Cited 10 times since 2010 (0.7 per year) source: EuropePMC European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 40, Issue 1, 10 2 2010, Pages 65-70 Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer. Bosman WM, Vlot J, van der Steenhoven TJ, van den Berg O, Hamming JF, de Vries AC, Brom HL, Jacobs MJ
Objective
This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model.
Design
Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created.
Material
The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS).
Methods
The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3).
Results
In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac.
Conclusions
These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.
