Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
154 results
Cited 43 times since 2008 (2.7 per year) source: EuropePMC
Heart rhythm, Volume 5, Issue 9, 6 1 2008, Pages 1257-1264 Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, Van de Veire NR, Delgado V, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony... Abstract
Cited 21 times since 2008 (1.3 per year) source: EuropePMC
Journal of human hypertension, Volume 23, Issue 1, 24 4 2008, Pages 27-32 Low blood pressure in the very old, a consequence of imminent heart failure: the Leiden 85-plus Study. van Bemmel T, Holman ER, Gussekloo J, Blauw GJ, Bax JJ, Westendorp RG
Low blood pressure in the very old has been associated with organ dysfunction and excess mortality but the underlying mechanism has yet to be elucidated. We hypothesized that cardiac dysfunction contributes to low blood pressure in the very old. We invited a convenience sample consisting of 82 participants all aged 90 years from a population-based cohort study in the very old. Blood pressure was measured twice, and all but one underwent echocardiography to assess cardiac dimensions and functiona... Abstract
Cited 73 times since 2008 (4.6 per year) source: EuropePMC
The American journal of cardiology, Volume 102, Issue 7, 18 3 2008, Pages 847-853 Comparison of left atrial volumes and function by real-time three-dimensional echocardiography in patients having catheter ablation for atrial fibrillation with persistence of sinus rhythm versus recurrent atrial fibrillation three months later. Marsan NA, Tops LF, Holman ER, Van de Veire NR, Zeppenfeld K, Boersma E, van der Wall EE, Schalij MJ, Bax JJ
Real-time 3-dimensional echocardiography (RT3DE) can provide a unique combination of accurate left atrial (LA) volume quantification and rapid, automatic assessment of LA function. The aim of the study was to evaluate the changes in LA volumes and function in patients with atrial fibrillation (AF) undergoing radiofrequency catheter ablation (RFCA) using RT3DE; 57 consecutive patients referred for RFCA were studied. Paroxysmal AF was present in 43 patients (75%) and persistent AF in 14 (25%). Aft... Abstract
Cited 11 times since 2008 (0.7 per year) source: EuropePMC
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 9, Issue 6, 16 3 2008, Pages 816-818 Safety of contrast-enhanced echocardiography within 24 h after acute myocardial infarction. Nucifora G, Marsan NA, Siebelink HM, van Werkhoven JM, Schuijf JD, Schalij MJ, Poldermans D, Holman ER, Bax JJ
Aims: Contrast-enhanced echocardiography is widely used to enhance left ventricular (LV) endocardial border delineation in stable patients with known or suspected coronary artery disease. In patients with acute myocardial infarction, accurate assessment of LV function and size is important, but data on the safety of contrast-enhanced echocardiography in the early stage of myocardial infarction (within 24 h) are lacking. In the current study, the experience on the safety of contrast-enhanced echo... Abstract
Cited 69 times since 2008 (4.3 per year) source: EuropePMC
The Journal of clinical endocrinology and metabolism, Volume 93, Issue 9, 17 3 2008, Pages 3348-3356 Aortic valve calcification and mild tricuspid regurgitation but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. Kars M, Delgado V, Holman ER, Feelders RA, Smit JW, Romijn JA, Bax JJ, Pereira AM
Objective: Treatment with ergot-derived dopamine agonists, pergolide, and cabergoline has been associated with an increased frequency of valvular heart disease in Parkinson's disease. The aim of the present study was to assess the prevalence of valvular heart disease in patients treated with dopamine agonists for prolactinomas. Design: This was a cross-sectional study. Patients: We performed two-dimensional and Doppler echocardiography in 78 consecutive patients with prolactinoma (mean age... Abstract
Cited 22 times since 2008 (1.4 per year) source: EuropePMC
European journal of endocrinology, Volume 159, Issue 2, 21 3 2008, Pages 97-103 Increased aortic root diameters in patients with acromegaly. van der Klaauw AA, Bax JJ, Smit JW, Holman ER, Delgado V, Bleeker GB, Biermasz NR, Roelfsema F, Romijn JA, Pereira AM
Objective: The clinical manifestations of acromegalic cardiomyopathy include arrhythmias, valvular regurgitation, concentric left ventricular (LV) hypertrophy, and LV systolic and diastolic dysfunction. At present, it is unknown whether acromegaly also affects the aortic root. Design: Aortic root diameters were prospectively assessed in 37 acromegalic patients (18 patients with active disease and 19 with controlled disease) by conventional two-dimensional and Doppler echocardiography before, and... Abstract
Cited 17 times since 2008 (1.1 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 27, Issue 5, 1 1 2008, Pages 992-997 Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Beeres SL, Lamb HJ, Roes SD, Holman ER, Kaandorp TA, Fibbe WE, de Roos A, van der Wall EE, Schalij MJ, Bax JJ, Atsma DE
Purpose: To evaluate the effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. Materials and methods: In 24 patients (19 male; 65 +/- 9 years) with refractory angina (Canadian Cardiovascular Society [CCS] class III-IV) 84.6 +/- 28.7 x 10(6) bone marrow-derived mononuclear cells were injected intramyocardially (using the NOGA system) in regions with ischemia on Tc-99m tetrofosmin single photon emission computed tomography (SPECT).... Abstract
