Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
174 results
Cited 15 times since 2017 (2.2 per year) source: EuropePMC
Scientific reports, Volume 7, Issue 1, 31 5 2017, Pages 10269 Deficiency of TLR4 homologue RP105 aggravates outward remodeling in a murine model of arteriovenous fistula failure. Bezhaeva T, Wong C, de Vries MR, van der Veer EP, van Alem CMA, Que I, Lalai RA, van Zonneveld AJ, Rotmans JI, Quax PHA
Arteriovenous access dysfunction is a major cause of morbidity for hemodialysis patients. The pathophysiology of arteriovenous fistula (AVF) maturation failure is associated with inflammation, impaired outward remodeling (OR) and intimal hyperplasia. RP105 is a critical physiologic regulator of TLR4 signaling in numerous cell types. In the present study, we investigated the impact of RP105 on AVF maturation, and defined cell-specific effects of RP105 on macrophages and vascular smooth muscle cel... Abstract
Cited 75 times since 2017 (10.6 per year) source: EuropePMC
European journal of pharmacology, Volume 816, 21 3 2017, Pages 107-115 Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis. Parma L, Baganha F, Quax PHA, de Vries MR
Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth and instability. The vessels' immaturity, with profound structural and functional abnormalities, leads to recurrent intraplaque hemorrhage. This review discusses new insights of atherosclerotic neovascularization, including the effects of lea... Abstract
Cited 22 times since 2017 (3.1 per year) source: EuropePMC
Atherosclerosis, Volume 261, 13 2 2017, Pages 26-36 Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis. Welten SMJ, de Jong RCM, Wezel A, de Vries MR, Boonstra MC, Parma L, Jukema JW, van der Sluis TC, Arens R, Bot I, Agrawal S, Quax PHA, Nossent AY
Background and aims: We aimed at investigating the role of 14q32 microRNAs in intimal hyperplasia and accelerated atherosclerosis; two major contributors to restenosis. Restenosis occurs regularly in patients treated for coronary artery disease and peripheral arterial disease. We have previously shown that inhibition of 14q32 microRNAs leads to increased post-ischemic neovascularization, and microRNA miR-494 also decreased atherosclerosis, while increasing plaque stability. We hypothesized that... Abstract
Cited 9 times since 2017 (1.3 per year) source: EuropePMC
Thrombosis and haemostasis, Volume 117, Issue 7, 6 1 2017, Pages 1412-1419 von Willebrand factor deficiency leads to impaired blood flow recovery after ischaemia in mice. de Vries MR, Peters EAB, Quax PHA, Nossent AY
Neovascularisation, i. e. arteriogenesis and angiogenesis, is an inflammatory process. Therefore attraction and extravasation of leukocytes is essential for effective blood flow recovery after ischaemia. Previous studies have shown that von Willebrand factor (VWF) is a negative regulator of angiogenesis. However, it has also been shown that VWF facilitates leukocyte attraction and extravasation. We aimed to investigate the role of VWF in arteriogenesis and angiogenesis during post-ischaemic neov... Abstract
Cited 21 times since 2017 (2.9 per year) source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America, Volume 114, Issue 15, 27 4 2017, Pages E3022-E3031 High-throughput identification of small molecules that affect human embryonic vascular development. Vazão H, Rosa S, Barata T, Costa R, Pitrez PR, Honório I, de Vries MR, Papatsenko D, Benedito R, Saris D, Khademhosseini A, Quax PH, Pereira CF, Mercader N, Fernandes H, Ferreira L
Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and limited mechanistic information regarding the biological pathways and potential adverse consequences in humans. To develop a screening platform for molecules that affect hum... Abstract
Cited 11 times since 2017 (1.5 per year) source: EuropePMC
Molecular therapy. Nucleic acids, Volume 7, 14 2 2017, Pages 61-70 Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494. Welten SMJ, de Vries MR, Peters EAB, Agrawal S, Quax PHA, Nossent AY
Improving the efficacy of neovascularization is a promising strategy to restore perfusion of ischemic tissues in patients with peripheral arterial disease. The 14q32 microRNA cluster is highly involved in neovascularization. The Mef2a transcription factor has been shown to induce transcription of the microRNAs within this cluster. We inhibited expression of Mef2a using gene-silencing oligonucleotides (GSOs) in an in vivo hind limb ischemia model. Treatment with GSO-Mef2a clearly improved blood f... Abstract
Cited 20 times since 2017 (2.8 per year) source: EuropePMC
Journal of the American Heart Association, Volume 6, Issue 3, 8 2 2017, Pages e005281 CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia. Nossent AY, Bastiaansen AJ, Peters EA, de Vries MR, Aref Z, Welten SM, de Jager SC, van der Pouw Kraan TC, Quax PH
