Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
511 results
Cited 21 times since 2009 (1.4 per year) source: EuropePMC
The European respiratory journal, Volume 33, Issue 3, 1 1 2009, Pages 670-672 Tuberculosis complicating imatinib treatment for chronic myeloid leukaemia. Daniels JM, Vonk-Noordegraaf A, Janssen JJ, Postmus PE, van Altena R
Although imatinib is not considered a predisposing factor for tuberculosis (TB), the present case report describes three patients in whom imatinib treatment for chronic myeloid leukaemia was complicated by TB. This raises the question of whether imatinib increases susceptibility to TB. There are several reports suggesting that imatinib might impair the immune system, leading to a variety of infections, including varicella zoster and hepatitis B. Control of TB in healthy individuals is achieved t... Abstract
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Volume 28, Issue 3, 1 1 2009, Pages 280-284 Addition of prostanoids in pulmonary hypertension deteriorating on oral therapy. Jacobs W, Boonstra A, Marcus JT, Postmus PE, Vonk-Noordegraaf A
Background: The aim of our study was to describe the efficacy of addition of intravenous or subscutaneous prostanoids in idiopathic pulmonary arterial hypertension (PAH) patients deteriorating on bosentan or on bosentan-sildenafil. Methods: PAH treatment at our hospital is standardized with first-line oral therapy in New York Heart Association class III patients followed by addition of prostanoids on clinical worsening. Results: Mean improvement in 6-minute walk distance after 4 months of prosta... Abstract
Cited 25 times since 2009 (1.6 per year) source: EuropePMC
Respiratory medicine, Volume 103, Issue 7, 20 3 2009, Pages 1013-1019 Predictors of mortality in inoperable chronic thromboembolic pulmonary hypertension. Saouti N, de Man F, Westerhof N, Boonstra A, Twisk J, Postmus PE, Vonk Noordegraaf A
Introduction: Recent studies suggest that medically treated patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) have an improved prognosis. However, only limited data are available concerning predictors of mortality in these patients. The aim of this study was to assess, and to identify, predictors of the long-term outcome of inoperable CTEPH patients. Methods: We analysed 84 inoperable CTEPH patients referred to our centre between 1999 and 2008. During follow-up (mean... Abstract
Cited 30 times since 2009 (2 per year) source: EuropePMC
Cellular oncology : the official journal of the International Society for Cellular Oncology, Volume 31, Issue 3, 1 1 2009, Pages 161-167 A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations. Kramer D, Thunnissen FB, Gallegos-Ruiz MI, Smit EF, Postmus PE, Meijer CJ, Snijders PJ, Heideman DA
Background: Increasing evidence points to a negative correlation between K-ras mutations and patient's response to, or survival benefit after, treatment with EGFR-inhibitors. Therefore, rapid and reliable assays for mutational analysis of the K-ras gene are strongly needed. Methods: We designed a high resolution melting (HRM) technology-based approach followed by direct sequencing to determine K-ras exon 1 (codons 12/13) tumour genotype. Results: Reconstruction experiments demonstrated an a... Abstract
Cited 41 times since 2009 (2.7 per year) source: EuropePMC
Cellular oncology : the official journal of the International Society for Cellular Oncology, Volume 31, Issue 5, 1 1 2009, Pages 329-333 A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes. Heideman DA, Thunnissen FB, Doeleman M, Kramer D, Verheul HM, Smit EF, Postmus PE, Meijer CJ, Meijer GA, Snijders PJ
Background: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use of EGFR-targeted therapies. Methods: In this study, we describe the development of high resolution melting (HRM) technology-based assays with direct sequencing confirmation possibility for mutation screening of the EGFR gene (exons 19, 20 and 21) in... Abstract
Cited 3 times since 2009 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 153, 1 1 2009, Pages A581 [Spontaneous pneumothorax as the first manifestation of a hereditary condition with an increased renal cancer risk]. Johannesma PC, Lammers JW, van Moorselaar RJ, Starink TM, Postmus PE, Menko FH
Spontaneous pneumothorax can be due to Birt-Hogg-Dubé syndrome (BHD syndrome), an autosomal dominant predisposition for fibrofolliculomas, multiple lung cysts, pneumothorax and renal cancer. The syndrome is the result of germline mutations in the FLCN (folliculin) gene. Its clinical presentation is highly variable. Consequently, this syndrome is probably under-diagnosed. An illustrative kindred is presented in which the index patient, a man aged 26, had recurrent episodes of pneumothorax without... Abstract
Cited 99 times since 2008 (6.4 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 27, Issue 1, 1 1 2008, Pages 78-84 Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lung Cancer Groups. Slotman BJ, Mauer ME, Bottomley A, Faivre-Finn C, Kramer GW, Rankin EM, Snee M, Hatton M, Postmus PE, Collette L, Senan S
