Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
7473 results
Cited 33 times since 2000 (1.4 per year) source: EuropePMC
Virology, Volume 270, Issue 1, 1 1 2000, Pages 84-97 Genetic manipulation of equine arteritis virus using full-length cDNA clones: separation of overlapping genes and expression of a foreign epitope. de Vries AA, Glaser AL, Raamsman MJ, de Haan CA, Sarnataro S, Godeke GJ, Rottier PJ
Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales. The unsegmented, infectious genome of EAV is 12,704 nt in length [exclusive of the poly(A) tail] and contains eight overlapping genes that are expressed from a 3'-coterminal nested set of seven leader-containing mRNAs. To investigate the importance of the overlapping gene arrangement in the viral life-cycle and to facilitate the genetic manipulation of th... Abstract
Cited 13 times since 2000 (0.5 per year) source: EuropePMC
European journal of nuclear medicine, Volume 27, Issue 3, 1 1 2000, Pages 302-307 Clinical evaluation of no-carrier-added meta-[123I]iodobenzylguanidine for myocardial scintigraphy. Knickmeier M, Matheja P, Wichter T, Schäfers KP, Kies P, Breithardt G, Schober O, Schäfers M
In clinical and research studies, images obtained using carrier-added meta-[123I]iodobenzylguanidine (c.a. [123I]MIBG) have shown quite variable quality, with varying levels of uptake in lung, liver and mediastinum; this is a significant problem for quantification of the myocardial uptake by means of region ratios. First experimental and preliminary human data in respect of no-carrier-added (n.c.a.) [123I]MIBG are indicative of improved imaging quality. The aim of the present study was to evalua... Abstract
Cited 44 times since 2000 (1.8 per year) source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology, Volume 20, Issue 3, 1 1 2000, Pages 744-750 Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation: reversal after lipid-lowering therapy by atorvastatin. de Man FH, Weverling-Rijnsburger AW, van der Laarse A, Smelt AH, Jukema JW, Blauw GJ
There is controversy regarding the relation between hypertriglyceridemia (HTG) and endothelial function. This study was designed to investigate endothelial function in a patient group with chronic HTG, before and during lipid-lowering therapy by atorvastatin. In addition, the effects of acute HTG on endothelial function were studied in normolipidemic individuals. Eight male patients with chronic HTG were studied before and after 6 weeks of lipid-lowering treatment with 80 mg atorvastatin once da... Abstract
Cited 114 times since 2000 (4.7 per year) source: EuropePMC
Journal of virology, Volume 74, Issue 5, 1 1 2000, Pages 2333-2342 Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E. Raamsman MJ, Locker JK, de Hooge A, de Vries AA, Griffiths G, Vennema H, Rottier PJ
The small envelope (E) protein has recently been shown to play an essential role in the assembly of coronaviruses. Expression studies revealed that for formation of the viral envelope, actually only the E protein and the membrane (M) protein are required. Since little is known about this generally low-abundance virion component, we have characterized the E protein of mouse hepatitis virus strain A59 (MHV-A59), an 83-residue polypeptide. Using an antiserum to the hydrophilic carboxy terminus of t... Abstract
Cited 3 times since 2000 (0.1 per year) source: EuropePMC
Medicine and science in sports and exercise, Volume 32, Issue 3, 1 1 2000, Pages 571-575 Correlated neurocardiologic and fitness changes in athletes interrupting training. Frederiks J, Swenne CA, Bruschke AV, van der Velde ET, Maan AC, TenVoorde BJ, Vanrooijen MG, Mosterd WL, Schiereck P
Purpose: We studied nine male Dutch top marathon skaters during a 1-month interruption of their training schedules after their last contest in the winter to investigate a possible decline in baroreflex sensitivity. Methods: Before and after this period, a maximal exercise test was done, and at days 0, 4, 7, 14, and 28 neurocardiologic measurement sessions--heart rate and noninvasive baroreflex sensitivity, recumbent and tilt--were performed. Results: Interruption of training resulted in a signif... Abstract
