Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
884 results
Cited 5 times since 2022 (2.5 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 9, 6 1 2022, Pages 883873 Performance of a HeartLogic<sup>TM</sup> Based Care Path in the Management of a Real-World Chronic Heart Failure Population. Feijen M, Egorova AD, Treskes RW, Mertens BJA, Jukema JW, Schalij MJ, Beeres SLMA
Aim: Early detection of impending fluid retention and timely adjustment of (medical) therapy can prevent heart failure related hospitalizations. The multisensory cardiac implantable electronic device (CIED) based algorithm HeartLogicTM aims to alert in case of impending fluid retention. The aim of the current analysis is to evaluate the performance of the HeartLogicTM guided heart failure care path in a real-world heart failure population and to investigate whether the height of the index and th... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
European heart journal open, Volume 2, Issue 4, 2 1 2022, Pages oeac031 A comprehensive analysis of the intramural segment in interarterial anomalous coronary arteries using computed tomography angiography. Koppel CJ, Verheijen DBH, Kiès P, Egorova AD, Lamb HJ, Voskuil M, Jukema JW, Koolbergen DR, Hazekamp MG, Schalij MJ, Jongbloed MRM, Vliegen HW
Aims: An anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS) with an interarterial course can be assessed using computed tomography angiography (CTA) for the presence of high-risk characteristics associated with sudden cardiac death. These features include a slit-like ostium, acute angle take-off, proximal luminal narrowing, and an intramural segment. To date, no robust CTA criteria exist to determine the presence of an intramural segment. We aimed to deduct new CTA... Abstract
Cited 2 times since 2022 (1 per year) source: EuropePMC
Journal of medical Internet research, Volume 24, Issue 4, 25 4 2022, Pages e30236 The Box-eHealth in the Outpatient Clinic Follow-up of Patients With Acute Myocardial Infarction: Cost-Utility Analysis. Treskes RW, van den Akker-van Marle ME, van Winden L, van Keulen N, van der Velde ET, Beeres S, Atsma D, Schalij MJ
Background: Smartphone compatible wearables have been released on the consumers market, enabling remote monitoring. Remote monitoring is often named as a tool to reduce the cost of care. Objective: The primary purpose of this paper is to describe a cost-utility analysis of an eHealth intervention compared to regular follow-up in patients with acute myocardial infarction (AMI). Methods: In this trial, of which clinical results have been published previously, patients with an AMI were randomized i... Abstract
The international journal of cardiovascular imaging, Volume 38, Issue 9, 16 3 2022, Pages 1951-1960 Myocardial function in COVID-19 patients after hospital discharge: a descriptive study comparing the first and second 'wave' patients. Elffers TW, de Graaf MA, Regeer MV, Omara S, Schalij MJ, Groeneveld GH, Roukens AHE, Geelhoed JJM, Antoni ML
In hospitalized COVID-19 patients, myocardial injury and echocardiographic abnormalities have been described. The present study investigates cardiac function in COVID-19 patients 6 weeks post-discharge and evaluates its relation to New York Heart Association (NYHA) class. Furthermore cardiac function post-discharge between the first and second wave COVID-19 patients was compared. We evaluated 146 patients at the outpatient clinic of the Leiden University Medical Centre. NYHA class of II or highe... Abstract
Cardiology and cardiovascular medicine, Volume 6, Issue 2, 14 2 2022, Pages 171-188 Development of Central Venous Stenosis Upon ICD Implantation in Dialysis Patients: A Non-Negligible Issue. Timal RJ, Karalis I, Cabezas JMM, Rotmans JI, Hensen LCR, Buiten MS, de Bie MK, van Erven L, Putter H, Schalij MJ, Rabelink TJ, Jukema JW
Background: In hemodialysis patients, implantable cardioverter-defibrillator (ICD) implantation may result in central venous stenosis (CVS) with associated symptoms, such as pain, edema of the ipsilateral arm, facial edema, and loss of dialysis access. However, literature concerning CVS in dialysis patients with a cardiac implantable electronic device is scarce. Methods: We conducted a prospective cohort study in which we investigated the incidence of CVS in end-stage renal disease patients on c... Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 8, 15 3 2022, Pages 779075 Continuum of Care: Positioning of the Virtual Hospital. van der Lande ACMH, Treskes RW, Beeres SLMA, Schalij MJ
Introduction: Patients with multiple chronic diseases suffer from reduced life expectancy. Care for these patients is often divided over multiple healthcare professionals. eHealth might help to integrate care for these patients and create a continuum. It is the primary purpose of this paper to describe an intervention that integrates first, second, and third line care in patients with multiple chronic conditions using remote monitoring, remote therapy and data automatization, all integrated in a... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 9, 11 2 2022, Pages 431-435 Emergency Heart failure Mortality Risk Grade may help to reduce heart failure admissions. van Hattem NE, Beeres SLMA, Mertens BJA, Antoni ML, Atsma DE, Schalij MJ, den Haan MC
