Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
95 results
Cited 48 times since 2011 (3.7 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13, Issue 11, 28 4 2011, Pages 1533-1540 Prognostic value of total atrial conduction time estimated with tissue Doppler imaging to predict the recurrence of atrial fibrillation after radiofrequency catheter ablation. den Uijl DW, Gawrysiak M, Tops LF, Trines SA, Zeppenfeld K, Schalij MJ, Bax JJ, Delgado V
Aims: Total atrial activation time has been identified as an independent predictor of new-onset atrial fibrillation (AF). Echocardiographic assessment of PA-TDI duration provides an estimation of total atrial conduction time. The aim of this study was to investigate the prognostic value of total atrial conduction time to predict AF recurrence after radiofrequency catheter ablation (RFCA). Methods and results: In 213 patients undergoing RFCA for symptomatic drug-refractory paroxysmal AF, the tota... Abstract
Cited 31 times since 2011 (2.4 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 91, Issue 3, 1 1 2011, Pages 716-723 Automated assessment of the aortic root dimensions with multidetector row computed tomography. Delgado V, Ng AC, Schuijf JD, van der Kley F, Shanks M, Tops LF, van de Veire NR, de Roos A, Kroft LJ, Schalij MJ, Bax JJ
Background: Accurate aortic root measurements and evaluation of spatial relationships with coronary ostia are crucial in preoperative transcatheter aortic valve implantation assessments. Standardization of measurements may increase intraobserver and interobserver reproducibility to promote procedural success rate and reduce the frequency of procedurally related complications. This study evaluated the accuracy and reproducibility of a novel automated multidetector row computed tomography (MDCT) i... Abstract
Cited 66 times since 2011 (5 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 97, Issue 22, 25 4 2011, Pages 1847-1851 Impact of left atrial fibrosis and left atrial size on the outcome of catheter ablation for atrial fibrillation. den Uijl DW, Delgado V, Bertini M, Tops LF, Trines SA, van de Veire NR, Zeppenfeld K, Schalij MJ, Bax JJ
Background: Left atrial (LA) dilatation is an important risk factor for recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA). However, the clinical applications to select patients eligible for RFCA according to LA size is limited. Additional pre-procedural assessment of LA fibrosis might improve patient selection for RFCA. Objective: To investigate the impact of LA size and LA fibrosis on the outcome of RFCA for AF. Methods: One hundred and seventy consecutive pat... Abstract
Cited 54 times since 2011 (4.1 per year) source: EuropePMC
The American journal of cardiology, Volume 107, Issue 2, 1 1 2011, Pages 243-249 Effect of pulmonary vein anatomy and left atrial dimensions on outcome of circumferential radiofrequency catheter ablation for atrial fibrillation. den Uijl DW, Tops LF, Delgado V, Schuijf JD, Kroft LJ, de Roos A, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, Bax JJ
Multislice computed tomography (MSCT) is commonly acquired before radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) to plan and guide the procedure. MSCT allows accurate measurement of the left atrial (LA) and pulmonary vein (PV) dimensions and classification of the PV anatomy. The aim of the present study was to investigate the effect of LA dimensions, PV dimensions, and PV anatomy on the outcome of circumferential RFCA for AF. A total of 100 consecutive patients undergoing R... Abstract
Cited 90 times since 2011 (6.8 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 57, Issue 3, 1 1 2011, Pages 324-331 Left atrial strain predicts reverse remodeling after catheter ablation for atrial fibrillation. Tops LF, Delgado V, Bertini M, Marsan NA, Den Uijl DW, Trines SA, Zeppenfeld K, Holman E, Schalij MJ, Bax JJ
Objectives: The purpose of this study was to assess left atrial (LA) strain during long-term follow-up after catheter ablation for atrial fibrillation and to find predictors for LA reverse remodeling. Background: The association between LA reverse remodeling and improvement in LA strain after catheter ablation has not been investigated thus far. Methods: In 148 patients undergoing catheter ablation for atrial fibrillation, LA volumes and LA strain were assessed with echocardiography at baseline... Abstract
Cited 29 times since 2011 (2.2 per year) source: EuropePMC
American heart journal, Volume 161, Issue 1, 1 1 2011, Pages 197-203 Natriuretic peptide levels predict recurrence of atrial fibrillation after radiofrequency catheter ablation. den Uijl DW, Delgado V, Tops LF, Ng AC, Boersma E, Trines SA, Zeppenfeld K, Schalij MJ, van der Laarse A, Bax JJ
Background: the presence of atrial fibrillation (AF) is related to increased levels of natriuretic peptides. In addition, increased natriuretic peptide levels are predictive of the development of AF. However, the role of natriuretic peptides to predict recurrence of AF after radiofrequency catheter ablation (RFCA) is controversial. Objective: the study aimed to investigate the role of natriuretic peptides in the prediction of AF recurrence after RFCA for AF. Methods: pre-procedural amino-termina... Abstract
Cited 10 times since 2010 (0.7 per year) source: EuropePMC
