Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
440 results
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
Biomarkers in medicine, Volume 13, Issue 13, 23 4 2019, Pages 1081-1091 Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study. van Paassen J, van Dissel JT, Hiemstra PS, Zwaginga JJ, Cobbaert CM, Juffermans NP, de Wilde RB, Stijnen T, de Jonge E, Klautz RJ, Arbous MS
Aim: Biomarkers of acute respiratory distress syndrome (ARDS) after cardiac-surgery may help risk-stratification and management. Preoperative single-value proADM increases predictive capacity of scoring-system EuroSCORE. To include the impact of surgery, we aim to assess the predictive value of the perioperative proADM-change on development of ARDS in 40 cardiac-surgery patients. Materials & methods: ProADM was measured in nine sequential blood samples. The Berlin definition of ARDS was used... Abstract
Cited 17 times since 2019 (3.6 per year) source: EuropePMC
PloS one, Volume 14, Issue 9, 17 3 2019, Pages e0222449 Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients. Tangedal S, Nielsen R, Aanerud M, Persson LJ, Wiker HG, Bakke PS, Hiemstra PS, Eagan TM
Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur disease progression. Infectious causes are frequent; however, it is unknown to what extent exacerbations are caused by larger shifts in the airways' microbiota. The aim of the current study was to analyse the changes in microbial composition between stable state and during exacerbations, and the corresponding immune response. Methods: The study sample included 36 COPD patients examined... Abstract
Cited 21 times since 2019 (4.5 per year) source: EuropePMC
Allergy, Volume 75, Issue 2, 10 2 2019, Pages 370-380 Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma. George L, Taylor AR, Esteve-Codina A, Soler Artigas M, Thun GA, Bates S, Pavlidis S, Wagers S, Boland A, Prasse A, Boschetto P, Parr DG, Nowinski A, Barta I, Hohlfeld J, Greulich T, van den Berge M, Hiemstra PS, Timens W, Hinks T, Wenzel S, Siddiqui S, Richardson M, Venge P, Heath S, Gut I, Tobin MD, Edwards L, Riley JH, Djukanovic R, Auffray C, De-Meulder B, Erik-Dahlen S, Adcock IM, Chung KF, Ziegler-Heitbrock L, Sterk PJ, Singh D, Brightling CE, U-BIOPRED and the EvA study teams
Background: Whether the clinical or pathophysiologic significance of the "treatable trait" high blood eosinophil count in COPD is the same as for asthma remains controversial. We sought to determine the relationship between the blood eosinophil count, clinical characteristics and gene expression from bronchial brushings in COPD and asthma. Methods: Subjects were recruited into a COPD (emphysema versus airway disease [EvA]) or asthma cohort (Unbiased BIOmarkers in PREDiction of respirat... Abstract
Obesity surgery, Volume 29, Issue 9, 1 1 2019, Pages 3076-3080 Prediction of Airflow Obstruction and the Risk of Complications in Morbidly Obese Patients Undergoing Bariatric Surgery. Türk Y, Singh HK, van Huisstede A, Birnie E, Biter U, Hiemstra PS, Braunstahl GJ
Morbidly obese subjects with airflow obstruction who underwent laparoscopic bariatric surgery appear to have the greatest risk to develop complications. In a retrospective cohort study, we identified a waist circumference ≥ 120 cm, smoking history ≥5PY and history of obstructive lung disease as statistically significant predictors of airflow obstruction. The resulting algorithm, aimed to identify subjects with airflow obstruction before bariatric surgery, was validated in a prospective study. Th... Abstract
Cited 11 times since 2019 (2.2 per year) source: EuropePMC
International archives of allergy and immunology, Volume 180, Issue 1, 26 4 2019, Pages 1-9 Extract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure. van Wijck Y, John-Schuster G, van Schadewijk A, van den Oever RL, Obieglo K, Hiemstra PS, Müller A, Smits HH, Taube C
Background: An inverse relation between Helicobacter pylori infection and asthma has been shown in epidemiological studies. Infection with H. pylori, or application of an extract of it before or after sensitization, inhibits allergic airway disease in mice. Objectives: The aim of this study was to investigate the effect of an extract of H. pylori on allergic airway disease induced by repeated allergen exposure in mice that were sensitized and challenged prior to extract application. Method: C57B... Abstract
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
EBioMedicine, Volume 43, 30 5 2019, Pages 22-23 Macrophage function in chronic obstructive pulmonary disease: The many faces of notch signalling. Hiemstra PS
Cited 23 times since 2019 (4.5 per year) source: EuropePMC
The European respiratory journal, Volume 53, Issue 4, 25 4 2019, Pages 1801202 Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M
