ, Jongbloed MR
Objective: In patients with bicuspid aortic valve (BAV), coronary anatomy is variable. High take-off coronary arteries have been described, but data are scarce, especially when associated with complex congenital heart disease (CHD). The purpose of this study was to describe coronary patterns in these patients. Methods: In 84 postmortem heart specimens with BAV and associated CHD, position and height of the coronary ostia were studied and related to BAV morphology. Results: High take-off right (R... Abstract
Cited 3 times since 2017 (0.4 per year) source: EuropePMC
International journal of cardiology, Volume 243, 2 1 2017, Pages 191-193 Clinical course of tricuspid regurgitation in repaired tetralogy of Fallot. Woudstra OI, Bokma JP, Winter MM, Kiès P, Jongbloed MRM, Vliegen HW, Groenink M, Meijboom FJ, Mulder BJM, Bouma BJ
Background: Little is known on the clinical course of tricuspid regurgitation (TR) in patients with repaired tetralogy of Fallot (rTOF) and which patients are at particular risk. This study aims to determine TR course, characteristics associated with TR progression, and the prognostic relevance of TR in rTOF patients. Methods: In this dualcenter cohort study, rTOF patients from a prospective national registry with ≥1 cardiac magnetic resonance imaging study and ≥2 echocardiograms available were... Abstract
Cited 5 times since 2017 (0.7 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 69, Issue 19, 1 1 2017, Pages 2465-2466 Role of Acquired Cardiovascular Disease in Tetralogy of Fallot Patients >50 Years of Age. Bokma JP, Winter MM, Kuijpers JM, Jongbloed MR, Duijnhouwer AL, Hoendermis ES, Sieswerda GT, Post MC, Mulder BJM, Bouma BJ
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 11, 1 1 2016, Pages 653-665 NT-proBNP and exercise capacity in adult patients with congenital heart disease and a prosthetic valve: a multicentre PROSTAVA study. Schoonbeek RC, Pieper PG, van Slooten YJ, Freling HG, Sieswerda GT, van Dijk AP, Jongbloed MR, Post MC, Bouma BJ, Berger RM, Ebels T, van Melle JP
Objectives: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity. Methods: In this multi-centre cross-sectional observational study, data regarding medical history, e... Abstract
Cited 8 times since 2016 (1.1 per year) source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists, Volume 245, Issue 11, 18 3 2016, Pages 1107-1123 14-3-3epsilon controls multiple developmental processes in the mouse heart. Gittenberger-de Groot AC, Hoppenbrouwers T, Miquerol L, Kosaka Y, Poelmann RE, Wisse LJ, Yost HJ, Jongbloed MR, Deruiter MC, Brunelli L
Background: 14-3-3ε plays an important role in the maturation of the compact ventricular myocardium by modulating the cardiomyocyte cell cycle via p27kip1 . However, additional cardiac defects are possible given the ubiquitous expression pattern of this protein. Results: Germ line deletion of 14-3-3ε led to malalignment of both the outflow tract (OFT) and atrioventricular (AV) cushions, with resulting tricuspid stenosis and atresia, mitral valve abnormalities, and perimembranous ventricular sept... Abstract
Cited 2 times since 2016 (0.2 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 24, Issue 6, 20 3 2016, Pages 400-409 Tailored circulatory intervention in adults with pulmonary hypertension due to congenital heart disease. Couperus LE, Henkens IR, Jongbloed MRM, Hazekamp MG, Schalij MJ, Vliegen HW
Background: Adults with pulmonary hypertension associated with congenital heart disease (PH-CHD) often have residual shunts. Invasive interventions aim to optimise pulmonary flow and prevent right ventricular failure. However, eligibility for procedures strongly depends on the adaptation potential of the pulmonary vasculature and right ventricle to resultant circulatory changes. Current guidelines are not sufficiently applicable to individual patients, who exhibit great diversity and complexity... Abstract