Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
239 results
Cited 14 times since 2019 (3.1 per year) source: EuropePMC
Frontiers in microbiology, Volume 10, 17 3 2019, Pages 2394 Metavirome Sequencing to Evaluate Norovirus Diversity in Sewage and Related Bioaccumulated Oysters. Strubbia S, Schaeffer J, Oude Munnink BB, Besnard A, Phan MVT, Nieuwenhuijse DF, de Graaf M, Schapendonk CME, Wacrenier C, Cotten M, Koopmans MPG, Le Guyader FS
Metagenomic sequencing is a promising method to determine the virus diversity in environmental samples such as sewage or shellfish. However, to identify the short RNA genomes of human enteric viruses among the large diversity of nucleic acids present in such complex matrices, method optimization is still needed. This work presents methodological developments focused on norovirus, a small ssRNA non-enveloped virus known as the major cause of human gastroenteritis worldwide and frequently present... Abstract
Cited 316 times since 2019 (69 per year) source: EuropePMC
The Journal of general virology, Volume 100, Issue 10, 1 1 2019, Pages 1393-1406 Updated classification of norovirus genogroups and genotypes. Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MPG, Vinjé J
Noroviruses are genetically diverse RNA viruses associated with acute gastroenteritis in mammalian hosts. Phylogenetically, they can be segregated into different genogroups as well as P (polymerase)-groups and further into genotypes and P-types based on amino acid diversity of the complete VP1 gene and nucleotide diversity of the RNA-dependent RNA polymerase (RdRp) region of ORF1, respectively. In recent years, several new noroviruses have been reported that warrant an update of the existing cla... Abstract
Cited 32 times since 2019 (6.5 per year) source: EuropePMC
Viruses, Volume 11, Issue 5, 25 4 2019, Pages E478 Animals as Reservoir for Human Norovirus. Villabruna N, Koopmans MPG, de Graaf M
Norovirus is the most common cause of non-bacterial gastroenteritis and is a burden worldwide. The increasing norovirus diversity is currently categorized into at least 10 genogroups which are further classified into more than 40 genotypes. In addition to humans, norovirus can infect a broad range of hosts including livestock, pets, and wild animals, e.g., marine mammals and bats. Little is known about norovirus infections in most non-human hosts, but the close genetic relatedness between some a... Abstract
Cited 8 times since 2018 (1.5 per year) source: EuropePMC
ACS nano, Volume 12, Issue 11, 31 5 2018, Pages 11244-11253 Tuning and Probing the Distribution of Cu<sup>+</sup> and Cu<sup>2+</sup> Trap States Responsible for Broad-Band Photoluminescence in CuInS<sub>2</sub> Nanocrystals. van der Stam W, de Graaf M, Gudjonsdottir S, Geuchies JJ, Dijkema JJ, Kirkwood N, Evers WH, Longo A, Houtepen AJ
The processes that govern radiative recombination in ternary CuInS2 (CIS) nanocrystals (NCs) have been heavily debated, but recently, several research groups have come to the same conclusion that a photoexcited electron recombines with a localized hole on a Cu-related trap state. Furthermore, it has been observed that single CIS NCs display narrower photoluminescence (PL) line widths than the ensemble, which led to the conclusion that within the ensemble there is a distribution of Cu-related tra... Abstract
Cited 12 times since 2018 (2 per year) source: EuropePMC
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, Volume 105, 24 4 2018, Pages 1-10 Chronic sequelae and severe complications of norovirus infection: A systematic review of literature. Petrignani M, Verhoef L, de Graaf M, Richardus JH, Koopmans M
Norovirus causes an estimated 18% of all cases of acute gastroenteritis worldwide and is found to be associated with mortality. To create a first overview of severe complications and chronic sequelae of norovirus infections, a systematic review of literature was performed. Of 3928 individual hits, 176 publications remained for data extraction. Study periods varied between 1974 and 2017, though strongly skewed towards the last decade (n = 122, 70%). Countries of studies were worldwide, though Afr... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
Acta dermato-venereologica, Volume 98, Issue 3, 1 1 2018, Pages 373-375 Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema. Garritsen FM, van der Schaft J, de Graaf M, Hijnen DJ, Bruijnzeel-Koomen CAF, van den Broek MPH, De Bruin-Weller MS
Cited 8 times since 2018 (1.3 per year) source: EuropePMC
JAAD case reports, Volume 4, Issue 2, 2 1 2018, Pages 192-195 Juvenile interleukin-36 receptor antagonist deficiency (DITRA) with c.80T>C (p.Leu27Pro) mutation successfully treated with etanercept and acitretin. Cuperus E, Koevoets R, van der Smagt JJ, Toonstra J, de Graaf M, Frenkel J, Pasmans SGMA
Cited 23 times since 2018 (3.7 per year) source: EuropePMC
