Cited 1 times since 1992 (0 per year) source: EuropePMC Nederlands tijdschrift voor geneeskunde, Volume 136, Issue 45, 1 1 1992, Pages 2236-2238 [2 patients with brain metastases who became pregnant during phenytoin administration]. van der Graaf WT, van Loon AJ, Postmus PE, Sleijfer DT
Two young women taking phenytoin because of symptomatic brain metastases are described. Both patients, one with end-stage lung cancer and the other in complete remission after intensive chemotherapeutic treatment of a choriocarcinoma, became pregnant while using oral contraceptives in combination with phenytoin. One patient had the child, but died a year after the metastases became apparent, in the other the pregnancy was terminated. When prescribing phenytoin, attention should be paid to fertility--even in patients with end-stage cancer or after intensive, possibly sterilising, chemotherapeutic treatment.
