Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
238 results
Frontiers in molecular biosciences, Volume 10, 5 1 2023, Pages 1223972 Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis. Buijsers B, Maciej-Hulme M, Jacobs M, Bebber MB, de Graaf M, Salmenov R, Parr N, Rabelink TJ, Nijenhuis T, van der Vlag J
Background: The glomerular endothelial glycocalyx is degraded during inflammation. The glycocalyx plays a pivotal role in endothelial function and is involved in many processes including binding of chemokines and cytokines, leukocyte trafficking, and preventing proteinuria. HS-based therapeutics are a promising novel class of anti-inflammatory drugs to restore a compromised endothelial glycocalyx under inflammatory conditions. Recently, we demonstrated that treatment with HS extracted from unsti... Abstract
The British journal of dermatology, Volume 189, Issue 1, 1 1 2023, Pages 129-147 Investigator Global Assessment for impetiginization in atopic dermatitis: development and initial reliability testing. Ragamin A, Tupker RA, de Graaf M, Rustemeyer T, Pasmans SGMA, Schappin R, Schuttelaar MLA
Frontiers in medicine, Volume 10, 16 3 2023, Pages 1112573 Endoglin and squamous cell carcinomas. Hakuno SK, Janson SGT, Trietsch MD, de Graaf M, de Jonge-Muller E, Crobach S, Harryvan TJ, Boonstra JJ, Dinjens WNM, Slingerland M, Hawinkels LJAC
Despite the fact that the role of endoglin on endothelial cells has been extensively described, its expression and biological role on (epithelial) cancer cells is still debatable. Especially its function on squamous cell carcinoma (SCC) cells is largely unknown. Therefore, we investigated SCC endoglin expression and function in three types of SCCs; head and neck (HNSCC), esophageal (ESCC) and vulvar (VSCC) cancers. Endoglin expression was evaluated in tumor specimens and 14 patient-derived cell... Abstract
Cited 3 times since 2023 (3.8 per year) source: EuropePMC
Science (New York, N.Y.), Volume 380, Issue 6650, 15 3 2023, Pages 1155-1160 Widespread diversity deficits of coral reef sharks and rays. Simpfendorfer CA, Heithaus MR, Heupel MR, MacNeil MA, Meekan M, Harvey E, Sherman CS, Currey-Randall LM, Goetze JS, Kiszka JJ, Rees MJ, Speed CW, Udyawer V, Bond ME, Flowers KI, Clementi GM, Valentin-Albanese J, Adam MS, Ali K, Asher J, Aylagas E, Beaufort O, Benjamin C, Bernard ATF, Berumen ML, Bierwagen S, Birrell C, Bonnema E, Bown RMK, Brooks EJ, Brown JJ, Buddo D, Burke PJ, Cáceres C, Cambra M, Cardeñosa D, Carrier JC, Casareto S, Caselle JE, Charloo V, Cinner JE, Claverie T, Clua EEG, Cochran JEM, Cook N, Cramp JE, D'Alberto BM, de Graaf M, Dornhege MC, Espinoza M, Estep A, Fanovich L, Farabaugh NF, Fernando D, Ferreira CEL, Fields CYA, Flam AL, Floros C, Fourqurean V, Gajdzik L, Barcia LG, Garla R, Gastrich K, George L, Giarrizzo T, Graham R, Guttridge TL, Hagan V, Hardenstine RS, Heck SM, Henderson AC, Heithaus P, Hertler H, Padilla MH, Hueter RE, Jabado RW, Joyeux JC, Jaiteh V, Johnson M, Jupiter SD, Kaimuddin M, Kasana D, Kelley M, Kessel ST, Kiilu B, Kirata T, Kuguru B, Kyne F, Langlois T, Lara F,
A global survey of coral reefs reveals that overfishing is driving resident shark species toward extinction, causing diversity deficits in reef elasmobranch (shark and ray) assemblages. Our species-level analysis revealed global declines of 60 to 73% for five common resident reef shark species and that individual shark species were not detected at 34 to 47% of surveyed reefs. As reefs become more shark-depleted, rays begin to dominate assemblages. Shark-dominated assemblages persist in wealthy n... Abstract
Heart rhythm, Volume 20, Issue 8, 2 1 2023, Pages 1128-1135 Five-year safety and efficacy of leadless pacemakers in a Dutch cohort. Breeman KTN, Oosterwerff EFJ, de Graaf MA, Juffer A, Saleem-Talib S, Maass AH, Wilde AAM, Boersma LVA, Ramanna H, van Dijk VF, van Erven L, Delnoy PHM, Tjong FVY, Knops RE
