Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Cited 11 times since 2011 (0.9 per year) source: EuropePMC
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, Volume 15, Issue 3, 1 1 2011, Pages 256-262 Determinants and outcome of unsuccessful referral after positive screening in a large birth-cohort study of population-based vision screening. Tjiam AM, Groenewoud JH, Passchier J, Loudon SE, De Graaf M, Hoogeveen WC, Lantau VK, Juttmann RE, De Koning HJ, Simonsz HJ
Purpose: The efficacy of population-based vision screening is hampered by unsuccessful referral after a positive screening test. We studied the nature and causes of unsuccessful referral in a 7-year birth cohort study of vision screening in Rotterdam, the Netherlands. Methods: All parents of children who had been unsuccessfully referred were asked whether they recalled the referral. Reasons for noncompliance, if any, were identified using semi-structured interviews. Screening records were checke... Abstract
Cited 93 times since 2011 (7.2 per year) source: EuropePMC
Journal of the American Academy of Dermatology, Volume 65, Issue 2, 20 3 2011, Pages 320-327 Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. de Graaf M, Breur JMPJ, Raphaël MF, Vos M, Breugem CC, Pasmans SGMA
Background: Infantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option. Objective: To describe the effects and side effects of propranolol treatment in 28 children with (complicated) IH. Methods: A protocol for treatment of IH with propranolol was designed and implemented. Propranolol was administered to 28 children (21 girls and 7 boys, mean age at onset of treatment: 8.8 months). Re... Abstract
Cited 33 times since 2011 (2.5 per year) source: EuropePMC
Pediatric dermatology, Volume 28, Issue 2, 1 1 2011, Pages 169-171 Hypoglycemia as a result of propranolol during treatment of infantile hemangioma: a case report. Breur JM, de Graaf M, Breugem CC, Pasmans SG
Propranolol is a new and promising treatment for hemangiomas of infancy. We report of a patient in whom steroid maintenance therapy is successfully tapered after introduction of propranolol. This patient, however, developed symptomatic hypoglycemic events presumably because of a concurrent deficiency of epinephrine and cortisol as a direct result of both beta-blockage by propranolol and adrenal insufficiency as a result of prednisone use. Extreme care should be taken in patients treated with bot... Abstract
Cited 16 times since 2010 (1.2 per year) source: EuropePMC
Journal of the American Society of Nephrology : JASN, Volume 22, Issue 3, 16 3 2010, Pages 508-517 γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter. Dimke H, San-Cristobal P, de Graaf M, Lenders JW, Deinum J, Hoenderop JG, Bindels RJ
The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal convoluted tubule. (22)Na(+) uptake experiments in the Xenopus laevis oocyte showed that γ-adducin stimulat... Abstract
Cited 46 times since 2010 (3.3 per year) source: EuropePMC
The Journal of biological chemistry, Volume 285, Issue 34, 28 4 2010, Pages 26081-26087 Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress. Cao G, Lee KP, van der Wijst J, de Graaf M, van der Kemp A, Bindels RJ, Hoenderop JG
Mg(2+) is an essential ion for many cellular processes, including protein synthesis, nucleic acid stability, and numerous enzymatic reactions. Mg(2+) homeostasis in mammals depends on the equilibrium between intestinal absorption, renal excretion, and exchange with bone. The transient receptor potential melastatin type 6 (TRPM6) is an epithelial Mg(2+) channel, which is abundantly expressed in the luminal membrane of the renal and intestinal cells. It functions as the gatekeeper of transepitheli... Abstract
Cited 19 times since 2010 (1.3 per year) source: EuropePMC
Disability and rehabilitation, Volume 32, Issue 2, 1 1 2010, Pages 142-147 Psychological intervention targets for people with visual impairments: the importance of cognitive coping and goal adjustment. Garnefski N, Kraaij V, De Graaf M, Karels L
Purpose: This study represents, to our knowledge, the first examination of the joint influence of cognitive coping strategies and goal-related coping on depressive symptoms in people with severe visual impairments with the aim of finding targets for intervention. Method: In total, data of 67 individuals with visual impairments were assembled by telephone interviews. Depressive symptomatology, cognitive coping strategies, and goal-related coping processes were measured. Relationships between thes... Abstract
Cited 10 times since 2009 (0.7 per year) source: EuropePMC
Molecular phylogenetics and evolution, Volume 54, Issue 2, 28 4 2009, Pages 336-343 Preliminary insight into the age and origin of the Labeobarbus fish species flock from Lake Tana (Ethiopia) using the mtDNA cytochrome b gene. de Graaf M, Megens HJ, Samallo J, Sibbing F