Cited 73 times since 2008 (4.5 per year) source: EuropePMC
European heart journal, Volume 29, Issue 6, 27 4 2008, Pages 757-765 Mechanism of improvement in mitral regurgitation after cardiac resynchronization therapy. Ypenburg C, Lancellotti P, Tops LF, Boersma E, Bleeker GB, Holman ER, Thomas JD, Schalij MJ, Piérard LA, Bax JJ
Aims: The aim of the current study was to evaluate the relationship between the presence of left ventricular (LV) dyssynchrony at baseline and acute vs. late improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). Methods and results: Sixty eight patients consecutive (LV ejection fraction 23 +/- 8%) with at least moderate MR (>or=grade 2+) were included. Echocardiography was performed at baseline, 1 day after CRT initiation and at 6 months follow-up. Speckle tr... Abstract
Cited 53 times since 2008 (3.3 per year) source: EuropePMC
The American journal of cardiology, Volume 101, Issue 7, 6 1 2008, Pages 1023-1029 Noninvasive imaging of cardiac venous anatomy with 64-slice multi-slice computed tomography and noninvasive assessment of left ventricular dyssynchrony by 3-dimensional tissue synchronization imaging in patients with heart failure scheduled for cardiac resynchronization therapy. Van de Veire NR, Marsan NA, Schuijf JD, Bleeker GB, Wijffels MC, van Erven L, Holman ER, De Sutter J, van der Wall EE, Schalij MJ, Bax JJ
Objectives of this study were to perform a prospective head-to-head comparison between multi-slice computed tomography (MSCT) venography and invasive venography in cardiac resynchronization therapy (CRT) candidates as well as to evaluate the relation between left ventricular (LV) lead position and effect on LV dyssynchrony and immediate response to CRT. Twenty-one consecutive heart failure patients scheduled for CRT implantation were prospectively enrolled to undergo 64-slice MSCT to visualize t... Abstract
Cited 146 times since 2008 (9 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 85, Issue 2, 1 1 2008, Pages 430-6; discussion 436-7 Restrictive mitral annuloplasty cures ischemic mitral regurgitation and heart failure. Braun J, van de Veire NR, Klautz RJ, Versteegh MI, Holman ER, Westenberg JJ, Boersma E, van der Wall EE, Bax JJ, Dion RA
Background: Restrictive mitral annuloplasty with revascularization is considered the best approach to ischemic mitral regurgitation with heart failure, but late results are controversial. We report late outcome in relation to preoperative left ventricular end-diastolic diameter (LVEDD) cutoff values, previously identified to predict intermediate-term left ventricular reverse remodeling. Methods: One hundred consecutive ischemic mitral regurgitation patients underwent restrictive mitral annulopla... Abstract
Cited 14 times since 2008 (0.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 2, 15 3 2008, Pages 119-124 Effect of intramyocardial bone marrow cell injection on left ventricular dyssynchrony and global strain. van Ramshorst J, Atsma DE, Beeres SL, Mollema SA, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Objective: To evaluate the effect of bone marrow cell injection on global strain and left ventricular (LV) dyssynchrony. Methods: In 14 patients with severe postinfarction heart failure, 93 (14) x 10(6) autologous bone marrow cells were percutaneously injected in the infarction border zone. LV ejection fraction (LVEF), LV dyssynchrony and echocardiographic global strain were assessed at baseline and 3 months in patients and in a non-randomised control group of 10 patients with a history of infar... Abstract
Cited 76 times since 2007 (4.6 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 19, Issue 4, 20 3 2007, Pages 392-399 Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Ghio S, van de Veire NR, Holman ER, van der Wall EE, Tavazzi L, Schalij MJ, Bax JJ
Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for... Abstract
Cited 85 times since 2007 (5.2 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 50, Issue 21, 7 1 2007, Pages 2071-2077 Acute effects of initiation and withdrawal of cardiac resynchronization therapy on papillary muscle dyssynchrony and mitral regurgitation. Ypenburg C, Lancellotti P, Tops LF, Bleeker GB, Holman ER, Piérard LA, Schalij MJ, Bax JJ
Objectives: The purpose of this study was to evaluate the relationship between dyssynchrony involving the mitral valve apparatus and the acute improvement in mitral regurgitation (MR) after cardiac resynchronization therapy (CRT). The effect of interruption of CRT at 6 months' follow-up on dyssynchrony and MR was also evaluated. Background: Mitral regurgitation may improve acutely after CRT, but the precise mechanism is not fully understood. Methods: Out of 63 consecutive patients with base... Abstract
Cited 19 times since 2007 (1.2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 94, Issue 3, 5 1 2007, Pages e9 Triplane tissue Doppler imaging: a novel three-dimensional imaging modality that predicts reverse left ventricular remodelling after cardiac resynchronisation therapy. Van de Veire NR, Yu CM, Ajmone-Marsan N, Bleeker GB, Ypenburg C, De Sutter J, Zhang Q, Fung JW, Chan JY, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Several two-dimensional (2-D) tissue Doppler imaging (TDI) echocardiographic techniques have proved useful to identify responders to cardiac resynchronisation therapy (CRT). Recently a 3-D probe allowing simultaneous acquisition of TDI data in three imaging planes became available. Objective: To evaluate the value of triplane TDI to predict reverse left ventricular (LV) remodelling after CRT. Methods: Sixty patients with heart failure, scheduled for CRT, underwent triplane echocardio... Abstract
