Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
440 results
Cited 14 times since 2020 (3.6 per year) source: EuropePMC
Intensive care medicine, Volume 46, Issue 10, 17 3 2020, Pages 1897-1900 Pulmonary immune responses against SARS-CoV-2 infection: harmful or not? Guillon A, Hiemstra PS, Si-Tahar M
Cited 6 times since 2020 (1.6 per year) source: EuropePMC
Frontiers in immunology, Volume 11, 10 2 2020, Pages 1433 Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases. Schrumpf JA, van der Does AM, Hiemstra PS
Vitamin D plays an active role in the modulation of innate and adaptive immune responses as well as in the protection against respiratory pathogens. Evidence for this immunomodulatory and protective role is derived from observational studies showing an association between vitamin D deficiency, chronic airway diseases and respiratory infections, and is supported by a range of experimental studies using cell culture and animal models. Furthermore, recent intervention studies have now shown that vi... Abstract
Cited 15 times since 2020 (3.9 per year) source: EuropePMC
The European respiratory journal, Volume 56, Issue 1, 2 1 2020, Pages 1901820 Short-term and long-term effect of a high-intensity pulmonary rehabilitation programme in obese patients with asthma: a randomised controlled trial. Türk Y, Theel W, van Huisstede A, van de Geijn GM, Birnie E, Hiemstra PS, Sont JK, Taube C, Braunstahl GJ
Objective: To determine the short-term and long-term effects of a high intensity pulmonary rehabilitation programme on asthma control, body composition, lung function and exercise capacity in obese asthma patients. Methods: Patients with obesity (body mass index (BMI)≥30 kg·m-2) and suboptimal controlled asthma (Asthma Control Questionnaire (ACQ)≥0.75) were randomly assigned to a 3-month pulmonary rehabilitation programme (PR only), pulmonary rehabilitation programme with the use of an internet... Abstract
Cited 4 times since 2020 (1 per year) source: EuropePMC
The Science of the total environment, Volume 741, 20 3 2020, Pages 140404 A new portable sampler to monitor pollen at street level in the environment of patients. de Weger LA, Molster F, de Raat K, den Haan J, Romein J, van Leeuwen W, de Groot H, Mostert M, Hiemstra PS
Allergic rhinitis caused by pollen exposure is one of the most common allergic diseases. Therefore monitoring pollen levels in ambient air is an important tool in research and health care. Most European monitoring stations collect airborne pollen at rooftop levels for measurements in the larger surrounding of the sampling station, and not in the direct environment of sensitized subjects. Here we present the development and evaluation of a portable pollen sampler, called "Pollensniffer"... Abstract
Cited 8 times since 2020 (2 per year) source: EuropePMC
Frontiers in cellular and infection microbiology, Volume 10, 19 3 2020, Pages 278 Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells. Wang Y, Ninaber DK, van Schadewijk A, Hiemstra PS
Human rhinoviruses (HRVs) are associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD) and asthma, which are accompanied by mucus hypersecretion. Whereas, various studies have shown that HRVs increase epithelial mucin production and thus may directly contribute to mucus hypersecretion. The effects of drugs used in the treatment of COPD and asthma on HRV-induced mucin production in epithelial cell cultures have not been studied. In the present study, we as... Abstract
Cited 28 times since 2020 (7.2 per year) source: EuropePMC
Stem cells (Dayton, Ohio), Volume 38, Issue 11, 18 3 2020, Pages 1467-1478 Wnt/β-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema. Hu Y, Ng-Blichfeldt JP, Ota C, Ciminieri C, Ren W, Hiemstra PS, Stolk J, Gosens R, Königshoff M
Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development and in various adult tissues. Ectopic activation of Wnt/β-catenin signaling promotes tissue repair in emphysema, a devastating lung disease with progressive loss of parenchymal lung tissue. The identity of Wnt/β-catenin responsive progenitor cells and the potential impact of Wnt/β-catenin signaling on adult distal lung epithelial progenitor cell function in emphysema are poorly understood. Here, we used TCF/... Abstract
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Cytokine, Volume 131, 20 3 2020, Pages 155104 Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin. Rafiq R, El Haddaoui H, de Mutsert R, Rosendaal FR, Hiemstra PS, Cobbaert CM, den Heijer M, de Jongh RT
