Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
75 results
Cited 6 times since 2015 (0.7 per year) source: EuropePMC
International journal of surgery case reports, Volume 19, 7 1 2015, Pages 8-10 Traumatic rupture of a Meckel's diverticulum due to blunt abdominal trauma in a soccer game: A case report. Tummers WS, van der Vorst JR, Swank DJ
Introduction: a Meckel's diverticulum is one of the most common congenital anomalies of the digestive tract. The reported lifetime complication rate is 4%, mostly due to hemorrhage, obstruction, perforation or inflammation. A symptomatic Meckel's diverticulum due to rupture after blunt abdominal trauma is very rare. We believe this case report is the first reporting a rupture of a Meckel's diverticulum after a low velocity blunt abdominal trauma and outlining the importance of a t... Abstract
Cited 24 times since 2014 (2.5 per year) source: EuropePMC
Journal of surgical oncology, Volume 110, Issue 7, 11 2 2014, Pages 845-850 Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging. Schaafsma BE, Verbeek FP, Elzevier HW, Tummers QR, van der Vorst JR, Frangioni JV, van de Velde CJ, Pelger RC, Vahrmeijer AL
Background and objectives: Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Methods: Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (co... Abstract
Cited 70 times since 2014 (6.9 per year) source: EuropePMC
Surgical endoscopy, Volume 28, Issue 4, 1 1 2014, Pages 1076-1082 Optimization of near-infrared fluorescence cholangiography for open and laparoscopic surgery. Verbeek FP, Schaafsma BE, Tummers QR, van der Vorst JR, van der Made WJ, Baeten CI, Bonsing BA, Frangioni JV, van de Velde CJ, Vahrmeijer AL, Swijnenburg RJ
Background: During laparoscopic cholecystectomy, common bile duct (CBD) injury is a rare but severe complication. To reduce the risk of injury, near-infrared (NIR) fluorescent cholangiography using indocyanine green (ICG) has recently been introduced as a novel method of visualizing the biliary system during surgery. To date, several studies have shown feasibility of this technique; however, liver background fluorescence remains a major problem during fluorescent cholangiography. The aim of the... Abstract
Cited 63 times since 2014 (6.2 per year) source: EuropePMC
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 40, Issue 7, 22 4 2014, Pages 850-858 Real-time intraoperative detection of breast cancer using near-infrared fluorescence imaging and Methylene Blue. Tummers QR, Verbeek FP, Schaafsma BE, Boonstra MC, van der Vorst JR, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: Despite recent developments in preoperative breast cancer imaging, intraoperative localization of tumor tissue can be challenging, resulting in tumor-positive resection margins during breast conserving surgery. Based on certain physicochemical similarities between Technetium((99m)Tc)-sestamibi (MIBI), an SPECT radiodiagnostic with a sensitivity of 83-90% to detect breast cancer preoperatively, and the near-infrared (NIR) fluorophore Methylene Blue (MB), we hypothesized that MB might... Abstract
Cited 28 times since 2014 (2.7 per year) source: EuropePMC
Annals of surgical oncology, Volume 21 Suppl 4, 11 2 2014, Pages S528-37 Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL
Background: Irradical tumor resections and iatrogenic ureteral injury remain a significant problem during lower abdominal surgery. The aim of the current study was to intraoperatively identify both colorectal tumors and ureters in subcutaneous and orthotopic animal models using cRGD-ZW800-1 and near-infrared (NIR) fluorescence. Methods: The zwitterionic fluorophore ZW800-1 was conjugated to the tumor specific peptide cRGD (targeting integrins) and to the a-specific peptide cRAD. One nmol cRGD-ZW... Abstract
Cited 49 times since 2013 (4.7 per year) source: EuropePMC
International journal of cancer, Volume 134, Issue 11, 12 2 2013, Pages 2663-2673 Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody. van Driel PB, van der Vorst JR, Verbeek FP, Oliveira S, Snoeks TJ, Keereweer S, Chan B, Boonstra MC, Frangioni JV, van Bergen en Henegouwen PM, Vahrmeijer AL, Lowik CW
Intraoperative near-infrared (NIR) fluorescence imaging is a technology with high potential to provide the surgeon with real-time visualization of tumors during surgery. Our study explores the feasibility for clinical translation of an epidermal growth factor receptor (EGFR)-targeting nanobody for intraoperative imaging and resection of orthotopic tongue tumors and cervical lymph node metastases. The anti-EGFR nanobody 7D12 and the negative control nanobody R2 were conjugated to the NIR fluoroph... Abstract
Cited 35 times since 2013 (3.3 per year) source: EuropePMC
Head & neck, Volume 36, Issue 6, 4 1 2013, Pages 853-858 Intraoperative near-infrared fluorescence imaging of parathyroid adenomas with use of low-dose methylene blue. van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Tummers QR, Hutteman M, Hamming JF, Kievit J, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Background: Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. Methods: MB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was performed using the Mini-FLARE imaging system. Results: In 10 of 12 patients, histology confirmed a par... Abstract
