Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
253 results
Cited 4 times since 2006 (0.2 per year) source: EuropePMC
Journal of pediatric gastroenterology and nutrition, Volume 43, Issue 2, 1 1 2006, Pages 265-266 Rhamnose and rhamnitol in dual sugar permeability tests. Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG
Rhamnose is one of the sugars regularly used to conduct the dual sugar permeability test. For more than 30 years, it has been assumed that rhamnose is an inert sugar not metabolized by the human body and only fermented by some colonic bacteria into rhamnulose. While conducting an investigation on gut permeability in children undergoing cardiac surgery, increased concentrations of rhamnitol were found in the urine samples. The present report suggests that rhamnose is not an inert sugar and it is... Abstract
Cited 2 times since 2006 (0.1 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 30, Issue 1, 26 4 2006, Pages 33-34 A mechanical prosthesis for pulmonary valve replacement? Hazekamp MG
Cited 74 times since 2006 (4.1 per year) source: EuropePMC
European heart journal, Volume 27, Issue 12, 17 3 2006, Pages 1478-1484 Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot. Oosterhof T, Meijboom FJ, Vliegen HW, Hazekamp MG, Zwinderman AH, Bouma BJ, van Dijk AP, Mulder BJ
Aims: To analyse the long-term outcomes after pulmonary valve replacement (PVR) in patients with a previous correction for tetralogy of Fallot. Methods and results: In a retrospective study, 158 adult patients with a diagnosis of tetralogy of Fallot, who had undergone a PVR after initial total correction in childhood, were identified from the CONCOR (CONgenital CORvitia) registry. All patients underwent 175 PVRs between June 1986 and June 2005. To analyse the predictors for homograft dysfunction... Abstract
Cited 9 times since 2006 (0.5 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 81, Issue 4, 1 1 2006, Pages 1455-1459 Phosphorylcholine coating of bypass systems used for young infants does not attenuate the inflammatory response. Draaisma AM, Hazekamp MG, Anes N, Schoof PH, Hack CE, Sturk A, Dion RA
Background: Contact of blood with the artificial surfaces of the cardiopulmonary bypass (CPB) system is considered to be a main cause of complement activation. Improving the biocompatibility of the system by reduction of contact activation of blood elements and thereby producing less inflammatory response is evidently desired, especially for neonates and infants who are more susceptible to the deleterious effects of CPB. A phosphorylcholine coating, Phisio, is designed to mimic the natural inter... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 150, Issue 8, 1 1 2006, Pages 413-414 [Mechanical circulatory support after paediatric cardiac surgery]. Hazekamp MG
When circulatory failure occurs after paediatric cardiac surgery despite conventional therapy (inotropic medication, optimising pre- and afterload) mechanical assist devices can be used. Assist devices can be categorised in different ways: according to the type of pump used (centrifugal, axial flow, or pneumatic), according to univentricular or biventricular support and in relation to the presence of an oxygenator. Paediatric devices are non-implantable. Extra-corporeal membrane oxygenation (ECM... Abstract
Cited 21 times since 2005 (1.1 per year) source: EuropePMC
Pediatric cardiology, Volume 26, Issue 6, 1 1 2005, Pages 756-761 High mortality rate after extubation failure after pediatric cardiac surgery. Harkel AD, van der Vorst MM, Hazekamp MG, Ottenkamp J
The objective of this study was to evaluate the different causes of extubation failure and the consequent mortality rates in a pediatric population after cardiac surgery. We studied 184 consecutive patients with a median age of 9 months (range, 0-165). In 158 patients, extubation was successful (group A). Nine patients were reintubated for upper airway obstruction and finally extubated successfully (group B). Seventeen patients were reintubated for cardiorespiratory failure, finally leading to d... Abstract
Neuropediatrics, Volume 36, Issue 5, 1 1 2005, Pages 324-327 An unexpected cause of a recurrent cerebral hemorrhage. Thijs RD, Hazekamp MG, Rijlaarsdam ME, Willems SM, Schutte PJ, Laan LA
A 4-year-old previously healthy boy presented with a non-traumatic right parietal hemorrhage. A second life-threatening left cerebral hemorrhage occurred three weeks later and was decompressed with a craniotomy. Transthoracic echocardiography revealed a hypermobile elongated tumor of the mitral valve. The cardiac tumor was successfully resected three weeks after the craniotomy. Histological examination of the cardiac tumor revealed a papillary lesion of spindle cells with smooth muscle cell diff... Abstract
