Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
63 results
Cited 12 times since 2014 (1.3 per year) source: EuropePMC
Heart rhythm, Volume 12, Issue 3, 7 1 2014, Pages 533-539 Epicardial leads in adult cardiac resynchronization therapy recipients: a study on lead performance, durability, and safety. Buiten MS, van der Heijden AC, Klautz RJM, Schalij MJ, van Erven L
Background: Transvenous left ventricular (LV) lead placement for cardiac resynchronization therapy-defibrillator (CRT-D) delivery is unsuccessful in 8% to 10% of cases. These patients might benefit from an epicardial lead. However, data on long-term epicardial lead performance are scarce. Furthermore, extracting an epicardial lead requires a rethoracotomy. Objective: The purpose of this study was to determine data on almost a decade of experience with epicardial leads and investigate the safety... Abstract
Cited 20 times since 2014 (2.1 per year) source: EuropePMC
European journal of heart failure, Volume 16, Issue 10, 19 3 2014, Pages 1104-1111 Super-responders to cardiac resynchronization therapy remain at risk for ventricular arrhythmias and benefit from defibrillator treatment. van der Heijden AC, Höke U, Thijssen J, Borleffs CJ, van Rees JB, van der Velde ET, Schalij MJ, van Erven L
Aims: Mortality and ventricular arrhythmias are reduced in patients responding to cardiac resynchronization therapy (CRT). This response is accompanied by improvement in LVEF, and some patients even outgrow original eligibility criteria for implantable cardioverter-defibrillator (ICD) implantation. It is however unclear if these patients still benefit from ICD treatment. The current study aimed to evaluate if the incidence of ICD therapy is related to the extent of CRT response. Methods and resu... Abstract
Cited 13 times since 2014 (1.3 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 25, Issue 9, 29 5 2014, Pages 998-1004 Chronic kidney disease and implantable cardioverter defibrillator related complications: 16 years of experience. Buiten MS, DE Bie MK, VAN DER Heijden AC, Rotmans JI, Bootsma M, Marc Groeneveld JH, Wolterbeek R, Rabelink TJ, Jukema JW, Schalij MJ, VAN Erven L
Introduction: Implantable cardioverter defibrillator (ICD) implantation has become an accepted therapy for the prevention of sudden cardiac death. However, serious comorbidities such as chronic kidney disease (CKD) are influencing the beneficial effects of ICD therapy. In this study, the association between kidney function and the occurrence of ICD related complications was assessed. Methods: All patients receiving an ICD or cardiac resynchronization therapy-defibrillator between 1996 and 2012 w... Abstract
Expert review of cardiovascular therapy, Volume 12, Issue 7, 16 3 2014, Pages 787-789 Primary prevention implantable cardioverter-defibrillator implantation in elderly patients: is it justified to withhold treatment? van der Heijden AC, van Erven L, Schalij MJ, Borleffs CJ
Implementation of primary prevention implantable cardioverter-defibrillator (ICD) treatment in the current clinical guidelines led to a significant increase in patients that may benefit from implantation of an ICD. Currently non-guideline-guided patient selection takes place by physicians whereby patients at higher age are more frequently excluded for ICD implantation. This editorial focuses on ICD treatment in the elderly and aims to clarify whether it is justified to withhold ICD treatment in... Abstract
Cited 18 times since 2014 (1.8 per year) source: EuropePMC
Annals of hematology, Volume 93, Issue 8, 29 5 2014, Pages 1401-1412 Clinical and biological impact of TET2 mutations and expression in younger adult AML patients treated within the EORTC/GIMEMA AML-12 clinical trial. Aslanyan MG, Kroeze LI, Langemeijer SM, Koorenhof-Scheele TN, Massop M, van Hoogen P, Stevens-Linders E, van de Locht LT, Tönnissen E, van der Heijden A, da Silva-Coelho P, Cilloni D, Saglio G, Marie JP, Tang R, Labar B, Amadori S, Muus P, Willemze R, Marijt EW, de Witte T, van der Reijden BA, Suciu S, Jansen JH
