Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
195 results
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Volume 13, Issue Pt 3, 1 1 2010, Pages 367-374 A strain energy filter for 3D vessel enhancement. Xiao C, Staring M, Shamonin D, Reiber JH, Stolk J, Stoel BC
The traditional Hessian-related vessel filters often suffer from the problem of handling non-cylindrical objects. To remedy the shortcoming, we present a shape-tuned strain energy density function to measure vessel likelihood in 3D images. Based on the tensor invariants and stress-strain principle in mechanics, a new shape discriminating and vessel strength measure function is formulated. The synthetical and clinical data experiments verify the performance of our method in enhancing complex vasc... Abstract
Cited 31 times since 2009 (2.1 per year) source: EuropePMC
Child: care, health and development, Volume 35, Issue 5, 23 4 2009, Pages 673-680 Parents' reactions to the diagnosis of cerebral palsy: associations between resolution, age and severity of disability. Schuengel C, Rentinck IC, Stolk J, Voorman JM, Loots GM, Ketelaar M, Gorter JW, Becher JG
Background: For parents, receiving a diagnosis, typically in early childhood, that their child has cerebral palsy may conjure up high distress and anxiety. Resolution of these initial reactions may help parents to focus on the challenges and needs of their children. Aims: of the study were to test whether parents of older children displayed resolution more often than parents of younger children, and whether parents of children with less severe cerebral palsy also showed more resolution. Method:... Abstract
Cited 18 times since 2008 (1.2 per year) source: EuropePMC
Proceedings of the American Thoracic Society, Volume 5, Issue 9, 1 1 2008, Pages 929-933 Quality control in longitudinal studies with computed tomographic densitometry of the lungs. Stoel BC, Bode F, Rames A, Soliman S, Reiber JH, Stolk J
To guarantee the reliability of densitometric data in clinical trials on pulmonary emphysema a quality control procedure is presented, to prevent that a measured progression in lung density could be reflected by a gradual change in the maintenance of the computed tomographic scanner. For that purpose, a foam phantom has been developed, which mimicks the densities of emphysematous lung tissue, fixed in a sealed Perspex box. Analysis software was developed to automatically compare the density read... Abstract
Cited 59 times since 2008 (3.8 per year) source: EuropePMC
Proceedings of the American Thoracic Society, Volume 5, Issue 9, 1 1 2008, Pages 919-924 Volume correction in computed tomography densitometry for follow-up studies on pulmonary emphysema. Stoel BC, Putter H, Bakker ME, Dirksen A, Stockley RA, Piitulainen E, Russi EW, Parr D, Shaker SB, Reiber JH, Stolk J
Lung densitometry in drug evaluation trials can be confounded by changes in inspiration levels between computed tomography (CT) scans, limiting its sensitivity to detect changes over time. Therefore our aim was to explore whether the sensitivity of lung densitometry could be improved by correcting the measurements for changes in lung volume, based on the estimated relation between density (as measured with the 15th percentile point) and lung volume. We compared four correction methods, using CT... Abstract
Cited 17 times since 2008 (1.1 per year) source: EuropePMC
Chest, Volume 134, Issue 5, 14 2 2008, Pages 931-937 Assessment of regional progression of pulmonary emphysema with CT densitometry. Bakker ME, Putter H, Stolk J, Shaker SB, Piitulainen E, Russi EW, Stoel BC
Background: Lung densitometry is an effective method to assess overall progression of emphysema, but generally the location of the progression is not estimated. We hypothesized that progression of emphysema is the result of extension from affected areas toward less affected areas in the lung. To test this hypothesis, a method was developed to assess emphysema severity at different levels in the lungs in order to estimate regional changes. Methods: Fifty subjects with emphysema due to alpha(1)-an... Abstract
Cited 21 times since 2008 (1.3 per year) source: EuropePMC
The European respiratory journal, Volume 32, Issue 4, 9 2 2008, Pages 931-937 Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Chappell S, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Lotya J, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N
The genetic factors that contribute to the development of chronic obstructive pulmonary disease (COPD) are poorly understood. Many candidate genes have been proposed, including enzymes that protect the lung against oxidative stress, such as microsomal epoxide hydrolase (EPHX1) and glutamate-cysteine ligase (GCL). To date, most reported findings have been for EPHX1, particularly in relation to functional variants associated with fast and slow metabolism of epoxide intermediates. The present study... Abstract
Cited 106 times since 2008 (6.7 per year) source: EuropePMC