American heart journal, Volume 160, Issue 5, 1 1 2010, Pages 870-876 Ventricular response to stress predicts outcome in adult patients with a systemic right ventricle. Winter MM, Scherptong RW, Kumar S, Bouma BJ, Tulevski II, Tops LF, Roest AA, Vliegen HW, de Roos A, Groenink M, Mulder BJ
Background: Previous studies demonstrated that ventricular response to stress cardiovascular magnetic resonance (CMR) is frequently abnormal in patients with a systemic right ventricle (RV). However, the clinical implications of these findings remained unknown. We sought to evaluate whether abnormal response to stress CMR predicts adverse outcome in patients with a systemic RV. Methods: Thirty-nine adult patients (54% male; mean age 26, range 18-65 years) with a systemic RV underwent stress CMR... Abstract
Cited 15 times since 2010 (1.1 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 27, Issue 6, 16 3 2010, Pages 777-785 Relationship between obstructive coronary artery disease and abnormal stress testing in patients with paroxysmal or persistent atrial fibrillation. Nucifora G, Schuijf JD, van Werkhoven JM, Trines SA, Kajander S, Tops LF, Turta O, Jukema JW, Schreur JH, Heijenbrok MW, Gaemperli O, Kaufmann PA, Knuuti J, van der Wall EE, Schalij MJ, Bax JJ
Atrial fibrillation (AF) has been linked to the presence of underlying coronary artery disease (CAD). However, whether the higher burden of CAD observed in AF patients translates into higher burden of myocardial ischemia is unknown. In 87 patients (71% male, mean age 61 ± 10 years) with paroxysmal or persistent AF and without history of CAD, MSCT coronary angiography and stress testing (exercise ECG test or myocardial perfusion imaging) were performed. CAD was classified as obstructive (≥50% lum... Abstract
Cited 208 times since 2010 (14.7 per year) source: Scopus
European heart journal, Volume 31, Issue 9, 19 3 2010, Pages 1114-1123 Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve function. Delgado V, Ng AC, van de Veire NR, van der Kley F, Schuijf JD, Tops LF, de Weger A, Tavilla G, de Roos A, Kroft LJ, Schalij MJ, Bax JJ
Aims: Aortic regurgitation after transcatheter aortic valve implantation (TAVI) is one of the most frequent complications. However, the underlying mechanisms of this complication remain unclear. The present evaluation studied the anatomic and morphological features of the aortic valve annulus that may predict aortic regurgitation after TAVI. Methods and results: In 53 patients with severe aortic stenosis undergoing TAVI, multi-detector row computed tomography (MDCT) assessment of the aortic valv... Abstract
Cited 26 times since 2010 (1.8 per year) source: EuropePMC
European heart journal, Volume 31, Issue 5, 1 1 2010, Pages 542-551 Imaging and atrial fibrillation: the role of multimodality imaging in patient evaluation and management of atrial fibrillation. Tops LF, Schalij MJ, Bax JJ
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is associated with an increased risk of cardiac morbidity and mortality. In this review, the role of multimodality imaging in the evaluation and treatment of AF is discussed in two main parts. First, an overview of the initial assessment of an AF patient is provided, including the role of different imaging techniques. Conditions that are associated with AF (coronary artery disease, heart failure, valvular heart disease, and left... Abstract
Cited 140 times since 2009 (9.7 per year) source: EuropePMC
European heart journal, Volume 30, Issue 24, 1 1 2009, Pages 3037-3047 Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Delgado V, Tops LF, van Bommel RJ, van der Kley F, Marsan NA, Klautz RJ, Versteegh MI, Holman ER, Schalij MJ, Bax JJ
Aims: To evaluate myocardial multidirectional strain and strain rate (S-and-SR) in severe aortic stenosis (AS) patients with preserved left ventricular (LV) ejection fraction (EF), using two-dimensional speckle-tracking strain imaging (2D-STI). The long-term effect of aortic valve replacement (AVR) on S-and-SR was also evaluated. Methods and results: Changes in LV radial, circumferential, and longitudinal S-and-SR were evaluated in 73 severe AS patients (65 +/- 13 years; aortic valve area 0.8 +/... Abstract
Cited 197 times since 2009 (13.6 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 3, Issue 1, 17 3 2009, Pages 94-102 Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography. Ng AC, Delgado V, van der Kley F, Shanks M, van de Veire NR, Bertini M, Nucifora G, van Bommel RJ, Tops LF, de Weger A, Tavilla G, de Roos A, Kroft LJ, Leung DY, Schuijf J, Schalij MJ, Bax JJ
Background: 3D transesophageal echocardiography (TEE) may provide more accurate aortic annular and left ventricular outflow tract (LVOT) dimensions and geometries compared with 2D TEE. We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI). Methods and results: Two-dimensional circular (pixr(2)), 3D circular, and 3D planimetered annular and LVOT are... Abstract
Cited 23 times since 2009 (1.6 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 22, 1 1 2009, Pages 1881-1890 Real-time three dimensional echocardiography: current and future clinical applications. Marsan NA, Tops LF, Nihoyannopoulos P, Holman ER, Bax JJ