We assessed the prognostic impact of TET2 mutations and mRNA expression in a prospective cohort of 357 adult AML patients < 60 years of age enrolled in the European Organization For Research and Treatment of Cancer (EORTC)/Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) AML-12 06991 clinical trial. In addition the co-occurrence with other genetic defects and the functional consequences of TET2 mutations were investigated. TET2 mutations occurred in 7.6 % of the patients and w... Abstract
Cited 3 times since 2014 (0.3 per year) source: EuropePMC
Journal of chromatography. A, Volume 1338, 2 1 2014, Pages 111-116 Accurate quantitation of pentaerythritol tetranitrate and its degradation products using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Brust H, van Asten A, Koeberg M, Dalmolen J, van der Heijden A, Schoenmakers P
After an explosion of pentaerythritol tetranitrate (PETN), its degradation products pentaerythritol trinitrate (PETriN), dinitrate (PEDiN) and mononitrate (PEMN) were detected using liquid chromatography-atmospheric-pressure chemical-ionization-mass spectrometry (LC-APCI-MS). Discrimination between post-explosion and naturally degraded PETN could be achieved based on the relative amounts of the degradation products. This information can be used as evidence when investigating a possible relations... Abstract
Cited 20 times since 2013 (1.8 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 99, Issue 17, 30 5 2013, Pages 1244-1249 Gender-specific differences in clinical outcome of primary prevention implantable cardioverter defibrillator recipients. van der Heijden AC, Thijssen J, Borleffs CJ, van Rees JB, Höke U, van der Velde ET, van Erven L, Schalij MJ
Objective: To assess differences in clinical outcome of implantable cardioverter-defibrillator (ICD) treatment in men and women. Design: Prospective cohort study. Setting: University Medical Center. Patients: 1946 primary prevention ICD recipients (1528 (79%) men and 418 (21%) women). Patients with congenital heart disease were excluded for this analysis. Main outcome measures: All-cause mortality, ICD therapy (antitachycardia pacing and shock) and ICD shock. Results: During a median follow-up o... Abstract
Cited 5 times since 2013 (0.5 per year) source: EuropePMC
Forensic science international, Volume 230, Issue 1-3, 23 4 2013, Pages 37-45 Pentaerythritol tetranitrate (PETN) profiling in post-explosion residues to constitute evidence of crime-scene presence. Brust H, van Asten A, Koeberg M, van der Heijden A, Kuijpers CJ, Schoenmakers P
Pentaerythritol tetranitrate (PETN) and its degradation products are analyzed to discriminate between residues originating from PETN explosions and residues obtained under other circumstances, such as natural degradation on textile, or after handling intact PETN. The degradation products observed in post-explosion samples were identified using liquid chromatography-mass spectrometry as the less-nitrated analogues of PETN: pentaerythritol trinitrate (PETriN), pentaerythritol dinitrate (PEDiN) and... Abstract
Cited 111 times since 2013 (10 per year) source: EuropePMC
Annals of neurology, Volume 73, Issue 3, 4 1 2013, Pages 397-407 Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis. Pluk H, van Hoeve BJ, van Dooren SH, Stammen-Vogelzangs J, van der Heijden A, Schelhaas HJ, Verbeek MM, Badrising UA, Arnardottir S, Gheorghe K, Lundberg IE, Boelens WC, van Engelen BG, Pruijn GJ
Objective: Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other inflammatory myopathies, myositis-specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as a source of antigens to detect autoantibodies in sIBM and to characterize the corresponding antigen. Methods: Autoantibodies to skeletal muscle antigens were detected by immunoblotting. Th... Abstract
Cited 10 times since 2012 (0.8 per year) source: EuropePMC
Breast cancer research and treatment, Volume 135, Issue 1, 16 3 2012, Pages 125-133 Expression of the BRCA1 complex member BRE predicts disease free survival in breast cancer. Noordermeer SM, Wennemers M, Bergevoet SM, van der Heijden A, Tönnissen E, Sweep FC, Jansen JH, Span PN, van der Reijden BA