Background: Adequate real-world safety and efficacy of leadless pacemakers (LPs) have been demonstrated up to 3 years after implantation. Longer-term data are warranted to assess the net clinical benefit of leadless pacing. Objective: The purpose of this study was to evaluate the long-term safety and efficacy of LP therapy in a real-world cohort. Methods: In this retrospective cohort study, all consecutive patients with a first LP implantation from December 21, 2012, to December 13, 2016, in 6 D... Abstract
Cited 1 times since 2023 (1.1 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 24, Issue 6, 1 1 2023, Pages 776-784 Importance of plaque volume and composition for the prediction of myocardial ischaemia using sequential coronary computed tomography angiography/positron emission tomography imaging. Wang X, van den Hoogen IJ, Butcher SC, Kuneman JH, de Graaf MA, Kamperidis V, Boukes M, Maaniitty T, Schultz J, van Rosendael AR, Saraste A, Knuuti J, Bax JJ
Aims: Coronary atherosclerosis with a large necrotic core has been postulated to reduce the vasodilatory capacity of vascular tissue. In the present analysis, we explored whether total plaque volume and necrotic core volume on coronary computed tomography angiography (CCTA) are independently associated with myocardial ischaemia on positron emission tomography (PET). Methods and results: From a registry of symptomatic patients with suspected coronary artery disease and clinically indicated CCTA w... Abstract
Cited 1 times since 2023 (1.1 per year) source: EuropePMC
Frontiers in pharmacology, Volume 14, 27 4 2023, Pages 1098184 Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy. Buijsers B, Garsen M, de Graaf M, Bakker-van Bebber M, Guo C, Li X, van der Vlag J
Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy to treat glomerular diseases. A possible HPSE1 inhibitor is heparanase-2 (HPSE2) because HPSE2 is a structural homolog of HPSE1 without enzymatic activity. The importance of HPSE2 has been recently demonstrated in HPSE2-deficient mice, since these m... Abstract
Cited 1 times since 2023 (1.1 per year) source: EuropePMC
The Science of the total environment, Volume 883, 25 4 2023, Pages 163599 Capturing the SARS-CoV-2 infection pyramid within the municipality of Rotterdam using longitudinal sewage surveillance. de Graaf M, Langeveld J, Post J, Carrizosa C, Franz E, Izquierdo-Lara RW, Elsinga G, Heijnen L, Been F, van Beek J, Schilperoort R, Vriend R, Fanoy E, de Schepper EIT, Koopmans MPG, Medema G
Despite high vaccination rates in the Netherlands, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate. Longitudinal sewage surveillance was implemented along with the notification of cases as two parts of the surveillance pyramid to validate the use of sewage for surveillance, as an early warning tool, and to measure the effect of interventions. Sewage samples were collected from nine neighborhoods between September 2020 and November 2021. Comparative analysis an... Abstract
Musculoskeletal science & practice, Volume 65, 14 2 2023, Pages 102764 Comparison between two patient-reported outcome measures for patients with cervical radiculopathy: A think-aloud study. Thoomes E, de Graaf M, Gallina A, Falla D, Stathi A
Background: The Cervical Radiculopathy Impact Scale (CRIS) and Patient Specific Functional Scale 2.0 (PSFS 2.0) are patient-reported outcome measures (PROMs) used to assess activity limitations in patients with cervical radiculopathy (CR). This study a) compared the CRIS subscale 3 and the PSFS 2.0 in patients with CR with respect to completeness and patient preference, b) established the correlation between both PROMs in assessing the individual patient's level of functional limitations an... Abstract
