Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
53 results
Cited 3 times since 2020 (0.8 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 22, Issue 9, 1 1 2020, Pages 1376-1383 The harm of delayed diagnosis of arrhythmogenic cardiac sarcoidosis: a case series. Hoogendoorn JC, Ninaber MK, Piers SRD, de Riva M, Grauss RW, Bogun FM, Zeppenfeld K
Aims: Cardiac sarcoidosis (CS) is a known cause of ventricular tachycardia (VT). However, an arrhythmogenic presentation may not prompt immediate comprehensive evaluation. We aimed to assess the diagnostic and disease course of patients with arrhythmogenic cardiac sarcoidosis (ACS). Methods and results: From the Leiden VT-ablation-registry, consecutive patients with CS as underlying aetiology were retrospectively included. Data on clinical presentation, time-to-diagnosis, cardiac function, and c... Abstract
Cited 8 times since 2020 (2.2 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 6, Issue 9, 29 5 2020, Pages 1103-1114 Prevalence and Prognostic Impact of Pathogenic Variants in Patients With Dilated Cardiomyopathy Referred for Ventricular Tachycardia Ablation. Ebert M, Wijnmaalen AP, de Riva M, Trines SA, Androulakis AFA, Glashan CA, Schalij MJ, Peter van Tintelen J, Jongbloed JDH, Zeppenfeld K
Objectives: This study aimed to assess the frequency of (likely) pathogenic variants (LP/Pv) among dilated cardiomyopathy (DCM) ventricular tachycardia (VT) patients referred for CA and their impact on procedural outcome and long-term prognosis. Background: The prevalence of genetic variants associated with monomorphic VT among DCM is unknown. Methods: Ninety-eight consecutive patients (age 56 ± 15 years; 84% men, left ventricular ejection fraction [LVEF] 39 ± 12%) referred for DCM-VT ablation w... Abstract
Cited 1 times since 2020 (0.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 6, Issue 7, 1 1 2020, Pages 874-876 Integration of Electroanatomical Mapping With Imaging to Guide Radiotherapy of VT Substrates With High Accuracy. Abdel-Kafi S, de Ridder M, de Riva M, van der Geest RJ, Rasch C, Zeppenfeld K
Cited 4 times since 2020 (1 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 6, Issue 9, 12 2 2020, Pages 1073-1085 RV Tissue Heterogeneity on CT: A Novel Tool to Identify the VT Substrate in ARVC. Venlet J, Tao Q, de Graaf MA, Glashan CA, de Riva Silva M, van der Geest RJ, Scholte AJ, Piers SRD, Zeppenfeld K
Objectives: This study sought to evaluate whether right ventricular (RV) tissue heterogeneity on computed tomography (CT): 1) is associated with conduction delay in arrhythmogenic right ventricular cardiomyopathy (ARVC); and 2) distinguishes patients with ARVC from those with exercise-induced arrhythmogenic remodeling (EIAR) and control individuals. Background: ARVC is characterized by fibrofatty replacement, related to conduction delay and ventricular tachycardias. Distinguishing ARVC from acqu... Abstract
Cited 5 times since 2020 (1.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 6, Issue 6, 29 5 2020, Pages 696-707 Electroanatomical Voltage Mapping to Distinguish Right-Sided Cardiac Sarcoidosis From Arrhythmogenic Right Ventricular Cardiomyopathy. Hoogendoorn JC, Sramko M, Venlet J, Siontis KC, Kumar S, Singh R, Nakajima I, Piers SRD, de Riva Silva M, Glashan CA, Crawford T, Tedrow UB, Stevenson WG, Bogun F, Zeppenfeld K
Objectives: This study sought to investigate the value of electroanatomical voltage mapping (EAVM) to distinguish cardiac sarcoidosis (CS) from arrhythmogenic right ventricular cardiomyopathy (ARVC) in patients with ventricular tachycardia from the right ventricle (RV). Background: CS can mimic ARVC. Because scar in ARVC is predominantly subepicardial, this study hypothesized that the relative sizes of endocardial low bipolar voltage (BV) to low unipolar voltage (UV) areas may distinguish CS fro... Abstract
Cited 5 times since 2019 (1.1 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 5, Issue 10, 28 4 2019, Pages 1115-1126 New Adjusted Cutoffs for "Normal" Endocardial Voltages in Patients With Post-Infarct LV Remodeling. Sramko M, Abdel-Kafi S, van der Geest RJ, de Riva M, Glashan CA, Lamb HJ, Zeppenfeld K