Introduction: Hospital admissions for heart failure (HF) are frequent and pose a heavy burden on health care resources. Currently, the decision to hospitalise is based on clinical judgement rather than on prognostic risk stratification. The Emergency Heart failure Mortality Risk Grade (EHMRG) was recently developed to identify high-risk HF patients in the emergency department (ED). Objective: To assess the ability of the EHMRG to predict 30-day mortality in Dutch HF patients visiting the ED and... Abstract
Cited 2 times since 2022 (0.9 per year) source: EuropePMC
European journal of cardiovascular nursing, Volume 21, Issue 2, 1 1 2022, Pages 169-173 Implantable cardioverter-defibrillators and the older patient: the Dutch clinical practice. Yilmaz D, Egorova AD, Schalij MJ, van Erven L
Background and objective: Balance between benefit and burden of implantable cardioverter-defibrillator (ICD) therapy is more debatable in older patients, compared to younger patients. Of around 6000 yearly implanted ICDs in the Netherlands, 1:4 is received by patients ≥75 years. We aimed to evaluate the current clinical practice in the Netherlands for ICD implants and generator replacements, with a special focus on the older ICD patients. Research design and methods: Cardiologists from all Dutch... Abstract
Cited 8 times since 2022 (3.5 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 3, 1 1 2022, Pages 412-422 The Leiden Convention coronary coding system: translation from the surgical to the universal view. Koppel CJ, Vliegen HW, Bökenkamp R, Ten Harkel ADJ, Kiès P, Egorova AD, Jukema JW, Hazekamp MG, Schalij MJ, Gittenberger-de Groot AC, Jongbloed MRM
Aims: The Leiden Convention coronary coding system structures the large variety of coronary anatomical patterns; isolated and in congenital heart disease. It is widely used by surgeons but not by cardiologists as the system uses a surgeons' cranial view. Since thoracic surgeons and cardiologists work closely together, a coronary coding system practical for both disciplines is mandatory. To this purpose, the 'surgical' coronary coding system was adapted to an 'imaging' sy... Abstract
Cited 11 times since 2022 (4.6 per year) source: EuropePMC
Nature biomedical engineering, Volume 6, Issue 4, 6 1 2022, Pages 389-402 Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation. Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 2, 3 1 2022, Pages 76-83 No substantial excess all-cause mortality among cardiac implantable electronic device patients during the first COVID‑19 lockdown in the Leiden area. Feijen M, Egorova AD, van der Velde ET, Schalij MJ, Beeres SLMA
In the Netherlands, the coronavirus disease 2019 (COVID‑19) pandemic has resulted in excess mortality nationwide. Chronic heart disease patients are at risk for a complicated COVID‑19 course. The current study investigates all-cause mortality among cardiac implantable electronic device (CIED) patients during the first peak of the pandemic and compares the data to the statistics for the corresponding period in the two previous years. Data of adult CIED patients undergoing follow-up at the Leiden... Abstract
Cited 2 times since 2021 (0.8 per year) source: EuropePMC
JMIR cardio, Volume 5, Issue 2, 16 3 2021, Pages e26072 Real-World Experience of mHealth Implementation in Clinical Practice (the Box): Design and Usability Study. Biersteker T, Hilt A, van der Velde E, Schalij MJ, Treskes RW
Background: Mobile health (mHealth) is an emerging field of scientific interest worldwide. Potential benefits include increased patient engagement, improved clinical outcomes, and reduced health care costs. However, mHealth is often studied in projects or trials, and structural implantation in clinical practice is less common. Objective: The purpose of this paper is to outline the design of the Box and its implementation and use in an outpatient clinic setting. The impact on logistical outcomes... Abstract
Cited 3 times since 2021 (1.2 per year) source: EuropePMC
International journal of cardiology. Heart & vasculature, Volume 38, 13 2 2021, Pages 100926 Ascending aorta curvature and flow displacement are associated with accelerated aortic growth at long-term follow-up: A MRI study in Marfan and thoracic aortic aneurysm patients. van Hout MJP, Juffermans JF, Lamb HJ, Kröner ESJ, van den Boogaard PJ, Schalij MJ, Dekkers IA, Scholte AJ, Westenberg JJ
Background: Aortic aneurysm formation is associated with increased risk of aortic dissection. Current diagnostic strategies are focused on diameter growth, the predictive value of aortic morphology and function remains underinvestigated. We aimed to assess the long-term prognostic value of ascending aorta (AA) curvature radius, regional pulse wave velocity (PWV) and flow displacement (FD) on aortic dilatation/elongation and evaluated adverse outcomes (proximal aortic surgery, dissection/rupture,... Abstract
Cardiology and therapy, Volume 11, Issue 1, 1 1 2021, Pages 81-92 Original Research: Long-Term Prognosis After ST-Elevation Myocardial Infarction in Patients with a Prior Cancer Diagnosis. Heemelaar JC, Polomski EAS, Mertens BJA, Jukema JW, Schalij MJ, Antoni ML
Introduction: It is unknown how long-term prognosis after ST-elevation myocardial infarction (STEMI) in patients with a prior cancer diagnosis is impacted by cancer-related factors as diagnosis, stage, and treatment. We aimed to assess long-term survival trends after STEMI in this population to evaluate both cardiovascular and cancer-related drivers of prognosis over a follow-up period of 5 years. Methods: In this retrospective single-center cohort study, patients with a prior cancer diagnosis a... Abstract
