Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
251 results
Journal of the American College of Cardiology, Volume 83, Issue 1, 1 1 2024, Pages 47-59 Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure. Alogna A, Berboth L, Faragli A, Ötvös J, Lo Muzio FP, di Mauro V, Modica J, Quarta E, Semmler L, Deißler PM, Berger YW, Tran KL, de Marchi B, Longinotti-Buitoni G, Degli Esposti L, Guillot E, Bazile D, Iafisco M, Dotti A, Bang ML, de Luca C, Brandenberger C, Benazzi L, di Silvestre D, de Palma A, Primeßnig U, Hohendanner F, Perna S, Buttini F, Colombo P, Mühlfeld C, Steendijk P, Mauri P, Tschöpe C, Borlaug B, Pieske BM, Attanasio P, Post H, Heinzel FR, Catalucci D
Background: The lack of disease-modifying drugs is one of the major unmet needs in patients with heart failure (HF). Peptides are highly selective molecules with the potential to act directly on cardiomyocytes. However, a strategy for effective delivery of therapeutics to the heart is lacking. Objectives: In this study, the authors sought to assess tolerability and efficacy of an inhalable lung-to-heart nano-in-micro technology (LungToHeartNIM) for cardiac-specific targeting of a mimetic peptide... Abstract
Cited 2 times since 2023 (2 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 81, Issue 20, 1 1 2023, Pages 1979-1991 Hemodynamic Assessment in Takotsubo Syndrome. Stiermaier T, Reil JC, Sequeira V, Rawish E, Mezger M, Pätz T, Paitazoglou C, Schmidt T, Frerker C, Steendijk P, Reil GH, Eitel I
Background: Takotsubo syndrome (TTS) is a reversible form of heart failure with incompletely understood pathophysiology. Objectives: This study analyzed altered cardiac hemodynamics during TTS to elucidate underlying disease mechanisms. Methods: Left ventricular (LV) pressure-volume loops were recorded in 24 consecutive patients with TTS and a control population of 20 participants without cardiovascular diseases. Results: TTS was associated with impaired LV contractility (end-systolic elastance... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 133, Issue 1, 12 2 2022, Pages 20-26 Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model. Berboth L, Zirngast B, Manninger M, Steendijk P, Tschöpe C, Scherr D, Hinghofer-Szalkay HG, Goswami N, Petersen LG, Mächler H, Alogna A
Lower body negative pressure (LBNP) is a tool to study compensatory mechanisms to central hypovolemia for decades. However, the underlying hemodynamic mechanisms were mostly assessed noninvasively and remain unclear. We hypothesized that incremental LBNP reduces diastolic filling and thereby affects left ventricular (LV) diastolic suction (DS). Here, we investigated the impact of graded LBNP at three different levels of seal as well as during β-adrenergic stimulation by invasive pressure-volume... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
BMC medical education, Volume 21, Issue 1, 8 2 2021, Pages 332 The effect of peer modelling and discussing modelled feedback principles on medical students' feedback skills: a quasi-experimental study. van Blankenstein FM, O'Sullivan JF, Saab N, Steendijk P
Background: Teaching is an important professional skill for physicians and providing feedback is an important part of teaching. Medical students can practice their feedback skills by giving each other peer feedback. Therefore, we developed a peer feedback training in which students observed a peer that modelled the use of good feedback principles. Students then elaborated on the modelled feedback principles through peer discussion. This combination of peer modelling and discussing the modelled f... Abstract
Cited 19 times since 2021 (6.4 per year) source: EuropePMC
ESC heart failure, Volume 8, Issue 4, 2 1 2021, Pages 2968-2981 Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction. Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC
Aims: Failure of right ventricular (RV) function worsens outcome in pulmonary hypertension (PH). The adaptation of RV contractility to afterload, the RV-pulmonary artery (PA) coupling, is defined by the ratio of RV end-systolic to PA elastances (Ees/Ea). Using pressure-volume loop (PV-L) technique we aimed to identify an Ees/Ea cut-off predictive for overall survival and to assess hemodynamic and morphologic conditions for adapted RV function in secondary PH due to heart failure with reduced eje... Abstract
Cited 2 times since 2021 (0.6 per year) source: EuropePMC
Teaching and learning in medicine, Volume 33, Issue 5, 15 3 2021, Pages 473-482 What Were You Thinking? Medical Students' Metacognition and Perceptions of Self-Regulated Learning. Versteeg M, Bressers G, Wijnen-Meijer M, Ommering BWC, de Beaufort AJ, Steendijk P
Phenomenon: As a component of self-regulated learning, metacognition is gaining attention in the medical education research community. Metacognition, simply put, is thinking about one's thinking. Having a metacognitive habit of mind is essential for healthcare professionals. This study identified the metacognitive competencies of medical students as they completed a conceptual learning task, and provided insight into students' perceptions of self-regulated learning in their curriculum.... Abstract
Cited 2 times since 2021 (0.6 per year) source: EuropePMC
European journal of applied physiology, Volume 121, Issue 5, 22 4 2021, Pages 1405-1418 Biventricular function in exercise during autonomic (thoracic epidural) block. Wink J, Steendijk P, Tsonaka R, de Wilde RBP, Friedericy HJ, Braun J, Veering BT, Aarts LPHJ, Wouters PF
