Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
482 results
The international journal of cardiovascular imaging, Volume 38, Issue 3, 16 3 2021, Pages 695-705 Subclinical leaflet thrombosis after transcatheter aortic valve implantation: no association with left ventricular reverse remodeling at 1-year follow-up. Kuneman JH, Singh GK, Hansson NC, Fusini L, Poulsen SH, Fortuni F, Vollema EM, Pedersen ALD, Annoni AD, Nørgaard BL, Pontone G, Ajmone Marsan N, Delgado V, Bax JJ, Knuuti J
Hypo-attenuated leaflet thickening (HALT) of transcatheter aortic valves is detected on multidetector computed tomography (MDCT) and reflects leaflet thrombosis. Whether HALT affects left ventricular (LV) reverse remodeling, a favorable effect of LV afterload reduction after transcatheter aortic valve implantation (TAVI) is unknown. The aim of this study was to examine the association of HALT after TAVI with LV reverse remodeling. In this multicenter case-control study, patients with HALT on MDC... Abstract
European heart journal. Cardiovascular Imaging, Volume 22, Issue 11, 1 1 2021, Pages 1219-1227 The year 2020 in the European Heart Journal - Cardiovascular Imaging: part I. Edvardsen T, Donal E, Marsan NA, Maurovich-Horvat P, Dweck MR, Maurer G, Petersen SE, Cosyns B
The European Heart Journal - Cardiovascular Imaging was launched in 2012 and has during these 9 years become one of the leading multimodality cardiovascular imaging journals. The journal is currently ranked as number 20 among all cardiovascular journals. Our journal is well established as one of the top cardiovascular journals and is the most important cardiovascular imaging journal in Europe. The most important studies published in our Journal in 2020 will be highlighted in two reports. Part I... Abstract
Cited 7 times since 2021 (2.7 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 14, Issue 9, 15 3 2021, Pages e012142 Prognostic Implications of Left Ventricular Myocardial Work Indices in Patients With Secondary Mitral Regurgitation. Yedidya I, Lustosa RP, Fortuni F, van der Bijl P, Namazi F, Vo NM, Meucci MC, Ajmone Marsan N, Bax JJ, Delgado V
Background: Assessment of left ventricular (LV) function in patients with secondary mitral regurgitation (SMR) remains challenging but is an important parameter for risk stratification. The association of LV myocardial work components (work index [GWI], constructive [GCW] and wasted [GWW] work, and work efficiency) derived from pressure-strain loops obtained with speckle tracking echocardiography, and all-cause mortality in patients with SMR was investigated. Methods: LV myocardial GWI, GCW, GWW... Abstract
Cited 5 times since 2021 (1.9 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 22, Issue 10, 1 1 2021, Pages 1098-1105 EACVI survey on the evaluation of left ventricular diastolic function. Sitges M, Ajmone Marsan N, Cameli M, D'Andrea A, Carvalho RF, Holte E, Michalski B, Podlesnikar T, Popescu BA, Schulz-Menger J, Stankovic I, Haugaa KH, Dweck MR
Aims: The aim of this study is to analyse how current recommendations on left ventricular (LV) diastolic function assessment have been adopted. Identifying potential discrepancies between recommendations and everyday clinical practice would enable us to better understand and address the remaining challenges in this controversial and complex field. Methods and results: A total of 93 centres, mainly from tertiary care settings, responded to the survey. More than three-quarters (77%) of centres fol... Abstract
Cited 7 times since 2021 (2.6 per year) source: EuropePMC
ESC heart failure, Volume 8, Issue 5, 6 1 2021, Pages 3539-3546 Sex differences in prognosis of significant secondary mitral regurgitation. Namazi F, van der Bijl P, Vo NM, van Wijngaarden SE, Ajmone Marsan N, Delgado V, Bax JJ
Aims: Secondary mitral regurgitation (MR) is more frequent in men than in women. However, little is known about differences in prognosis between men and women with secondary MR. The objective of this study is to investigate the sex distribution of secondary MR and the prognostic differences between sexes. Methods: Patients with significant secondary MR, of both ischaemic and non-ischaemic aetiologies, were identified through the departmental electronic patient files and retrospectively analysed.... Abstract
Cited 5 times since 2021 (1.8 per year) source: EuropePMC
The American journal of cardiology, Volume 157, 6 1 2021, Pages 15-21 Changes in Global Left Ventricular Myocardial Work Indices and Stunning Detection 3 Months After ST-Segment Elevation Myocardial Infarction. Lustosa RP, Fortuni F, van der Bijl P, Mahdiui ME, Montero-Cabezas JM, Kostyukevich MV, Knuuti J, Marsan NA, Delgado V, Bax JJ
Global left ventricular (LV) myocardial work (MW) indices (GLVMWI) are derived from speckle tracking echocardiographic strain data in combination with non-invasive blood pressure measurements. Changes in global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE) after ST-segment elevation myocardial infarction (STEMI) have not been explored. The aim of present study was to assess the evolution of GLVMWI in STEMI patients from baseline (inde... Abstract
