Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
95 results
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 3, 2 1 2020, Pages 173-174 Broad complex tachycardia; never judge a book by its cover. Regeer MV, Tops LF, de Riva Silva M
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 3, 2 1 2020, Pages 168-171 Broad complex tachycardia; never judge a book by its cover. Regeer MV, Tops LF, de Riva Silva M
Clinical chemistry and laboratory medicine, Volume 59, Issue 1, 18 3 2020, Pages e13-e17 Successfully meeting analytical expectations for the fast 0/1-h algorithm for NSTEMI by internal control procedures for cardiac troponin T. Endlich W, Mensink WJ, den Elzen WPJ, Tops LF, Cobbaert CM
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue Suppl 1, 1 1 2020, Pages 115-121 The role of long-term mechanical circulatory support in patients with advanced heart failure. Felix SEA, de Jonge N, Caliskan K, Birim O, Damman K, Kuijpers M, Tops LF, Palmen M, Ramjankhan FZ
In patients with end-stage heart failure, advanced therapies such as heart transplantation and long-term mechanical circulatory support (MCS) with a left ventricular assist device (LVAD) have to be considered. LVADs can be implanted as a bridge to transplantation or as an alternative to heart transplantation: destination therapy. In the Netherlands, long-term LVAD therapy is gaining importance as a result of increased prevalence of heart failure together with a low number of heart transplantatio... Abstract
European heart journal. Cardiovascular Imaging, Volume 21, Issue 3, 1 1 2020, Pages 299-306 Exercise haemodynamics after restrictive mitral annuloplasty for functional mitral regurgitation. Petrus AHJ, Tops LF, Holman ER, Marsan NA, Bax JJ, Schalij MJ, Steendijk P, Klautz RJM, Braun J
Aims: Restrictive mitral annuloplasty (RMA) can provide a durable solution for functional mitral regurgitation (MR), but might result in obstruction to antegrade mitral flow. Aim of this study was to assess the magnitude of change in mitral valve area (MVA) during exercise after RMA, to relate the change in MVA to left ventricular (LV) geometry and function, and to assess its haemodynamic and clinical impact. Methods and results: Bicycle exercise echocardiography was performed in 32 patients aft... Abstract
Cited 7 times since 2019 (1.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 12, 1 1 2019, Pages 590-593 Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF
Ventricular assist device (VAD) implantation is an established treatment modality for patients with end-stage heart failure, and improves symptoms and survival. In the Netherlands, it is not yet routinely considered in patients with congenital heart disease and failing systemic right ventricle (SRV). Recently, a VAD was implanted in 2 SRV patients, one who underwent a Mustard procedure during infancy for transposition of the great arteries (male, 47 years old) and one with a congenitally correct... Abstract
Cited 11 times since 2019 (2.4 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 12, Issue 10, 1 1 2019, Pages 2029-2048 Transcatheter Interventions for Mitral Regurgitation: Multimodality Imaging for Patient Selection and Procedural Guidance. Bax JJ, Debonnaire P, Lancellotti P, Ajmone Marsan N, Tops LF, Min JK, Piazza N, Leipsic J, Hahn RT, Delgado V
Transcatheter therapies to treat mitral regurgitation are rapidly developing. Currently, there are several devices commercially available to treat mitral regurgitation. The underlying cause of mitral regurgitation and specific anatomical aspects of the mitral valve and surrounding structures are considered when patients with symptomatic severe mitral regurgitation for transcatheter mitral valve therapies are selected. Multimodality imaging plays an important central role in the selection of pati... Abstract
Cited 12 times since 2019 (2.5 per year) source: EuropePMC
European heart journal, Volume 40, Issue 27, 1 1 2019, Pages 2206-2214 Impact of recurrent mitral regurgitation after mitral valve repair for functional mitral regurgitation: long-term analysis of competing outcomes. Petrus AHJ, Dekkers OM, Tops LF, Timmer E, Klautz RJM, Braun J
Aims: Recurrent mitral regurgitation (MR) has been reported after mitral valve repair for functional MR. However, the impact of recurrent MR on long-term survival remains poorly defined. In the present study, mortality-adjusted recurrent MR rates, the clinical impact of recurrent MR and its determinants were studied in patients after mitral valve repair with revascularization for functional MR in the setting of ischaemic heart disease. Methods and results: Long-term clinical and echocardiographi... Abstract