Purpose: Prophylactic cranial irradiation (PCI) in patients with extensive-disease small-cell lung cancer (ED-SCLC) leads to significantly fewer symptomatic brain metastases and improved survival. Detailed effects of PCI on health-related quality of life (HRQOL) are reported here. Patients and methods: Patients (age, 18 to 75 years; WHO < or = 2) with ED-SCLC, and any response to chemotherapy, were randomly assigned to either observation or PCI. Health-related quality of life (HRQOL) and pati... Abstract
Cited 38 times since 2008 (2.5 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 10, 5 1 2008, Pages 51 Non-invasive stroke volume assessment in patients with pulmonary arterial hypertension: left-sided data mandatory. Mauritz GJ, Marcus JT, Boonstra A, Postmus PE, Westerhof N, Vonk-Noordegraaf A
Background: Cardiovascular magnetic resonance (CMR) is an emerging modality in the diagnosis and follow-up of patients with pulmonary arterial hypertension (PAH). Derivation of stroke volume (SV) from the pulmonary flow curves is considered as a standard in this respect. Our aim was to investigate the accuracy of pulmonary artery (PA) flow for measuring SV. Methods: Thirty-four PAH patients underwent both CMR and right-sided heart catheterisation. CMR-derived SV was measured by PA flow, left (LV... Abstract
Cited 1 times since 2008 (0.1 per year) source: EuropePMC
Expert review of anticancer therapy, Volume 8, Issue 10, 1 1 2008, Pages 1529-1531 Screening and early diagnosis in lung cancer. Postmus PE
Cited 83 times since 2008 (5.3 per year) source: EuropePMC
Medicine and science in sports and exercise, Volume 40, Issue 10, 1 1 2008, Pages 1725-1732 Exercise testing to estimate survival in pulmonary hypertension. Groepenhoff H, Vonk-Noordegraaf A, Boonstra A, Spreeuwenberg MD, Postmus PE, Bogaard HJ
Background: : The 6-min walk distance (6MWD) predicts survival in pulmonary hypertension (PH). The peak oxygen consumption (V O2peak) measured during a cardiopulmonary exercise test (CPET) also relates to survival in PH, and it is unknown how the prognostic information from measurements of ventilatory responses and gas exchange during CPET compares to the prognostic information obtained by the 6MWD alone. The aims of our study were to compare prognostic values of different exercise parameters in... Abstract
Cited 2 times since 2008 (0.1 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 19 Suppl 7, 1 1 2008, Pages vii25-7 Screening for lung cancer, an ongoing debate. Postmus PE
Cited 10 times since 2008 (0.6 per year) source: EuropePMC
Lung cancer (Amsterdam, Netherlands), Volume 62, Issue 3, 19 3 2008, Pages 309-315 Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy? Lee P, de Bree R, Brokx HA, Leemans CR, Postmus PE, Sutedja TG
Background: Head and neck cancer (HNC) is the 5th most common cancer worldwide. As good locoregional tumor control can be achieved with current treatment strategies, patients who develop second primary tumors from field cancerization have poorer prognosis. Objectives: To determine if autofluorescence bronchoscopy (AF) played a role in the detection of second primary lung cancer (SPLC), and impact of SPLC on survival of patients with HNC and no cervical lymph node metastasis (N0). Methods: Patien... Abstract
Cited 27 times since 2008 (1.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 2, 12 2 2008, Pages 137-141 Stroke volume increase to exercise in chronic obstructive pulmonary disease is limited by increased pulmonary artery pressure. Holverda S, Rietema H, Westerhof N, Marcus JT, Gan CT, Postmus PE, Vonk-Noordegraaf A
Aims: This study was designed to investigate the mechanisms by which the right ventricle is able to increase stroke volume (SV) during exercise in chronic obstructive pulmonary disease (COPD). A second aim was to determine whether resting pulmonary artery pressure (Ppa) is predictive of exercise SV. Methods: 16 COPD patients (GOLD stages II-IV) underwent right heart catheterisation at rest and during exercise. In this group and eight age-matched controls resting and exercise right ventricular SV... Abstract
Cited 3 times since 2008 (0.2 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 152, Issue 17, 1 1 2008, Pages 1000-1004 [Prophylactic cranial irradiation in patients with extensive disease caused by small-cell lung cancer responsive to chemotherapy: fewer symptomatic brain metastases and improved survival]. Slotman BJ, Faivre-Finn C, Kramer GW, Rankin E, Snee M, Hatton M, Postmus PE, Collette L, Musat E, Senan S
Objective: To determine the effect of prophylactic cranial irradiation (PCI) in patients with extensive-disease small-cell lung cancer (ED-SCLC) who responded to chemotherapy. Design: Randomised, controlled clinical trial; phase III study (EORTC nr 08993-22993; www.clinicaltrials.gov, nr NCT00016211). Method: Patients aged 18-75 years with a functional status according to WHO < or = 2, and with ED-SCLC and any response to chemotherapy, were randomized to observation (standard care) or PCI. Th... Abstract