Breast cancer is one of the leading causes of cancer mortality in women. Recent advances in gene expression profiling have indicated that breast cancer is a heterogeneous disease and the current prognostication using clinico-pathological features is not sufficient to fully predict therapy response and disease outcome. In this retrospective study, we show that expression levels of BRE, which encodes a member of the BRCA1 DNA damage repair complex, predicted disease-free survival (DFS) in non-fami... Abstract
Cited 23 times since 2011 (1.8 per year) source: EuropePMC
Blood, Volume 118, Issue 20, 21 3 2011, Pages 5613-5621 High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients. Noordermeer SM, Sanders MA, Gilissen C, Tönnissen E, van der Heijden A, Döhner K, Bullinger L, Jansen JH, Valk PJ, van der Reijden BA
Aberrations in protein ubiquitination have recently been identified in the pathogenesis of acute myeloid leukemia (AML). We studied whether expression changes of more than 1600 ubiquitination related genes correlated with clinical outcome in 525 adult AML patients. High expression of one of these genes, BRE, was observed in 3% of the cases and predicted favorable prognosis independently of known prognostic factors (5-year overall survival: 57%). Remarkably, unsupervised expression profiling show... Abstract
Cited 1 times since 2011 (0.1 per year) source: EuropePMC
Nurse education today, Volume 32, Issue 4, 17 3 2011, Pages 373-377 Student nurses' perceptions of mental health care: validation of a questionnaire. van der Heijden A, van der Bijl J, Latour CH, Hoekstra H, van Meijel B
Aim: This article describes the results of a study into the psychometric properties of a questionnaire about student nurses' perceptions of mental health care. The questionnaire was constructed in 2008, but has not yet been tested in terms of construct validity and reliability. A validated questionnaire is essential as a standardized method of analyzing student nurses' perceptions of mental health care. Method: To investigate the construct validity, an exploratory factor analysis was p... Abstract
Cited 36 times since 2011 (2.8 per year) source: EuropePMC
Pediatric nephrology (Berlin, Germany), Volume 26, Issue 8, 27 4 2011, Pages 1275-1283 Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study. Taal HR, Geelhoed JJ, Steegers EA, Hofman A, Moll HA, Lequin M, van der Heijden AJ, Jaddoe VW
An adverse fetal environment leads to smaller kidneys, with fewer nephrons, which might predispose an individual to the development of kidney disease and hypertension in adult life. In a prospective cohort study among 1,072 children followed from early fetal life onward, we examined whether maternal smoking during pregnancy, as a significant adverse fetal exposure, is associated with fetal (third trimester of pregnancy, n = 1,031) and infant kidney volume (2 years of age, n = 538) measured by ul... Abstract
Cited 6 times since 2010 (0.4 per year) source: EuropePMC
British journal of haematology, Volume 152, Issue 4, 19 3 2010, Pages 493-496 Rapid identification of IDH1 and IDH2 mutations in acute myeloid leukaemia using high resolution melting curve analysis. Noordermeer SM, Tönnissen E, Vissers I, van der Heijden A, van de Locht LT, Deutz-Terlouw PP, Marijt EW, Jansen JH, van der Reijden BA
Cited 515 times since 2010 (37.3 per year) source: EuropePMC
Nature genetics, Volume 42, Issue 8, 4 1 2010, Pages 665-667 Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tönnissen ER, van der Heijden A, Scheele TN, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH
In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS. Abstract
Cited 23 times since 2009 (1.6 per year) source: EuropePMC
Pediatric nephrology (Berlin, Germany), Volume 25, Issue 2, 7 1 2009, Pages 289-298 Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Geelhoed JJ, Taal HR, Steegers EA, Arends LR, Lequin M, Moll HA, Hofman A, van der Heijden AJ, Jaddoe VW
