Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
195 results
Cited 14 times since 2013 (1.3 per year) source: EuropePMC
COPD, Volume 10 Suppl 1, 1 1 2013, Pages 50-53 Alpha-1 antitrypsin deficiency: the European experience. Stockley RA, Dirksen A, Stolk J
AATD is a European genetic condition that has disseminated along human migration routes. The discovery, function, phenotyping methodologies and biochemical mechanisms have been led by several European countries. The variable availability of augmentation therapy has permitted a better understanding of the natural history and the ability to deliver controlled clinical trials. The establishment of a worldwide registry remains central to the future of understanding and managing AATD. Abstract
Cited 24 times since 2012 (2.1 per year) source: EuropePMC
International journal of molecular sciences, Volume 13, Issue 11, 29 5 2012, Pages 13894-13910 Profiling the proteome of exhaled breath condensate in healthy smokers and COPD patients by LC-MS/MS. Fumagalli M, Ferrari F, Luisetti M, Stolk J, Hiemstra PS, Capuano D, Viglio S, Fregonese L, Cerveri I, Corana F, Tinelli C, Iadarola P
Three pools of exhaled breath condensate (EBC) from non-smokers plus healthy smokers (NS + HS, n = 45); chronic obstructive pulmonary disease (COPD) without emphysema (COPD, n = 15) and subjects with pulmonary emphysema associated with α(1)-antitrypsin deficiency (AATD, n = 23) were used for an exploratory proteomic study aimed at generating fingerprints of these groups that can be used in future pathophysiological and perhaps even clinical research. Liquid chromatography-tandem mass spectrome... Abstract
Cited 5 times since 2012 (0.4 per year) source: EuropePMC
Journal of chromatography. A, Volume 1266, 13 2 2012, Pages 103-109 Micellar electrokinetic chromatography with laser induced detection and liquid chromatography tandem mass-spectrometry-based desmosine assays in urine of patients with Chronic Obstructive Pulmonary Disease: a comparative analysis. Ferrari F, Fumagalli M, Piccinini P, Stolk J, Luisetti M, Viglio S, Tinelli C, Iadarola P
Evidences accumulated over the past years that desmosines could be attractive indicators of elastic fibre degradation in Chronic Obstructive Pulmonary Disease have raised substantial interest with the development of reliable assays to measure their concentration in body fluids. It is a firm belief of researchers working in this field that accurate assessment of desmosine concentration would improve the understanding of elastin metabolism disorders and allow these cross-links to become a useful t... Abstract
Cited 6 times since 2012 (0.5 per year) source: EuropePMC
The European respiratory journal, Volume 39, Issue 4, 1 1 2012, Pages 797-798 Desmosine, a biomarker for COPD: old and in the way. Luisetti M, Stolk J, Iadarola P
Cited 48 times since 2012 (3.9 per year) source: EuropePMC
The European respiratory journal, Volume 40, Issue 2, 26 4 2012, Pages 306-312 Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor. Stolk J, Stockley RA, Stoel BC, Cooper BG, Piitulainen E, Seersholm N, Chapman KR, Burdon JG, Decramer M, Abboud RT, Mannes GP, Wouters EF, Garrett JE, Barros-Tizon JC, Russi EW, Lomas DA, MacNee WA, Rames A
Palovarotene is an oral γ-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promoted structural repair and functional improvement. REPAIR (Retinoid treatment of Emphysema in Patients on the α(1)-antitrypsin International Registry), was an investigator-initiated, double-blind, placebo-controlled randomised study to assess the safety and efficacy of 5 mg·day(-1) palovarotene given for 1 year to 262 patients with severe α(1)-antitrypsin deficiency and emphys... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 156, Issue 34, 1 1 2012, Pages A4860 [A man who could only sleep sitting]. Schimmel RJ, Stolk J, Versteegh MI, Rommes JH
Bilateral diaphragm paralysis is a serious condition causing failure to sleep in the supine position and this condition often results into severe hypercapnia leading to respiratory failure. Here we describe two cases that required mechanical ventilation, and subsequently failed to respond to intermittent non-invasive ventilation. Subjects were successfully taken from mechanical ventilation after unilateral plication of a hemidiafragm and one of them further improved after plication of the contra... Abstract
Cited 20 times since 2011 (1.6 per year) source: EuropePMC
American journal of respiratory cell and molecular biology, Volume 46, Issue 5, 8 2 2011, Pages 607-613 α1-antitrypsin production by proinflammatory and antiinflammatory macrophages and dendritic cells. van 't Wout EF, van Schadewijk A, Savage ND, Stolk J, Hiemstra PS
