Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
511 results
Cited 8 times since 2007 (0.5 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 175, Issue 10, 8 2 2007, Pages 1061-1065 The influence of fluticasone inhalation on markers of carcinogenesis in bronchial epithelium. van den Berg RM, van Tinteren H, van Zandwijk N, Visser C, Pasic A, Kooi C, Sutedja TG, Baas P, Grünberg K, Mooi WJ, Snijders PJ, Postmus PE, Smit EF
Rationale: Bronchial epithelium exposed to cigarette smoke undergoes a series of histologic changes that may ultimately lead to invasive cancer. Inhaled corticosteroids reduce the number of lung tumors developing in rats exposed to cigarette smoke. Objectives: We studied the effect of inhaled fluticasone on premalignant lesions in smokers and patients curatively treated for head and neck cancer or lung cancer. Methods: Participants were screened for premalignant lesions by bronchoscopy. Biopsies... Abstract
The New England journal of medicine, Volume 356, Issue 7, 1 1 2007, Pages 745; author reply 746-7 CT screening for lung cancer. Lee P, Postmus PE, Sutedja TG
Cited 418 times since 2007 (24.1 per year) source: EuropePMC
European heart journal, Volume 28, Issue 10, 22 4 2007, Pages 1250-1257 Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. van Wolferen SA, Marcus JT, Boonstra A, Marques KM, Bronzwaer JG, Spreeuwenberg MD, Postmus PE, Vonk-Noordegraaf A
Aims: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH). Methods and results: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV... Abstract
Cited 31 times since 2006 (1.8 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 92, Issue 12, 1 1 2006, Pages 1860-1861 Right ventricular reverse remodelling after sildenafil in pulmonary arterial hypertension. van Wolferen SA, Boonstra A, Marcus JT, Marques KM, Bronzwaer JG, Postmus PE, Vonk-Noordegraaf A
Cited 7 times since 2006 (0.4 per year) source: EuropePMC
Physiological measurement, Volume 28, Issue 1, 17 3 2006, Pages 1-11 Stroke volume response during exercise measured by acetylene uptake and MRI. Groepenhoff H, Holverda S, Marcus JT, Postmus PE, Boonstra A, Vonk-Noordegraaf A
The intra-breath technique to measure acetylene absorption offers the possibility to determine augmentation of the pulmonary blood flow per heart beat (Q(C)) as an estimate of the stroke volume response during exercise. However, this method has not been compared with a validated test until now. Therefore, the aim of this study was to compare Q(C) with stroke volume (SV(MRI)) determined by magnetic resonance imaging (MRI) at rest and during exercise in healthy subjects and patients. For this purp... Abstract
Cited 47 times since 2006 (2.7 per year) source: EuropePMC
The European respiratory journal, Volume 28, Issue 6, 13 2 2006, Pages 1190-1194 NT-proBNP reflects right ventricular structure and function in pulmonary hypertension. Gan CT, McCann GP, Marcus JT, van Wolferen SA, Twisk JW, Boonstra A, Postmus PE, Vonk-Noordegraaf A
The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no signif... Abstract
Cited 1 times since 2006 (0.1 per year) source: EuropePMC
British journal of cancer, Volume 95, Issue 4, 8 2 2006, Pages 470-474 Multicenter phase II trial of accelerated cisplatin and high-dose epirubicin followed by surgery or radiotherapy in patients with stage IIIa non-small-cell lung cancer with mediastinal lymph node involvement (N2-disease). Phernambucq EC, Biesma B, Smit EF, Paul MA, vd Tol A, Schramel FM, Bolhuis RJ, Postmus PE
To assess the therapeutic activity of accelerated cisplatin and high-dose epirubicin with erythropoietin and G-CSF support as induction therapy for patients with stage IIIa-N2 non-small-cell lung cancer (NSCLC). Patients with stage IIIa-N2 NSCLC were enrolled in a phase II trial. They received cisplatin 60 mg m(-2) and epirubicin 135 mg m(-2) every 2 weeks for three courses combined with erythropoietin and G-CSF. Depending on results of clinical response to induction therapy and restaging, patie... Abstract
