Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
194 results
Cited 36 times since 2002 (1.7 per year) source: EuropePMC
Journal of intellectual disability research : JIDR, Volume 46, Issue Pt 6, 1 1 2002, Pages 445-453 Understanding challenging behaviour in people with severe and profound intellectual disability: a stress-attachment model. Janssen CG, Schuengel C, Stolk J
Background: Advances in our knowledge of attachment, stress and coping may foster new explanations for the development of challenging behaviour in people with intellectual disability (ID). Method: Research on stress and coping among people with ID was reviewed initially, and then studies on the security of the attachment relationships of people with ID with their caregivers were analysed. Results: There is evidence that people with ID are more vulnerable to stress and use less effective coping s... Abstract
Cited 262 times since 2002 (12 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 166, Issue 4, 1 1 2002, Pages 490-495 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Rahman I, van Schadewijk AA, Crowther AJ, Hiemstra PS, Stolk J, MacNee W, De Boer WI
Cigarette smoking results in oxidative stress and inflammation in the lungs, which are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 4-Hydroxy-2-nonenal (4-HNE), a highly reactive diffusible product of lipid peroxidation, is a key mediator of oxidant-induced cell signaling and apoptosis. 4-HNE has a high affinity toward cysteine, histidine, and lysine groups and forms direct protein adducts. We investigated the presence of 4-HNE-modified proteins in lung tissue ob... Abstract
Cited 58 times since 2002 (2.6 per year) source: EuropePMC
Journal of biomechanics, Volume 35, Issue 4, 1 1 2002, Pages 499-510 Finite element and experimental models of cemented hip joint reconstructions can produce similar bone and cement strains in pre-clinical tests. Stolk J, Verdonschot N, Cristofolini L, Toni A, Huiskes R
Finite element (FE) models could be used for pre-clinical testing of cemented hip replacement implants against the damage accumulation failure scenario. To accurately predict mechanical failure, the models should accurately predict stresses and strains. This should be the case for various implants. In the current study, two FE models of composite hip reconstructions with two different implants were validated relative to experimental bone and cement strains. The objective was an overall agreement... Abstract
Cited 53 times since 2001 (2.4 per year) source: EuropePMC
Free radical biology & medicine, Volume 31, Issue 11, 1 1 2001, Pages 1442-1447 Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics. Peters EA, Hiltermann JT, Stolk J
Apocynin is an inhibitor of NADPH oxidase present in inflammatory cells such as eosinophils and neutrophils. We investigated the effect of inhaled apocynin on ozone-induced bronchial hyperresponsiveness in vivo. Seven mild atopic asthmatics participated in a placebo-controlled, cross-over study with two exposures to O(3) at 2-week intervals. Apocynin (3 ml of 0.5 mg/ml) was inhaled 2 times before and 6 times after O(3) exposure at hourly intervals. At 36 h before and 16 h after O(3) exposure, me... Abstract
Cited 50 times since 2001 (2.2 per year) source: EuropePMC
Investigative radiology, Volume 36, Issue 11, 1 1 2001, Pages 648-651 Repeatability of lung density measurements with low-dose computed tomography in subjects with alpha-1-antitrypsin deficiency-associated emphysema. Stolk J, Dirksen A, van der Lugt AA, Hutsebaut J, Mathieu J, de Ree J, Reiber JH, Stoel BC
Rationale and objectives: Multislice computed tomography (MSCT) of the lungs provides a new opportunity for longitudinal assessment of lung densities because of shorter scan duration. The aim of the present study was to assess the intraindividual variation of lung densities measured by MSCT of patients with emphysema. Methods: Ten patients with emphysema participated in a study in which MSCT was obtained on two occasions, approximately 2 weeks apart. Scanning parameters were 140 kV, 20 mAs, 4 x... Abstract
Cited 25 times since 2001 (1.1 per year) source: EuropePMC
The International journal of prosthodontics, Volume 14, Issue 4, 1 1 2001, Pages 310-315 Generation of 3-D finite element models of restored human teeth using micro-CT techniques. Verdonschot N, Fennis WM, Kuijs RH, Stolk J, Kreulen CM, Creugers NH
Purpose: This article describes the development of a three-dimensional finite element model of a premolar based on a microscale computed tomographic (CT) data-acquisition technique. The development of the model is part of a project studying the optimal design and geometry of adhesive tooth-colored cusp-replacing restorations. Materials and methods: The premolar was digitized with a micro CT scanner with a resolution of 13 microns. Surface contours were fitted to the various materials, after whic... Abstract
Cited 70 times since 2001 (3.1 per year) source: EuropePMC
Journal of biomechanics, Volume 34, Issue 7, 1 1 2001, Pages 917-926 Hip-joint and abductor-muscle forces adequately represent in vivo loading of a cemented total hip reconstruction. Stolk J, Verdonschot N, Huiskes R