Allergy, Volume 78, Issue 8, 29 5 2023, Pages 2266-2276 Dupilumab-associated ocular surface disease in atopic dermatitis patients: Clinical characteristics, ophthalmic treatment response and conjunctival goblet cell analysis. Achten R, Thijs J, van der Wal M, van Luijk C, de Graaf M, Bakker D, de Boer J, van Wijk F, de Bruin-Weller M
Background: Dupilumab-associated ocular surface disease (DAOSD) is frequently reported as side effect in atopic dermatitis (AD) patients. Therefore, the aim of this study was to investigate the frequency and severity of DAOSD, ophthalmic treatment response and to learn more about the effect of dupilumab on conjunctival goblet cells (GC). Methods: This prospective study included dupilumab-treated AD patients between February 2020 and June 2022 from the University Medical Centre Utrecht. Patients... Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 53, Issue 5, 16 3 2023, Pages 586-589 Switching from dupilumab to tralokinumab in atopic dermatitis patients with ocular surface disease: Preliminary case series. Achten R, Dekkers C, Bakker D, van Luijk C, de Graaf M, van Wijk F, de Boer J, de Bruin-Weller M, Thijs J
Cited 1 times since 2023 (1 per year) source: EuropePMC
Journal of cardiovascular computed tomography, Volume 17, Issue 3, 13 2 2023, Pages 177-184 Plaque volume, composition, and fraction versus ischemia and outcomes in patients with coronary artery disease. Kuneman JH, van den Hoogen IJ, Schultz J, Maaniitty T, van Rosendael AR, Kamperidis V, de Graaf MA, Broersen A, Jukema JW, Bax JJ, Saraste A, Knuuti J
Background: The various plaque components have been associated with ischemia and outcomes in patients with coronary artery disease (CAD). The main goal of this analysis was to test the hypothesis that, at patient level, the fraction of non-calcified plaque volume (PV) of total PV is associated with ischemia and outcomes in patients with CAD. This ratio could be a simple and clinically useful parameter, if predicting outcomes. Methods: Consecutive patients with suspected CAD undergoing coronary c... Abstract
Acta dermato-venereologica, Volume 103, 8 2 2023, Pages adv00881 Economic and Humanistic Burden in Paediatric Patients with Atopic Dermatitis. Achten R, Van der Rijst L, Piena M, Lamers H, De Beer F, De Bruin-Weller M, De Graaf M
Data concerning the economic and humanistic burden in patients with paediatric atopic dermatitis (AD) and their families are scarce. This retrospective study investigated these burdens in paediatric patients with AD using maintenance treatment with topical corticosteroids and/or conventional systemic immunosuppressants. Patient-reported outcomes regarding quality of life, AD severity, and parental work-related impairment were completed at inclusion. Data on healthcare resource utilization and me... Abstract
EBioMedicine, Volume 90, 6 1 2023, Pages 104506 Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuria. Garsen M, Buijsers B, Sol M, Gockeln L, Sonneveld R, van Kuppevelt TH, de Graaf M, van den Born J, Kamps JAAM, van Raalte DH, van der Meer RW, Lamb HJ, Hillebrands JL, Rabelink TJ, Maciej-Hulme ML, Krenning G, Nijenhuis T, van der Vlag J
Background: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proliferator-activated receptor ɣ (PPARɣ) agonists can ameliorate proteinuria. Since a recent study showed that PPARɣ regulates HPSE expression in liver cancer cells, we hypothesized that PPARɣ agonists exert their reno-protective effect by inhibiting glomerular H... Abstract