Cited 36 times since 2005 (1.9 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 46, Issue 8, 23 4 2005, Pages 1559-1564 Time course of diastolic and systolic function improvement after pulmonary valve replacement in adult patients with tetralogy of Fallot. van Straten A, Vliegen HW, Lamb HJ, Roes SD, van der Wall EE, Hazekamp MG, de Roos A
Objectives: The aim of this research was to assess right ventricular diastolic and systolic function before and after pulmonary valve replacement (PVR) in adult patients after repair of tetralogy of Fallot. Background: Pulmonary valve replacement (PVR) in adult patients late after repair of tetralogy of Fallot leads to rapid improvement of right ventricular (RV) systolic function. Methods: A total of 16 patients and 8 healthy subjects were included. Median age at initial repair was 4.9 (0.9 to 1... Abstract
Cited 17 times since 2005 (0.9 per year) source: EuropePMC
Intensive care medicine, Volume 31, Issue 10, 16 3 2005, Pages 1420-1426 Effect of dexamethasone on postoperative cardiac troponin T production in pediatric cardiac surgery. Malagon I, Hogenbirk K, van Pelt J, Hazekamp MG, Bovill JG
Objective: Pediatric cardiac surgery is associated with a temporary rise in cardiac troponin T (cTnT) during the postoperative period. We examined whether dexamethasone given before cardiopulmonary bypass has myocardial protective effects as assessed by the postoperative production of cTnT. Design and setting: Prospective randomized interventional study in the pediatric intensive care unit in a university hospital. Interventions: Patients were randomly allocated to act as controls or receive a s... Abstract
Cited 5 times since 2005 (0.3 per year) source: EuropePMC
ASAIO journal (American Society for Artificial Internal Organs : 1992), Volume 51, Issue 5, 1 1 2005, Pages 663-664 Coated versus noncoated circuits in pediatric cardiopulmonary bypass. Draaisma AM, Hazekamp MG
Cited 19 times since 2005 (1 per year) source: EuropePMC
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 6, Issue 5, 1 1 2005, Pages 547-549 Gut permeability in neonates after a stage 1 Norwood procedure. Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG
Objective: Intestinal mucosal ischemia can occur during and after cardiac surgery. Severe decreases in mucosal perfusion may be a causative factor for postoperative mortality or complications such as necrotizing enterocolitis. Mesenteric perfusion is challenged preoperatively due to an imbalance between the systemic and pulmonary circulations and challenged intraoperatively due to hypothermic circulatory arrest. We have investigated gut permeability in seven patients undergoing stage 1 of the No... Abstract
Cited 10 times since 2005 (0.5 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 130, Issue 2, 1 1 2005, Pages 265-271 Dexamethasone reduces gut permeability in pediatric cardiac surgery. Malagon I, Onkenhout W, Klok M, Linthorst L, van der Poel PF, Bovill JG, Hazekamp MG
Objectives: Little attention has been paid to the effect of the systemic inflammatory response syndrome on intestinal dysfunction in the postoperative period. Several proinflammatory cytokines have been reported to increase the permeability of intestinal mucosa in vitro. We investigated the effect of dexamethasone on gut permeability in pediatric patients undergoing cardiac surgery by using the dual sugar permeability test and absorption of 2 other saccharides. Methods: Thirty-four patients sche... Abstract
Cited 31 times since 2005 (1.6 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 27, Issue 6, 1 1 2005, Pages 975-979 Results of the Ross operation in a pediatric population. Hazekamp MG, Grotenhuis HB, Schoof PH, Rijlaarsdam ME, Ottenkamp J, Dion RA
Objective: To analyse the results of the mid-term clinical and echocardiographic follow-up of the pediatric Ross operation. Methods: Echo-Doppler follow-up of 53 consecutive pediatric Ross procedures performed between 1994 and 2003. Median age was 9.7 years at time of operation (2 weeks-17.7 years). Six patients were younger than 3 months. Median age at follow-up was 15.6 years. Aortic valve/left ventricular outflow tract (LVOT) anomalies were congenital in 49 (92%). Seventy percent had previous... Abstract
Cited 29 times since 2005 (1.5 per year) source: EuropePMC
British journal of anaesthesia, Volume 94, Issue 6, 15 3 2005, Pages 805-809 Effect of three different anaesthetic agents on the postoperative production of cardiac troponin T in paediatric cardiac surgery. Malagon I, Hogenbirk K, van Pelt J, Hazekamp MG, Bovill JG
