Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
440 results
Cited 45 times since 1989 (1.3 per year) source: EuropePMC
Journal of immunology (Baltimore, Md. : 1950), Volume 142, Issue 6, 1 1 1989, Pages 2024-2030 Biosynthesis of complement factor H by human umbilical vein endothelial cells. Regulation by T cell growth factor and IFN-gamma. Brooimans RA, Hiemstra PS, van der Ark AA, Sim RB, van Es LA, Daha MR
The present studies were initiated to characterize a 150-kDa molecule with inhibitory activity for C3bBb formation, which is present in human umbilical vein endothelial cells (HUVEC). Therefore, human endothelial culture supernatants (HECS) were analyzed for the presence of human complement factor H by ELISA. It was found that H was present in HECS. An immunoblot analysis of affinity purified H from HECS showed that the size of HUVEC H was identical to that of plasma H. The mean production of H... Abstract
Cited 33 times since 1989 (0.9 per year) source: EuropePMC
Experimental hematology, Volume 17, Issue 3, 1 1 1989, Pages 229-234 Interleukin 1 and poly(rI).poly(rC) induce production of granulocyte CSF, macrophage CSF, and granulocyte-macrophage CSF by human endothelial cells. Fibbe WE, Daha MR, Hiemstra PS, Duinkerken N, Lurvink E, Ralph P, Altrock BW, Kaushansky K, Willemze R, Falkenburg JH
Electrophoretically pure human interleukin 1 (IL-1) beta was found to stimulate human endothelial cells in monolayer culture to elaborate colony-stimulating activity (CSA). Supernatant fluids from cultures stimulated with increasing concentrations of IL-1 were found to stimulate colony formation of myeloid (CFU-GM), erythroid (BFU-E), and multipotent (CFU-GEMM) progenitor cells in a dose-dependent fashion. The effect on mixed colony formation, however, was less than on CFU-GM and BFU-E growth. S... Abstract
Cited 1 times since 1989 (0 per year) source: EuropePMC
Monographs in allergy, Volume 26, 1 1 1989, Pages 82-95 Rheumatoid factor and complement activation. Doekes G, Hiemstra PS
Cited 3 times since 1989 (0.1 per year) source: EuropePMC
Progress in clinical and biological research, Volume 297, 1 1 1989, Pages 247-60; discussion 260-1 Interaction of immunoglobulin A with complement and phagocytic cells. Daha MR, Gorter A, Rits M, van Es LA, Hiemstra PS
Cited 14 times since 1988 (0.4 per year) source: EuropePMC
European journal of immunology, Volume 18, Issue 12, 1 1 1988, Pages 1873-1880 Activation of rat complement by soluble and insoluble rat IgA immune complexes. Rits M, Hiemstra PS, Bazin H, Van Es LA, Vaerman JP, Daha MR
The ability of rat monoclonal IgA, specific for 2,4-dinitrophenyl (DNA), to activate the complement (C) system of the rat was investigated using aggregated IgA or IgA immune complexes (IC). IgA was coated onto a solid phase, and tested for its capacity to bind C3 upon incubation at 37 degrees C in normal rat serum (NRS) in the presence of Mg-EGTA. Binding of C3 was observed dependent on the dose of dimeric (d-), polymeric (p-) and secretory IgA tested. In contrast, little C3 fixation was observe... Abstract
Cited 32 times since 1988 (0.9 per year) source: EuropePMC
Clinical and experimental immunology, Volume 74, Issue 1, 1 1 1988, Pages 115-120 Serum levels and in vitro production of IgA subclasses in patients with primary IgA nephropathy. van den Wall Bake AW, Daha MR, van der Ark A, Hiemstra PS, Radl J, van Es LA
Patients with primary IgA nephropathy have deposits of IgA1 in their kidneys, and increased plasma levels of macromolecular IgA1. Total serum IgA concentrations are frequently elevated, but studies on the subclass distribution have been few and conflicting. Several investigators found that production of IgA by peripheral blood lymphocytes in culture is increased. However, the distribution of the IgA subclasses produced has not been studied previously. We studied the serum IgA subclasses in 14 pa... Abstract
Cited 11 times since 1988 (0.3 per year) source: EuropePMC
Immunology, Volume 64, Issue 4, 1 1 1988, Pages 703-708 Binding, internalization and degradation of soluble aggregates of human secretory IgA by resident rat peritoneal macrophages. Gorter A, Hiemstra PS, Klar-Mohamad N, van Es LA, Daha MR