Cited 12 times since 2006 (0.7 per year) source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 1, Issue 5, 1 1 2006, Pages 497-498 The Liverpool Statement 2005: priorities for the European Union/United States spiral computed tomography collaborative group. Field JK, Smith RA, Duffy SW, Berg CD, van Klaveren R, Henschke CI, Carbone D, Postmus PE, Paci E, Hirsch FR, Mulshine JL
The Liverpool Statement 2005 was developed at the Fourth International Lung Cancer Molecular Biomarkers Workshop in Liverpool (October 27-29, 2005) and focused on the priorities for the European Union/United States (EU-US) Spiral Computed Tomography (CT) Collaborative Group. The application of spiral CT technology for early lung cancer screening has gained enormous momentum in the past 5 years. The EU-US Spiral CT Collaboration was initiated in 2001 in Liverpool, and subsequent meetings througho... Abstract
Cited 167 times since 2006 (9.3 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 291, Issue 4, 12 2 2006, Pages H1731-7 Quantification of right ventricular afterload in patients with and without pulmonary hypertension. Lankhaar JW, Westerhof N, Faes TJ, Marques KM, Marcus JT, Postmus PE, Vonk-Noordegraaf A
Right ventricular (RV) afterload is commonly defined as pulmonary vascular resistance, but this does not reflect the afterload to pulsatile flow. The purpose of this study was to quantify RV afterload more completely in patients with and without pulmonary hypertension (PH) using a three-element windkessel model. The model consists of peripheral resistance (R), pulmonary arterial compliance (C), and characteristic impedance (Z). Using pulmonary artery pressure from right-heart catheterization and... Abstract
Cited 5 times since 2006 (0.3 per year) source: EuropePMC
Circulation, Volume 113, Issue 18, 1 1 2006, Pages e743-4 Images in cardiovascular medicine. Compression of the pulmonary vein after right-sided pneumonectomy. Smulders SA, Marcus JT, Holverda S, Paul MA, Postmus PE, Vonk-Noordegraaf A
Cited 74 times since 2006 (4.1 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 47, Issue 8, 29 5 2006, Pages 1732-1733 Impaired stroke volume response to exercise in pulmonary arterial hypertension. Holverda S, Gan CT, Marcus JT, Postmus PE, Boonstra A, Vonk-Noordegraaf A
Cited 78 times since 2006 (4.3 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 24, Issue 12, 27 4 2006, Pages 1800-1806 Traditional versus up-front [18F] fluorodeoxyglucose-positron emission tomography staging of non-small-cell lung cancer: a Dutch cooperative randomized study. Herder GJ, Kramer H, Hoekstra OS, Smit EF, Pruim J, van Tinteren H, Comans EF, Verboom P, Uyl-de Groot CA, Welling A, Paul MA, Boers M, Postmus PE, Teule GJ, Groen HJ, POORT Study Group
Purpose: We investigated whether application of positron emission tomography (PET) immediately after first presentation might simplify staging while maintaining accuracy, as compared with traditional strategy in routine clinical setting. Methods: At first presentation, patients with a provisional diagnosis of lung cancer without overt dissemination were randomly assigned to traditional work-up (TWU) according to international guidelines or early PET followed by histologic/cytologic verification... Abstract
Cited 7 times since 2006 (0.4 per year) source: EuropePMC
Cancer chemotherapy and pharmacology, Volume 58, Issue 4, 7 1 2006, Pages 509-516 Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer. Kroep JR, Smit EF, Giaccone G, Van der Born K, Beijnen JH, Van Groeningen CJ, Van der Vijgh WJ, Postmus PE, Pinedo HM, Peters GJ
Purpose: To compare the pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer (NSCLC). Patients and methods: Twenty-four chemo-naive patients with advanced NSCLC were randomized to receive one of the three regimens. Plasma pharmacokinetics and pharmacologic parameters in mononuclear cells were compared and related to toxicity and efficacy. Results: Pharmacological parameters of gemcitabine and... Abstract
Cited 2 times since 2006 (0.1 per year) source: EuropePMC
Thrombosis and haemostasis, Volume 95, Issue 3, 1 1 2006, Pages 584-585 Pulmonary embolism as a first clinical sign of occult malignancy: a prospective follow-up study. van der Heiden PL, Prins MH, de Monyé W, van Strijen ML, Banga JD, Postmus PE, Ten Wolde M, Büller HR, Brandjes DP, Huisman MV, ANTELOPE study group