α(1)-Antitrypsin (AAT) acts as an important neutrophil elastase inhibitor in the lung. Although the hepatocyte is considered to be the primary source of AAT, local production by monocytes, macrophages, and epithelial cells may contribute to the formation of an antielastase screen. Because monocytes can differentiate into a heterogeneous population of macrophages with subpopulations ranging from proinflammatory properties (MΦ-1) to antiinflammatory properties (ΜΦ-2) and into dendritic cells (DCs)... Abstract
Cited 15 times since 2011 (1.2 per year) source: EuropePMC
Respiratory medicine, Volume 106, Issue 5, 5 1 2011, Pages 677-686 Influence of inspiration level on bronchial lumen measurements with computed tomography. Bakker ME, Stolk J, Reiber JH, Stoel BC
Background: Bronchial dimensions measured in CT images generally do not take inspiration level into consideration. However, some studies showed that the bronchial membrane is distensible with airway inflation. Therefore, re-examination of the elasticity of bronchi is needed. Purpose: To assess the influence of respiration on bronchial lumen area (defined as distensibility) in different segmental bronchi and to explore the correlations between distensibility and both lung function and emphysema s... Abstract
Cited 60 times since 2011 (4.8 per year) source: EuropePMC
Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ
Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract
Cited 100 times since 2011 (8 per year) source: EuropePMC
Cell stress & chaperones, Volume 17, Issue 2, 31 5 2011, Pages 275-279 A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress. van Schadewijk A, van't Wout EF, Stolk J, Hiemstra PS
Endoplasmic reticulum (ER) stress is increasingly recognized as an important mechanism in a wide range of diseases including cystic fibrosis, alpha-1 antitrypsin deficiency, Parkinson's and Alzheimer's disease. Therefore, there is an increased need for reliable and quantitative markers for detection of ER stress in human tissues and cells. Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum can cause ER stress, which leads to the activation of the unfolded prote... Abstract
Cited 18 times since 2011 (1.4 per year) source: EuropePMC
COPD, Volume 8, Issue 5, 27 4 2011, Pages 329-333 Long-term variability of desmosine/isodesmosine as biomarker in alpha-1-antritrypsin deficiency-related COPD. Fregonese L, Ferrari F, Fumagalli M, Luisetti M, Stolk J, Iadarola P
Desmosine and isodesmosine are products of elastin breakdown which are candidate biomarkers to measure lung destruction in COPD. Data exist on the burden of desmosines in urine and plasma in COPD but long-term changes have never been investigated. We determined the changes of desmosine levels over 14 months in urine and plasma of patients with type ZZ alpha-1-antitryspsin deficiency-related COPD. Urines and plasma for determination of desmosines were collected from 11 ex-smokers with moderate/se... Abstract
Cited 9 times since 2011 (0.7 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 183, Issue 12, 1 1 2011, Pages 1578-1580 Lung densitometry to assess progression of emphysema in chronic obstructive pulmonary disease: time to apply in the clinic? Stolk J, Stoel BC
Cited 30 times since 2011 (2.3 per year) source: EuropePMC
Arthritis care & research, Volume 63, Issue 6, 1 1 2011, Pages 909-917 Randomized comparison of a multidisciplinary team care program with usual care in patients with systemic sclerosis. Schouffoer AA, Ninaber MK, Beaart-van de Voorde LJ, van der Giesen FJ, de Jong Z, Stolk J, Voskuyl AE, Scherptong RW, van Laar JM, Schuerwegh AJ, Huizinga TW, Vlieland TP
Objective: To compare the effectiveness of a multidisciplinary team care program with usual outpatient care in patients with systemic sclerosis (SSc; scleroderma). Methods: We performed a randomized controlled trial comparing a 12-week multidisciplinary team care program (1 day per week; individual treatments, group exercises, and group education) with outpatient clinic care. Outcome measures included the Hand Mobility in Scleroderma (HAMIS) test, grip strength, maximal mouth opening (MMO), 6-mi... Abstract
Radiology, Volume 259, Issue 2, 1 1 2011, Pages 610-1; author reply 611-2 Eureka? Stoel BC, Dirksen A, Stockley RA, Parr D, Piitulainen E, Shaker SB, Russi EW, Bakker ME, Reiber JH, Stolk J
Cited 29 times since 2011 (2.2 per year) source: EuropePMC