Objective: The role of adiposity in the relationship between vitamin D and inflammation is unknown. Our aim was therefore to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this relationship. Methods: This is a cross-sectional analysis of The Netherlands Epidemiology of Obesity Study (NEO), a population-based cohort study in men and women aged 45 to 65 years. Main outcome measures were CRP, leptin an... Abstract
Cited 13 times since 2020 (3.2 per year) source: EuropePMC
PloS one, Volume 15, Issue 4, 14 2 2020, Pages e0231573 Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media. Peek NFAW, Nell MJ, Brand R, Jansen-Werkhoven T, van Hoogdalem EJ, Verrijk R, Vonk MJ, Wafelman AR, Valentijn ARPM, Frijns JHM, Hiemstra PS, Drijfhout JW, Nibbering PH, Grote JJ
Objective: Chronic suppurative otitis media (CSOM) is a chronic infectious disease with worldwide prevalence that causes hearing loss and decreased quality of life. As current (antibiotic) treatments often unsuccessful and antibiotic resistance is emerging, alternative agents and/or strategies are urgently needed. We considered the synthetic antimicrobial and anti-biofilm peptide P60.4Ac to be an interesting candidate because it also displays anti-inflammatory activities including lipopolysaccha... Abstract
Cited 10 times since 2020 (2.4 per year) source: EuropePMC
Journal of innate immunity, Volume 12, Issue 5, 14 2 2020, Pages 410-421 Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages. van Riet S, van Schadewijk A, de Vos S, Vandeghinste N, Rottier RJ, Stolk J, Hiemstra PS, Khedoe P
Airway epithelial cells and macrophages participate in inflammatory responses to external noxious stimuli, which can cause epithelial injury. Upon injury, epithelial cells and macrophages act in concert to ensure rapid restoration of epithelial integrity. The nature of the interactions between these cell types during epithelial repair is incompletely understood. We used an in vitro human coculture model of primary bronchial epithelial cells cultured at the air-liquid interface (ALI-PBEC) and pol... Abstract
Cited 22 times since 2020 (5.3 per year) source: EuropePMC
Scientific reports, Volume 10, Issue 1, 26 4 2020, Pages 5499 In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells. van Riet S, Ninaber DK, Mikkers HMM, Tetley TD, Jost CR, Mulder AA, Pasman T, Baptista D, Poot AA, Truckenmüller R, Mummery CL, Freund C, Rottier RJ, Hiemstra PS
Research on acute and chronic lung diseases would greatly benefit from reproducible availability of alveolar epithelial cells (AEC). Primary alveolar epithelial cells can be derived from human lung tissue but the quality of these cells is highly donor dependent. Here, we demonstrated that culture of EpCAM+ cells derived from human induced pluripotent stem cells (hiPSC) at the physiological air-liquid interface (ALI) resulted in type 2 AEC-like cells (iAEC2) with alveolar characteristics. iAEC2 c... Abstract
Cited 56 times since 2020 (13.1 per year) source: EuropePMC
Cancer immunology, immunotherapy : CII, Volume 69, Issue 5, 12 2 2020, Pages 771-777 Tumor mutational load, CD8<sup>+</sup> T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients. Hurkmans DP, Kuipers ME, Smit J, van Marion R, Mathijssen RHJ, Postmus PE, Hiemstra PS, Aerts JGJV, von der Thüsen JH, van der Burg SH
Objectives: A minority of NSCLC patients benefit from anti-PD1 immune checkpoint inhibitors. A rational combination of biomarkers is needed. The objective was to determine the predictive value of tumor mutational load (TML), CD8+ T cell infiltration, HLA class-I and PD-L1 expression in the tumor. Materials and methods: Metastatic NSCLC patients were prospectively included in an immune-monitoring trial (NTR7015) between April 2016-August 2017, retrospectively analyzed in FFPE tissue for TML (NGS:... Abstract
Cited 8 times since 2020 (1.9 per year) source: EuropePMC
Seminars in immunopathology, Volume 42, Issue 1, 4 1 2020, Pages 95-110 Modulating local airway immune responses to treat allergic asthma: lessons from experimental models and human studies. Voskamp AL, Kormelink TG, van Wijk RG, Hiemstra PS, Taube C, de Jong EC, Smits HH
