Indian journal of thoracic and cardiovascular surgery, Volume 39, Issue Suppl 2, 25 4 2023, Pages 270-279 The role of transforming growth factor beta in bicuspid aortic valve aortopathy. Grewal N, Dolmaci O, Klautz A, Legue J, Driessen A, Klautz R, Poelmann R
A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-β) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients.