Cited 25 times since 2000 (1 per year) source: EuropePMC
Congestive heart failure (Greenwich, Conn.), Volume 6, Issue 2, 1 1 2000, Pages 86-89 Bioimpedance monitoring: better than chest x-ray for predicting abnormal pulmonary fluid? Peacock WF, Albert NM, Kies P, White RD, Emerman CL
Bioimpedance monitoring may aid in treating heart failure. Mean thoracic electrical impedance (Zo) is inversely proportional to thoracic fluid volume and may offer greater sensitivity for detecting thoracic fluid. OBJECTIVE. Compare bioimpedance monitoring thoracic fluid detection to that of chest x-ray. METHOD. Prospective convenience sample. SETTING. 1000 bed teaching hospital. PARTICIPANTS. Patients with suspected heart failure and shortness of breath. A single blinded radiologist interpreted... Abstract
Cited 31 times since 2000 (1.3 per year) source: EuropePMC
Biochemistry, Volume 39, Issue 11, 1 1 2000, Pages 3023-3033 Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, van Venrooij WJ, Pruijn GJ
The La (SS-B) autoantigen is an evolutionarily conserved phosphoprotein which plays an important role, most likely as an RNA chaperone, in various processes, such as the biosynthesis and maturation of RNA polymerase III transcripts in the cell nucleus and (internal) initiation of translation in the cytoplasm. In this study, the phosphorylation state of this protein from human HeLa and HEp-2 cells was characterized by high-resolution two-dimensional IEF/SDS-PAGE analysis, and phosphorylation site... Abstract
Cited 5 times since 2000 (0.2 per year) source: EuropePMC
Medicine and science in sports and exercise, Volume 32, Issue 3, 1 1 2000, Pages 701-705 Prediction of peak oxygen uptake in men using pulmonary and hemodynamic variables during exercise. Bogaard HJ, Woltjer HH, van Keimpema AR, Postmus PE, de Vries PM
Purpose: Many attempts have been made to predict peak VO2 from data obtained at rest or submaximal exercise. Predictive submaximal tests using the heart rate (HR) response have limited accuracy. Some tests incorporate submaximal gas exchange data, but a predictive test without gas exchange measurements would be of benefit. Addition of stroke volume and pulmonary function (PF) measurements might increase the predictability of a submaximal exercise test. Methods: In this study, an incremental exer... Abstract
Cited 62 times since 2000 (2.6 per year) source: EuropePMC
Thorax, Volume 55, Issue 3, 1 1 2000, Pages 189-193 Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Rahman I, Swarska E, Henry M, Stolk J, MacNee W
Background: It has been suggested that oxidative stress is an important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). We have shown that an oxidant/antioxidant imbalance occurs in the distal air spaces of smokers and in patients with COPD which is reflected systemically in the plasma. A study was undertaken to determine whether plasma antioxidant status correlated with lung function as assessed by forced expiratory volume in one second (FEV(1)) and forced vital capa... Abstract
Cited 23 times since 2000 (1 per year) source: EuropePMC
Chest, Volume 117, Issue 3, 1 1 2000, Pages 786-789 Long-term effect of bilateral plication of the diaphragm. Stolk J, Versteegh MI
Study objectives: To assess the feasibility and clinical outcome of bilateral plication of the diaphragm in patients with bilateral diaphragmatic paralysis (BDP) caused by neuralgic amyotrophy (NA), a mononeuritis of the phrenic nerves. Design: Prospective, case-control study over a 1-year period. Setting: A university hospital in The Netherlands. Patients: Six patients who presented with BDP caused by NA. Methods: The diagnosis of BDP was based on the absence of muscle response after cervical m... Abstract
Cited 26 times since 2000 (1.1 per year) source: EuropePMC