Objectives: This study sought to determine new reference cutoffs for normal unipolar voltage (UV) and bipolar voltage (BV) that would be adjusted for the LV remodeling. Background: The definition of "normal" left ventricular (LV) endocardial voltage in patients with post-infarct scar is still lacking. The reference voltage of the noninfarcted myocardium (NIM) may differ between patients depending on LV structural remodeling and the ensuing interstitial fibrosis. Methods: Electroanatomi... Abstract
Cited 5 times since 2019 (1 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 30, Issue 6, 29 5 2019, Pages 902-909 Optimizing ablation duration using dormant conduction to reveal incomplete isolation with the second generation cryoballoon: A randomized controlled trial. Keçe F, de Riva M, Naruse Y, Alizadeh Dehnavi R, Wijnmaalen AP, Schalij MJ, Zeppenfeld K, Trines SA
Introduction: Efficacy of cryoballoon ablation depends on balloon-tissue contact and ablation duration. Prolonged duration may increase extracardiac complications. The aim of this study is to determine the optimal additional ablation duration after acute pulmonary vein isolation (PVI). Methods: Consecutive patients with paroxysmal AF were randomized to three groups according to additional ablation duration (90, 120, or 150 seconds) after acute PVI (time-to-isolation). Primary outcome was reconne... Abstract
Cited 23 times since 2019 (4.5 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 5, Issue 4, 27 4 2019, Pages 480-489 Entropy as a Novel Measure of Myocardial Tissue Heterogeneity for Prediction of Ventricular Arrhythmias and Mortality in Post-Infarct Patients. Androulakis AFA, Zeppenfeld K, Paiman EHM, Piers SRD, Wijnmaalen AP, Siebelink HJ, Sramko M, Lamb HJ, van der Geest RJ, de Riva M, Tao Q
Objectives: This study proposed entropy as a new late gadolinium enhanced cardiac magnetic resonance-derived parameter to evaluate tissue inhomogeneity, independent of signal intensity thresholds. This study hypothesized that entropy within the scar is associated with ventricular arrhythmias (VAs), whereas entropy of the entire left ventricular (LV) myocardium is associated with mortality. Background: In patients after myocardial infarction, the heterogeneity of fibrosis determines the substrate... Abstract
Cited 4 times since 2019 (0.8 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 42, Issue 2, 9 2 2019, Pages 208-215 Impact of left atrial box surface ratio on the recurrence after ablation for persistent atrial fibrillation. Keçe F, Scholte AJ, de Riva M, Naruse Y, Watanabe M, Alizadeh Dehnavi R, Schalij MJ, Zeppenfeld K, Trines SA
Background: The posterior wall of the left atrium (LA) is a well-known substrate for atrial fibrillation (AF) maintenance. Isolation of the posterior wall between the pulmonary veins (box lesion) may improve ablation success. Box lesion surface area size varies depending on the individual anatomy. This retrospective study evaluates the influence of box lesion surface area as a ratio of total LA surface area (box surface ratio) on arrhythmia recurrence. Methods: Seventy consecutive patients with... Abstract
Cited 8 times since 2018 (1.5 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 5, Issue 3, 26 4 2018, Pages 318-326 Incidence and Clinical Significance of Cerebral Embolism During Atrial Fibrillation Ablation With Duty-Cycled Phased-Radiofrequency Versus Cooled-Radiofrequency: A Randomized Controlled Trial. Keçe F, Bruggemans EF, de Riva M, Alizadeh Dehnavi R, Wijnmaalen AP, Meulman TJ, Brugman JA, Rooijmans AM, van Buchem MA, Middelkoop HA, Eikenboom J, Schalij MJ, Zeppenfeld K, Trines SA
Objectives: The purpose of this study was to randomly compare the incidence of asymptomatic cerebral embolism (ACE) between the second-generation pulmonary vein ablation catheter (PVAC Gold) and the irrigated Thermocool catheter. Background: Pulmonary vein isolation (PVI) with the PVAC is associated with ACE. The PVAC Gold was designed to avoid this complication. Methods: Patients with paroxysmal atrial fibrillation were randomized 1:1 to PVI with the PVAC Gold or Thermocool catheter. Cerebral m... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