Cited 1 times since 2019 (0.2 per year) source: EuropePMC
JMIR cardio, Volume 3, Issue 1, 19 3 2019, Pages e9894 Mobile Health for Central Sleep Apnea Screening Among Patients With Stable Heart Failure: Single-Cohort, Open, Prospective Trial. Treskes RW, Maan AC, Verwey HF, Schot R, Beeres SLMA, Tops LF, Tops LF, Van Der Velde ET, Schalij MJ, Slats AM
Background: Polysomnography is the gold standard for detection of central sleep apnea in patients with stable heart failure. However, this procedure is costly, time consuming, and a burden to the patient and therefore unsuitable as a screening method. An electronic health (eHealth) app to measure overnight oximetry may be an acceptable screening alternative, as it can be automatically analyzed and is less burdensome to patients. Objective: This study aimed to assess whether overnight pulse oxime... Abstract
Cited 1 times since 2019 (0.2 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 108, Issue 1, 30 5 2019, Pages 81-88 10-Year Outcomes After Left Ventricular Reconstruction: Rethinking the Impact of Mitral Regurgitation. Petrus AHJ, Klein P, Tops LF, Dekkers OM, Hoogervorst LA, Couperus LE, Beeres SLMA, Klautz RJM, Braun J
Background: Heart failure with reduced ejection fraction due to a post-infarction anteroseptal aneurysm carries a poor prognosis. Patients with refractory heart failure may be considered for advanced surgery, including left ventricular assist device implantation, heart transplantation and left ventricular reconstruction. The aim of this study was to evaluate outcomes after an integrated approach of left ventricular reconstruction with concomitant procedures (mitral/tricuspid valve repair, corona... Abstract
Interactive cardiovascular and thoracic surgery, Volume 27, Issue 5, 1 1 2018, Pages 657-663 Prognostic value of left ventricular reverse remodelling and recurrent mitral regurgitation after personalized surgical treatment of patients with non-ischaemic cardiomyopathy and functional mitral regurgitation. Petrus AHJ, Tops LF, Timmer E, Versteegh MIM, Dekkers OM, Klautz RJM, Braun J
Objectives: The aim of this study was to determine the prevalence of left ventricular reverse remodelling (LVRR) and recurrent mitral regurgitation (MR) at mid-term follow-up (1-2 years after surgery) in patients after personalized surgical treatment of heart failure and functional MR due to non-ischaemic cardiomyopathy and to assess their prognostic impact on long-term clinical outcomes. Methods: Consecutive patients with refractory heart failure and non-ischaemic MR, who underwent mitral valve... Abstract
Cited 4 times since 2017 (0.6 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 52, Issue 6, 1 1 2017, Pages 1161-1167 Right ventricular dysfunction after surgical left ventricular restoration: prevalence, risk factors and clinical implications. Couperus LE, Delgado V, van Vessem ME, Tops LF, Palmen M, Braun J, Verwey HF, Klautz RJM, Schalij MJ, Beeres SLMA
Objectives: Surgical left ventricular (LV) restoration (SVR) induces changes in LV systolic and diastolic function that may affect postoperative right ventricular (RV) function. This study aimed to evaluate the long-term effect of SVR on RV function, with specific focus on determinants and prognostic implications of RV dysfunction. Methods: Eighty-six patients (age 60 ± 10 years, 73% male) with clinical and echocardiographic follow-up 2 years after SVR were included. RV dysfunction was defined a... Abstract
Cited 65 times since 2017 (10.3 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 70, Issue 25, 1 1 2017, Pages 3157-3172 Structure and Function of the Left Atrium and Left Atrial Appendage: AF and Stroke Implications. Delgado V, Di Biase L, Leung M, Romero J, Tops LF, Casadei B, Marrouche N, Bax JJ
Atrial fibrillation (AF) and stroke are important major health problems that share common risk factors and frequently coexist. Left atrial (LA) remodeling is an important underlying substrate for AF and stroke. LA dilation and dysfunction form a prothrombotic milieu characterized by blood stasis and endothelial dysfunction. In addition, alterations of the atrial cardiomyocytes, increase of noncollagen deposits in the interstitial space and fibrosis, favor the occurrence of re-entry that predispo... Abstract
Cited 4 times since 2017 (0.6 per year) source: EuropePMC
ASAIO journal (American Society for Artificial Internal Organs : 1992), Volume 63, Issue 3, 1 1 2017, Pages 266-272 Pump Speed Optimization in Stable Patients with a Left Ventricular Assist Device. Couperus LE, Delgado V, Khidir MJH, Vester MPM, Palmen M, Fiocco M, Holman ER, Tops LF, Klautz RJM, Verwey HF, Schalij MJ, Beeres SLMA
Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N = 17, age 61 [interquartile range {IQR} 51-66] years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images w... Abstract
Cited 5 times since 2017 (0.7 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 19, Issue 4, 1 1 2017, Pages 560-567 Limited left atrial surgical ablation effectively treats atrial fibrillation but decreases left atrial function. Compier MG, Tops LF, Braun J, Zeppenfeld K, Klautz RJ, Schalij MJ, Trines SA
Aims: Limited left atrial (LA) surgical ablation with bipolar radiofrequency is considered to be an effective procedure for treatment of atrial fibrillation (AF). We studied whether limited LA surgical ablation concomitant to cardiac surgery is able to maintain LA function. Methods and results: Thirty-six consecutive patients (age 66 ± 12 years, 53% male, 78% persistent AF) scheduled for valve surgery and/or coronary revascularization and concomitant LA surgical ablation were included. Epicardia... Abstract
Cited 13 times since 2017 (1.8 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 51, Issue 3, 1 1 2017, Pages 532-538 Incidence and predictors of vasoplegia after heart failure surgery. van Vessem ME, Palmen M, Couperus LE, Mertens B, Berendsen RR, Tops LF, Verwey HF, de Jonge E, Klautz RJ, Schalij MJ, Beeres SL
Objectives: Vasoplegia has been described as a complication after cardiac surgery, particularly in patients with a poor left ventricular ejection fraction. The aim of this study was to assess the incidence, survival and predictors of vasoplegia in patients undergoing heart failure surgery and to propose a risk model. Methods: A retrospective study including heart failure patients who underwent surgical left ventricular restoration, CorCap implantation or left ventricular assist device implantati... Abstract
Cited 82 times since 2016 (11.2 per year) source: EuropePMC
European journal of heart failure, Volume 19, Issue 3, 27 4 2016, Pages 307-313 Myocardial strain to detect subtle left ventricular systolic dysfunction. Tops LF, Delgado V, Marsan NA, Bax JJ
In daily clinical practice, LV systolic function is routinely assessed with the use of two-dimensional echocardiography. Using biplane LV end-diastolic and end-systolic volumes, LVEF is calculated. The introduction of real-time three-dimensional echocardiography has improved the accuracy of echocardiographic assessment of LVEF. However, calculated LVEF may not truly represent LV systolic function in specific cardiac diseases or when subtle LV dysfunction is present. Two-dimensional speckle track... Abstract
Cited 9 times since 2016 (1.2 per year) source: EuropePMC
The Journal of thoracic and cardiovascular surgery, Volume 153, Issue 4, 23 4 2016, Pages 845-852 Right ventricular dysfunction affects survival after surgical left ventricular restoration. Couperus LE, Delgado V, Palmen M, van Vessem ME, Braun J, Fiocco M, Tops LF, Verwey HF, Klautz RJ, Schalij MJ, Beeres SL
Objective: Several clinical and left ventricular parameters have been associated with prognosis after surgical left ventricular restoration in patients with ischemic heart failure. The aim of this study was to determine the prognostic value of right ventricular function. Methods: A total of 139 patients with ischemic heart failure (62 ± 10 years; 79% were male; left ventricular ejection fraction 27% ± 7%) underwent surgical left ventricular restoration. Biventricular function was assessed with e... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
JAMA, Volume 311, Issue 22, 1 1 2014, Pages 2335 Left atrial fibrosis and recurrent arrhythmia. Tops LF, Schalij MJ
Cited 6 times since 2014 (0.6 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 25, Issue 6, 29 5 2014, Pages 631-637 Effect of induced LV dyssynchrony by right ventricular apical pacing on all-cause mortality and heart failure hospitalization rates at long-term follow-up. Auger D, Hoke U, Marsan NA, Tops LF, Leong DP, Bertini M, Schalij MJ, Bax JJ, Delgado V
Background: Right ventricular apical (RVA) pacing may induce left ventricular (LV) dyssynchrony. The long-term prognostic implications of induction of LV dyssynchrony were retrospectively evaluated in a cohort of patients who underwent RVA pacing. Methods: A total of 169 patients (62 ± 13 years, 69% male) with high RVA pacing burden were included. Echocardiographic evaluation of LV volumes, ejection fraction, and dyssynchrony were performed before and after device implantation. LV dyssynchrony w... Abstract