Chest, Volume 117, Issue 3, 1 1 2000, Pages 887-891 Tissue effects of bronchoscopic electrocautery: bronchoscopic appearance and histologic changes of bronchial wall after electrocautery. van Boxem TJ, Westerga J, Venmans BJ, Postmus PE, Sutedja TG
Study objectives: To study tissue effects of bronchoscopic electrocautery (BE). Design: In six patients with non-small cell lung cancer, a BE procedure was performed immediately before surgery. After patients were placed on ventilation, normal mucosa on different carinae was treated with a cautery probe (2-mm(2) surface area) at a power setting of 30 W with a variable time of application of 1 to 5 s. Bronchoscopic appearance of the treated area was documented photographically, and histologic cha... Abstract
Cited 38 times since 2000 (1.6 per year) source: EuropePMC
Free radical biology & medicine, Volume 28, Issue 6, 1 1 2000, Pages 920-925 Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease. Rahman I, van Schadewijk AA, Hiemstra PS, Stolk J, van Krieken JH, MacNee W, de Boer WI
Cigarette smoking results in an oxidant/antioxidant imbalance in the lungs and inflammation, which are considered to be key factors in the pathogenesis of chronic obstructive pulmonary disease (COPD). Glutathione (GSH) is an important protective antioxidant in lung epithelial cells and epithelial lining fluid. De novo GSH synthesis in cells occurs by a two-enzyme process. The rate-limiting enzyme is gamma-glutamylcysteine synthetase (gamma-GCS), in which the heavy subunit (HS) constitutes most o... Abstract
Cited 5 times since 2000 (0.2 per year) source: EuropePMC
Thrombosis research, Volume 97, Issue 5, 1 1 2000, Pages 275-280 The -323Ins10 polymorphism for factor VII is not associated with coronary atherosclerosis in symptomatic men. The REGRESS study group. Lievers KJ, Mennen LI, Rattink AP, Zwinderman AH, Jukema JW, Schouten EG, de Maat MP
Elevated factor VII coagulant activity (FVII:C) has been associated with an increased risk of ischaemic heart disease, particularly for fatal events. Results of studies on the association between FVII:C and atherosclerosis are not consistent. FVII:C levels are influenced by several environmental factors and by genetic factors. One of the genetic factors is the -323Ins10 polymorphism in the promoter region of the factor VII gene, which is strongly related to FVII:C, and thus may be associated wit... Abstract
Cited 6 times since 2000 (0.2 per year) source: EuropePMC
International journal of cardiac imaging, Volume 16, Issue 1, 1 1 2000, Pages 35-41 Imaging of an aneurysm of the sinus of Valsalva with transesophageal echocardiography, contrast angiography and MRI. Baur LH, Vliegen HW, van der Wall EE, Hazekamp M, Bootsma M, de Roos A, Bruschke AV
A sinus of Valsalva aneurysm is an uncommon congenital defect, which requires appropriate diagnosis with either echocardiography, magnetic resonance imaging or contrast angiography. Treatment consists of aortic valve repair. We describe a young woman with an aneurysm of the non-coronary sinus of Valsalva, an atrial septal defect and pulmonary insufficiency. The different imaging techniques and possibilities of surgical correction are described. Abstract
Cited 51 times since 2000 (2.1 per year) source: EuropePMC
The Journal of asthma : official journal of the Association for the Care of Asthma, Volume 37, Issue 1, 1 1 2000, Pages 17-29 Physical and psychological correlates of functioning in patients with chronic obstructive pulmonary disease. Scharloo M, Kaptein AA, Weinman JA, Willems LN, Rooijmans HG
We studied the contribution of coping and illness perceptions to outcome in patients with chronic obstructive pulmonary disease (COPD). In a longitudinal study, 64 patients completed the Medical Outcomes Study Instrument and the Illness Perception Questionnaire. Data on coping and severity of illness (spirometry) were also collected. Regression analyses showed that first-time illness perceptions and coping significantly contributed to the prediction of social functioning, mental health, health p... Abstract
