Cited 52 times since 2008 (3.3 per year) source: EuropePMC Diabetes care, Volume 32, Issue 2, 10 2 2008, Pages 308-310 Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. Welsh P, Murray HM, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Sattar N
Objective
To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women.
Research design and methods
We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up.
Results
In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]).
Conclusions
Leptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.