In the present study the in vitro binding, internalization and degradation of IgA immune complexes (IC) by phagocytes was studied. As a model for IgA IC, heat-aggregated human secretory IgA (AsIgA) was prepared and resident rat peritoneal macrophages (PM phi) were used as a source of phagocytes. First, binding of 125I-AsIgA to rat PM phi was investigated. Binding of 125I-AsIgA to PM phi at 4 degrees was saturable and reached plateau values after 2 hr. At 37 degrees, degradation of membrane-bound... Abstract
Cited 11 times since 1988 (0.3 per year) source: EuropePMC
Immunology, Volume 64, Issue 2, 1 1 1988, Pages 207-212 Binding of human IgA1 to rat peritoneal macrophages. Gorter A, Hiemstra PS, van der Voort EA, van Es LA, Daha MR
In the present study we have investigated whether bovine erythrocytes (Eb) specifically sensitized with human polyclonal IgA1 (Eb-IgA1) are able to bind to resident adherent rat peritoneal cells (PM phi). Rat PM phi formed rosettes with Eb-IgA1 at room temperature and at 37 degrees. The formation of these rosettes could be blocked completely by excess human serum IgA or myeloma IgA1. In contrast, human IgG or rat IgG did not inhibit the formation of rosettes, whereas human polymeric myeloma IgA2... Abstract
Cited 46 times since 1988 (1.3 per year) source: EuropePMC
Molecular immunology, Volume 25, Issue 6, 1 1 1988, Pages 527-533 Activation of complement by human serum IgA, secretory IgA and IgA1 fragments. Hiemstra PS, Biewenga J, Gorter A, Stuurman ME, Faber A, van Es LA, Daha MR
Unlabelled: Activation of the complement (C) system by human IgA was studied. Both subclasses of IgA, IgA1 and IgA2, and secretory IgA were shown to activate C, as determined by deposition of C3 on glutaraldehyde-activated microwells coated with IgA. The activation of the C system occurred in the presence of MgEGTA and not in D-deficient serum. In addition to C3, deposition of properdin (P) but not of C4 was detected. These results indicate that C activation, as determined by measuring depositio... Abstract
Cited 34 times since 1988 (0.9 per year) source: EuropePMC
European journal of immunology, Volume 18, Issue 5, 1 1 1988, Pages 783-787 The complement subcomponent C1q mediates binding of immune complexes and aggregates to endothelial cells in vitro. Daha MR, Miltenburg AM, Hiemstra PS, Klar-Mohamad N, Van Es LA, Van Hinsbergh VW
The present studies were initiated to investigate whether soluble immune complexes, upon interaction with complement, can bind to endothelial cells. Human umbilical vein endothelial cells (HUVE) were incubated with purified human 125I-labeled C1q at 4 degrees C in RPMI-0.5% bovine serum albumin and assayed for binding. Optimal binding of 125I-labeled C1q to HUVE was reached within 2 h, and saturation of binding was found at concentrations of 5 micrograms/well input. The binding of 125I-labeled C... Abstract
Cited 12 times since 1988 (0.3 per year) source: EuropePMC
Transplantation, Volume 45, Issue 4, 1 1 1988, Pages 701-705 Polymeric IgA antibody response to rabbit antithymocyte globulin in renal transplant recipients. Hiemstra PS, Baldwin WM, van der Voort EA, Paul LC, van Es LA, Daha MR
Treatment of transplant recipients with heterologous antithymocyte globulin (ATG) can induce the production of antibodies to the ATG itself. Such responses have, however, not been fully defined in terms of the kinetics, class, and quantities of antibodies produced. We have studied these parameters in 32 renal transplant recipients who had received rabbit ATG as treatment for acute rejection episodes. Antibodies to rabbit IgG were detected in the sera of all patients; employing an enzyme-linked i... Abstract
Monographs in allergy, Volume 24, 1 1 1988, Pages 129-133 Activation of rat complement by soluble and insoluble immune complexes of rat IgA. Rits M, Hiemstra PS, Bazin H, van Es LA, Daha M, Vaerman JP
Cited 10 times since 1987 (0.3 per year) source: EuropePMC
Molecular immunology, Volume 24, Issue 10, 1 1 1987, Pages 1047-1053 Complement-mediated solubilization of rat IgA immune precipitates. Rits M, Hiemstra PS, van Es LA, Bazin M, Vaerman JP, Daha MR
