Cited 45 times since 2010 (3.3 per year) source: EuropePMC International journal of cardiology, Volume 154, Issue 2, 8 2 2010, Pages 168-172 Circumstances of death in adult congenital heart disease. Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, van den Merkhof LF, Baur LH, Ansink TJ, Cozijnsen L, Pieper PG, Meijboom FJ, Grobbee DE, Mulder BJ
Background
Circumstances of death have been described for various cardiovascular diseases, but this study is the first for adults with congenital heart disease (CHD).
Methods
Review of medical records and additional information from treating cardiologists and general practitioners, for circumstances of all deaths in a national registry of over 8000 adults with CHD.
Results
Of 8595 patients, 231 (2.7%) patients died over 26,500 patient years. Main causes of death were progressive heart failure (26%) and sudden cardiac death (22%). Mortality was highest in the northern, most rural region of the country (p ≤ 0.05). Overall, death occurred out-of-hospital in approximately 35%, but more frequently in rural than in urban areas (55% versus 32%, p ≤ 0.05). Mortality was almost equally distributed throughout the seasons, although fall showed a slightly higher mortality rate. Cardiovascular death occurred suddenly in nearly 40%. Sudden cardiovascular death occurred in 8% during exercise, and most often out-of-hospital (62%). Of non-sudden cardiovascular deaths 18% had occurred out-of-hospital.
Conclusion
In adult patients with congenital heart disease, mortality shows substantial regional and subtle seasonal variation. Death usually occurs at rest; approximately 1 of 10 sudden cardiovascular deaths occur during exercise.