The high diversity of Cyprinid fish in Ethiopia's Lake Tana appears to be an example of ecological differentiation and assortative mating leading to rapid sympatric speciation. Lake Tana's Labeobarbus species flock consists of 15 morphological and ecological distinct species. This is the first attempt to determine the age and origin and inter-species relationships of Lake Tana's Labeobarbus species using the mtDNA cytochrome b gene. Analysis of cytchrome b sequences shows that Lak... Abstract
Cited 1502 times since 2009 (101.1 per year) source: EuropePMC
Science (New York, N.Y.), Volume 325, Issue 5937, 22 4 2009, Pages 197-201 Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier RA, Pappas C, Alpuche-Aranda CM, López-Gatell H, Olivera H, López I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson PD, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ
Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecu... Abstract
Cited 16 times since 2009 (1.1 per year) source: EuropePMC
The Journal of general virology, Volume 90, Issue Pt 6, 4 1 2009, Pages 1408-1416 Fusion protein is the main determinant of metapneumovirus host tropism. de Graaf M, Schrauwen EJA, Herfst S, van Amerongen G, Osterhaus ADME, Fouchier RAM
Human metapneumovirus (HMPV) and avian metapneumovirus subgroup C (AMPV-C) infect humans and birds, respectively. This study confirmed the difference in host range in turkey poults, and analysed the contribution of the individual metapneumovirus genes to host range in an in vitro cell-culture model. Mammalian Vero-118 cells supported replication of both HMPV and AMPV-C in contrast to avian quail fibroblast (QT6) cells in which only AMPV-C replicated to high titres. Inoculation of Vero-118 and QT... Abstract
Cited 57 times since 2008 (3.7 per year) source: EuropePMC
The Journal of general virology, Volume 89, Issue Pt 12, 1 1 2008, Pages 2933-2942 Evolutionary dynamics of human and avian metapneumoviruses. de Graaf M, Osterhaus ADME, Fouchier RAM, Holmes EC
Human (HMPV) and avian (AMPV) metapneumoviruses are closely related viruses that cause respiratory tract illnesses in humans and birds, respectively. Although HMPV was first discovered in 2001, retrospective studies have shown that HMPV has been circulating in humans for at least 50 years. AMPV was first isolated in the 1970s, and can be classified into four subgroups, A-D. AMPV subgroup C is more closely related to HMPV than to any other AMPV subgroup, suggesting that HMPV has emerged from AMPV... Abstract
Cited 22 times since 2008 (1.4 per year) source: EuropePMC
The Journal of general virology, Volume 89, Issue Pt 7, 1 1 2008, Pages 1553-1562 Generation of temperature-sensitive human metapneumovirus strains that provide protective immunity in hamsters. Herfst S, de Graaf M, Schrauwen EJA, Sprong L, Hussain K, van den Hoogen BG, Osterhaus ADME, Fouchier RAM
Human metapneumovirus (HMPV) causes acute respiratory tract illness primarily in young children, immunocompromised individuals and the elderly. Vaccines would be desirable to prevent severe illnesses in these risk groups. Here, we describe the generation and evaluation of cold-passage (cp) temperature-sensitive (ts) HMPV strains as vaccine candidates. Repeated passage of HMPV at low temperatures in Vero cells resulted in the accumulation of mutations in the viral genome. Introduction of these mu... Abstract
Cited 31 times since 2008 (2 per year) source: EuropePMC
Vaccine, Volume 26, Issue 33, 6 1 2008, Pages 4224-4230 Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Herfst S, Schrauwen EJ, de Graaf M, van Amerongen G, van den Hoogen BG, de Swart RL, Osterhaus AD, Fouchier RA
Human metapneumovirus (HMPV) is an important cause of acute respiratory tract disease for which the development of vaccine candidates is warranted. We have previously described the generation of an iscom matrix-adjuvanted HMPV fusion protein subunit vaccine (Fsol) and a live-attenuated vaccine (HMPVM11). Here, we evaluate the immunogenicity and efficacy of these vaccines in cynomolgus macaques. Immunization with Fsol induced HMPV F-specific antibody responses, virus neutralizing antibody titers,... Abstract
Cited 12 times since 2008 (0.7 per year) source: EuropePMC
The Journal of general virology, Volume 89, Issue Pt 4, 1 1 2008, Pages 975-983 Specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses. de Graaf M, Herfst S, Schrauwen EJA, Choi Y, van den Hoogen BG, Osterhaus ADME, Fouchier RAM
Human metapneumovirus (HMPV) and avian metapneumovirus (AMPV) have a similar genome organization and protein composition, but a different host range. AMPV subgroup C (AMPV-C) is more closely related to HMPV than other AMPVs. To investigate the specificity and functional interaction of the polymerase complex proteins of human and avian metapneumoviruses, a minireplicon system was generated for AMPV-C and used in combination with minireplicon systems for HMPV lineages A1 and B1. Viral RNA-like mol... Abstract
Cited 19 times since 2008 (1.2 per year) source: EuropePMC