Cited 28 times since 2006 (1.5 per year) source: EuropePMC
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine, Volume 19, Issue 3, 1 1 2006, Pages 385-391 Assessing a system to capture stray aerosol during inhalation of nebulized liposomal cisplatin. Wittgen BP, Kunst PW, Perkins WR, Lee JK, Postmus PE
The aim of this study was to determine the efficacy of using a high-efficiency particulate air (HEPA) filter air cleaning system, a demistifier, to reduce the potential risk of fugitive aerosol contact in health care personnel working with patients inhaling nebulized liposomal encapsulated SLIT (Sustained-release Lipid Inhalation Targeting) Cisplatin. Filters were used to sample platinum in the air outside the tent and from the tent's exhaust stream. Air collection was performed under three... Abstract
Cited 4 times since 2006 (0.2 per year) source: EuropePMC
Substance use & misuse, Volume 41, Issue 1, 1 1 2006, Pages 45-60 Effects on smoking cessation: naltrexone combined with a cognitive behavioral treatment based on the community reinforcement approach. Roozen HG, Van Beers SE, Weevers HJ, Breteler MH, Willemsen MC, Postmus PE, Kerkhof AJ
A promising option in substance abuse treatment is the Community Reinforcement Approach (CRA). The opioid antagonist naltrexone (NTX) may work in combination with nicotine replacement therapy (NRT) to block the effects of smoking stimuli in abstinent smokers. Effects of lower doses than 50 mg/dd. have not been reported. A study was conducted in Amsterdam in 2000/2001 with the objective to explore the effects of the combination NTX (25/50-mg dd.), NRT, and CRA in terms of craving and abstinence.... Abstract
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 1, Issue 1, 1 1 2006, Pages 69-70 Where is the heart after left-sided pneumonectomy? Smulders SA, van den Bosch HC, Post JC, Vonk Noordegraaf A, Postmus PE
Cited 27 times since 2005 (1.5 per year) source: EuropePMC
Chest, Volume 128, Issue 6 Suppl, 1 1 2005, Pages 628S-630S Interventricular mechanical asynchrony due to right ventricular pressure overload in pulmonary hypertension plays an important role in impaired left ventricular filling. Vonk-Noordegraaf A, Marcus JT, Gan CT, Boonstra A, Postmus PE
Cited 146 times since 2005 (7.9 per year) source: EuropePMC
American journal of physiology. Heart and circulatory physiology, Volume 290, Issue 4, 11 2 2005, Pages H1528-33 Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension. Gan C, Lankhaar JW, Marcus JT, Westerhof N, Marques KM, Bronzwaer JG, Boonstra A, Postmus PE, Vonk-Noordegraaf A
The aim of this study was to investigate the contribution of direct right-to-left ventricular interaction to left ventricular filling and stroke volume in 46 patients with pulmonary arterial hypertension (PAH) and 18 control subjects. Stroke volume, right and left ventricular volumes, left ventricular filling rate, and interventricular septum curvature were measured by magnetic resonance imaging and left atrial filling by transesophageal echocardiography. Stroke volume, left ventricular end-dias... Abstract
Cited 143 times since 2005 (7.7 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 23, Issue 33, 1 1 2005, Pages 8362-8370 Prognostic relevance of response evaluation using [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with locally advanced non-small-cell lung cancer. Hoekstra CJ, Stroobants SG, Smit EF, Vansteenkiste J, van Tinteren H, Postmus PE, Golding RP, Biesma B, Schramel FJ, van Zandwijk N, Lammertsma AA, Hoekstra OS
Purpose: The objective of this study was to determine the accuracy of (early) response measurements using [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG PET) with respect to survival of patients with stage IIIA-N2 non-small-cell lung cancer (NSCLC) undergoing induction chemotherapy (IC), with a comparative analysis of PET methods. Patients and methods: In a prospective multicenter study, PET was performed in patients before IC and after one and three cycles. Computed tomogr... Abstract