Background: In order to identify factors that stimulate arteriogenesis after ischemia, we followed gene expression profiles in two extreme models for collateral artery formation over 28 days after hindlimb ischemia, namely "good-responding" C57BL/6 mice and "poor-responding" BALB/c mice. Methods and results: Although BALB/c mice show very poor blood flow recovery after ischemia, most known proarteriogenic genes were upregulated more excessively and for a longer period than in... Abstract
Cited 9 times since 2016 (1.2 per year) source: EuropePMC
Case reports in surgery, Volume 2016, 9 2 2016, Pages 9306262 Xiphoidectomy: A Surgical Intervention for an Underdocumented Disorder. Hogerzeil DP, Hartholt KA, de Vries MR
Two patients who presented with nonspecific thoracic and upper abdominal symptoms and tenderness of the xiphoid process are discussed. Both patients had undergone extensive examinations, but no source for their symptoms could be found. Plain chest radiographs revealed an anterior displacement of the xiphoid process in both patients. Physical examination confirmed this to be the primary source of discomfort. Anterior displacement of the xiphoid process may be the result of significant weight gain... Abstract
Cited 58 times since 2016 (7.6 per year) source: EuropePMC
Current opinion in lipidology, Volume 27, Issue 5, 1 1 2016, Pages 499-506 Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization. de Vries MR, Quax PH
Purpose of review: The review discusses the recent literature on plaque angiogenesis and its relation to inflammation and plaque destabilization. Furthermore, it discusses how plaque angiogenesis can be used to monitor atherosclerosis and serve as a therapeutic target. Recent findings: Histopathologic studies have shown a clear relationship between plaque angiogenesis, intraplaque hemorrhage (IPH), plaque vulnerability, and cardiovascular events. Hypoxia is a main driver of plaque angiogenesis a... Abstract
Cited 23 times since 2016 (2.9 per year) source: EuropePMC
Scientific reports, Volume 6, 27 4 2016, Pages 30439 Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model. Wong C, Bezhaeva T, Rothuizen TC, Metselaar JM, de Vries MR, Verbeek FP, Vahrmeijer AL, Wezel A, van Zonneveld AJ, Rabelink TJ, Quax PH, Rotmans JI
Arteriovenous fistulas (AVF) for hemodialysis access have a 1-year primary patency rate of only 60%, mainly as a result of maturation failure that is caused by insufficient outward remodeling and intimal hyperplasia. The exact pathophysiology remains unknown, but the inflammatory vascular response is thought to play an important role. In the present study we demonstrate that targeted liposomal delivery of prednisolone increases outward remodeling of the AVF in a murine model. Liposomes accumulat... Abstract
Cited 132 times since 2016 (16.5 per year) source: EuropePMC
Nature reviews. Cardiology, Volume 13, Issue 8, 19 3 2016, Pages 451-470 Vein graft failure: from pathophysiology to clinical outcomes. de Vries MR, Simons KH, Jukema JW, Braun J, Quax PH
Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside from balloon angioplasty, bypass graft surgery is the most commonly performed revascularization technique for occlusive arterial disease. Coronary artery bypass graft surgery is performed in patients with left main coronary artery disease and three-vessel coronary disease, whereas peripheral artery bypass graft surgery is used to treat patients with late-stage peripheral artery occlusive disease. The great... Abstract
Cited 11 times since 2016 (1.4 per year) source: EuropePMC
Scientific reports, Volume 6, 7 1 2016, Pages 24248 Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response. Wezel A, de Vries MR, Maassen JM, Kip P, Peters EA, Karper JC, Kuiper J, Bot I, Quax PHA
Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls. In a hypercholesterolemic setting (LDLr(-/-)/RP105(-/-) versus LDLr(-/-) mice),... Abstract
Cited 9 times since 2016 (1.1 per year) source: EuropePMC
Journal of internal medicine, Volume 279, Issue 6, 23 4 2016, Pages 592-605 Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages. Frodermann V, van Duijn J, van Puijvelde GH, van Santbrink PJ, Lagraauw HM, de Vries MR, Quax PH, Bot I, Foks AC, de Jager SC, Kuiper J
Background: Staphylococcus aureus cell wall components can induce IL-10 responses by immune cells, which may be atheroprotective. Therefore, in this study, we investigated whether heat-killed S. aureus (HK-SA) could inhibit the development of atherosclerosis. Methods: Atherosclerosis-susceptible LDL receptor-deficient mice were administered intraperitoneal HK-SA twice weekly and fed a Western-type diet for 6 weeks. Results: HK-SA administration resulted in a 1.6-fold increase in IL-10 production... Abstract
Cited 7 times since 2016 (0.8 per year) source: EuropePMC
BMJ case reports, Volume 2016, 15 3 2016, Pages bcr2015213106 Multiple carpometacarpal dislocations and an associated fracture of the hamate: an uncommon injury. Brinkman JN, Hartholt KA, de Vries MR