Cited 11 times since 2013 (1 per year) source: EuropePMC
Journal of surgical education, Volume 71, Issue 2, 14 2 2013, Pages 222-228 Quality of life of surgical oncology residents and fellows across Europe. Mordant P, Deneuve S, Rivera C, Carrabin N, Mieog JS, Malyshev N, Van Der Vorst JR, Audisio RA, French Association of Young Surgical Oncologists (AJCO), European Society of Surgical Oncology Young Surgeons and Alumni Club (EYSAC)
Background: Data are currently lacking regarding the quality of life of surgical oncology (SO) trainees. We sought to assess the training conditions and quality of life of SO residents and fellows across Europe. Material and methods: Members of the European Society for Surgical Oncology were invited to complete a Web-based survey that included a questionnaire specifically designed for SO trainees. Demographics, timing, and incentive to choose for SO, quality of life, and symptoms of fatigue, sle... Abstract
Cited 549 times since 2013 (50.7 per year) source: EuropePMC
Nature reviews. Clinical oncology, Volume 10, Issue 9, 23 4 2013, Pages 507-518 Image-guided cancer surgery using near-infrared fluorescence. Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV
Paradigm shifts in surgery arise when surgeons are empowered to perform surgery faster, better and less expensively than current standards. Optical imaging that exploits invisible near-infrared (NIR) fluorescent light (700-900 nm) has the potential to improve cancer surgery outcomes, minimize the time patients are under anaesthesia and lower health-care costs largely by way of its improved contrast and depth of tissue penetration relative to visible light. Accordingly, the past few years have wi... Abstract
Cited 160 times since 2013 (14.7 per year) source: EuropePMC
Cancer, Volume 119, Issue 18, 21 3 2013, Pages 3411-3418 Near-infrared fluorescence-guided resection of colorectal liver metastases. van der Vorst JR, Schaafsma BE, Hutteman M, Verbeek FP, Liefers GJ, Hartgrink HH, Smit VT, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation. Methods: The high... Abstract
Cited 74 times since 2013 (6.7 per year) source: EuropePMC
The British journal of surgery, Volume 100, Issue 8, 21 3 2013, Pages 1037-1044 Clinical trial of combined radio- and fluorescence-guided sentinel lymph node biopsy in breast cancer. Schaafsma BE, Verbeek FP, Rietbergen DD, van der Hiel B, van der Vorst JR, Liefers GJ, Frangioni JV, van de Velde CJ, van Leeuwen FW, Vahrmeijer AL
Background: Combining radioactive colloids and a near-infrared (NIR) fluorophore permits preoperative planning and intraoperative localization of deeply located sentinel lymph nodes (SLNs) with direct optical guidance by a single lymphatic tracer. The aim of this clinical trial was to evaluate and optimize a hybrid NIR fluorescence and radioactive tracer for SLN detection in patients with breast cancer. Methods: Patients with breast cancer undergoing SLN biopsy were enrolled. The day before surg... Abstract
Cited 36 times since 2013 (3.3 per year) source: EuropePMC
Journal of vascular surgery, Volume 59, Issue 1, 15 3 2013, Pages 192-201.e1 Vascular remodeling and intimal hyperplasia in a novel murine model of arteriovenous fistula failure. Wong CY, de Vries MR, Wang Y, van der Vorst JR, Vahrmeijer AL, van Zonneveld AJ, Roy-Chaudhury P, Rabelink TJ, Quax PH, Rotmans JI
Objective: The arteriovenous fistula (AVF) still suffers from a high number of failures caused by insufficient outward remodeling and intimal hyperplasia (IH) formation from which the exact mechanism is largely unknown. A suitable animal model is of vital importance in the unraveling of the underlying pathophysiology. However, current murine models of AVF failure do not incorporate the surgical configuration that is commonly used in humans. Because the hemodynamic profile is one of the key deter... Abstract
Cited 68 times since 2013 (6.1 per year) source: EuropePMC
The Journal of urology, Volume 190, Issue 2, 1 1 2013, Pages 574-579 Intraoperative near infrared fluorescence guided identification of the ureters using low dose methylene blue: a first in human experience. Verbeek FP, van der Vorst JR, Schaafsma BE, Swijnenburg RJ, Gaarenstroom KN, Elzevier HW, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Purpose: Near infrared fluorescence imaging is a promising technique that offers real-time visual information during surgery. In this study we report the first clinical results to our knowledge of ureteral imaging using near infrared fluorescence after a simple peripheral infusion of methylene blue. Furthermore, we assessed the optimal timing and dose of methylene blue. Materials and methods: A total of 12 patients who underwent lower abdominal surgery were included in this prospective feasibili... Abstract
