Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
39 results
Cited 39 times since 2017 (5.3 per year) source: EuropePMC
European heart journal, Volume 38, Issue 4, 1 1 2017, Pages 268-276 Arrhythmogenic anatomical isthmuses identified by electroanatomical mapping are the substrate for ventricular tachycardia in repaired Tetralogy of Fallot. Kapel GF, Sacher F, Dekkers OM, Watanabe M, Blom NA, Thambo JB, Derval N, Schalij MJ, Jalal Z, Wijnmaalen AP, Zeppenfeld K
Cardiac electrophysiology clinics, Volume 9, Issue 1, 24 4 2016, Pages 107-117 Ablation of Ventricular Tachycardia in Congenital and Infiltrative Heart Disease. Wijnmaalen AP, Zeppenfeld K
Radiofrequency catheter ablation (RFCA) is an important treatment modality to prevent ventricular tachycardia (VT) recurrence in patients with repaired congenital heart disease. Identification and ablation of anatomic isthmuses has improved acute ablation outcome with excellent VT-free survival in those with preserved biventricular function. Reports on RFCA for VT in patients with infiltrative disease are sparse and cardiac sarcoidosis seems to be the most prevalent cause for ventricular arrhyth... Abstract
Cited 9 times since 2015 (1 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 6, 18 3 2015, Pages 1452-1459 Fatigue as Presenting Symptom and a High Burden of Premature Ventricular Contractions Are Independently Associated With Increased Ventricular Wall Stress in Patients With Normal Left Ventricular Function. van Huls van Taxis CF, Piers SR, de Riva Silva M, Dekkers OM, Pijnappels DA, Schalij MJ, Wijnmaalen AP, Zeppenfeld K
Background: High idiopathic premature ventricular contractions (PVC) burden has been associated with PVC-induced cardiomyopathy. Patients may be symptomatic before left ventricular (LV) dysfunction develops. N-terminal pro-B-type natriuretic peptide (NT-proBNP) and circumferential end-systolic wall stress (cESS) on echocardiography are markers for increased ventricular wall stress. This study aimed to evaluate the relation between presenting symptoms, PVC burden, and increased ventricular wall s... Abstract
Cited 38 times since 2014 (4 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 8, Issue 1, 24 4 2014, Pages 102-109 Re-entry using anatomically determined isthmuses: a curable ventricular tachycardia in repaired congenital heart disease. Kapel GF, Reichlin T, Wijnmaalen AP, Piers SR, Holman ER, Tedrow UB, Schalij MJ, Stevenson WG, Zeppenfeld K
Background: Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired congenital heart disease. Methods and results: Thirty-four patients (49±13 years; 74% male) with repa... Abstract
Cited 22 times since 2014 (2.3 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 7, Issue 5, 23 4 2014, Pages 889-897 Left-sided ablation of ventricular tachycardia in adults with repaired tetralogy of Fallot: a case series. Kapel GF, Reichlin T, Wijnmaalen AP, Tedrow UB, Piers SR, Schalij MJ, Hazekamp MG, Jongbloed MR, Stevenson WG, Zeppenfeld K
Background: Radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in repaired Tetralogy of Fallot focuses on isthmuses in the right ventricle but may be hampered by hypertrophied myocardium or prosthetic material. These patients may benefit from ablation at the left side of the ventricular septum. Methods and results: Records from 28 consecutive repaired Tetralogy of Fallot patients from 2 centers who underwent VT ablation were reviewed. Ablation targeted anatomic isthmuses con... Abstract
Cited 32 times since 2013 (2.8 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 6, Issue 1, 1 1 2013, Pages 42-52 Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K
Objectives: This study aimed to evaluate the feasibility and accuracy of real-time integration of multidetector computed tomography (MDCT) derived coronary anatomy and epicardial fat distribution and its impact on electroanatomical mapping and ablation. Background: Epicardial catheter ablation for ventricular arrhythmias (VA) is an important therapeutic option in patients after endocardial ablation failure. However, epicardial mapping and ablation are limited by the presence of coronary arteries... Abstract
Cited 121 times since 2011 (9.5 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 4, Issue 5, 13 2 2011, Pages 653-659 Epicardial ablation for ventricular tachycardia: a European multicenter study. Della Bella P, Brugada J, Zeppenfeld K, Merino J, Neuzil P, Maury P, Maccabelli G, Vergara P, Baratto F, Berruezo A, Wijnmaalen AP