Dislocation of the four ulnar carpometacarpal (CMC) joints with a concurrent fracture of the hamate is a rare injury, with a paucity of published cases. A great force is required to dislocate a CMC joint. Diagnosis can easily be missed, due to other serious associated injuries. Appropriate treatment of CMC joint dislocations usually leads to excellent outcomes. We present a case of dorsal dislocation of the four ulnar CMC joints after punching a wall. The injury was treated with a closed reducti... Abstract
Cited 13 times since 2016 (1.6 per year) source: EuropePMC
Journal of visualized experiments : JoVE, Issue 108, 3 1 2016, Pages e53294 A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail. Wong CY, de Vries MR, Wang Y, van der Vorst JR, Vahrmeijer AL, van Zonneveld AJ, Hamming JF, Roy-Chaudhury P, Rabelink TJ, Quax PH, Rotmans JI
The arteriovenous fistula (AVF) still suffers from a high number of failures caused by insufficient remodeling and intimal hyperplasia from which the exact pathophysiology remains unknown. In order to unravel the pathophysiology a murine model of AVF-failure was developed in which the configuration of the anastomosis resembles the preferred situation in the clinical setting. A model was described in which an AVF is created by connecting the venous end of the branch of the external jugular vein t... Abstract
Cited 29 times since 2015 (3.4 per year) source: EuropePMC
Annals of surgery, Volume 262, Issue 5, 1 1 2015, Pages 841-7; discussion 847-8 Inhibition of MicroRNA-494 Reduces Carotid Artery Atherosclerotic Lesion Development and Increases Plaque Stability. Wezel A, Welten SM, Razawy W, Lagraauw HM, de Vries MR, Goossens EA, Boonstra MC, Hamming JF, Kandimalla ER, Kuiper J, Quax PH, Nossent AY, Bot I
Objectives: Unstable atherosclerotic lesions in carotid arteries require surgical endarterectomy to reduce the risk of ischemic stroke. We aimed to identify microRNAs that exert a broad effect on atherosclerotic plaque formation and stability in the carotid artery. Background: We made a selection of 164 genes involved in atherosclerosis. Using www.targetscan.org, we determined which microRNAs potentially regulate expression of these genes. We identified multiple microRNAs from the 14q32 microRNA... Abstract
The Journal of hand surgery, European volume, Volume 41, Issue 7, 14 2 2015, Pages 776-777 The use of single photon emission computed tomography/computed tomography to differentiate between pain arising from trapeziometacarpal joint and scaphotrapeziotrapezoid joint osteoarthritis. van Rijn SF, de Vries MR, Kraan GA
Cited 2 times since 2015 (0.2 per year) source: EuropePMC
International journal of surgery case reports, Volume 15, 30 5 2015, Pages 133-136 Case report of nail bed injury after blunt trauma; what lies beneath the nail? Nanninga GL, de Leur K, van den Boom AL, de Vries MR, van Ginhoven TM
Introduction: A stable, mobile and sensate fingertip is of paramount importance to perform daily tasks and sense dangerous situations. Unfortunately, fingertips are easily injured with various extents of soft tissue damage. Delayed and inadequate treatment of nail bed injuries may cause substantial clinical problems. The aim is to increase awareness about nail bed injuries among physicians who often treat these patients. Presentation of case: We present a 26-year-old male with blunt trauma to a... Abstract
Cited 34 times since 2015 (3.7 per year) source: EuropePMC
PloS one, Volume 10, Issue 4, 17 3 2015, Pages e0124347 Galectin-2 induces a proinflammatory, anti-arteriogenic phenotype in monocytes and macrophages. Yıldırım C, Vogel DY, Hollander MR, Baggen JM, Fontijn RD, Nieuwenhuis S, Haverkamp A, de Vries MR, Quax PH, Garcia-Vallejo JJ, van der Laan AM, Dijkstra CD, van der Pouw Kraan TC, van Royen N, Horrevoets AJ
Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients. The inhibiting effect of galectin-2 on arteriogenesis was confirmed in vivo, but the mechanism is largely unknown. In this study we aimed to explore the effects of galectin-2 on monocyte/macrophage phenotype in vitro and vivo, and to identify the receptor by which galectin-... Abstract
Cited 20 times since 2015 (2.2 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 49, Issue 4, 18 3 2015, Pages 480-486 Elastin is a key regulator of outward remodeling in arteriovenous fistulas. Wong CY, Rothuizen TC, de Vries MR, Rabelink TJ, Hamming JF, van Zonneveld AJ, Quax PH, Rotmans JI
Objectives: Maturation failure is the major limitation of arteriovenous fistulas (AVFs) as hemodialysis access conduits. Indeed, 30-50% of AVFs fail to mature due to intimal hyperplasia and insufficient outward remodeling. Elastin has emerged as an important determinant of vascular remodeling. Here the role of elastin in AVF remodeling in elastin haplodeficient (eln(+/-)) mice undergoing AVF surgery has been studied. Methods: Unilateral AVFs between the branch of the jugular vein and carotid art... Abstract