The aim was to investigate whether microRNA (miRNA) expression is modulated by inhaled corticosteroid (ICS) treatmentWe performed genome-wide miRNA analysis on bronchial biopsies of 69 moderate/severe chronic obstructive pulmonary disease (COPD) patients at baseline and after 6- and 30-month treatment with the ICS fluticasone propionate or placebo. The effect of ICS on miRNA expression was validated in differentiated primary bronchial epithelial cultures, and functional studies were conducted in... Abstract
Cited 22 times since 2019 (4.3 per year) source: EuropePMC
Journal of innate immunity, Volume 12, Issue 1, 10 2 2019, Pages 74-89 TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms. Schrumpf JA, Ninaber DK, van der Does AM, Hiemstra PS
Airway epithelium is an important site for local vitamin D (VD) metabolism; this can be negatively affected by inflammatory mediators. VD is an important regulator of respiratory host defense, for example, by increasing the expression of hCAP18/LL-37. TGF-β1 is increased in chronic obstructive pulmonary disease (COPD), and known to decrease the expression of constitutive host defense mediators such as secretory leukocyte protease inhibitor (SLPI) and polymeric immunoglobulin receptor (pIgR). VD... Abstract
Cited 28 times since 2019 (5.5 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 317, Issue 1, 10 2 2019, Pages L14-L28 TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation. Ng-Blichfeldt JP, de Jong T, Kortekaas RK, Wu X, Lindner M, Guryev V, Hiemstra PS, Stolk J, Königshoff M, Gosens R
Transforming growth factor-β (TGF-β)-induced fibroblast-to-myofibroblast differentiation contributes to remodeling in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, but whether this impacts the ability of fibroblasts to support lung epithelial repair remains little explored. We pretreated human lung fibroblasts [primary (phFB) or MRC5 cells] with recombinant human TGF-β to induce myofibroblast differentiation, then cocultured them with adult mouse lung epithelial cell a... Abstract
Cited 2 times since 2019 (0.4 per year) source: EuropePMC
ERJ open research, Volume 5, Issue 2, 1 1 2019, Pages 194-2018 From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science." Nikolić MZ, Garrido-Martin EM, Greiffo FR, Fabre A, Heijink IH, Boots A, Greene CM, Hiemstra PS, Bartel S
The European Respiratory Society (ERS) International Congress is the largest respiratory congress and brings together leading experts in all fields of respiratory medicine and research. ERS Assembly 3 shapes the basic and translational science aspects of this congress, aiming to combine cutting-edge novel developments in basic research with novel clinical findings. In this article, we summarise a selection of the scientific highlights from the perspective of the three groups within Assembly 3. I... Abstract
Cited 55 times since 2019 (10.4 per year) source: EuropePMC
The European respiratory journal, Volume 53, Issue 2, 31 5 2019, Pages 1801151 Electronic cigarettes: a task force report from the European Respiratory Society. Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F
There is a marked increase in the development and use of electronic nicotine delivery systems or electronic cigarettes (ECIGs). This statement covers electronic cigarettes (ECIGs), defined as "electrical devices that generate an aerosol from a liquid" and thus excludes devices that contain tobacco. Database searches identified published articles that were used to summarise the current knowledge on the epidemiology of ECIG use; their ingredients and accompanied health effects; second-ha... Abstract
Cited 43 times since 2019 (8 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 1117, 1 1 2019, Pages 149-171 Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects. van der Does AM, Hiemstra PS, Mookherjee N
Cationic host defence peptides (CHDPs), also known as antimicrobial peptides, exhibit a wide range of activities contributing to immune responses and resolution of infections. CHDPs are expressed across diverse species, are generally amphipathic with less than 50 amino acids in length, and differ significantly in sequence and structure. This chapter focuses on the role of these peptides in immunity. CHDPs are known to function in both innate and adaptive immune responses. These peptides exert bo... Abstract
Cited 19 times since 2018 (3.5 per year) source: EuropePMC
Biochimica et biophysica acta. Molecular and cell biology of lipids, Volume 1864, Issue 3, 5 1 2018, Pages 224-233 Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls. van der Does AM, Heijink M, Mayboroda OA, Persson LJ, Aanerud M, Bakke P, Eagan TM, Hiemstra PS, Giera M
Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators here collectively named oxylipins. These include classical eicosanoids, but also pro-resolving mediators. A balanced production of pro-inflammatory and pro-resolving oxylipins is of importance for adequate inflammatory responses and subsequent return to homeostasis. Objecti... Abstract