Background: Blockade of cardiac sympathetic fibers by thoracic epidural anesthesia (TEA) was previously shown to reduce right and left ventricular systolic function and effective pulmonary arterial elastance. At conditions of constant paced heart rate, cardiac output and systemic hemodynamics were unchanged. In this study, we further investigated the effect of cardiac sympathicolysis during physical stress and increased oxygen demand. Methods: In a cross-over design, 12 patients scheduled to und... Abstract
Cited 15 times since 2021 (4.5 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 22, Issue 2, 1 1 2021, Pages 168-176 Pressure-volume loop validation of TAPSE/PASP for right ventricular arterial coupling in heart failure with pulmonary hypertension. Schmeisser A, Rauwolf T, Groscheck T, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Steendijk P, Braun-Dullaeus RC
Aims: The aim of this study was to validate the tricuspid annular plane systolic excursion/systolic pulmonary artery (PA) pressure (TAPSE/PASP) ratio with the invasive pressure-volume (PV) loop-derived end-systolic right ventricular (RV) elastance/PA elastance (Ees/Ea) ratio in patients with heart failure with reduced ejection fraction (HFREF) and secondary pulmonary hypertension (PH). Methods and results: The relationship of TAPSE and TAPSE/PASP with RV-PV loop (single-beat)-derived contractili... Abstract
BMC medical education, Volume 20, Issue 1, 5 1 2020, Pages 250 Refuting misconceptions in medical physiology. Versteeg M, van Loon MH, Wijnen-Meijer M, Steendijk P
Background: In medical physiology, educators and students face a serious challenge termed misconceptions. Misconceptions are incorrect ideas that do not match current scientific views. Accordingly, they have shown to hamper teaching and learning of physiological concepts. Conceptual Change Theory forms the basis of new teaching and learning practices that may alleviate misconceptions and facilitate critical thinking skills that are essential in becoming knowledgeable, self-regulated health profe... Abstract
Cited 14 times since 2020 (3.6 per year) source: EuropePMC
The Journal of physiology, Volume 598, Issue 15, 14 2 2020, Pages 3129-3153 CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect. Reil JC, Reil GH, Kovács Á, Sequeira V, Waddingham MT, Lodi M, Herwig M, Ghaderi S, Kreusser MM, Papp Z, Voigt N, Dobrev D, Meyhöfer S, Langer HF, Maier LS, Linz D, Mügge A, Hohl M, Steendijk P, Hamdani N
Key points: The Anrep effect represents the alteration of left ventricular (LV) contractility to acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at constant preload. As a result of the missing preload stretch in our model, the Anrep effect differs from the slow force response and has a different mechanism. The Anrep effect demonstrated two different phases. First, the sudden increased afterload was momentary equilibrated by the enhanced LV contractility as a re... Abstract
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Medical science educator, Volume 30, Issue 3, 9 2 2020, Pages 1211-1219 Making a Lecture Stick: the Effect of Spaced Instruction on Knowledge Retention in Medical Education. Timmer MCJ, Steendijk P, Arend SM, Versteeg M
Introduction: Poor knowledge retention is a persistent problem among medical students. This challenging issue may be addressed by optimizing frequently used instructional designs, such as lectures. Guided by neuroscientific literature, we designed a spaced learning lecture in which the educator repeats the to-be-learned information using short temporal intervals. We investigated if this modified instructional design could enhance students' retention. Materials and methods: Second-year medic... Abstract
European heart journal. Cardiovascular Imaging, Volume 21, Issue 3, 1 1 2020, Pages 299-306 Exercise haemodynamics after restrictive mitral annuloplasty for functional mitral regurgitation. Petrus AHJ, Tops LF, Holman ER, Marsan NA, Bax JJ, Schalij MJ, Steendijk P, Klautz RJM, Braun J
Aims: Restrictive mitral annuloplasty (RMA) can provide a durable solution for functional mitral regurgitation (MR), but might result in obstruction to antegrade mitral flow. Aim of this study was to assess the magnitude of change in mitral valve area (MVA) during exercise after RMA, to relate the change in MVA to left ventricular (LV) geometry and function, and to assess its haemodynamic and clinical impact. Methods and results: Bicycle exercise echocardiography was performed in 32 patients aft... Abstract
Cited 20 times since 2019 (4.6 per year) source: EuropePMC
Medical education, Volume 54, Issue 3, 20 3 2019, Pages 205-216 Conceptualising spaced learning in health professions education: A scoping review. Versteeg M, Hendriks RA, Thomas A, Ommering BWC, Steendijk P
Objectives: To investigate the definitions and applications of 'spaced learning' and to propose future directions for advancing its study and practice in health professions education. Method: The authors searched five online databases for articles published on spaced learning in health professions education prior to February 2018. Two researchers independently screened articles for eligibility with set inclusion criteria. They extracted and analysed key data using both quantitative and... Abstract