The complement-mediated solubilization (CMS) of immunoprecipitates (IP) consisting of DNP-rat serum albumin (RSA) and rat monoclonal anti-DNP antibodies of the IgA [both polymeric (p-) and monomeric (m-)] or IgG2b (sub)class was studied. In contrast to IgG2b IP, solubilization of IgA IP was only observed in an autologous system, with rat serum as the source of complement. IP prepared using m-IgA were solubilized faster than those prepared using p-IgA. Analysis of both affinity and avidity of the... Abstract
Cited 16 times since 1987 (0.4 per year) source: EuropePMC
Scandinavian journal of immunology, Volume 26, Issue 2, 1 1 1987, Pages 111-117 The IgA-binding lectin jacalin induces complement activation by inhibition of C-1-inactivator function. Hiemstra PS, Gorter A, Stuurman ME, Van Es LA, Daha MR
Jacalin, a D-galactose-specific lectin from jackfruit, interacts with human IgA and one or two other serum proteins. Incubation of jacalin with fresh human serum was shown to result in activation of the complement system. Therefore the mechanism of complement activation by jacalin was studied. Jacalin was extracted from jackfruit seeds (crude preparation) and purified to homogeneity by affinity chromatography on IgA-Sepharose to yield a pure preparation of jacalin. Both crude and pure jacalin we... Abstract
Cited 55 times since 1987 (1.5 per year) source: EuropePMC
Immunology, Volume 61, Issue 3, 1 1 1987, Pages 303-309 IgA- and secretory IgA-opsonized S. aureus induce a respiratory burst and phagocytosis by polymorphonuclear leucocytes. Gorter A, Hiemstra PS, Leijh PC, van der Sluys ME, van den Barselaar MT, van Es LA, Daha MR
The aim of the present study was to investigate whether corpuscular immune complexes containing human IgA were able to interact with human polymorphonuclear leucocytes (PMN). As a model for corpuscular IgA immune complexes (IgA IC), heat-killed Staphylococcus aureus (S. aureus) opsonized with either purified human serum IgA or purified secretory IgA (sIgA) isolated from human colostrum was used. In order to determine the capacity of IgA and sIgA to opsonize S. aureus the phagocytosis of these Ig... Abstract
Cited 109 times since 1987 (2.9 per year) source: EuropePMC
European journal of immunology, Volume 17, Issue 3, 1 1 1987, Pages 321-326 Activation of the alternative pathway of complement by human serum IgA. Hiemstra PS, Gorter A, Stuurman ME, Van Es LA, Daha MR
In order to study the activation of complement by soluble aggregates of human polyclonal serum IgA, lysis of sheep erythrocytes (E) coated with several IgA preparations was used as a model. A complement nonactivating monoclonal mouse IgG1 against IgA was used to coat the cells. IgA, isolated from normal human serum, was aggregated by either N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP), glutaraldehyde, carbodiimide or heating. Depending on the size of the aggregates, and on the method of a... Abstract
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1325-1331 Stimulation of human polymorphonuclear leukocytes by serum IgA or secretory IgA. Gorter A, Hiemstra PS, Leijh PC, van Es LA, Daha MR
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1333-1338 Binding and degradation of soluble aggregates of IgA by rat peritoneal macrophages. Gorter A, Hiemstra PS, Klar-Mohamad N, van Es LA, Daha MR
Cited 3 times since 1987 (0.1 per year) source: EuropePMC
Advances in experimental medicine and biology, Volume 216B, 1 1 1987, Pages 1297-1302 Activation of the alternative pathway of complement by human serum IgA. Hiemstra PS, Gorter A, Stuurman ME, van Es LA, Daha MR
Cited 9 times since 1985 (0.2 per year) source: EuropePMC
Thrombosis research, Volume 38, Issue 5, 1 1 1985, Pages 491-503 Activation of factor B of the complement system by kallikrein and its light chain. Hiemstra PS, Daha MR, Bouma BN
The cleavage of factor B, a protein of the alternative pathway of complement, by kallikrein was studied. Like factor D, kallikrein can cleave B to generate the alternative pathway C3 convertase C3bBb. When this convertase was formed on erythrocytes previously coated with C3b, lysis was observed indicating that a functionally active C3 convertase was formed. B was also cleaved by kallikrein in the presence of fluid phase C3b, and this resulted in B fragments comparable in size to those generated... Abstract