Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
482 results
Cited 3 times since 2022 (1.4 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 9, 17 3 2022, Pages 845359 The Prognostic Value of Right Atrial and Right Ventricular Functional Parameters in Systemic Sclerosis. Vos JL, Butcher SC, Fortuni F, Galloo X, Rodwell L, Vonk MC, Bax JJ, van Leuven SI, de Vries-Bouwstra JK, Snoeren M, El Messaoudi S, Marsan NA, Nijveldt R
Introduction: Right ventricular (RV) function is of particular importance in systemic sclerosis (SSc), since common SSc complications, such as interstitial lung disease and pulmonary hypertension may affect RV afterload. Cardiovascular magnetic resonance (CMR) is the gold standard for measuring RV function. CMR-derived RV and right atrial (RA) strain is a promising tool to detect subtle changes in RV function, and might have incremental value, however, prognostic data is lacking. Therefore, the... Abstract
Cited 5 times since 2022 (2.3 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 8, 15 3 2022, Pages 791-800.e4 Left Ventricular Global Longitudinal Strain in Patients with Moderate Aortic Stenosis. Stassen J, Pio SM, Ewe SH, Singh GK, Hirasawa K, Butcher SC, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ
Moderate aortic stenosis (AS) is associated with an increased risk for adverse events. Although reduced left ventricular (LV) global longitudinal strain (GLS) is associated with worse outcomes in patients with severe AS, its prognostic value in patients with moderate AS is unknown. The aim of this study was to investigate the prognostic implications of LV GLS in patients with moderate AS. Methods: LV GLS was evaluated using speckle-tracking echocardiography in patients with moderate AS (aortic v... Abstract
Cited 3 times since 2022 (1.4 per year) source: EuropePMC
Diagnostics (Basel, Switzerland), Volume 12, Issue 3, 9 2 2022, Pages 669 Sclerodermic Cardiomyopathy-A State-of-the-Art Review. Giucă A, Gegenava T, Mihai CM, Jurcuţ C, Săftoiu A, Gȋrniţă DM, Popescu BA, Ajmone Marsan N, Jurcuț R
Systemic sclerosis (SSc) is a chronic autoimmune disorder with unknown triggering factors, and complex pathophysiologic links which lead to fibrosis of skin and internal organs, including the heart, lungs, and gut. However, more than 100 years after the first description of cardiac disease in SSc, sclerodermic cardiomyopathy (SScCmp) is an underrecognized, occult disease with important adverse long-term prognosis. Laboratory tests, electrocardiography (ECG) and cardiovascular multimodality imagi... Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
ESC heart failure, Volume 9, Issue 3, 9 2 2022, Pages 1597-1607 Right ventricular-pulmonary artery coupling in cardiac resynchronization therapy: evolution and prognosis. Stassen J, Galloo X, Hirasawa K, Chimed S, Marsan NA, Delgado V, van der Bijl P, Bax JJ
Aims: Chronic pressure overload and right ventricular (RV) dysfunction can lead to RV-pulmonary artery (PA) uncoupling in patients with heart failure. The evolution and prognostic values of RV-PA coupling assessed by echocardiography in patients undergoing cardiac resynchronization therapy (CRT) have not been thoroughly investigated. The aim of this study was to evaluate the evolution and prognostic value of tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (P... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 4, 1 1 2022, Pages 578-585 Prognostic implications of cardiac damage classification based on computed tomography in severe aortic stenosis. Hirasawa K, vanRosendael PJ, Fortuni F, Singh GK, Kuneman JH, Vollema EM, Ajmone Marsan N, Knuuti J, Bax JJ, Delgado V
Aims: An echocardiographic staging system of severe aortic stenosis (AS) based on additional extra-valvular cardiac damage has been associated with prognosis after transcatheter aortic valve implantation (TAVI). Multidetector row computed tomography (MDCT) is key in the evaluation of AS patients undergoing TAVI and can potentially detect extra-valvular cardiac damage. This study aimed at evaluating the prognostic implications of an MDCT staging system of severe AS in patients undergoing TAVI. Me... Abstract