PloS one, Volume 13, Issue 1, 30 5 2018, Pages e0191442 Quantitative MRI in early intervertebral disc degeneration: T1rho correlates better than T2 and ADC with biomechanics, histology and matrix content. Paul CPL, Smit TH, de Graaf M, Holewijn RM, Bisschop A, van de Ven PM, Mullender MG, Helder MN, Strijkers GJ
Introduction: Low-back pain (LBP) has been correlated to the presence of intervertebral disc (IVD) degeneration on T2-weighted (T2w) MRI. It remains challenging, however, to accurately stage degenerative disc disease (DDD) based on T2w MRI and measurements of IVD height, particularly for early DDD. Several quantitative MRI techniques have been introduced to detect changes in matrix composition signifying early DDD. In this study, we correlated quantitative T2, T1rho and Apparent Diffusion Coeffi... Abstract
Cited 116 times since 2018 (18.5 per year) source: EuropePMC
The Lancet. Infectious diseases, Volume 18, Issue 5, 26 4 2018, Pages 545-553 Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network. van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, Di Bartolo I, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MPG, NoroNet
Background: The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network. Methods: We included genetic sequences of norovirus specimens obtained from outbreak investigations and sporadic gastroenteritis cases between 2005 and 2016 in Europe, Asia, Oceania, and Africa. We genotyped norovirus sequences and analysed sequences that overlapped at op... Abstract
Cited 23 times since 2017 (3.6 per year) source: EuropePMC
The Journal of infectious diseases, Volume 216, Issue 12, 1 1 2017, Pages 1513-1524 Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection. van Beek J, de Graaf M, Smits S, Schapendonk CME, Verjans GMGM, Vennema H, van der Eijk AA, Phan MVT, Cotten M, Koopmans M
Background: The genus Norovirus comprises large genetic diversity, and new GII.4 variants emerge every 2-3 years. It is unknown in which host these new variants originate. Here we study whether prolonged shedders within the immunocompromised population could be a reservoir for newly emerging strains. Methods: Sixty-five fecal samples from 16 immunocompromised patients were retrospectively selected. Isolated viral RNA was enriched by hybridization with a custom norovirus whole-genome RNA bait set... Abstract
Cited 1 times since 2017 (0.2 per year) source: EuropePMC
The Journal of dermatological treatment, Volume 29, Issue 4, 26 4 2017, Pages 375-382 Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine. Garritsen FM, van der Schaft J, Bruijnzeel-Koomen CAF, van Schaik RH, de Graaf M, van den Broek MPH, de Bruin-Weller MS
Background: Azathioprine is frequently used in severe eczema. It is converted in the liver into active metabolites, including 6-thioguanine nucleotide (6-TGN) and methylated 6-methylmercaptopurine (6-MMP). In the past, the therapeutic potential of azathioprine may have not been fully utilized. Recent investigations on inflammatory bowel disease have led to a better understanding of azathioprine metabolism and optimizing treatment. Objective: To investigate whether measuring thiopurine metabolite... Abstract
Cited 10 times since 2017 (1.5 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 18, Issue 9, 1 1 2017, Pages 969-977 Impact of computed tomography myocardial perfusion following computed tomography coronary angiography on downstream referral for invasive coronary angiography, revascularization and, outcome at 12 months. van Rosendael AR, Dimitriu-Leen AC, de Graaf MA, van Zwet EW, Jukema JW, Bax JJ, Kroft LJ, Scholte AJ
Aims: The aim of this study was to assess the impact of adding stress computed tomography (CT) myocardial perfusion (CTP) to coronary CT angiography (CTA) on downstream referral for invasive coronary angiography (ICA), revascularization, and outcome in patients presenting with new-onset chest pain. Methods and results: Three hundred and eighty-four patients were referred for cardiac CT. Patients with lesions ≥50% stenosis underwent subsequently stress CTP. Perfusion scans were considered abnorma... Abstract
Cited 39 times since 2017 (5.8 per year) source: EuropePMC
Emerging infectious diseases, Volume 23, Issue 8, 1 1 2017, Pages 1359-1354 Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016. Chan MCW, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MPG, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, Chan PKS
Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global spread of a sublineage SL2 was identified. A new sublineage SL3 emerged in China in 2016. Abstract
Cited 7 times since 2017 (1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 33, Issue 11, 24 4 2017, Pages 1809-1819 Automatic identification of coronary tree anatomy in coronary computed tomography angiography. Cao Q, Broersen A, de Graaf MA, Kitslaar PH, Yang G, Scholte AJ, Lelieveldt BPF, Reiber JHC, Dijkstra J