Background: The purpose of this study was to describe the epicardial percutaneous ablation experience of 6 European high-volume ventricular tachycardia (VT) ablation centers. Methods and results: Data from 218 patients with coronary artery disease (CAD, n=85 [39.0%]), idiopathic dilated of patients with idiopathic VT cardiomyopathy (IDCM, n=67 [30.7%]), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARCD/C, n=13 [6%]), hypertrophic cardiomyopathy (HCM, n=5 [2.3%]), and absence of str... Abstract
Cited 8 times since 2011 (0.6 per year) source: EuropePMC
Heart rhythm, Volume 9, Issue 1, 5 1 2011, Pages 10-17 Catheter ablation of ventricular tachycardia after left ventricular reconstructive surgery for ischemic cardiomyopathy. Wijnmaalen AP, Roberts-Thomson KC, Steven D, Klautz RJ, Willems S, Schalij MJ, Stevenson WG, Zeppenfeld K
Background: After surgical ventricular restoration (SVR) for ischemic cardiomyopathy, ventricular tachycardias (VTs) are an important reason for postoperative morbidity and mortality. Objective: The purpose of this study was to elucidate the VT substrate, VT characteristics, and outcome of radiofrequency catheter ablation (RFCA) in patients with VT after SVR. Methods: Twelve (3%) of 416 patients referred for RFCA for VT after myocardial infarction in three centers had undergone SVR. After induct... Abstract
Cited 11 times since 2011 (0.8 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 4, Issue 4, 11 2 2011, Pages 486-493 ECG identification of scar-related ventricular tachycardia with a left bundle-branch block configuration. Wijnmaalen AP, Stevenson WG, Schalij MJ, Field ME, Stephenson K, Tedrow UB, Koplan BA, Putter H, Epstein LM, Zeppenfeld K
Background: A left bundle-branch block (LBBB)-like pattern with a dominant S-wave in V(1) is common in idiopathic ventricular arrhythmias (VA). Discrimination between idiopathic and scar-related LBBB pattern VA has important clinical implications. We hypothesized that the VA QRS morphology is influenced by the presence of ventricular scar, allowing ECG discrimination of VA arising from structurally normal versus scarred myocardium. Methods and results: Twelve-lead ECGs of 297 LBBB pattern monomo... Abstract
Cited 2 times since 2011 (0.2 per year) source: EuropePMC
Minerva cardioangiologica, Volume 59, Issue 2, 1 1 2011, Pages 149-169 Ventricular tachycardia ablation: indications and techniques. Wijnmaalen AP, Zeppenfeld K
Over the last decades indications have broadened and techniques have been developed resulting in an increasing use of catheter ablation for different types of ventricular tachycardia (VT). Due to the high ablation success for non scar-related ventricular arrhythmia (VA) catheter ablation has become a first line therapy for symptomatic idiopathic VA or VA presumed to cause ventricular dysfunction. For the ablation of scar-related VTs individual patient factors and operator experience play an impo... Abstract
Cited 25 times since 2011 (1.9 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 4, Issue 2, 1 1 2011, Pages 195-201 Early reperfusion therapy affects inducibility, cycle length, and occurrence of ventricular tachycardia late after myocardial infarction. Piers SR, Wijnmaalen AP, Borleffs CJ, van Huls van Taxis CF, Thijssen J, van Rees JB, Cannegieter SC, Bax JJ, Schalij MJ, Zeppenfeld K
Background: This study aimed to evaluate the impact of early reperfusion during acute myocardial infarction (MI) on ventricular tachycardia (Vt) inducibility, inducible Vt cycle length (CL), and occurrence of spontaneous Vt late after MI. Methods and results: Five hundred six patients (440 men; age, 63±11 years) with prior MI who underwent electrophysiology study before implantation of an implantable cardioverter-defibrillator for primary or secondary prevention were assessed. Patients were clas... Abstract
Cited 16 times since 2011 (1.2 per year) source: EuropePMC
Heart rhythm, Volume 8, Issue 5, 4 1 2011, Pages 665-671 Reversed polarity of bipolar electrograms for predicting a successful ablation site in focal idiopathic right ventricular outflow tract arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, den Uijl DW, Gawrysiak M, Putter H, Schalij MJ, Zeppenfeld K
Background: Radiofrequency catheter ablation (RFCA) for idiopathic right ventricular outflow tract (RVOT) arrhythmias is typically guided by local activation time (LAT) mapping and unipolar electrogram morphology (QS configuration). However, LAT mapping is limited by the large variation among patients, and the area demonstrating a QS configuration of the unipolar electrogram may be larger than the focal source. Reversed polarity has been proposed as a criterion for guiding RFCA. Objective: The p... Abstract
Cited 10 times since 2010 (0.7 per year) source: EuropePMC