The international journal of cardiovascular imaging, 26 4 2022 Patterns of cardiac involvement characterized by strain echocardiography in amyloidosis. Tjahjadi C, Fortuni F, Stassen J, Marsan NA, Delgado V, Bax JJ
The American journal of cardiology, Volume 170, 21 3 2022, Pages 1-9 Prognostic Relevance of Right Ventricular Remodeling after ST-Segment Elevation Myocardial Infarction in Patients Treated With Primary Percutaneous Coronary Intervention. Chimed S, van der Bijl P, Lustosa RP, Hirasawa K, Yedidya I, Fortuni F, van der Velde E, Montero-Cabezas JM, Marsan NA, Gersh BJ, Delgado V, Bax JJ
ST-segment elevation myocardial infarction (STEMI) often leads to changes in right ventricular (RV) function and size over time. The prognostic implications of RV remodeling after STEMI, however, are unknown. RV remodeling in patients who underwent STEMI with primary percutaneous coronary intervention (PCI) was defined by RV end-systolic area (RV ESA) change at 6 months after STEMI compared with baseline. The optimal threshold of RV ESA change (≥40%) to define RV remodeling was derived from spli... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
International journal of cardiology, Volume 355, 18 3 2022, Pages 65-71 Prognostic implications of staging cardiac remodeling in patients undergoing cardiac resynchronization therapy. Stassen J, Khidir M, Galloo X, Hirasawa K, Knuuti J, Marsan NA, Delgado V, van der Bijl P, Bax JJ
Background: Cardiac resynchronization therapy (CRT) candidates often present with significant mitral and tricuspid regurgitation, pulmonary hypertension and right ventricular dysfunction when referred for device implantation. This study investigated the prognostic value of a novel cardiac staging system, based on the extent of cardiac remodeling prior to implantation. Methods: Data were collected from an ongoing registry of CRT recipients. Patients were divided into 4 groups according to the ext... Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
Heart rhythm, Volume 19, Issue 6, 18 3 2022, Pages 927-936 Impact of baseline left ventricular volume on left ventricular reverse remodeling after cardiac resynchronization therapy. Galloo X, Stassen J, Hirasawa K, Chimed S, Cosyns B, Ajmone Marsan N, Delgado V, van der Bijl P, Bax JJ
Background: Left ventricular (LV) dilatation may limit LV reverse remodeling after cardiac resynchronization therapy (CRT). Objective: The purpose of this study was to evaluate the impact of baseline LV volumes on LV reverse remodeling after CRT and whether this is associated with improved survival. Methods: Patients were stratified into quintiles according to baseline LV end-diastolic volume indexed for body surface area (LVEDVi). LV reverse remodeling was defined as ≥15% reduction in LV end-sy... Abstract
Cited 8 times since 2022 (3.5 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 7, 26 4 2022, Pages 703-711.e3 Noninvasive Left Ventricular Myocardial Work in Patients with Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. Meucci MC, Butcher SC, Galloo X, van der Velde ET, Marsan NA, Bax JJ, Delgado V
Background: Left ventricular (LV) global longitudinal strain (GLS) has been proposed as a sensitive marker of myocardial damage in patients with chronic severe aortic regurgitation (AR) and preserved LV ejection fraction (LVEF). However, LV GLS does not take into account the afterload. Noninvasive LV myocardial work is a novel parameter of LV myocardial performance, which integrates measurements of myocardial deformation and noninvasive blood pressure (afterload). The aims of this study were (1)... Abstract
The American journal of cardiology, Volume 169, 23 4 2022, Pages 93-99 Long-Term Impact of Preventive Tricuspid Valve Annuloplasty on Right Ventricular Remodeling. Dietz MF, van Wijngaarden AL, Mack MJ, Braun J, Ajmone Marsan N, Delgado V, Klautz R, Bax JJ