Cited 23 times since 2007 (1.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 93, Issue 11, 1 1 2007, Pages 1339-1350 Optimal use of echocardiography in cardiac resynchronisation therapy. Bleeker GB, Yu CM, Nihoyannopoulos P, de Sutter J, Van de Veire N, Holman ER, Schalij MJ, van der Wall EE, Bax JJ
Echocardiography has several roles in patients with cardiac resynchronisation therapy (CRT). First, it can optimise selection of CRT candidates by demonstration of left ventricular (LV) dyssynchrony. Second, it can be used to assess immediate response to CRT, including detection of acute LV resynchronisation. Echocardiography is also useful to evaluate long-term benefit from CRT. Finally, echocardiography is important in optimisation of pacemaker settings, including AV and VV optimisation. Abstract
Cited 67 times since 2007 (4 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 50, Issue 16, 1 1 2007, Pages 1532-1540 Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling. Mollema SA, Liem SS, Suffoletto MS, Bleeker GB, van der Hoeven BL, van de Veire NR, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Gorcsan J, Bax JJ
Objectives: We sought to identify predictors of left ventricular (LV) remodeling after acute myocardial infarction. Background: Left ventricular remodeling after myocardial infarction is associated with an adverse long-term prognosis. Early identification of patients prone to LV remodeling is needed to optimize therapeutic management. Methods: A total of 178 consecutive patients presenting with acute myocardial infarction who underwent primary percutaneous coronary intervention were included. Wi... Abstract
Cited 56 times since 2007 (3.4 per year) source: EuropePMC
American heart journal, Volume 154, Issue 6, 14 2 2007, Pages 1160-1165 Myocardial contractile reserve predicts improvement in left ventricular function after cardiac resynchronization therapy. Ypenburg C, Sieders A, Bleeker GB, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Myocardial contractile reserve has been shown to provide important prognostic information in patients with heart failure. We hypothesized that myocardial contractile reserve would predict left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). Methods: Thirty-one consecutive patients with heart failure (LV ejection fraction [LVEF] 26% +/- 7%, 35% nonischemic cardiomyopathy) underwent echocardiography during low-dose dobutamine infusion before CRT impla... Abstract
Cited 137 times since 2007 (8.2 per year) source: EuropePMC
Circulation, Volume 116, Issue 13, 4 1 2007, Pages 1440-1448 Left ventricular resynchronization is mandatory for response to cardiac resynchronization therapy: analysis in patients with echocardiographic evidence of left ventricular dyssynchrony at baseline. Bleeker GB, Mollema SA, Holman ER, Van de Veire N, Ypenburg C, Boersma E, van der Wall EE, Schalij MJ, Bax JJ
Background: Recent studies have demonstrated that a positive response to cardiac resynchronization therapy (CRT) is related to the presence of preimplantation left ventricular (LV) dyssynchrony. The time course and the extent of LV resynchronization after CRT implantation and their relationship to response are currently unknown. Methods and results: One hundred consecutive patients scheduled for implantation of a CRT device were prospectively included if they met the following criteria: New York... Abstract
Cited 16 times since 2007 (0.9 per year) source: EuropePMC
The American journal of cardiology, Volume 100, Issue 3, 14 2 2007, Pages 476-482 Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy. Van de Veire NR, Bleeker GB, Ypenburg C, De Sutter J, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
This study evaluated the value of triplane tissue Doppler imaging (TDI) to predict acute response after cardiac resynchronization therapy (CRT). Forty-nine patients scheduled for CRT underwent triplane echocardiography with simultaneous TDI acquisition before and 48 hours after implantation. A 3-dimensional left ventricular (LV) volume was generated and LV volumes and ejection fraction were calculated. A parametric imaging technique, tissue synchronization imaging, was applied to portray the are... Abstract
Cited 11 times since 2007 (0.6 per year) source: EuropePMC
Heart rhythm, Volume 4, Issue 9, 24 4 2007, Pages 1144-1148 Does left ventricular dyssynchrony immediately after acute myocardial infarction result in left ventricular dilatation? Mollema SA, Bleeker GB, Liem SS, Boersma E, van der Hoeven BL, Holman ER, van der Wall EE, Schalij MJ, Bax JJ
Background: Reverse remodeling of the left ventricle (LV) is one of the advantageous mechanisms of cardiac resynchronization therapy (CRT). Substantial LV dyssynchrony seems mandatory for echocardiographic response to CRT. Conversely, LV dyssynchrony early after acute myocardial infarction may result in LV dilatation during follow-up. Objective: The purpose of this study was to evaluate the relation between LV dyssynchrony early after acute myocardial infarction and the occurrence of long-term L... Abstract