Orphanet journal of rare diseases, Volume 3, 19 3 2008, Pages 16 Hereditary alpha-1-antitrypsin deficiency and its clinical consequences. Fregonese L, Stolk J
Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of AAT, the main protease inhibitor (PI) in human serum. The prevalence in Western Europe and in the USA is estimated at approximately 1 in 2,500 and 1 : 5,000 newborns, and is highly dependent on the Scandinavian descent within the population. The most common deficiency alleles in North Europe a... Abstract
Cited 4 times since 2008 (0.2 per year) source: EuropePMC
Radiology, Volume 247, Issue 1, 1 1 2008, Pages 293-4; author reply 294 Can the extent of low-attenuation areas on CT scans really demonstrate changes in the severity of emphysema? Stoel BC, Parr DG, Bakker EM, Putter H, Stolk J, Gietema HA, Schilham AM, van Ginneken B, van Klaveren RJ, Lammers JW, Prokop M
Cited 19 times since 2008 (1.2 per year) source: EuropePMC
Journal of proteomics, Volume 71, Issue 2, 27 4 2008, Pages 211-221 Proteomic analysis of exhaled breath condensate from single patients with pulmonary emphysema associated to alpha1-antitrypsin deficiency. Fumagalli M, Dolcini L, Sala A, Stolk J, Fregonese L, Ferrari F, Viglio S, Luisetti M, Iadarola P
The non-invasive character of exhaled breath (EBC) collection makes this fluid attractive for monitoring the respiratory tract by the measurement of various compounds. Because EBC is likely to reflect the composition of the airway-lining fluid, it can provide valuable information on possible disease states. Aim of our study was to apply proteomic technology to the study of EBC samples collected from single patients with pulmonary emphysema associated to alpha(1)-antitrypsin deficiency. The prote... Abstract
Cited 51 times since 2008 (3.2 per year) source: EuropePMC
Respiratory medicine, Volume 102, Issue 6, 18 3 2008, Pages 876-884 Alpha-1 antitrypsin Null mutations and severity of emphysema. Fregonese L, Stolk J, Frants RR, Veldhuisen B
Background: Alpha-1 antitrypsin (AAT) deficiency is an autosomal-codominant disorder, caused by mutations in the SERPINA1 gene on chromosome 14. Individuals affected by the most common mutations, SZ and ZZ, have serum AAT concentrations of 25% and 15% of normal levels, and present a higher risk of emphysema. Mutations causing total absence of serum AAT (Null mutations) were suggested to be associated with very early onset emphysema but their clinical phenotype is poorly known. Hypothesis: Absenc... Abstract
Cited 2 times since 2007 (0.1 per year) source: EuropePMC
Respiration; international review of thoracic diseases, Volume 76, Issue 2, 6 1 2007, Pages 187-192 A syringe simulation of biological controls for quality assessment of prospective lung volume measurements. Ninaber MK, Schot R, Fregonese L, Stolk J
Background: At present a syringe is being used for calibration of lung function devices, but biological controls are used to detect prospectively the variability and reproducibility of lung volumes measured by spirometers. Laboratory personnel is often used as biological control and therefore the cost for these measurements is substantial and may be reduced by replacement of a syringe procedure to increase the capacity of the laboratory to measure more patients. Objectives: To develop a mechanic... Abstract
Cited 32 times since 2007 (2 per year) source: EuropePMC
The European respiratory journal, Volume 31, Issue 3, 5 1 2007, Pages 509-515 Value of chest radiography in phenotyping chronic obstructive pulmonary disease. Miniati M, Monti S, Stolk J, Mirarchi G, Falaschi F, Rabinovich R, Canapini C, Roca J, Rabe KF
The objectives of the present study were to reappraise chest radiography for the diagnosis of emphysema, using computed tomography (CT) as the reference standard, and to establish whether or not chest radiography is useful for phenotyping chronic obstructive pulmonary disease (COPD). Patients (n = 154) who had undergone posteroanterior and lateral chest radiography and CT for diagnostic purposes were studied. CT data were scored for emphysema using the picture-grading method. Chest radiographs w... Abstract
Cited 8 times since 2007 (0.5 per year) source: EuropePMC
The European respiratory journal, Volume 30, Issue 4, 1 1 2007, Pages 810-812 Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD. Chappell S, Daly L, Morgan K, Baranes TG, Roca J, Rabinovich R, Millar A, Donnelly SC, Keatings V, Macnee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N
Cited 59 times since 2007 (3.5 per year) source: EuropePMC
Respiratory medicine, Volume 101, Issue 9, 20 3 2007, Pages 1924-1930 Progression parameters for emphysema: a clinical investigation. Stolk J, Putter H, Bakker EM, Shaker SB, Parr DG, Piitulainen E, Russi EW, Grebski E, Dirksen A, Stockley RA, Reiber JH, Stoel BC
In patients with airflow limitation caused by cigarette smoking, lung density measured by computed tomography is strongly correlated with quantitative pathology scores of emphysema, but the ability of lung densitometry to detect progression of emphysema is disputed. We assessed the sensitivity of lung densitometry as a parameter of disease progression of emphysema in comparison to FEV(1) and gas transfer. At study baseline and after 30 months we measured computed tomography (CT)-derived lung den... Abstract
