Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
112 results
Cited 55 times since 2006 (3.1 per year) source: EuropePMC
Alimentary pharmacology & therapeutics, Volume 24, Issue 7, 1 1 2006, Pages 1087-1097 Once daily MMX mesalazine for the treatment of mild-to-moderate ulcerative colitis: a phase II, dose-ranging study. D'Haens G, Hommes D, Engels L, Baert F, van der Waaij L, Connor P, Ramage J, Dewit O, Palmen M, Stephenson D, Joseph R
Background: SPD476 (MMX mesalazine), is a novel, once daily, high-strength mesalazine formulation (1.2 g/tablet) that utilizes Multi Matrix System (MMX) technology to delay and extend delivery of the active drug throughout the colon. Aim: To assess the safety and efficacy of MMX mesalazine in patients with mild-to-moderately active ulcerative colitis, in a pilot, phase II, randomized, multicentre, double-blind, parallel-group, dose-ranging study (SPD476-202). Methods: Thirty-eight patients with... Abstract
Cited 7 times since 2006 (0.4 per year) source: EuropePMC
Inflammopharmacology, Volume 14, Issue 1-2, 1 1 2006, Pages 36-41 Chronic effects of celecoxib, a cyclooxygenase-2 inhibitor, cause enhanced alcohol-induced liver steatosis in rats. Bykov IL, Palmen M, Rainsford KD, Lindros KO
Background: The pathogenetic role of prostaglandins in steatosis, the first stage of alcoholic liver injury, is not well understood, especially that involving the inflammatory reactions controlled by prostaglandins and pro-inflammatory cytokines in the liver. We, therefore, studied the chronic effects of the COX-2 inhibitor, celecoxib, given to ethanol-treated rats. Methods: Rats were fed ethanol and a low dose of celecoxib (approximately 20 mg/kg daily) in a high-fat/low-carbohydrate liquid die... Abstract
Future cardiology, Volume 1, Issue 4, 1 1 2005, Pages 479-488 The role of insulin-like growth factor during a postischemic period - new insights into pathophysiologic pathways in cardiac tissue. Palmen M, Twickler MT, Daemen MJ, Cramer MJ, Doevendans PA
Despite an improvement in the therapeutic strategies available for an acute ischemic event, cardiac disease is still the principal cause of morbidity and mortality in Western societies. A shift from acute towards more chronic heart disease due to atherosclerotic disease has been recognized. Modification of adaptive capacities of the cardiac muscle after damage remains a key component in the prevention of chronic cardiac disease, such as overt heart failure. It has recently been demonstrated that... Abstract
Cited 8 times since 2004 (0.4 per year) source: EuropePMC
Alcohol and alcoholism (Oxford, Oxfordshire), Volume 39, Issue 6, 11 2 2004, Pages 499-502 Oral chronic ethanol administration to rodents by agar gel diet. Bykov I, Palmén M, Piirainen L, Lindros KO
Background: Chronic ethanol administration to rodents requires specially designed equipment and is labor intensive. Here we report a new procedure. Method: A commercial liquid diet preparation was made into a gel by addition of 0.5% agar. The gel, containing 5.3% ethanol, was offered in Falcon tubes equipped with a feeding opening. Results: The gel consumption by C57/Bl mice resulted in high blood ethanol levels (average 43 mM). After 6 weeks, marked liver steatosis and significantly increased s... Abstract
Cited 39 times since 2004 (2 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 44, Issue 5, 1 1 2004, Pages 1113-1123 Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. Palmen M, Daemen MJ, De Windt LJ, Willems J, Dassen WR, Heeneman S, Zimmermann R, Van Bilsen M, Doevendans PA
Objectives: We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion. Background: The FGFs display cardioprotective effects during ischemia and reperfusion. Methods: We investigated FGF-1-induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion. Results: Cardiac-specific human FGF-1 overexpression wa... Abstract
Cited 39 times since 2004 (1.9 per year) source: EuropePMC
Basic research in cardiology, Volume 99, Issue 5, 16 3 2004, Pages 351-359 Left ventricular pressure-volume measurements in mice: comparison of closed-chest versus open-chest approach. Lips DJ, van der Nagel T, Steendijk P, Palmen M, Janssen BJ, van Dantzig JM, de Windt LJ, Doevendans PA