Background: Paediatric cardiac surgery is associated with some degree of myocardial injury. Ischaemic preconditioning (IP) has been investigated widely in the adult population. Volatile agents have been shown to simulate IP providing extra protection to the myocardium during adult cardiopulmonary bypass (CPB) while propofol seems to act through different mechanisms. IP has not been investigated in the paediatric population to the same extent. Cardiac troponin T (cTnT) is a reliable marker of myo... Abstract
Cited 112 times since 2005 (5.9 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 27, Issue 4, 1 1 2005, Pages 566-571 Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Grauss RW, Hazekamp MG, Oppenhuizen F, van Munsteren CJ, Gittenberger-de Groot AC, DeRuiter MC
Objective: Several decellularisation techniques have been developed to produce acellular matrix scaffolds for the purpose of tissue engineering, mostly comprising (non-)ionic detergents or enzymatic extraction methods. However, the effect of chemically induced decellularisation on the major structural and adhesion molecules as well as glycosaminoglycans, and the possible replenishment of lost compounds have escaped attention. Methods: Porcine aortic valves were treated with two different methods... Abstract
Cited 29 times since 2005 (1.5 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 27, Issue 4, 1 1 2005, Pages 544-547 Intraoperative stenting of pulmonary arteries. Bökenkamp R, Blom NA, De Wolf D, Francois K, Ottenkamp J, Hazekamp MG
Objective: The surgical treatment of pulmonary artery stenoses in small children with complex cardiac lesions can be technically difficult. A hybrid-approach combining corrective surgery and intraoperative stent placement may be complementary in these patients. Methods: Descriptive study in 11 small children (age: one week to 12 years, median of 12 months, weight: 2.5-20 kg) after previous cardiac surgery. Intraoperative stenting of pulmonary arteries was performed involving paediatric cardiolog... Abstract
Cited 6 times since 2005 (0.3 per year) source: EuropePMC
European heart journal, Volume 26, Issue 9, 10 2 2005, Pages 941 Aortic arch morphology and hypertension in post-coarctectomy patients. Vriend JW, Oosterhof T, Hazekamp MG, Mulder BJ
Cited 4 times since 2005 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 11, 1 1 2005, Pages 589-593 [Complete atrioventricular septal defect in children with Down's syndrome: good results of surgical correction at younger and younger ages]. Kortenhorst MS, Hazekamp MG, Rammeloo LA, Schoof PH, Ottenkamp J
Objective: To evaluate the results of cardiosurgical treatment of children with Down's syndrome and a complete atrioventricular septal defect (cAVSD). Design: Retrospective. Method: Data were collected from the records of all patients with Down's syndrome who had been subjected to primary corrective surgery for cAVSD in the period 1980-2003 in Leiden, The Netherlands. Exclusion criteria were: concomitant tetralogy of Fallot or interruption of the aortic arch and palliative banding of t... Abstract
Cited 27 times since 2005 (1.4 per year) source: EuropePMC
European radiology, Volume 15, Issue 4, 22 4 2005, Pages 702-707 Right ventricular function late after total repair of tetralogy of Fallot. van Straten A, Vliegen HW, Hazekamp MG, de Roos A
Over the past decades, life expectancy in patients with congenital heart disease has increased dramatically. However, serious complications may develop late after total repair in infancy. These complications are usually the result of longstanding pulmonary regurgitation, which leads to dilatation of the right ventricle and an increased risk for severe arrhythmias. Therefore lifelong follow-up in these patients is required. Cardiac magnetic resonance imaging is the current imaging tool of choice... Abstract
Cited 55 times since 2005 (2.9 per year) source: EuropePMC
European heart journal, Volume 26, Issue 9, 16 3 2005, Pages 928-932 Reduction of QRS duration after pulmonary valve replacement in adult Fallot patients is related to reduction of right ventricular volume. van Huysduynen BH, van Straten A, Swenne CA, Maan AC, van Eck HJ, Schalij MJ, van der Wall EE, de Roos A, Hazekamp MG, Vliegen HW
Aims: Late after total correction, Fallot patients with a long QRS duration are prone to serious arrhythmias and sudden cardiac death. Pulmonary regurgitation is a common cause of right ventricular (RV) failure and QRS lengthening. We studied the effects of pulmonary valve replacement (PVR) on QRS duration and RV volume. Methods and results: Twenty-six consecutive Fallot patients were evaluated both pre-operatively and 6-12 months post-operatively by cardiac magnetic resonance (CMR). In this stu... Abstract