Cited 47 times since 2007 (2.8 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 32, Issue 3, 19 3 2007, Pages 449-456 Diaphragm plication in adult patients with diaphragm paralysis leads to long-term improvement of pulmonary function and level of dyspnea. Versteegh MI, Braun J, Voigt PG, Bosman DB, Stolk J, Rabe KF, Dion RA
Objective: There is still controversy about the feasibility and long-term outcome of surgical treatment of acquired diaphragm paralysis. We analyzed the long-term effects on pulmonary function and level of dyspnea after unilateral or bilateral diaphragm plication. Methods: Between December 1996 and January 2006, 22 consecutive patients underwent diaphragm plication. Before surgery, spirometry in both seated and supine positions and a Baseline Dyspnea Index were assessed. The uncut diaphragm was... Abstract
Cited 20 times since 2007 (1.2 per year) source: EuropePMC
The European respiratory journal, Volume 29, Issue 6, 1 1 2007, Pages 1138-1143 Densitometry for assessment of effect of lung volume reduction surgery for emphysema. Stolk J, Versteegh MI, Montenij LJ, Bakker ME, Grebski E, Tutic M, Wildermuth S, Weder W, el Bardiji M, Reiber JH, Rabe KF, Russi EW, Stoel BC
To explore if change in the extent of emphysema correlated with change in lung function, the effect of resection of emphysematous tissue was studied by computed tomography (CT) densitometry. In addition, the current authors studied how surgery-induced change in emphysema related to lung density in control subjects. In total, 30 patients (14 females; mean+/-sd age 59+/-10 yrs) with severe emphysema before and 3 months after lung volume reduction surgery (LVRS), 48 patients with moderate emphysema... Abstract
Cited 17 times since 2007 (1 per year) source: EuropePMC
Clinical orthopaedics and related research, Volume 456, 1 1 2007, Pages 138-147 Finite element-based preclinical testing of cemented total hip implants. Stolk J, Janssen D, Huiskes R, Verdonschot N
We developed a finite element model to preclinically test cemented hip implants for damage accumulation, including cement crack formation, creep, and stem migration. Using this model, we simulated the mechanical failure processes of four cemented total hip arthroplasty implants (Lubinus SPII, Mueller Curved, Exeter and Charnley, all with known clinical results) during cyclic normal walking and stair-climbing loads. These four implants were selected to ascertain whether the simulation predicted g... Abstract
Cited 14 times since 2007 (0.8 per year) source: EuropePMC
Journal of separation science, Volume 30, Issue 2, 1 1 2007, Pages 202-213 Progress in the methodological strategies for the detection in real samples of desmosine and isodesmosine, two biological markers of elastin degradation. Viglio S, Annovazzi L, Luisetti M, Stolk J, Casado B, Iadarola P
Desmosines are crosslinking amino acids unique to mature elastin in humans. Owing to this unicity, they have been discussed as potentially attractive indicators of connective tissue disorders whose clinical manifestations are mostly the result of elastin degradation. This review covers advances in immunochemical, chromatographic, and electrophoretic procedures applied in the last 25 years to detect and quantitate these crosslinksin a variety of biological samples. Recent applications of CE with... Abstract
Cited 8 times since 2007 (0.5 per year) source: EuropePMC
International journal of chronic obstructive pulmonary disease, Volume 2, Issue 2, 1 1 2007, Pages 131-139 Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema. Lenssen J, Stolk J
A common feature of lung disorders with poor treatment options, including emphysema, is a failure to initiate a repair process of the alveolar epithelium. Several putative stem cell niches in the lung thought to be involved in lung homeostasis have been described. Apparently, under pathophysiological conditions these resident progenitor cells are unable to recover damaged alveolar epithelium, in particular in emphysema. The potential therapeutic effect of retinoic acid receptor agonists on vario... Abstract
Cited 11 times since 2007 (0.6 per year) source: EuropePMC
Drugs, Volume 67, Issue 7, 1 1 2007, Pages 985-996 Scleroderma lung: pathogenesis, evaluation and current therapy. van Laar JM, Stolk J, Tyndall A
The lungs are frequently involved in systemic sclerosis ('scleroderma'), a rare, disabling disease of unknown origin, characterised by skin thickening and Raynaud's phenomenon. The pathogenesis of scleroderma is complex, but signs and symptoms of excessive fibrosis, vasculopathy and inflammation are almost universally present. Dyspnoea in scleroderma patients can be due to chest wall tightening from skin thickening, pleural disease, cardiac involvement, myositis of intercostal mus... Abstract