With asthma affecting over 300 million individuals world-wide and estimated to affect 400 million by 2025, developing effective, long-lasting therapeutics is essential. Allergic asthma, where Th2-type immunity plays a central role, represents 90% of child and 50% of adult asthma cases. Research based largely on animal models of allergic disease have led to the generation of a novel class of drugs, so-called biologicals, that target essential components of Th2-type inflammation. Although highly e... Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
Scientific reports, Volume 10, Issue 1, 15 3 2020, Pages 754 Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells. Ali MN, Mori M, Mertens TCJ, Siddhuraj P, Erjefält JS, Önnerfjord P, Hiemstra PS, Egesten A
An amendment to this paper has been published and can be accessed via a link at the top of the paper. Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
ERJ open research, Volume 6, Issue 1, 1 1 2020, Pages 350-2019 ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. Ubags ND, Baker J, Boots A, Costa R, El-Merhie N, Fabre A, Faiz A, Heijink IH, Hiemstra PS, Lehmann M, Meiners S, Rolandsson Enes S, Bartel S
In this review, the Basic and Translational Sciences Assembly of the European Respiratory Society (ERS) provides an overview of the 2019 ERS International Congress highlights. In particular, we discuss how the novel and very promising technology of single cell sequencing has led to the development of a comprehensive map of the human lung, the lung cell atlas, including the discovery of novel cell types and new insights into cellular trajectories in lung health and disease. Further, we summarise... Abstract
Cited 3 times since 2019 (0.7 per year) source: EuropePMC
Journal of innate immunity, Volume 12, Issue 1, 4 1 2019, Pages 1-3 Innate Immunity of the Lung. Greene CM, Hiemstra PS
Cited 33 times since 2019 (7.3 per year) source: EuropePMC
The European respiratory journal, Volume 54, Issue 5, 7 1 2019, Pages 1900742 Airway and alveolar epithelial cells in culture. Hiemstra PS, Tetley TD, Janes SM
Cited 47 times since 2019 (10.4 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 318, Issue 1, 6 1 2019, Pages L149-L164 Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH
Disturbances in mitochondrial structure and function in lung epithelial cells have been implicated in the pathogenesis of various lung diseases, including chronic obstructive pulmonary disease (COPD). Such disturbances affect not only cellular energy metabolism but also alter a range of indispensable cellular homeostatic functions in which mitochondria are known to be involved. These range from cellular differentiation, cell death pathways, and cellular remodeling to physical barrier function an... Abstract
Cited 8 times since 2019 (1.8 per year) source: EuropePMC
Scientific reports, Volume 9, Issue 1, 29 5 2019, Pages 15566 Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells. Ali MN, Mori M, Mertens TCJ, Siddhuraj P, Erjefält JS, Önnerfjord P, Hiemstra PS, Egesten A
Osteopontin (OPN) plays a role in inflammation via recruitment of neutrophils and tissue remodeling. In this study, we investigated the distribution of OPN-expressing cells in the airway epithelium of normal lung tissue and that from patients with chronic obstructive pulmonary disease (COPD). OPN was detected on the epithelial cell surface of small airways and in scattered cells within the epithelial cell layer. Staining revealed higher OPN concentrations in tissue showing moderate to severe COP... Abstract
Cited 24 times since 2019 (5.3 per year) source: EuropePMC
PloS one, Volume 14, Issue 10, 24 4 2019, Pages e0223952 The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease. van Rijn AL, van Boheemen S, Sidorov I, Carbo EC, Pappas N, Mei H, Feltkamp M, Aanerud M, Bakke P, Claas ECJ, Eagan TM, Hiemstra PS, Kroes ACM, de Vries JJC
Introduction: Exacerbations are major contributors to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), and respiratory bacterial and viral infections are an important trigger. However, using conventional diagnostic techniques, a causative agent is not always found. Metagenomic next-generation sequencing (mNGS) allows analysis of the complete virome, but has not yet been applied in COPD exacerbations. Objectives: To study the respiratory virome in nasopharyng... Abstract
Cited 1 times since 2019 (0.2 per year) source: EuropePMC
The European respiratory journal, Volume 54, Issue 4, 10 2 2019, Pages 1901759 Translation of <i>in vitro</i> findings to patients with asthma: a timely and compelling challenge. Hiemstra PS, Sterk PJ