Cited 2 times since 2018 (0.4 per year) source: EuropePMC
Breathe (Sheffield, England), Volume 14, Issue 4, 1 1 2018, Pages 319-321 How to write a response to the reviewers of your manuscript. Hiemstra PS
Organising the process of writing a response to reviewers' comments and making best use of the expertise of your co-authors increases your chances of being successful in getting your paper published http://ow.ly/WAxV30lF1g3. Abstract
Cited 50 times since 2018 (9.1 per year) source: EuropePMC
The Journal of clinical investigation, Volume 129, Issue 1, 26 4 2018, Pages 169-181 An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous smoking-related disease characterized by airway obstruction and inflammation. This inflammation may persist even after smoking cessation and responds variably to corticosteroids. Personalizing treatment to biologically similar "molecular phenotypes" may improve therapeutic efficacy in COPD. IL-17A is involved in neutrophilic inflammation and corticosteroid resistance, and thus may be particularly important in a... Abstract
Cited 42 times since 2018 (7.4 per year) source: EuropePMC
EBioMedicine, Volume 36, 17 3 2018, Pages 461-474 Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. Ng-Blichfeldt JP, Schrik A, Kortekaas RK, Noordhoek JA, Heijink IH, Hiemstra PS, Stolk J, Königshoff M, Gosens R
Background: Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease (COPD), clinical trials using retinoids for emphysema patients have failed. Crucial information about the specific role of RA signaling in adult rodent and human lung epithelial progenitor cells is largely missing. Methods: Adult lung organoid cultures were generated from isolated primary mouse and human lung epithelial cells, a... Abstract
Cited 26 times since 2018 (4.6 per year) source: EuropePMC
The European respiratory journal, Volume 52, Issue 3, 6 1 2018, Pages 1701556 microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD. Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA
Chronic mucus hypersecretion (CMH) is a common feature in chronic obstructive pulmonary disease (COPD) and is associated with worse prognosis and quality of life. This study aimed to identify microRNA (miRNA)-mRNA regulatory networks underlying CMH.The expression profiles of miRNA and mRNA in bronchial biopsies from 63 COPD patients were associated with CMH using linear regression. Potential mRNA targets of each CMH-associated miRNA were identified using Pearson correlations. Gene set enrichment... Abstract
Cited 5 times since 2018 (0.9 per year) source: EuropePMC
Vaccines, Volume 6, Issue 3, 28 4 2018, Pages E49 Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases. van der Does AM, Amatngalim GD, Keijser B, Hiemstra PS, Villenave R
The respiratory tract harbours a variety of microorganisms, collectively called the respiratory microbiota. Over the past few years, alterations in respiratory and gut microbiota composition have been associated with chronic inflammatory diseases of the lungs. How these changes influence disease development and progression is an active field of investigation. Identifying and understanding host-microbiota interactions and factors contributing to these interactions could promote the development of... Abstract
Cited 24 times since 2018 (4.1 per year) source: EuropePMC
Advanced drug delivery reviews, Volume 140, 25 4 2018, Pages 12-32 Stem cell-based Lung-on-Chips: The best of both worlds? Nawroth JC, Barrile R, Conegliano D, van Riet S, Hiemstra PS, Villenave R
Pathologies of the respiratory system such as lung infections, chronic inflammatory lung diseases, and lung cancer are among the leading causes of morbidity and mortality, killing one in six people worldwide. Development of more effective treatments is hindered by the lack of preclinical models of the human lung that can capture the disease complexity, highly heterogeneous disease phenotypes, and pharmacokinetics and pharmacodynamics observed in patients. The merger of two novel technologies, Or... Abstract
Cited 26 times since 2018 (4.4 per year) source: EuropePMC
BMC infectious diseases, Volume 18, Issue 1, 4 1 2018, Pages 303 Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D<sub>3</sub> as host directed therapy. Rekha RS, Mily A, Sultana T, Haq A, Ahmed S, Mostafa Kamal SM, van Schadewijk A, Hiemstra PS, Gudmundsson GH, Agerberth B, Raqib R
Background: We have previously shown that 8 weeks' treatment with phenylbutyrate (PBA) (500mgx2/day) with or without vitamin D3 (vitD3) (5000 IU/day) as host-directed therapy (HDT) accelerated clinical recovery, sputum culture conversion and increased expression of cathelicidin LL-37 by immune cells in a randomized, placebo-controlled trial in adults with pulmonary tuberculosis (TB). In this study we further aimed to examine whether HDT with PBA and vitD3 promoted clinically beneficial immu... Abstract