An automatic coronary artery tree labeling algorithm is described to identify the anatomical segments of the extracted centerlines from coronary computed tomography angiography (CCTA) images. This method will facilitate the automatic lesion reporting and risk stratification of cardiovascular disease. Three-dimensional (3D) models for both right dominant (RD) and left dominant (LD) coronary circulations were built. All labels in the model were matched with their possible candidates in the extract... Abstract
Cited 8 times since 2017 (1.2 per year) source: EuropePMC
Journal of clinical research in pediatric endocrinology, Volume 9, Issue 4, 7 1 2017, Pages 366-370 Successful Growth Hormone Therapy in Cornelia de Lange Syndrome. de Graaf M, Kant SG, Wit JM, Willem Redeker EJ, Eduard Santen GW, Henriëtta Verkerk AJM, Uitterlinden AG, Losekoot M, Oostdijk W
Cornelia de Lange syndrome (CdLS) is a both clinically and genetically heterogeneous syndrome. In its classical form, it is characterised by distinctive facial features, intra-uterine growth retardation, short stature, developmental delay, and anomalies in multiple organ systems. NIPBL, SMC1A, SMC3, RAD21 and HDAC8, all involved in the cohesin pathway, have been identified to cause CdLS. Growth hormone (GH) secretion has been reported as normal, and to our knowledge, there are no reports on the... Abstract
Cited 8 times since 2017 (1.2 per year) source: EuropePMC
Acta dermato-venereologica, Volume 97, Issue 6, 1 1 2017, Pages 724-730 Risk of Non-melanoma Skin Cancer in Patients with Atopic Dermatitis Treated with Oral Immunosuppressive Drugs. Garritsen FM, van der Schaft J, van den Reek JM, Politiek K, van Os-Medendorp H, van Dijk M, Hijnen DJ, de Graaf M, Bruijnzeel-Koomen CA, de Jong EM, Schuttelaar MA, Bruin-Weller MS
There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunosuppressive treatment was reported in 18 patients (3.2%). The standardized incidence ratio for develo... Abstract
Cited 7 times since 2017 (1 per year) source: EuropePMC
Clinical and experimental dermatology, Volume 42, Issue 5, 22 4 2017, Pages 536-538 Guttate psoriasis triggered by perianal streptococcal infection. Garritsen FM, Kraag DE, de Graaf M
The association of guttate psoriasis (GP) with streptococcal pharyngitis is well accepted. However, less is known about the association with perianal streptococcal infection. We report a case of a 19-month-old boy with GP after a preceding perianal streptococcal dermatitis, with no clinical signs of a streptococcal pharyngitis. Treatment with phenethicillin was given together with mometasone ointment. After 4 weeks, the perianal redness was reduced and the psoriasis had improved significantly. A... Abstract
Cited 5 times since 2017 (0.7 per year) source: EuropePMC
Journal of cardiovascular computed tomography, Volume 11, Issue 4, 27 4 2017, Pages 274-280 Coronary computed tomography angiography derived risk score in predicting cardiac events. Uusitalo V, Kamperidis V, de Graaf MA, Maaniitty T, Stenström I, Broersen A, Dijkstra J, Scholte AJ, Saraste A, Bax JJ, Knuuti J
Background: We evaluated the prognostic value of an integrated atherosclerosis risk score combining the markers of coronary plaque burden, location and composition as assessed by computed tomography angiography (CTA). Methods: 922 consecutive patients underwent CTA for suspected coronary artery disease (CAD). Patients without atherosclerosis (n = 261) and in whom quantitative CTA analysis was not feasible due to image quality, step-artefacts or technical factors related to image acquisition or d... Abstract
Cited 16 times since 2017 (2.3 per year) source: EuropePMC
PloS one, Volume 12, Issue 4, 6 1 2017, Pages e0174278 Static axial overloading primes lumbar caprine intervertebral discs for posterior herniation. Paul CP, de Graaf M, Bisschop A, Holewijn RM, van de Ven PM, van Royen BJ, Mullender MG, Smit TH, Helder MN
Introduction: Lumbar hernias occur mostly in the posterolateral region of IVDs and mechanical loading is an important risk factor. Studies show that dynamic and static overloading affect the nucleus and annulus of the IVD differently. We hypothesize there is also variance in the effect of overloading on the IVD's anterior, lateral and posterior annulus, which could explain the predilection of herniations in the posterolateral region. We assessed the regional mechanical and cellular response... Abstract
Cited 4 times since 2017 (0.6 per year) source: EuropePMC
Environmental management, Volume 62, Issue 1, 21 3 2017, Pages 170-181 Participatory Planning, Monitoring and Evaluation of Multi-Stakeholder Platforms in Integrated Landscape Initiatives. Kusters K, Buck L, de Graaf M, Minang P, van Oosten C, Zagt R
Integrated landscape initiatives typically aim to strengthen landscape governance by developing and facilitating multi-stakeholder platforms. These are institutional coordination mechanisms that enable discussions, negotiations, and joint planning between stakeholders from various sectors in a given landscape. Multi-stakeholder platforms tend to involve complex processes with diverse actors, whose objectives and focus may be subjected to periodic re-evaluation, revision or reform. In this articl... Abstract