Cited 1 times since 2000 (0 per year) source: EuropePMC
Biology of the neonate, Volume 78, Issue 2, 1 1 2000, Pages 98-105 Influence of inhibition of nitric oxide synthesis on cardiac function in the newborn lamb after hypoxic-ischemic injury. Dorrepaal CA, van Bel F, Steendijk P, Shadid M, van de Velde ET, Moison RM, Berger HM, Baan J
The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(omega)-nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a placebo. Left ventricular (LV) contractility, cardiac output (CO), non-protein-bound iron (NPBI), ratio of reduced/oxidized ascorbic acid, alpha-tocoph... Abstract
Cited 23 times since 2000 (0.9 per year) source: EuropePMC
Clinical & experimental metastasis, Volume 18, Issue 6, 1 1 2000, Pages 445-453 Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro. Brooks TD, Slomp J, Quax PH, De Bart AC, Spencer MT, Verheijen JH, Charlton PA
Recent reports suggest that elevated levels of plasminogen activator inhibitor-1 (PAI-1) may contribute to tumour progression. The studies reported here were designed to help elucidate PAI-1's contribution to the invasive and migratory phenotype. Antibodies to PA-1 dose-dependently, and significantly, inhibited the invasive and migratory potential of human HT1080 fibrosarcoma cells, as did an antibody to uPA and the plasmin inhibitor aprotinin. Invasion of the human melanoma cell line, BLM,... Abstract
Cited 12 times since 2000 (0.5 per year) source: EuropePMC
Respiration; international review of thoracic diseases, Volume 67, Issue 6, 1 1 2000, Pages 689-692 Endobronchial lipoma: a series of three cases and the role of electrocautery. Huisman C, van Kralingen KW, Postmus PE, Sutedja TG
Lipomas are rare endobronchial tumors that may cause severe parenchymal damage due to bronchus obstruction and subsequent pneumonia. Therefore, accurate diagnosis and radical treatment are essential. We describe three cases of endobronchial lipoma. One patient presented with hemoptysis, two patients were initially diagnosed as COPD. They were all treated by electrocautery which achieved complete removal. We recommend electrocautery as an easy and cost-effective alternative for removal of intralu... Abstract
Cited 32 times since 2000 (1.3 per year) source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology, Volume 11, Issue 1, 1 1 2000, Pages 109-112 A phase I-II study of gemcitabine and paclitaxel in advanced non-small-cell lung cancer patients. Giaccone G, Smit EF, van Meerbeeck JP, Splinter T, Golding RP, Pinedo HM, Laan D, van Tinteren H, Postmus PE
Thirty patients with chemotherapy-naïve advanced non-small-cell lung cancer (NSCLC) were given escalating doses of paclitaxel (150, 175, 200 mg/m2) on day 1 in three consecutive cycles, together with a fixed dose of gemcitabine 1000 mg/m2 on days 1 and 8; cycles were repeated every three weeks. The dose escalation of paclitaxel was feasible in the majority of patients. Subsequently, 30 other NSCLC patients received a dose of 200 mg/m2 paclitaxel with gemcitabine 1000 mg/m2 in a phase II study. T... Abstract
Cited 53 times since 2000 (2.2 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 278, Issue 1, 1 1 2000, Pages L51-8 Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins. van Wetering S, van der Linden AC, van Sterkenburg MA, de Boer WI, Kuijpers AL, Schalkwijk J, Hiemstra PS
Secretory leukocyte proteinase inhibitor (SLPI) is a serine proteinase inhibitor that is produced locally in the lung by cells of the submucosal bronchial glands and by nonciliated epithelial cells. Its main function appears to be the inhibition of neutrophil elastase (NE). Recently, NE was found to enhance SLPI mRNA levels while decreasing SLPI protein release in airway epithelial cells. Furthermore, glucocorticoids were shown to increase both constitutive and NE-induced SLPI mRNA levels. In ad... Abstract