Using finite element analyses, we investigated which muscle groups acting around the hip-joint most prominently affected the load distributions in cemented total hip reconstructions with a bonded and debonded femoral stem. The purpose was to determine which muscle groups should be included in pre-clinical tests, predicting bone adaptation and mechanical failure of cemented reconstructions, ensuring an adequate representation of in vivo loading of the reconstruction. Loads were applied as occurri... Abstract
Cited 167 times since 2000 (6.9 per year) source: EuropePMC
The Journal of pathology, Volume 190, Issue 5, 1 1 2000, Pages 619-626 Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. de Boer WI, Sont JK, van Schadewijk A, Stolk J, van Krieken JH, Hiemstra PS
Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death, with cigarette smoking among the main risk factors. Hallmarks of COPD include chronic airflow obstruction and chronic inflammation in the airway walls or alveolar septa. An earlier study reported elevated numbers of macrophages and mast cells within the bronchiolar epithelium in smokers with COPD, compared with smokers without. Since specific chemokines may be involved in this influx, the in situ protein and... Abstract
Cited 62 times since 2000 (2.6 per year) source: EuropePMC
Thorax, Volume 55, Issue 3, 1 1 2000, Pages 189-193 Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Rahman I, Swarska E, Henry M, Stolk J, MacNee W
Background: It has been suggested that oxidative stress is an important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). We have shown that an oxidant/antioxidant imbalance occurs in the distal air spaces of smokers and in patients with COPD which is reflected systemically in the plasma. A study was undertaken to determine whether plasma antioxidant status correlated with lung function as assessed by forced expiratory volume in one second (FEV(1)) and forced vital capa... Abstract
Cited 23 times since 2000 (1 per year) source: EuropePMC
Chest, Volume 117, Issue 3, 1 1 2000, Pages 786-789 Long-term effect of bilateral plication of the diaphragm. Stolk J, Versteegh MI
Study objectives: To assess the feasibility and clinical outcome of bilateral plication of the diaphragm in patients with bilateral diaphragmatic paralysis (BDP) caused by neuralgic amyotrophy (NA), a mononeuritis of the phrenic nerves. Design: Prospective, case-control study over a 1-year period. Setting: A university hospital in The Netherlands. Patients: Six patients who presented with BDP caused by NA. Methods: The diagnosis of BDP was based on the absence of muscle response after cervical m... Abstract
Cited 38 times since 2000 (1.6 per year) source: EuropePMC
Free radical biology & medicine, Volume 28, Issue 6, 1 1 2000, Pages 920-925 Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease. Rahman I, van Schadewijk AA, Hiemstra PS, Stolk J, van Krieken JH, MacNee W, de Boer WI
Cigarette smoking results in an oxidant/antioxidant imbalance in the lungs and inflammation, which are considered to be key factors in the pathogenesis of chronic obstructive pulmonary disease (COPD). Glutathione (GSH) is an important protective antioxidant in lung epithelial cells and epithelial lining fluid. De novo GSH synthesis in cells occurs by a two-enzyme process. The rate-limiting enzyme is gamma-glutamylcysteine synthetase (gamma-GCS), in which the heavy subunit (HS) constitutes most o... Abstract
Cited 33 times since 1999 (1.4 per year) source: EuropePMC
Free radical biology & medicine, Volume 27, Issue 11-12, 1 1 1999, Pages 1448-1454 Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma. Hiltermann JT, Lapperre TS, van Bree L, Steerenberg PA, Brahim JJ, Sont JK, Sterk PJ, Hiemstra PS, Stolk J
We investigated correlations between ozone-induced increases in inflammatory markers in induced sputum and in bronchial lavage fluid. Sixteen volunteers with intermittent asthma participated in a placebo-controlled parallel study with two exposures. Six days before and 16 h after the first exposure to ozone (0.4 ppm during 2 h) sputum was induced with hypertonic saline. This resulted in a significant increase in the sputum levels of eosinophil cationic protein (ECP; 1.8-fold; p = .03), neutrophi... Abstract
Cited 265 times since 1999 (10.8 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 160, Issue 5 Pt 1, 1 1 1999, Pages 1468-1472 A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy. Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DC, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, Vrooman HA, Reiber JH, Hansen NC, Heckscher T, Viskum K, Stolk J
We have investigated whether restoration of the balance between neutrophil elastase and its inhibitor, alpha(1)-antitrypsin, can prevent the progression of pulmonary emphysema in patients with alpha(1)-antitrypsin deficiency. Twenty-six Danish and 30 Dutch ex-smokers with alpha(1)-antitrypsin deficiency of PI*ZZ phenotype and moderate emphysema (FEV(1) between 30% and 80% of predicted) participated in a double-blind trial of alpha(1)-antitrypsin augmentation therapy. The patients were randomized... Abstract
Cited 40 times since 1999 (1.6 per year) source: EuropePMC
Investigative radiology, Volume 34, Issue 4, 1 1 1999, Pages 303-309 Sources of error in lung densitometry with CT. Stoel BC, Vrooman HA, Stolk J, Reiber JH