Journal of atrial fibrillation, Volume 11, Issue 3, 31 5 2018, Pages 2068 Effect of Non-fluoroscopic Catheter Tracking on Radiation Exposure during Pulmonary Vein Isolation: Comparison of Four ablation systems. Naruse Y, Keçe F, de Riva M, Watanabe M, Wijnmaalen AP, Dehnavi RA, Schalij MJ, Zeppenfeld K, Trines SA
Background: A novel non-fluoroscopic catheter tracking system (Mediguide) can be used in combination with a 3D mapping system for atrial fibrillation (AF) ablation. However, the benefit on radiation exposure of the Mediguide system compared to other ablation systems is unknown. Methods: We retrospectively enrolled consecutive 73 patients (51 men; 59±11 years; 60 paroxysmal AF) undergoing pulmonary vein isolation by the same operator. Radiation time, radiation effective dose, procedure time, AF r... Abstract
Cited 2 times since 2018 (0.4 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 4, Issue 10, 29 5 2018, Pages 1308-1318 Noninvasive Identification of Ventricular Tachycardia-Related Anatomical Isthmuses in Repaired Tetralogy of Fallot: What Is the Role of the 12-Lead Ventricular Tachycardia Electrocardiogram. Brouwer C, Kapel GFL, Jongbloed MRM, Schalij MJ, de Riva Silva M, Zeppenfeld K
Objectives: This study sought to evaluate the relation between 12-lead ventricular tachycardia (VT) electrocardiography (ECG) and VT-related anatomical isthmuses (AIs) in repaired tetralogy of Fallot (rTOF). Background: Slow-conducting AIs are the dominant VT substrate in rTOF. Whether an AI is considered critical relies on pace mapping (PM) guided by the VT ECG. Methods: VT ECGs, electroanatomical mapping data and PM results were analyzed in 25 rTOF patients (group 1) (age 57 ± 13 years). Selec... Abstract
Cited 41 times since 2018 (7.2 per year) source: EuropePMC
European heart journal, Volume 39, Issue 31, 1 1 2018, Pages 2867-2875 Whole human heart histology to validate electroanatomical voltage mapping in patients with non-ischaemic cardiomyopathy and ventricular tachycardia. Glashan CA, Androulakis AFA, Tao Q, Glashan RN, Wisse LJ, Ebert M, de Ruiter MC, van Meer BJ, Brouwer C, Dekkers OM, Pijnappels DA, de Bakker JMT, de Riva M, Piers SRD, Zeppenfeld K
Aims: Electroanatomical voltage mapping (EAVM) is an important diagnostic tool for fibrosis identification and risk stratification in non-ischaemic cardiomyopathy (NICM); currently, distinct cut-offs are applied. We aimed to evaluate the performance of EAVM to detect fibrosis by integration with whole heart histology and to identify the fibrosis pattern in NICM patients with ventricular tachycardias (VTs). Methods and results: Eight patients with NICM and VT underwent EAVM prior to death or hear... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 4, Issue 6, 28 4 2018, Pages 781-793 Slow Conducting Electroanatomic Isthmuses: An Important Link Between QRS Duration and Ventricular Tachycardia in Tetralogy of Fallot. Kapel GFL, Brouwer C, Jalal Z, Sacher F, Venlet J, Schalij MJ, Thambo JB, Jongbloed MRM, Blom NA, de Riva M, Zeppenfeld K
Objectives: This study sought to evaluate the influence of slow conducting anatomic isthmuses (SCAI) as dominant ventricular tachycardia (VT) substrate on QRS duration. Background: QRS prolongation has been associated with VT in repaired tetralogy of Fallot. Methods: Seventy-eight repaired tetralogy of Fallot patients (age 37 ± 15 years, 52 male, QRS duration 153 ± 29 ms, 67 right bundle branch blocks [RBBB]) underwent programmed stimulation and electroanatomic activation mapping during sinus rh... Abstract
Cited 26 times since 2018 (4.3 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 4, Issue 3, 19 3 2018, Pages 316-327 Targeting the Hidden Substrate Unmasked by Right Ventricular Extrastimulation Improves Ventricular Tachycardia Ablation Outcome After Myocardial Infarction. de Riva M, Naruse Y, Ebert M, Androulakis AFA, Tao Q, Watanabe M, Wijnmaalen AP, Venlet J, Brouwer C, Trines SA, Schalij MJ, Zeppenfeld K
Objectives: This study sought to determine whether ablation of hidden substrate unmasked by right ventricular extrastimulation (RVE) improves ablation outcome of post-myocardial infarction (MI) ventricular tachycardia (VT). Background: In patients with small or nontransmural scars after MI, part of the VT substrate may be functional and, in addition, masked by high-voltage far-field signals arising from adjacent normal myocardium. Methods: In 60 consecutive patients, systematic analysis of elect... Abstract