Ocular immunology and inflammation, 28 4 2023, Pages 1-5 Non-Infectious Uveitis Secondary to Dupilumab Treatment in Atopic Dermatitis Patients Shows a Pro-Inflammatory Molecular Profile. Achten R, van Luijk C, Thijs J, Drylewicz J, Delemarre E, Nierkens S, Bakker D, van Wijk F, de Graaf M, de Bruin-Weller M, de Boer J, Kuiper J
Severe uveitis is a rare complication of interleukin-4 receptor alpha blocking by dupilumab in topic dermatitis (AD) patients. The aim of this study was to describe five moderate-to-severe AD patients who developed uveitis during dupilumab treatment and to compare the proteomic profile of aqueous humor (AqH) of dupilumab-associated uveitis (n=3/5 available samples) with non-infectious uveitis (n=27) and cataract controls (n=11). Included patients were treated at the University Medical Center Utr... Abstract
American heart journal plus : cardiology research and practice, Volume 27, 23 4 2023, Pages 100280 Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks. Groen RA, de Graaf MA, Stöger JL, van Dijkman PRM, Jukema JW, Schalij MJ, Geelhoed JJM, Antoni ML
Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role, of which severity can be assessed by calculating the coronary artery calcium (CAC) score. This study aims to determine the relation between coronary atherosclerosis and cardiac manifestations in COVID... Abstract
JAAD international, Volume 11, 18 3 2023, Pages 137-139 Propranolol or atenolol for the management of infantile hemangioma: Implications for long-term health. Hermans MM, Pasmans SGMA, de Laat PCJ, Slieker MG, Mendels EJ, de Graaf M, Langeveld HR, Schappin R, Rietman AB, Breugem CC, Breur JMPJ, de Wildt SN, Raphael MF
Cited 3 times since 2023 (2.7 per year) source: EuropePMC
Acta dermato-venereologica, Volume 103, 16 3 2023, Pages adv00872 Effectiveness of Upadacitinib in Patients with Atopic Dermatitis including those with Inadequate Response to Dupilumab and/or Baricitinib: Results from the BioDay Registry. Boesjes CM, Van der Gang LF, Zuithoff NPA, Bakker DS, Spekhorst LS, Haeck I, Kamsteeg M, De Graaf M, De Bruin-Weller MS
Clinical trials showed that upadacitinib, a selective Janus kinase-1 inhibitor, is effective for treatment of moderate-to-severe atopic dermatitis. However, daily practice studies are limited. This multicentre prospective study evaluated the effectiveness of 16 weeks of upadacitinib treatment for moderate-to-severe atopic dermatitis in adult patients, including those with previous inadequate response to dupilumab and/or baricitinib, in daily practice. A total of 47 patients from the Dutch BioDay... Abstract
Cited 1 times since 2023 (0.9 per year) source: EuropePMC
The Science of the total environment, Volume 873, 14 2 2023, Pages 162209 Rise and fall of SARS-CoV-2 variants in Rotterdam: Comparison of wastewater and clinical surveillance. Izquierdo-Lara RW, Heijnen L, Oude Munnink BB, Schapendonk CME, Elsinga G, Langeveld J, Post J, Prasad DK, Carrizosa C, Been F, van Beek J, Schilperoort R, Vriend R, Fanoy E, de Schepper EIT, Sikkema RS, Molenkamp R, Aarestrup FM, Medema G, Koopmans MPG, de Graaf M
Monitoring of SARS-CoV-2 in wastewater (WW) is a promising tool for epidemiological surveillance, correlating not only viral RNA levels with the infection dynamics within the population, but also to viral diversity. However, the complex mixture of viral lineages in WW samples makes tracking of specific variants or lineages circulating in the population a challenging task. We sequenced sewage samples of 9 WW-catchment areas within the city of Rotterdam, used specific signature mutations from indi... Abstract
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 53, Issue 5, 13 2 2023, Pages 582-585 Muscle and joint pain during dupilumab treatment for atopic dermatitis: Lack of association with antinuclear antibodies. Boesjes CM, van Emst M, Bakker DS, Spekhorst LS, van Wijk F, de Graaf M, de Bruin-Weller MS