Objective: We investigated whether in vivo closed-chest left ventricular pressure-volume measurements would yield similar values for LV hemodynamics compared with open-chest PV measurements under several anesthetics. Methods: The right common carotid of C57Bl/6 mice was cannulated with a combined pressure-conductance catheter and inserted retrogradely into the left ventricle in the closed-chest model. The open-chest model consisted of an abdominal approach involving the opening of the thoracic c... Abstract
Cited 32 times since 2002 (1.5 per year) source: EuropePMC
Cardiovascular research, Volume 55, Issue 4, 1 1 2002, Pages 768-777 Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Buehler A, Martire A, Strohm C, Wolfram S, Fernandez B, Palmen M, Wehrens XH, Doevendans PA, Franz WM, Schaper W, Zimmermann R
Objective: This study was performed to evaluate the cardioprotective role of acidic fibroblast growth factor-1 (FGF-1) in transgenic mice with cardiac-specific overexpression of human FGF-1. Methods: Mice were subjected to coronary artery occlusion for 15-75 min with a continuously recorded 3-lead electrocardiogram (ECG). Infarct size was measured and ERK-1 and -2 activity was assessed by Western blot analysis. Creatine kinase and lactate dehydrogenase activity as marker for cell viability were... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 9, Issue 6, 1 1 2001, Pages 256-261 Scientific conference on therapeutic angiogenesis and myocardial laser revascularisation: Santa Fe, United States, 24-27 January 2001. Palmen M, Dekkers SC
Cited 27 times since 2001 (1.2 per year) source: EuropePMC
Cardiovascular research, Volume 50, Issue 3, 1 1 2001, Pages 516-524 Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice. Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA
Objective: To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function. Methods: A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured. Results: No significa... Abstract
Cited 34 times since 2001 (1.5 per year) source: EuropePMC
European journal of immunology, Volume 31, Issue 1, 1 1 2001, Pages 146-155 Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer. van der Burg SH, de Cock K, Menon AG, Franken KL, Palmen M, Redeker A, Drijfhout J, Kuppen PJ, van de Velde C, Erdile L, Tollenaar RA, Melief CJ, Offringa R
Colorectal carcinoma is commonly associated with mutation and overexpression of p53, making this antigen a potential target for immune intervention. We analyzed humoral and proliferative immunity against p53 in the blood of patients with resected primary colorectal cancer. The majority of these patients displayed anti-p53 T helper (Th) immunity in the absence of measurable p53 specific antibody levels. The Th responses were long-lasting since they could be detected up to several years after rese... Abstract
Cited 13 times since 1998 (0.5 per year) source: EuropePMC
Vision research, Volume 38, Issue 5, 1 1 1998, Pages 659-668 Stereoscopic segregation of transparent surfaces and the effect of motion contrast. Lankheet MJ, Palmen M
Stereoscopic segregation in depth was studied using two superimposed frontoparallel surfaces displayed in dynamic random dot stereograms. The two patterns were positioned symmetrically in front of and behind a binocular fixation point. They were either stationary, or they could move relative to each other. Sensitivity for segregation was established by adding gaussian distributed disparity noise to the disparities specifying the two planes, and finding the noise amplitude that gave threshold seg... Abstract
Cited 15 times since 1993 (0.5 per year) source: EuropePMC
Veterinary immunology and immunopathology, Volume 36, Issue 4, 1 1 1993, Pages 369-378 Effects of inoculum route and dose on the immune response of common carp, Cyprinus carpio to the blood parasite, Trypanoplasma borreli. Jones SR, Palmen M, van Muiswinkel WB
Carp were inoculated intramuscularly (im) or intraperitoneally (ip) with different doses of live Trypanoplasma borreli. Prepatent period was shortened by using the im route and by increasing the dose. Haematocrit was reduced following im inoculation with 9.5 x 10(5) parasites. Most fish recovered between 8 and 13 weeks post-inoculation (wpi). Neither parasitaemia nor anaemia was detected in any recovered fish following homologous challenge. An enzyme-linked immunosorbent assay was developed to q... Abstract