Cited 31 times since 2013 (2.8 per year) source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology, Volume 120, Issue 6, 19 3 2013, Pages 758-764 Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers. Schaafsma BE, Verbeek FP, Peters AA, van der Vorst JR, de Kroon CD, van Poelgeest MI, Trimbos JB, van de Velde CJ, Frangioni JV, Vahrmeijer AL, Gaarenstroom KN
This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were bl... Abstract
Cited 14 times since 2013 (1.2 per year) source: EuropePMC
The Journal of surgical research, Volume 183, Issue 1, 25 4 2013, Pages 253-257 Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging. Schaafsma BE, Verbeek FP, van der Vorst JR, Hutteman M, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Background: The sentinel lymph node procedure has been proposed to improve nodal staging in colon cancer patients. The aim of this study was to assess the added value of near-infrared (NIR) fluorescence imaging to conventional blue dye staining for ex vivo sentinel lymph node mapping. Materials and methods: We included 22 consecutive patients undergoing surgery for colon cancer. After tumor resection, we submucosally injected a premixed cocktail of the near-infrared lymphatic tracer HSA800 and b... Abstract
Cited 42 times since 2013 (3.7 per year) source: EuropePMC
The British journal of dermatology, Volume 168, Issue 1, 1 1 2013, Pages 93-98 Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma. van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Hutteman M, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. Objectives: To assess the potential of intraoperative NIR fluorescence imaging to improve SLN mapping in patients with melanoma and to examine t... Abstract
Cited 47 times since 2012 (4.1 per year) source: EuropePMC
Journal of hepato-biliary-pancreatic sciences, Volume 19, Issue 6, 1 1 2012, Pages 626-637 Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light. Verbeek FP, van der Vorst JR, Schaafsma BE, Hutteman M, Bonsing BA, van Leeuwen FW, Frangioni JV, van de Velde CJ, Swijnenburg RJ, Vahrmeijer AL
Background: Improved imaging methods and surgical techniques have created a new era in hepatopancreatobiliary (HPB) surgery. Despite these developments, visual inspection, palpation, and intraoperative ultrasound remain the most utilized tools during surgery today. This is problematic, though, especially in laparoscopic HPB surgery, where palpation is not possible. Optical imaging using near-infrared (NIR) fluorescence can be used for the real-time assessment of both anatomy (e.g., sensitive det... Abstract
Cited 62 times since 2012 (5.3 per year) source: EuropePMC
Oral oncology, Volume 49, Issue 1, 28 4 2012, Pages 15-19 Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients. van der Vorst JR, Schaafsma BE, Verbeek FP, Keereweer S, Jansen JC, van der Velden LA, Langeveld AP, Hutteman M, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Objectives: Elective neck dissection is frequently performed during surgery in head and neck cancer patients. The sentinel lymph node (SLN) procedure can prevent the morbidity of a neck dissection and improve lymph node staging by fine pathology. Near-infrared (NIR) fluorescence imaging is a promising technique to identify the sentinel lymph node (SLN) intraoperatively. This feasibility study explored the use of indocyanine green adsorbed to human serum albumin (ICG:HSA) for SLN mapping in head... Abstract
Cited 48 times since 2012 (4 per year) source: EuropePMC
Gynecologic oncology, Volume 127, Issue 1, 10 2 2012, Pages 126-130 Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer. Schaafsma BE, van der Vorst JR, Gaarenstroom KN, Peters AA, Verbeek FP, de Kroon CD, Trimbos JB, van Poelgeest MI, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Objective: Near-infrared fluorescence imaging using indocyanine green (ICG) has recently been introduced as a novel technique for sentinel lymph node (SLN) mapping in early-stage cervical cancer. Although preclinical research has shown that ICG adsorbed to human serum albumin (ICG:HSA) improves its performance, the need for HSA has not yet been confirmed in cervical cancer patients. The current randomized study aims to determine whether ICG:HSA offers advantages over using ICG alone. Methods: Ei... Abstract
Cited 74 times since 2012 (6.2 per year) source: EuropePMC
Annals of surgical oncology, Volume 19, Issue 13, 3 1 2012, Pages 4104-4111 Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients. van der Vorst JR, Schaafsma BE, Verbeek FP, Hutteman M, Mieog JS, Lowik CW, Liefers GJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL
Background: Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has the potential to improve sentinel lymph node (SLN) mapping of breast cancer. We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers. Methods: Clinical trial subjects were 24 consecutive breast cancer patients scheduled to undergo SLN biopsy. All patien... Abstract