JTCVS open, Volume 8, 5 1 2021, Pages 300 Reply from authors: Many roads lead to Rome. Wijngaarden AL, Tomšič A, Marsan NA, Palmen M
Cited 3 times since 2021 (1.1 per year) source: EuropePMC
The American journal of cardiology, Volume 156, 31 5 2021, Pages 9-15 Prevalence and Long-term Outcomes of Patients with Coronary Artery Ectasia Presenting with Acute Myocardial Infarction. Wang X, Montero-Cabezas JM, Mandurino-Mirizzi A, Hirasawa K, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V
Coronary artery ectasia (CAE) is described in 5% of patients undergoing coronary angiography. Previous studies have shown controversial results regarding the prognostic impact of CAE. The prevalence and prognostic value of CAE in patients with acute myocardial infarction (AMI) remain unknown. In 4788 patients presenting with AMI referred for coronary angiography the presence of CAE (defined as dilation of a coronary segment with a diameter ≥1.5 times of the adjacent normal segment) was confirmed... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
Journal of cardiovascular development and disease, Volume 8, Issue 7, 8 2 2021, Pages 79 Superimposed Tissue Formation in Human Aortic Valve Disease: Differences between Regurgitant and Stenotic Valves. Kruithof BPT, van Wijngaarden AL, Mousavi Gourabi B, Hjortnaes J, Palmen M, Ajmone Marsan N
The formation of superimposed tissue (SIT), a layer on top of the original valve leaflet, has been described in patients with mitral regurgitation as a major contributor to valve thickening and possibly as a result of increased mechanical stresses. However, little is known whether SIT formation also occurs in aortic valve disease. We therefore performed histological analyses to assess SIT formation in aortic valve leaflets (n = 31) from patients with aortic stenosis (n = 17) or aortic regurgitat... Abstract
Cited 4 times since 2021 (1.4 per year) source: EuropePMC
The American journal of cardiology, Volume 153, 22 4 2021, Pages 30-35 Prevalence of Aortic Valve Stenosis in Patients With ST-Segment Elevation Myocardial Infarction and Effect on Long-Term Outcome. Singh GK, van der Bijl P, Goedemans L, Vollema EM, Abou R, Ajmone Marsan N, Bax JJ, Delgado V
Several studies have shown an association between aortic valve stenosis (AS), atherosclerosis and cardiovascular risk factors. These risk factors are frequently encountered in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to evaluate the prevalence and the prognostic implications of AS in patients presenting with STEMI. A total of 2041 patients (61 ± 12 years old, 76% male) admitted with STEMI and treated with primary percutaneous coronary interventi... Abstract
Cited 1 times since 2021 (0.3 per year) source: EuropePMC
The American journal of cardiology, Volume 152, 20 3 2021, Pages 11-18 Prognostic Value of Multilayer Left Ventricular Global Longitudinal Strain in Patients with ST-segment Elevation Myocardial Infarction with Mildly Reduced Left Ventricular Ejection Fractions. Abou R, Goedemans L, Montero-Cabezas JM, Prihadi EA, El Mahdiui M, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Multilayer (epi-, mid- and endocardium) left ventricular (LV) global longitudinal strain (GLS) reflects the extent of myocardial damage after ST-segment myocardial infarction (STEMI). However, the prognostic implications of multilayer LV GLS remain unclear. We studied the association between multilayer LV GLS and prognosis in patients with mildly reduced or preserved LV ejection fraction (EF) after STEMI. Patients with first STEMI and LVEF>45% were evaluated retrospectively. Baseline multilay... Abstract
Cited 1 times since 2021 (0.3 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 17, Issue 2, 11 2 2021, Pages e156-e157 Computed tomography-derived transoesophageal echocardiographic views for preprocedural planning of direct transcatheter mitral valve annuloplasty. Fortuni F, van der Kley F, Ajmone Marsan N, Delgado V
Cited 5 times since 2021 (1.7 per year) source: EuropePMC
Journal of internal medicine, Volume 290, Issue 3, 10 2 2021, Pages 715-727 Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications. Butcher SC, Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, Ajmone Marsan N, Bax JJ, Delgado V
Background: The pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which pathophysiological mechanisms related to TR are independently associated with renal dysfunction and to evaluate the impact of renal impairment on long-term prognosis in patients with significant (≥ moderate) secondary TR. Methods: A total of 1234 individuals (72 [IQR 63-78] years, 50% male) with significant secondary TR were follo... Abstract
Cited 3 times since 2021 (1 per year) source: EuropePMC
Open heart, Volume 8, Issue 1, 1 1 2021, Pages e001639 Discordant severity criteria in patients with moderate aortic stenosis: prognostic implications. Pio SM, Amanullah MR, Butcher SC, Sin KY, Ajmone Marsan N, Pibarot P, Van Mieghem NM, Ding ZP, Généreux P, Leon MB, Ewe SH, Delgado V, Bax JJ