Cited 11 times since 2009 (0.8 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 95, Issue 18, 1 1 2009, Pages 1538-1546 Percutaneous aortic valve therapy: clinical experience and the role of multi-modality imaging. Tops LF, Delgado V, van der Kley F, Bax JJ
Cited 181 times since 2009 (12.3 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 54, Issue 9, 1 1 2009, Pages 764-776 The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy. Tops LF, Schalij MJ, Bax JJ
Cardiac pacing is the only effective treatment for patients with sick sinus syndrome and atrioventricular conduction disorders. In cardiac pacing, the endocardial pacing lead is typically positioned at the right ventricular (RV) apex. At the same time, there is increasing indirect evidence, derived from large pacing mode selection trials and observational studies, that conventional RV apical pacing may have detrimental effects on cardiac structure and left ventricular function, which are associa... Abstract
Cited 71 times since 2009 (4.8 per year) source: EuropePMC
European heart journal, Volume 30, Issue 19, 4 1 2009, Pages 2360-2367 Magnetic resonance imaging and response to cardiac resynchronization therapy: relative merits of left ventricular dyssynchrony and scar tissue. Marsan NA, Westenberg JJ, Ypenburg C, van Bommel RJ, Roes S, Delgado V, Tops LF, van der Geest RJ, Boersma E, de Roos A, Schalij MJ, Bax JJ
Aim: To assess the relative value of a novel measure of left ventricular (LV) dyssynchrony derived from magnetic resonance imaging (MRI) and the extent of scar tissue for prediction of response to cardiac resynchronization therapy (CRT). Methods and results: Thirty-five heart failure patients scheduled for CRT were included. Left ventricular dyssynchrony was defined as the standard deviation of 16 segment time-to-maximum radial wall thickness (SDt-16) obtained from a cine-set of short-axis slice... Abstract
Cited 16 times since 2009 (1.1 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 54, Issue 5, 1 1 2009, Pages 445-451 Prevalence and pathophysiologic attributes of ventricular dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy. Tops LF, Prakasa K, Tandri H, Dalal D, Jain R, Dimaano VL, Dombroski D, James C, Tichnell C, Daly A, Marcus F, Schalij MJ, Bax JJ, Bluemke D, Calkins H, Abraham TP
Objectives: This study sought to investigate the prevalence and mechanisms underlying right ventricular (RV) dyssynchrony in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) using tissue Doppler echocardiography (TDE). Background: An ARVD/C is characterized by fibrofatty replacement of RV myocardium and RV dilation. These pathologic changes may result in electromechanical dyssynchrony. Methods: Echocardiography, both conventional and TDE, was performed in 52 ARVD/C patients ful... Abstract
Cited 3 times since 2009 (0.2 per year) source: EuropePMC
The American journal of cardiology, Volume 104, Issue 3, 6 1 2009, Pages 440-446 Usefulness of multimodality imaging for detecting differences in temporal occurrence of left ventricular systolic mechanical events in healthy young adults. Marsan NA, Tops LF, Westenberg JJ, Delgado V, de Roos A, van der Wall EE, Schalij MJ, Bax JJ
Detailed information about the absolute temporal occurrence of myocardial motion and deformation events during the cardiac cycle is still lacking. However, the normal time range of these parameters may be of great importance as a reference for detecting and interpreting mechanical dyssynchrony and for identifying a delayed contraction in case of left ventricular (LV) dysfunction. The aim of this study was to determine in young healthy subjects and for different LV segments the value of (1) time... Abstract
Cited 104 times since 2009 (6.9 per year) source: EuropePMC
The American journal of cardiology, Volume 103, Issue 9, 1 1 2009, Pages 1295-1301 Role of multislice computed tomography in transcatheter aortic valve replacement. Wood DA, Tops LF, Mayo JR, Pasupati S, Schalij MJ, Humphries K, Lee M, Al Ali A, Munt B, Moss R, Thompson CR, Bax JJ, Webb JG
Transcatheter aortic valve replacement (TAVR) required precise knowledge of the anatomic dimensions and physical characteristics of the aortic valve, annulus, and aortic root. Most groups currently use angiography, transthoracic echocardiography (TTE), or transesophageal echocardiography (TEE) to assess aortic annulus dimensions and anatomy. However, multislice computed tomography (MSCT) may allow more detailed 3-dimensional assessment of the aortic root. Twenty-six patients referred for TAVR un... Abstract
Cited 64 times since 2009 (4.3 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 2, Issue 5, 1 1 2009, Pages 556-565 Assessment of mitral valve anatomy and geometry with multislice computed tomography. Delgado V, Tops LF, Schuijf JD, de Roos A, Brugada J, Schalij MJ, Thomas JD, Bax JJ
Objectives: The purpose of the present study was to assess the anatomy and geometry of the mitral valve by using 64-slice multislice computed tomography (MSCT). Background: Because it yields detailed anatomic information, MSCT may provide more insight into the underlying mechanisms of functional mitral regurgitation (FMR). Methods: In 151 patients, including 67 patients with heart failure (HF) and 29 patients with moderate to severe FMR, 64-slice MSCT coronary angiography was performed. The anat... Abstract