Information about growth of kidney structures in early life is limited. In a population-based prospective cohort study, from foetal life onwards, we constructed reference curves for kidney growth from the third trimester of pregnancy until early childhood, using data from 1,158 healthy children. Kidney size, defined as length, width, depth and volume, was measured in the third trimester of pregnancy and at the postnatal ages of 6 months and 24 months. Analyses were based on more than 2,500 kidne... Abstract
Cited 253 times since 2009 (17.3 per year) source: EuropePMC
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 27, Issue 31, 14 2 2009, Pages 5195-5201 Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study. Cilloni D, Renneville A, Hermitte F, Hills RK, Daly S, Jovanovic JV, Gottardi E, Fava M, Schnittger S, Weiss T, Izzo B, Nomdedeu J, van der Heijden A, van der Reijden BA, Jansen JH, van der Velden VH, Ommen H, Preudhomme C, Saglio G, Grimwade D
Purpose: Risk stratification in acute myeloid leukemia (AML) is currently based on pretreatment characteristics. It remains to be established whether relapse risk can be better predicted through assessment of minimal residual disease (MRD). One proposed marker is the Wilms tumor gene WT1, which is overexpressed in most patients with AML, thus providing a putative target for immunotherapy, although in the absence of a standardized assay, its utility for MRD monitoring remains controversial. Patie... Abstract
Cited 22 times since 2009 (1.5 per year) source: EuropePMC
American heart journal, Volume 158, Issue 1, 1 1 2009, Pages 71-77 Cardiac structures track during the first 2 years of life and are associated with fetal growth and hemodynamics: the Generation R Study. Geelhoed JJ, Steegers EA, van Osch-Gevers L, Verburg BO, Hofman A, Witteman JC, van der Heijden AJ, Helbing WA, Jaddoe VW
Background: The aim of this study is to examine whether cardiac size and function track in early childhood and are associated with fetal and early postnatal growth and blood flow characteristics. Methods: This study was embedded in a population-based prospective cohort study from fetal life onward. Fetal growth and fetal and placental blood flow parameters in second and third trimester of pregnancy were measured by ultrasound and Doppler. Left cardiac structures and shortening fraction were meas... Abstract
Cited 27 times since 2009 (1.8 per year) source: EuropePMC
Pediatric nephrology (Berlin, Germany), Volume 24, Issue 7, 12 2 2009, Pages 1345-1353 Reliability of renal ultrasound measurements in children. Geelhoed JJ, Kleyburg-Linkers VE, Snijders SP, Lequin M, Nauta J, Steegers EA, van der Heijden AJ, Jaddoe VW
The aim of the investigation reported here was to assess the intraobserver and interobserver variability of renal measurements in children. The study comprised 56 paired measurements in 28 children (median age 7.5 years, range 3.0-15.0 years) without renal or ureterovesical anomalies. Intraobserver and interobserver reproducibility was assessed by repeated measurements of the left and right renal length, width, and thickness. Intraclass correlation coefficients (ICCs) with the corresponding 95%... Abstract
Cited 23 times since 2008 (1.5 per year) source: EuropePMC
American journal of kidney diseases : the official journal of the National Kidney Foundation, Volume 53, Issue 2, 10 2 2008, Pages 248-258 Tracking and determinants of kidney size from fetal life until the age of 2 years: the Generation R Study. Geelhoed JJ, Verburg BO, Nauta J, Lequin M, Hofman A, Moll HA, Witteman JC, van der Heijden AJ, Steegers EA, Jaddoe VW
Background: An adverse fetal environment may lead to smaller kidneys and subsequently kidney disease and hypertension in adulthood. The aims of this study are to examine whether kidney size tracks from fetal life to childhood and whether maternal and fetal characteristics are associated with kidney size at the age of 2 years. Study design: Prospective cohort study from fetal life onward. Setting & participants: The study was conducted in a group of 688 infants in Rotterdam, The Netherlands.... Abstract