Cited 6 times since 2019 (1.3 per year) source: EuropePMC
BMC cardiovascular disorders, Volume 19, Issue 1, 15 3 2019, Pages 217 Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs. Abawi D, Faragli A, Schwarzl M, Manninger M, Zweiker D, Kresoja KP, Verderber J, Zirngast B, Maechler H, Steendijk P, Pieske B, Post H, Alogna A
Background: Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects left ventricular stroke work (LV SW). Dividing LV SW by time, a measure of LV SW min- 1 is obtained sharing the same unit as CPO (W). We aimed to validate CPO as a marker of LV SW min- 1 und... Abstract
Cited 10 times since 2019 (2.1 per year) source: EuropePMC
PloS one, Volume 14, Issue 6, 14 2 2019, Pages e0217582 Hypercholesterolemia affects cardiac function, infarct size and inflammation in APOE*3-Leiden mice following myocardial ischemia-reperfusion injury. Pluijmert NJ, den Haan MC, van Zuylen VL, Steendijk P, de Boer HC, van Zonneveld AJ, Fibbe WE, Schalij MJ, Quax PHA, Atsma DE
Background: Hypercholesterolemia is a major risk factor for ischemic heart disease including acute myocardial infarction. However, long-term effects of hypercholesterolemia in a rodent myocardial ischemia-reperfusion injury model are unknown. Therefore, the effects of diet-induced hypercholesterolemia on cardiac function and remodeling were investigated up to eight weeks after myocardial ischemia-reperfusion (MI-R) injury which was induced in either normocholesterolemic (NC-MI) or hypercholester... Abstract
Cited 3 times since 2019 (0.6 per year) source: EuropePMC
Advances in physiology education, Volume 43, Issue 1, 1 1 2019, Pages 7-14 Informing the uninformed: a multitier approach to uncover students' misconceptions on cardiovascular physiology. Versteeg M, Wijnen-Meijer M, Steendijk P
Misconceptions about physiology are a major threat to accurate scientific and clinical reasoning in medical education. Awareness is often mentioned as a prerequisite to achieve conceptual understanding; however, students are frequently unaware of their incorrect understanding. We explored the multitier approach as a tool to obtain insight into students' awareness and misconceptions regarding cardiovascular physiology. Biomedical sciences students ( N = 81) participated in a diagnostic multi... Abstract
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
Perspectives on medical education, Volume 8, Issue 1, 5 1 2019, Pages 9-16 Putting post-decision wagering to the test: a measure of self-perceived knowledge in basic sciences? Versteeg M, Steendijk P
Introduction: Students learn more effectively when they know what they do not know. Gaining insight into students' metacognitive awareness is needed as misalignment between actual and self-perceived knowledge impedes their learning process. The optimal method of measuring self-perceived knowledge is still under debate. In this study, we evaluate the use of psychology-derived post-decision wagering for mapping students self-perceived knowledge. Methods: Students (n = 71) performed a pre-test... Abstract
Cited 17 times since 2018 (3.2 per year) source: EuropePMC
The Journal of pediatrics, Volume 207, 18 3 2018, Pages 109-116.e2 Low Cerebral Oxygenation in Preterm Infants Is Associated with Adverse Neurodevelopmental Outcome. Alderliesten T, van Bel F, van der Aa NE, Steendijk P, van Haastert IC, de Vries LS, Groenendaal F, Lemmers P
Objective: To assess whether high and low levels of cerebral oxygenation (regional cerebral oxygenation [rScO2]) in infants born at Abstract
Cited 4 times since 2018 (0.7 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 20, Issue 12, 1 1 2018, Pages 1989-1996 Electrical latency predicts the optimal left ventricular endocardial pacing site: results from a multicentre international registry. Sieniewicz BJ, Behar JM, Sohal M, Gould J, Claridge S, Porter B, Niederer S, Gamble JHP, Betts TR, Jais P, Derval N, Spragg DD, Steendijk P, van Gelder BM, Bracke FA, Rinaldi CA
Aims: The optimal site for biventricular endocardial (BIVENDO) pacing remains undefined. Acute haemodynamic response (AHR) is reproducible marker of left ventricular (LV) contractility, best expressed as the change in the maximum rate of LV pressure (LV-dp/dtmax), from a baseline state. We examined the relationship between factors known to impact LV contractility, whilst delivering BIVENDO pacing at a variety of LV endocardial (LVENDO) locations. Methods and results: We compiled a registry of ac... Abstract
Cited 9 times since 2018 (1.6 per year) source: EuropePMC
Advances in health sciences education : theory and practice, Volume 24, Issue 1, 20 3 2018, Pages 151-165 Peer instruction improves comprehension and transfer of physiological concepts: a randomized comparison with self-explanation. Versteeg M, van Blankenstein FM, Putter H, Steendijk P
Comprehension of physiology is essential for development of clinical reasoning. However, medical students often struggle to understand physiological concepts. Interactive learning through Peer instruction (PI) is known to stimulate students' comprehension, but its relative efficacy and working mechanisms remain to be elucidated. In this study, we investigated if and how PI could optimize comprehension of physiological concepts and transfer relative to Self-explanation (SE) which is consider... Abstract