Journal of neuroimmunology, Volume 195, Issue 1-2, 20 3 2008, Pages 164-170 B and T cell imbalances in CSF of patients with Hu-antibody associated PNS. de Graaf M, de Beukelaar J, Bergsma J, Kraan J, van den Bent M, Klimek M, van Norden Y, Kusuma A, Smitt PS, Gratama JW
In paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (approximately 20x) and relative (approximately 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolut... Abstract
Cited 32 times since 2007 (1.9 per year) source: EuropePMC
The Journal of general virology, Volume 88, Issue Pt 10, 1 1 2007, Pages 2702-2709 Immunization of Syrian golden hamsters with F subunit vaccine of human metapneumovirus induces protection against challenge with homologous or heterologous strains. Herfst S, de Graaf M, Schrauwen EJA, Ulbrandt ND, Barnes AS, Senthil K, Osterhaus ADME, Fouchier RAM, van den Hoogen BG
Human metapneumovirus (hMPV), a newly discovered paramyxovirus, is associated with acute respiratory-tract illness, primarily in young children, individuals with underlying disease and the elderly. Two genetic lineages of hMPV circulate around the world, and viruses from these two lineages demonstrate antigenic differences. The clinical impact of hMPV warrants the development of vaccines. Recombinant soluble fusion (F) proteins of prototype viruses of the two main lineages of hMPV that can be pr... Abstract
Cited 32 times since 2007 (1.9 per year) source: EuropePMC
Journal of virological methods, Volume 143, Issue 2, 8 2 2007, Pages 169-174 An improved plaque reduction virus neutralization assay for human metapneumovirus. de Graaf M, Herfst S, Schrauwen EJ, van den Hoogen BG, Osterhaus AD, Fouchier RA
Virus-neutralizing antibodies against human metapneumovirus (hMPV) have been shown to be important indicators for protection in experimental animal models. An improved plaque reduction virus neutralization assay to detect hMPV-specific neutralizing antibodies was designed using two prototype recombinant hMPV strains expressing green fluorescent protein (GFP). These prototypes represented each of the main antigenic variants of hMPV, because antigenic variability could have implications for vaccin... Abstract
Cited 30 times since 2007 (1.8 per year) source: EuropePMC
The Journal of general virology, Volume 88, Issue Pt 4, 1 1 2007, Pages 1251-1259 Experimental infection of macaques with human metapneumovirus induces transient protective immunity. van den Hoogen BG, Herfst S, de Graaf M, Sprong L, van Lavieren R, van Amerongen G, Yüksel S, Fouchier RAM, Osterhaus ADME, de Swart RL
Human metapneumovirus (hMPV), a member of the family Paramyxoviridae, is a causative agent of acute respiratory-tract illness. Two main hMPV lineages circulate worldwide and reinfections occur frequently. It is unclear what level of protection is induced by natural hMPV infection, what the durability of this protection is and whether it differs for reinfection with homologous or heterologous viruses. Here, protective immunity in cynomolgus macaques at different time points after inoculation with... Abstract
Cited 41 times since 2006 (2.3 per year) source: EuropePMC
The British journal of ophthalmology, Volume 91, Issue 3, 11 2 2006, Pages 313-318 Accuracy of GDx VCC, HRT I, and clinical assessment of stereoscopic optic nerve head photographs for diagnosing glaucoma. Reus NJ, de Graaf M, Lemij HG
Aims: To determine and compare the accuracy and reproducibility of GDx variable cornea compensation (VCC) scanning laser polarimetry (SLP) with VCC, Heidelberg retina tomograph (HRT) I confocal scanning laser ophthalmoscopy (CSLO), and clinical assessment of stereoscopic optic nerve head (ONH) photographs for diagnosing glaucoma. Methods: One eye each of 40 healthy subjects, 48 glaucoma patients, and six patients with ocular hypertension were measured with SLP-VCC and CSLO. Simultaneous stereosc... Abstract
Cited 2 times since 2005 (0.1 per year) source: EuropePMC
Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 38, 1 1 2005, Pages 2112 [An infant with a swelling of the cheek]. de Graaf M, van der Meer SB
A 2-weeks-old girl was presented with a swelling of the right parotid gland, due to acute suppurative parotitis caused by Staphylococcus aureus. Abstract
Cited 62 times since 2005 (3.3 per year) source: EuropePMC
Cardiovascular research, Volume 67, Issue 2, 1 1 2005, Pages 245-255 Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin. van Tuyn J, Knaän-Shanzer S, van de Watering MJ, de Graaf M, van der Laarse A, Schalij MJ, van der Wall EE, de Vries AA, Atsma DE
Objective: Myocardin is a recently discovered transcriptional regulator of cardiac and smooth muscle development. Its ability to transactivate smooth muscle-specific genes has been firmly established in animal cells but its effect on heart muscle genes has been investigated less extensively and the consequences of ectopic myocardin expression in human cells are unknown. Methods: In this study, primary human mesenchymal stem cells and foreskin fibroblasts were transduced with human adenovirus vec... Abstract