In patients with primary mitral regurgitation (MR), concomitant tricuspid valve (TV) annuloplasty at the time of left-sided valve surgery is indicated in case of a dilated TV annulus ≥40 mm independent of the presence or severity of tricuspid regurgitation (TR). However, the long-term impact on right ventricular (RV) adverse remodeling is less well established and the benefit of preventive TV annuloplasty remains controversial. The aim of the study was to assess differences in long-term RV adver... Abstract
Cited 4 times since 2022 (1.8 per year) source: EuropePMC
ESC heart failure, Volume 9, Issue 2, 22 4 2022, Pages 912-924 Functional classification of left ventricular remodelling: prognostic relevance in myocardial infarction. Chimed S, van der Bijl P, Lustosa R, Fortuni F, Montero-Cabezas JM, Ajmone Marsan N, Gersh BJ, Delgado V, Bax JJ
Aims: The current definition of post ST-segment elevation myocardial infarction (STEMI) left ventricular (LV) remodelling is purely structural (LV dilatation) and does not consider LV function (ejection fraction, EF), even though it is known to be a predictor of long-term post-STEMI outcome. This study aimed to reclassify LV remodelling after STEMI by integrating LV dilatation and function (LVEF) and to investigate the prognostic implications. Methods and results: Data from an ongoing registry o... Abstract
Cited 6 times since 2022 (2.6 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 5, 21 3 2022, Pages 477-485.e3 Left Atrial Reservoir Function and Outcomes in Secondary Mitral Regurgitation. Stassen J, Namazi F, van der Bijl P, van Wijngaarden SE, Kamperidis V, Marsan NA, Delgado V, Bax JJ
Background: Left atrial (LA) size is a marker of disease severity and is related to worse outcomes in secondary mitral regurgitation (MR). The prognostic value of LA function assessed by LA reservoir strain (LARS), however, remains unknown. The aim of this study was to investigate the prognostic implications of LARS in patients with significant secondary MR. Methods: LARS was evaluated using speckle-tracking echocardiography in patients with more than mild (grade ≥ 2) secondary MR. The populatio... Abstract
Cited 1 times since 2022 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 171, 19 3 2022, Pages 151-158 Prognostic Implications of Right Ventricular Free Wall Strain in Recipients of Cardiac Resynchronization Therapy. Stassen J, van der Bijl P, Galloo X, Hirasawa K, Prihadi EA, Marsan NA, Bax JJ
Right ventricular (RV) function is an important prognostic marker in cardiac resynchronization therapy (CRT) recipients. Measuring RV systolic function with echocardiography, however, remains challenging due to the complexity of right heart morphology. Evaluation of RV function with RV free wall strain (FWS) may improve risk stratification in recipients of CRT compared with conventional RV function parameters. In 871 recipients of CRT (mean age 65 ± 11 years, 75% were men), RV function was asses... Abstract
Cited 8 times since 2022 (3.5 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 15, Issue 6, 12 2 2022, Pages 961-970 Prognostic Impact of Extra-Mitral Valve Cardiac Involvement in Patients With Primary Mitral Regurgitation. van Wijngaarden AL, Mantegazza V, Hiemstra YL, Volpato V, van der Bijl P, Pepi M, Palmen M, Delgado V, Ajmone Marsan N, Tamborini G, Bax JJ
Background: In patients with severe primary mitral regurgitation (MR), the indication for surgery is currently based on the presence of symptoms, left ventricular dilatation and dysfunction, atrial fibrillation, and pulmonary hypertension. Objectives: The aim of this study was to evaluate the prognostic impact of the presence of extra-mitral valve cardiac involvement (including known risk factors but also severe left atrial [LA] dilatation and right ventricular [RV] dysfunction) in a large multi... Abstract
Cited 3 times since 2021 (1.3 per year) source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 35, Issue 5, 23 4 2021, Pages 486-494.e2 Left Atrial Deformation Imaging and Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis. Stassen J, Butcher SC, Namazi F, Ajmone Marsan N, Bax JJ, Delgado V
