Cited 5 times since 1997 (0.2 per year) source: EuropePMC Scandinavian journal of immunology, Volume 46, Issue 6, 1 1 1997, Pages 597-600 Difference in binding of killed and live Streptococcus pneumoniae serotypes by C-reactive protein. de Beaufort AJ, Langermans JA, Matze-van der Lans AM, Hiemstra PS, Vossen JM, van Furth R
The binding and opsonic properties of C-reactive protein (CRP) for various species of bacteria were investigated. CRP bound more avidly to killed than to live Streptococcus pneumoniae, the binding varying among various serotypes; CRP hardly bound to a number of other bacterial species studied. CRP enhanced complement-dependent phagocytosis of live S. pneumoniae by granulocytes but did not enhance the phagocytosis of live Staphylococcus aureus or group B streptococci. We suppose that CRP may serve as an opsonin for killed bacteria and bacterial debris but is probably not an important opsonin for live bacteria other than S. pneumoniae.