Background: The criteria to define the grade of aortic stenosis (AS)-aortic valve area (AVA) and mean gradient (MG) or peak jet velocity-do not always coincide into one grade. Although in severe AS, this discrepancy is well characterised, in moderate AS, the phenomenon of discordant grading has not been investigated and its prognostic implications are unknown. Objectives: To investigate the occurrence of discordant grading in patients with moderate AS (defined by an AVA between 1.0 cm² and 1.5 c... Abstract
Cited 8 times since 2021 (2.7 per year) source: EuropePMC
The American journal of cardiology, Volume 151, 24 4 2021, Pages 1-9 Myocardial Work, an Echocardiographic Measure of Post Myocardial Infarct Scar on Contrast-Enhanced Cardiac Magnetic Resonance. Mahdiui ME, van der Bijl P, Abou R, de Paula Lustosa R, van der Geest R, Ajmone Marsan N, Delgado V, Bax JJ
This study investigates the relation of non-invasive myocardial work and myocardial viability following ST-segment elevation myocardial infarction (STEMI) assessed on late gadolinium contrast enhanced cardiac magnetic resonance (LGE CMR) and characterizes the remote zone using non-invasive myocardial work parameters. STEMI patients who underwent primary percutaneous coronary intervention (PCI) were included. Several non-invasive myocardial work parameters were derived from speckle tracking strai... Abstract
Cited 6 times since 2021 (2 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 14, Issue 9, 19 3 2021, Pages 1724-1737 Prognostic Implications of Associated Cardiac Abnormalities Detected on Echocardiography in Patients With Moderate Aortic Stenosis. Amanullah MR, Pio SM, Ng ACT, Sin KYK, Marsan NA, Ding ZP, Leon MB, Généreux P, Delgado V, Ewe SH, Bax JJ
Objectives: This study aimed to evaluate the prevalence and prognostic value of the extent of extra-aortic valvular cardiac abnormalities in a large multicenter registry of patients with moderate AS. Background: The prognostic significance of a new classification system that incorporates the extent of cardiac injury (beyond the aortic valve) has been proposed in patients with severe aortic stenosis (AS). Whether this can be applied to patients with moderate AS is unclear. Methods: Based on the e... Abstract
Cited 3 times since 2021 (1 per year) source: EuropePMC
RMD open, Volume 7, Issue 2, 1 1 2021, Pages e001524 New risk model is able to identify patients with a low risk of progression in systemic sclerosis. van Leeuwen NM, Maurits M, Liem S, Ciaffi J, Ajmone Marsan N, Ninaber M, Allaart C, Gillet van Dongen H, Goekoop R, Huizinga T, Knevel R, De Vries-Bouwstra J
Objectives: To develop a prediction model to guide annual assessment of systemic sclerosis (SSc) patients tailored in accordance to disease activity. Methods: A machine learning approach was used to develop a model that can identify patients without disease progression. SSc patients included in the prospective Leiden SSc cohort and fulfilling the ACR/EULAR 2013 criteria were included. Disease progression was defined as progression in ≥1 organ system, and/or start of immunosuppression or death. U... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 14, Issue 6, 14 2 2021, Pages 1110-1112 Valve Strain: A Further Step Toward a Full Understanding of Mitral Valve Function and Dysfunction. Marsan NA, van Wijngaarden AL
Cited 5 times since 2021 (1.6 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 108, Issue 2, 8 2 2021, Pages 137-144 Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve. Butcher SC, Fortuni F, Kong W, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, González-Gómez A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian-Gay L, Fijalkowski M, Liang M, Tay E, Ajmone Marsan N, Selvanayagam JB, Pinto FJ, Zamorano J, Pibarot P, Evangelista A, Bax JJ, Delgado V
Objective: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV). Methods: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or severe AR were selected from an international, multicentre registry. The association between LAVI and the combined endpoint of all-cause mortality or aortic valve surgery was investigated with Cox proportional hazard regression analyses. Re... Abstract
Cited 6 times since 2021 (2 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 34, Issue 9, 8 2 2021, Pages 944-954 Ratio between Vena Contracta Width and Tricuspid Annular Diameter: Prognostic Value in Secondary Tricuspid Regurgitation. Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, De Ferrari GM, Bax JJ, Delgado V, Marsan NA
Background: Conventional approaches for the assessment of secondary tricuspid regurgitation (STR) severity do not correct for right heart dimensions. The authors hypothesized that STR severity can be proportional or disproportional to the dilation of the tricuspid annulus (TA) and investigated the prognostic impact of this novel definition. Methods: A total of 334 patients with moderate to severe STR and preserved left ventricular systolic function were included. The ratio between vena contracta... Abstract