Rationale and objectives: To determine and analyze the most important error sources in lung CT densitometry in vivo. Methods: The authors examined the influences of CT acquisition errors, physiologic changes, and image segmentation errors on lung densitometry. Among others, spatial dependency and long-term reproducibility of the density measurements of blood and air were examined over a period of 4 years in a group of 28 patients with pulmonary emphysema. These results were related to the measur... Abstract
Cited 53 times since 1999 (2.1 per year) source: EuropePMC
FEBS letters, Volume 443, Issue 2, 1 1 1999, Pages 235-239 Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells. Lapperre TS, Jimenez LA, Antonicelli F, Drost EM, Hiemstra PS, Stolk J, MacNee W, Rahman I
Apocynin (4-hydroxy-3-methoxy-acetophenone) is a potent intracellular inhibitor of superoxide anion production in neutrophils. In this study, we studied the effect of apocynin on the regulation of the antioxidant glutathione (GSH) and activation of the transcription factor AP-I in human alveolar epithelial cells (A549). Apocynin enhanced intracellular GSH by increasing gamma-glutamylcysteine synthetase activity in A549 cells. Apocynin also increased the expression of gamma-GCS heavy subunit mRNA... Abstract
Cited 187 times since 1998 (7.3 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 158, Issue 6, 1 1 1998, Pages 1951-1957 Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. de Boer WI, van Schadewijk A, Sont JK, Sharma HS, Stolk J, Hiemstra PS, van Krieken JH
Chronic airways inflammation is one of the features of chronic obstructive pulmonary disease (COPD). We demonstrated previously that bronchiolar epithelium in COPD contains increased numbers of macrophages and mast cells. Transforming growth factor beta1 (TGF-beta1) may be involved in this influx because it has chemotactic activity for macrophages and mast cells. In this study, we examined expression patterns of TGF-beta1, TGF-beta receptors type I and II (TGF-betaRI and TGF-betaRII) by immunohi... Abstract
Cited 71 times since 1998 (2.8 per year) source: EuropePMC
The European respiratory journal, Volume 12, Issue 5, 1 1 1998, Pages 1200-1208 Neutrophil serine proteinases and defensins in chronic obstructive pulmonary disease: effects on pulmonary epithelium. Hiemstra PS, van Wetering S, Stolk J
Neutrophils have the capacity to accumulate in high numbers in the lung during infection and inflammation. Because they play an important role in host defence against infection, but may also cause tissue injury, these cells are thought to be involved in the pathogenesis of various inflammatory lung disorders, including chronic bronchitis and chronic obstructive pulmonary disease. Neutrophil products that may mediate tissue injury at sites of neutrophil-dominated inflammation include the neutroph... Abstract
Cited 27 times since 1998 (1 per year) source: EuropePMC
The European respiratory journal, Volume 11, Issue 5, 1 1 1998, Pages 1116-1120 Prospective evaluation of World Health Organization criteria to assist diagnosis of tuberculosis in children. Houwert KA, Borggreven PA, Schaaf HS, Nel E, Donald PR, Stolk J
Because of the difficulty in confirming childhood tuberculosis (TB), the World Health Organization (WHO) proposes a hierarchical approach to diagnosis using history and certain clinical features to help to improve the control of TB in communities. The objective of this study was to evaluate prospectively in children the diagnostic value of recent weight loss or failure to gain weight adequately, cough or wheezing for >2 weeks and recent household contact with an adult case of pulmonary TB. Th... Abstract
Cited 16 times since 1998 (0.6 per year) source: EuropePMC
Free radical biology & medicine, Volume 24, Issue 6, 1 1 1998, Pages 952-958 Ozone-induced airway hyperresponsiveness in patients with asthma: role of neutrophil-derived serine proteinases. Hiltermann TJ, Peters EA, Alberts B, Kwikkers K, Borggreven PA, Hiemstra PS, Dijkman JH, van Bree LA, Stolk J
Proteinase inhibitors may be of potential therapeutic value in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) or asthma. Our aim was to study the role of neutrophils, and neutrophil-derived serine proteinases in an acute model in patients with asthma. Exposure to ozone induces an acute neutrophilic inflammatory reaction accompanied by an increase in airway hyperresponsiveness. It is thought that these two effects of ozone are linked, and that neutrophi... Abstract
Cited 33 times since 1998 (1.3 per year) source: EuropePMC
The European respiratory journal, Volume 11, Issue 3, 1 1 1998, Pages 686-693 Asthma severity and susceptibility to air pollution. Hiltermann TJ, Stolk J, van der Zee SC, Brunekreef B, de Bruijne CR, Fischer PH, Ameling CB, Sterk PJ, Hiemstra PS, van Bree L
Exacerbations of asthma have been associated with exposure to ozone or particles with a 50% cut-off aerodynamic diameter of 10 microm (PM10). We postulated in this study that the association of summertime air pollution (i.e. ozone and PM10) with acute respiratory symptoms, medication use and peak expiratory flow differs among patients grouped according to asthma severity. During the summer of 1995, effects of ambient air pollution on these parameters were studied in a panel of 60 nonsmoking pati... Abstract