Background: Atrial fibrillation (AF) is a frequent complication of rheumatic mitral stenosis (MS) and is associated with worse outcomes. Prediction of new-onset AF by assessing left atrial (LA) mechanics with speckle-tracking echocardiography might be useful for risk stratification and guiding therapeutic strategies. Therefore, the aim of this study was to assess the association of LA reservoir strain (LASr) and strain rate (LASRr) with AF at follow-up in patients with rheumatic MS. Methods: Lef... Abstract
Cited 2 times since 2021 (0.8 per year) source: EuropePMC
Journal of the American Heart Association, Volume 10, Issue 24, 16 3 2021, Pages e023300 Cardiovascular Effects of Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Therapy With Early Tacrolimus Withdrawal in Renal Transplant Recipients: An Analysis of the Randomized TRITON Study. Meucci MC, Reinders MEJ, Groeneweg KE, Bezstarosti S, Ajmone Marsan N, Bax JJ, De Fijter JW, Delgado V
Background After renal transplantation, there is a need of immunosuppressive regimens that effectively prevent allograft rejection while minimizing cardiovascular complications. This substudy of the TRITON trial evaluated the cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in renal transplant recipients. Methods and Results Renal transplant recipients were randomized to MSC therapy, infused at weeks 6 and 7 after transplantation, with withdrawal at week... Abstract
Cited 4 times since 2021 (1.7 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 1, 1 1 2021, Pages 95-101 Comparison of left atrial strain measured by feature tracking computed tomography and speckle tracking echocardiography in patients with aortic stenosis. Hirasawa K, Kuneman JH, Singh GK, Gegenava T, Hautemann D, Reiber JHC, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Peak left atrial longitudinal strain (PALS) is a marker of the left atrial (LA) reservoir function. Novel feature tracking (FT) software allows assessment of LA strain from multidetector computed tomography (MDCT) data. This study aimed at evaluating the agreement between speckle tracking echocardiography (STE) and FT MDCT for the measurement of PALS in patients with sinus rhythm (SR) and with atrial fibrillation (AF). Methods and results: The current study included 318 patients (80 ± 7 ye... Abstract
The American journal of cardiology, Volume 162, 29 5 2021, Pages 170-176 Value of Global Longitudinal Strain for Identification and Monitoring of Left Ventricular Dysfunction in Becker Muscular Dystrophy. van de Velde NM, Gegenava T, Koeks Z, Butcher SC, Roest AA, Bax JJ, Atsma DE, Spitali P, Ajmone Marsan N, Niks EH
Cardiac involvement is the main cause of death in Becker muscular dystrophy (BMD). Identification of left ventricular (LV) function is crucial, but standard echocardiographic measurements such as LV ejection fraction (LVEF) might not be sensitive enough to detect early myocardial dysfunction. We explored the value of LV global longitudinal strain (GLS) as a more accurate echocardiographic parameter to detect and monitor LV dysfunction in BMD. Furthermore, we studied possible factors associated w... Abstract
Cited 1 times since 2021 (0.4 per year) source: EuropePMC
The American journal of cardiology, Volume 162, 24 4 2021, Pages 143-149 Extramitral Valvular Cardiac Involvement in Patients With Significant Secondary Mitral Regurgitation. Singh GK, Namazi F, Hirasawa K, van der Bijl P, van Wijngaarden AL, Vo NM, Stone GW, Ajmone Marsan N, Delgado V, Bax JJ
Patients with secondary mitral regurgitation (SMR) often have extramitral valve cardiac involvement, which can influence the prognosis. SMR can be defined according to groups of extramitral valve cardiac involvement. The prognostic implications of such groups in patients with moderate and severe SMR (significant SMR) are unknown. A total of 325 patients with significant SMR were classified according to the extent of cardiac involvement on echocardiography: left ventricular involvement (group 1),... Abstract