Cited 77 times since 2008 (4.8 per year) source: EuropePMC
Annals of the rheumatic diseases, Volume 68, Issue 2, 28 4 2008, Pages 191-195 Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosis. Hofstee HM, Vonk Noordegraaf A, Voskuyl AE, Dijkmans BA, Postmus PE, Smulders YM, Serné EH
Objective: The aim of this study was to investigate whether there are differences in capillary nailfold changes in patients with systemic sclerosis (SSc) with and without pulmonary arterial hypertension (PAH), and whether these changes are associated with PAH severity and disease specificity. Methods: Capillary density and loop dimensions were studied in 21 healthy controls, 20 patients with idiopathic PAH (IPAH) and 40 patients with SSc. Of the 40 patients with SSc, 19 had no PAH (SSc-nonPAH) a... Abstract
Cited 143 times since 2008 (8.9 per year) source: EuropePMC
European heart journal, Volume 29, Issue 13, 17 3 2008, Pages 1688-1695 Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension. Lankhaar JW, Westerhof N, Faes TJ, Gan CT, Marques KM, Boonstra A, van den Berg FG, Postmus PE, Vonk-Noordegraaf A
Aims: Pulmonary arterial compliance (C) is increasingly being recognized as an important contributor to right ventricular afterload, but for monitoring of treatment of pulmonary hypertension (PH) most often still only pulmonary vascular resistance (R) is used. We aimed at testing the hypothesis that R and C are coupled during treatment of PH and that substantial changes in both R and C would result in more haemodynamic improvement than changes in R alone. Methods and results: Data were analysed... Abstract
Cited 23 times since 2008 (1.4 per year) source: EuropePMC
Pulmonary pharmacology & therapeutics, Volume 21, Issue 3, 8 2 2008, Pages 558-564 Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD. Holverda S, Rietema H, Bogaard HJ, Westerhof N, Postmus PE, Boonstra A, Vonk-Noordegraaf A
Background: We investigated in chronic obstructive pulmonary disease (COPD) patients whether a single dose of sildenafil can attenuate the exercise-induced increase in pulmonary artery pressure, thereby allowing augmentation of stroke volume (SV), and improving maximal exercise capacity. Methods: Eighteen COPD patients (GOLD II-IV) underwent right heart catheterization at rest and submaximal exercise. Mean pulmonary artery pressure (mPpa) and cardiac output (CO) were assessed. Resting and exerci... Abstract
Cited 59 times since 2007 (3.6 per year) source: EuropePMC
The European respiratory journal, Volume 31, Issue 4, 19 3 2007, Pages 759-764 Sildenafil treatment in COPD does not affect stroke volume or exercise capacity. Rietema H, Holverda S, Bogaard HJ, Marcus JT, Smit HJ, Westerhof N, Postmus PE, Boonstra A, Vonk-Noordegraaf A
In chronic obstructive pulmonary disease (COPD) patients, stroke volume response to exercise is impaired. The aim of the present study was to investigate whether 3 months of sildenafil treatment improves stroke volume and, if so, whether this improvement is related to the pulmonary artery pressure and translated into an improved exercise capacity. A total of 15 stable COPD patients (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent right heart catheterisation at rest... Abstract
Cited 124 times since 2007 (7.6 per year) source: EuropePMC
European heart journal, Volume 29, Issue 1, 8 2 2007, Pages 120-127 Right coronary artery flow impairment in patients with pulmonary hypertension. van Wolferen SA, Marcus JT, Westerhof N, Spreeuwenberg MD, Marques KM, Bronzwaer JG, Henkens IR, Gan CT, Boonstra A, Postmus PE, Vonk-Noordegraaf A
Aims: This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion. Methods: In 25 subjects, five patients with idiopathic pulmonary arterial hypertension, nine patients with chronic thromboembolic pulmonary arterial hypertension, and 11 healthy controls, flow of the RCA and left anterior descending (LAD) artery was measured with MR flow quantification. Results: In PH, RCA peak systolic and mean... Abstract
Cited 240 times since 2007 (14.6 per year) source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 2, Issue 12, 1 1 2007, Pages 1067-1077 The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer. Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, Chansky K, Shaikh Z, Goldstraw P, International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions
Background: Small cell lung cancer (SCLC) is usually classified using the limited and extensive definition. The tumor, node, metastasis (TNM) classification should also be applicable to SCLC, but it has only been reported in small surgical series. The current analysis looks to the impact of the TNM system on the clinical staging of SCLC and of the new International Association for the study of Lung Cancer (IASLC) proposals. Methods: Using the IASLC database, survival analyses were performed for... Abstract