American heart journal, Volume 160, Issue 4, 1 1 2010, Pages 729-736 Longitudinal mechanics of the periinfarct zone and ventricular tachycardia inducibility in patients with chronic ischemic cardiomyopathy. Bertini M, Ng AC, Borleffs CJ, Delgado V, Wijnmaalen AP, Nucifora G, Ewe SH, Shanks M, Thijssen J, Zeppenfeld K, Biffi M, Leung DY, Schalij MJ, Bax JJ
Background: Quantification of segmental left ventricular (LV) strain by speckle-tracking echocardiography can identify transmural infarcts in patients with chronic ischemic cardiomyopathy. The aim of the study was to explore the relationship between the LV longitudinal peak systolic strain (LPSS) of the infarct, periinfarct, and remote zones and monomorphic ventricular tachycardia (VT) inducibility on electrophysiologic (EP) study. Methods: A total of 134 patients with chronic ischemic cardiomyo... Abstract
Cited 107 times since 2010 (7.9 per year) source: EuropePMC
European heart journal, Volume 32, Issue 1, 23 4 2010, Pages 104-114 Head-to-head comparison of contrast-enhanced magnetic resonance imaging and electroanatomical voltage mapping to assess post-infarct scar characteristics in patients with ventricular tachycardias: real-time image integration and reversed registration. Wijnmaalen AP, van der Geest RJ, van Huls van Taxis CF, Siebelink HM, Kroft LJ, Bax JJ, Reiber JH, Schalij MJ, Zeppenfeld K
Aims: Substrate-based ablation of ventricular tachycardia (VT) relies on electroanatomical voltage mapping (EAVM). Integration of scar information from contrast-enhanced magnetic resonance imaging (CE-MRI) with EAVM may provide supplementary information. This study assessed the relation between electrogram voltages and CE-MRI scar characteristics using real-time integration and reversed registration. Methods and results: Fifteen patients without implantable cardiac defibrillator (14 males, 64 ±... Abstract
Cited 52 times since 2010 (3.8 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 96, Issue 16, 1 1 2010, Pages 1275-1280 Beneficial effects of catheter ablation on left ventricular and right ventricular function in patients with frequent premature ventricular contractions and preserved ejection fraction. Wijnmaalen AP, Delgado V, Schalij MJ, van Huls van Taxis CF, Holman ER, Bax JJ, Zeppenfeld K
Background: Improvement of left ventricular ejection fraction (LVEF) after radiofrequency catheter ablation (RFCA) of frequent premature ventricular contractions (PVCs) has been reported. However, most patients with frequent PVCs have a normal LVEF. In these patients subtle and early forms of PVC-induced left and right ventricular (RV) impairment may not be detected by standard echocardiographic techniques. Objective: To assess the effect of frequent PVCs on ventricular function in patients with... Abstract
Cited 43 times since 2010 (3.1 per year) source: EuropePMC
Circulation, Volume 121, Issue 17, 19 3 2010, Pages 1887-1895 Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate. Wijnmaalen AP, Schalij MJ, von der Thüsen JH, Klautz RJ, Zeppenfeld K
Background: Reperfusion therapy during acute myocardial infarction results in myocardial salvage and improved ventricular function but may also influence the arrhythmogenic substrate for ventricular tachycardia (VT). This study used electroanatomic mapping and infarct histology to assess the impact of reperfusion on the substrate and on VT characteristics late after acute myocardial infarction. Methods and results: The study population consisted of 36 patients (32 men; age, 63+/-15 years) referr... Abstract
Cited 5 times since 2009 (0.3 per year) source: EuropePMC
Circulation. Arrhythmia and electrophysiology, Volume 2, Issue 5, 1 1 2009, Pages e28-30 Real-time integration of intracardiac echocardiography to facilitate atrial tachycardia ablation in a patient with a Senning baffle. den Uijl DW, Blom NA, Wijnmaalen AP, Bax JJ, Schalij MJ, Zeppenfeld K
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 20, Issue 10, 26 4 2009, Pages 1119-1127 Patients with scar-related right ventricular tachycardia: determinants of long-term outcome. Wijnmaalen AP, Schalij MJ, Bootsma M, Kies P, DE Roos A, Putter H, Bax JJ, Zeppenfeld K
Introduction: Patients with established arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) based on task force (TF) criteria and ventricular tachycardia (VT) are at risk of VT recurrence and sudden death. Data on patients with VT due to right ventricular (RV) scar not fulfilling TF criteria are lacking. The purpose of this study was to assess the long-term arrhythmia recurrence rate and outcome in patients with scar-related right VT with and without a diagnosis of ARVC/D. Methods... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 6, 1 1 2006, Pages 232-238 From the waste paper basket: total AV block? Wijnmaalen AP, van den Berg TM, Delemarre BJ