Cited 4 times since 2021 (1.5 per year) source: EuropePMC
European heart journal. Quality of care & clinical outcomes, Volume 7, Issue 6, 1 1 2021, Pages 583-590 Utilization of diagnostic resources and costs in patients with suspected cardiac chest pain. Vester MPM, Eindhoven DC, Bonten TN, Wagenaar H, Holthuis HJ, Schalij MJ, de Grooth GJ, van Dijkman PRM
Aims: Non-acute chest pain is a common complaint and can be caused by various conditions. With the rising healthcare expenditures of today, it is necessary to use our healthcare resources effectively. This study aims to give insight into the diagnostic effort and costs for patients with non-acute chest pain. Methods and results: Financial data of patients without a cardiac history from four hospitals (January 2012-October 2018), who were registered with the national diagnostic code 'no card... Abstract
Cited 18 times since 2021 (6.7 per year) source: EuropePMC
Frontiers in physiology, Volume 12, 16 3 2021, Pages 665298 Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function. Zandstra TE, Notenboom RGE, Wink J, Kiès P, Vliegen HW, Egorova AD, Schalij MJ, De Ruiter MC, Jongbloed MRM
The cardiac autonomic nervous system (cANS) regulates cardiac adaptation to different demands. The heart is an asymmetrical organ, and in the selection of adequate treatment of cardiac diseases it may be relevant to take into account that the cANS also has sidedness as well as regional differences in anatomical, functional, and molecular characteristics. The left and right ventricles respond differently to adrenergic stimulation. Isoforms of nitric oxide synthase, which plays an important role i... Abstract
Cited 4 times since 2021 (1.5 per year) source: EuropePMC
International journal of cardiology. Heart & vasculature, Volume 36, 20 3 2021, Pages 100858 Referral and participation in cardiac rehabilitation of patients following acute coronary syndrome; lessons learned. Rodrigo SF, Van Exel HJ, Van Keulen N, Van Winden L, Beeres SLMA, Schalij MJ
Purpose: Cardiac rehabilitation (CR) after hospitalization for acute coronary syndrome (ACS) has shown to reduce mortality, readmissions, and improve quality of life. CR is recommended by international guidelines but previous studies have shown low participation rates. Systematic CR referral might improve CR participation. Methods: The present study evaluates CR referral and CR participation of patients hospitalized for ACS in 2017 and treated according to local protocol, which includes systemat... Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 23, Issue 8, 1 1 2021, Pages 1275-1284 Myocardial calcification is associated with endocardial ablation failure of post-myocardial infarction ventricular tachycardia. de Riva M, Naruse Y, Ebert M, Watanabe M, Scholte AJ, Wijnmaalen AP, Trines SA, Schalij MJ, Montero-Cabezas JM, Zeppenfeld K
Aims: In patients with post-myocardial infarction (post-MI) ventricular tachycardia (VT), the presence of myocardial calcification (MC) may prevent heating of a subepicardial VT substrate contributing to endocardial ablation failure. The aims of this study were to assess the prevalence of MC in patients with post-MI VT and evaluate the impact of MC on outcome after endocardial ablation. Methods and results: In 158 patients, the presence of MC was retrospectively assessed on fluoroscopy recording... Abstract
Cited 6 times since 2021 (2.1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 38, Issue 1, 25 4 2021, Pages 183-193 Estimated pulse wave velocity (ePWV) as a potential gatekeeper for MRI-assessed PWV: a linear and deep neural network based approach in 2254 participants of the Netherlands Epidemiology of Obesity study. van Hout MJ, Dekkers IA, Lin L, Westenberg JJ, Schalij MJ, Jukema JW, Widya RL, Boone SC, de Mutsert R, Rosendaal FR, Scholte AJ, Lamb HJ
Pulse wave velocity (PWV) assessed by magnetic resonance imaging (MRI) is a prognostic marker for cardiovascular events. Prediction modelling could enable indirect PWV assessment based on clinical and anthropometric data. The aim was to calculate estimated-PWV (ePWV) based on clinical and anthropometric measures using linear ridge regression as well as a Deep Neural Network (DNN) and to determine the cut-off which provides optimal discriminative performance between lower and higher PWV values. I... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 8, 7 1 2021, Pages 699492 Prognostic Value of Natriuretic Peptides for All-Cause Mortality, Right Ventricular Failure, Major Adverse Events, and Myocardial Recovery in Advanced Heart Failure Patients Receiving a Left Ventricular Assist Device: A Systematic Review. Janssen E, Jukema JW, Beeres SLMA, Schalij MJ, Tops LF
Aims: Major adverse event (MAE) rates during left ventricular assist device (LVAD) therapy in advanced heart failure (HF) patients are high, and impair quality of life and survival. Prediction and risk stratification of MAEs in order to improve patient selection and thereby outcome during LVAD therapy is therefore warranted. Circulating natriuretic peptides (NPs) are strong predictors of MAEs and mortality in chronic HF patients. However, whether NPs can identify patients who are at risk of MAEs... Abstract