Cited 5 times since 2018 (0.8 per year) source: EuropePMC
Heart rhythm, Volume 15, Issue 5, 8 2 2018, Pages 668-676 Fast nonclinical ventricular tachycardia inducible after ablation in patients with structural heart disease: Definition and clinical implications. Watanabe M, de Riva M, Piers SRD, Dekkers OM, Ebert M, Venlet J, Trines SA, Schalij MJ, Pijnappels DA, Zeppenfeld K
Background: Noninducibility of ventricular tachycardia (VT) with an equal or longer cycle length (CL) than that of the clinical VT is considered the minimum ablation endpoint in patients with structural heart disease. Because their clinical relevance remains unclear, fast nonclinical VTs are often not targeted. However, an accepted definition for fast VT is lacking. The shortest possible CL of a monomorphic reentrant VT is determined by the ventricular refractory period (VRP). Objective: The pur... Abstract
Cited 9 times since 2017 (1.4 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 10, Issue 8, 1 1 2017, Pages e005175 Unipolar Endocardial Voltage Mapping in the Right Ventricle: Optimal Cutoff Values Correcting for Computed Tomography-Derived Epicardial Fat Thickness and Their Clinical Value for Substrate Delineation. Venlet J, Piers SRD, Kapel GFL, de Riva M, Pauli PFG, van der Geest RJ, Zeppenfeld K
Background: Low endocardial unipolar voltage (UV) at sites with normal bipolar voltage (BV) may indicate epicardial scar. Currently applied UV cutoff values are based on studies that lacked epicardial fat information. This study aimed to define endocardial UV cutoff values using computed tomography-derived fat information and to analyze their clinical value for right ventricular substrate delineation. Methods and results: Thirty-three patients (50±14 years; 79% men) underwent combined endocardia... Abstract
Cited 27 times since 2017 (3.8 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 69, Issue 5, 1 1 2017, Pages 497-507 Isolated Subepicardial Right Ventricular Outflow Tract Scar in Athletes With Ventricular Tachycardia. Venlet J, Piers SR, Jongbloed JD, Androulakis AF, Naruse Y, den Uijl DW, Kapel GF, de Riva M, van Tintelen JP, Barge-Schaapveld DQ, Schalij MJ, Zeppenfeld K
Background: High-level endurance training has been associated with right ventricular pathological remodeling and ventricular tachycardia (VT). Although overlap with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been suggested, the arrhythmogenic substrate for VTs in athletes is unknown. Objectives: The goal of this study was to evaluate whether electroanatomic scar patterns related to sustained VT can distinguish exercise-induced arrhythmogenic remodeling from ARVC and post-inflamma... Abstract
Cited 3 times since 2015 (0.4 per year) source: EuropePMC
Heart rhythm, Volume 13, Issue 4, 14 2 2015, Pages 860-869 QRS prolongation after premature stimulation is associated with polymorphic ventricular tachycardia in nonischemic cardiomyopathy: Results from the Leiden Nonischemic Cardiomyopathy Study. Piers SR, Askar SF, Venlet J, Androulakis AF, Kapel GF, de Riva Silva M, Jongbloed JJ, van Tintelen JP, Schalij MJ, Pijnappels DA, Zeppenfeld K
Background: Progressive activation delay after premature stimulation has been associated with ventricular fibrillation in nonischemic cardiomyopathy (NICM). Objectives: The objectives of this study were (1) to investigate prolongation of the paced QRS duration (QRSd) after premature stimulation as a marker of activation delay in NICM, (2) to assess its relation to induced ventricular arrhythmias, and (3) to analyze its underlying substrate by late gadolinium enhancement cardiac magnetic resonanc... Abstract
Journal of the American College of Cardiology, Volume 66, Issue 22, 1 1 2015, Pages 2576-2577 Reply: Elimination of All Inducible Ventricular Tachycardias as the Endpoint for Ablation. Yokokawa M, Kim HM, Baser K, Stevenson W, Nagashima K, Della Bella P, Vergara P, Hindricks G, Arya A, Zeppenfeld K, de Riva Silva M, Daoud EG, Kumar S, Kuck KH, Tilz R, Mathew S, Ghanbari H, Latchamsetty R, Morady F, Bogun F