BMC medical genetics, Volume 12, 14 2 2011, Pages 24 The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study. Chappell SL, Daly L, Lotya J, Alsaegh A, Guetta-Baranes T, Roca J, Rabinovich R, Morgan K, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N
Background: Genetic factors are known to contribute to COPD susceptibility and these factors are not fully understood. Conflicting results have been reported for many genetic studies of candidate genes based on their role in the disease. Genome-wide association studies in combination with expression profiling have identified a number of new candidates including IREB2. A meta-analysis has implicated transforming growth factor beta-1 (TGFbeta1) as a contributor to disease susceptibility. Methods:... Abstract
Cited 25 times since 2010 (1.8 per year) source: EuropePMC
Therapeutic advances in respiratory disease, Volume 4, Issue 6, 6 1 2010, Pages 319-332 Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments. Stolk J, Cooper BG, Stoel B, Rames A, Rutman O, Soliman S, Stockley R
Emphysema is characterized by the destruction of alveolar wall and enlargement of alveolar airspaces, resulting in a reduction of the total lung gas exchange area, loss of lung elastic recoil and hyperinflation. The REPAIR study (Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry) is the first proof-of-concept study of a new potential disease-modifying drug, Palovarotene©, an orally active, gamma selective retinoid agonist in patients with emphysema secondary to al... Abstract
Cited 89 times since 2010 (6.6 per year) source: EuropePMC
Respiratory research, Volume 11, 5 1 2010, Pages 136 Therapeutic efficacy of α-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry. Stockley RA, Parr DG, Piitulainen E, Stolk J, Stoel BC, Dirksen A
Background: Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. Methods: Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT scan as Lung Endpoints (EXACTLE) study (n = 65), were pooled to increase the statistical power. The change in 15th percentile of lung density (PD15) measured by CT scan was obtained... Abstract
Cited 23 times since 2010 (1.7 per year) source: EuropePMC
Medical image analysis, Volume 15, Issue 1, 24 4 2010, Pages 112-124 A strain energy filter for 3D vessel enhancement with application to pulmonary CT images. Xiao C, Staring M, Shamonin D, Reiber JH, Stolk J, Stoel BC
The traditional Hessian-related vessel filters often suffer from detecting complex structures like bifurcations due to an over-simplified cylindrical model. To solve this problem, we present a shape-tuned strain energy density function to measure vessel likelihood in 3D medical images. This method is initially inspired by established stress-strain principles in mechanics. By considering the Hessian matrix as a stress tensor, the three invariants from orthogonal tensor decomposition are used inde... Abstract
Cited 13 times since 2010 (0.9 per year) source: EuropePMC
Child: care, health and development, Volume 36, Issue 5, 15 3 2010, Pages 703-708 Short-term changes in parents' resolution regarding their young child's diagnosis of cerebral palsy. Rentinck IC, Ketelaar M, Schuengel C, Stolk J, Lindeman E, Jongmans MJ, Gorter JW
Objective: This study aimed to describe changes in parents' resolution regarding their young child's diagnosis of cerebral palsy over a period of 1 year, and to describe the changes in strategies of resolution. Methods: In this longitudinal study, 38 parents of children with cerebral palsy (mean age 18.4 months, SD = 1.1 at baseline) were followed with the Reaction to Diagnosis Interview, assessing their personal reactions to their child's diagnosis (i.e. resolution status). Chang... Abstract
Cited 42 times since 2010 (2.9 per year) source: EuropePMC
BMC medical genetics, Volume 11, 15 3 2010, Pages 7 Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. Haq I, Chappell S, Johnson SR, Lotya J, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Millar AB, Donnelly SC, Keatings V, MacNee W, Stolk J, Hiemstra PS, Miniati M, Monti S, O'Connor CM, Kalsheker N
Background: Genetic factors play a role in chronic obstructive pulmonary disease (COPD) but are poorly understood. A number of candidate genes have been proposed on the basis of the pathogenesis of COPD. These include the matrix metalloproteinase (MMP) genes which play a role in tissue remodelling and fit in with the protease--antiprotease imbalance theory for the cause of COPD. Previous genetic studies of MMPs in COPD have had inadequate coverage of the genes, and have reported conflicting asso... Abstract