Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
194 results
Cited 19 times since 2016 (2.4 per year) source: EuropePMC
Annals of the rheumatic diseases, Volume 75, Issue 8, 29 5 2016, Pages 1575-1576 Anti-carbamylated protein antibodies: a specific hallmark for rheumatoid arthritis. Comparison to conditions known for enhanced carbamylation; renal failure, smoking and chronic inflammation. Verheul MK, van Erp SJ, van der Woude D, Levarht EW, Mallat MJ, Verspaget HW, Stolk J, Toes RE, van der Meulen-de Jong AE, Hiemstra PS, van Kooten C, Trouw LA
Cited 6 times since 2016 (0.8 per year) source: EuropePMC
ERJ open research, Volume 2, Issue 2, 1 1 2016, Pages 45-2015 Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients. Broekman W, Roelofs H, Zarcone MC, Taube C, Stolk J, Hiemstra PS
Autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) are evaluated for clinical use in chronic obstructive pulmonary disease (COPD) patients, but it is unclear whether COPD affects BM-MSCs. To investigate this, BM-MSCs from nine COPD patients and nine non-COPD age-matched controls were compared with regard to immunophenotype, growth and differentiation potential, and migration capacity. Other functional assays included the response to pro-inflammatory stimuli and inducers of the nu... Abstract
Cited 63 times since 2016 (7.7 per year) source: EuropePMC
QJM : monthly journal of the Association of Physicians, Volume 109, Issue 5, 27 4 2016, Pages 331-336 A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema. Stolk J, Broekman W, Mauad T, Zwaginga JJ, Roelofs H, Fibbe WE, Oostendorp J, Bajema I, Versteegh MI, Taube C, Hiemstra PS
Background: Mesenchymal stromal cells (MSCs) may reduce inflammation and promote tissue repair in pulmonary emphysema. Aim: To study the safety and feasibility of bone marrow-derived autologous (BM-) MSC intravenous administration to patients with severe emphysema. Design: A phase I, prospective open-label study registered at ClinicalTrials.gov as NCT01306513 Eligible patients had lung volume reduction surgery (LVRS) on two separate occasions. During the first LVRS bone marrow was collected, fro... Abstract
Cited 4 times since 2016 (0.5 per year) source: EuropePMC
IEEE transactions on medical imaging, Volume 35, Issue 6, 13 2 2016, Pages 1488-1500 Pulmonary Fissure Detection in CT Images Using a Derivative of Stick Filter. Xiao C, Stoel BC, Bakker ME, Peng Y, Stolk J, Staring M
Pulmonary fissures are important landmarks for recognition of lung anatomy. In CT images, automatic detection of fissures is complicated by factors like intensity variability, pathological deformation and imaging noise. To circumvent this problem, we propose a derivative of stick (DoS) filter for fissure enhancement and a post-processing pipeline for subsequent segmentation. Considering a typical thin curvilinear shape of fissure profiles inside 2D cross-sections, the DoS filter is presented by... Abstract
Cited 48 times since 2016 (5.8 per year) source: EuropePMC
Respiratory research, Volume 17, 11 2 2016, Pages 3 TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor. Broekman W, Amatngalim GD, de Mooij-Eijk Y, Oostendorp J, Roelofs H, Taube C, Stolk J, Hiemstra PS
Background: Mesenchymal stromal cells (MSCs) are investigated for their potential to reduce inflammation and to repair damaged tissue. Inflammation and tissue damage are hallmarks of chronic obstructive pulmonary disease (COPD) and MSC infusion is a promising new treatment for COPD. Inflammatory mediators attract MSCs to sites of inflammation and affect their immune-modulatory properties, but little is known about their effect on regenerative properties of MSCs. This study investigates the effec... Abstract
Nederlands tijdschrift voor geneeskunde, Volume 160, 1 1 2016, Pages D1022 [To reimburse or not? Evaluating expensive drugs differently]. Stolk J
Health insurance organisations grant reimbursement for drug treatment on the basis of results of placebo-controlled randomised clinical trials showing a clinically meaningful and statistically significant effect over placebo. This often proves problematic in rare diseases as well as in many chronic diseases that are difficult to treat. Clinical scientists may address the issue by testing the drug on surrogate outcome parameters and ask for post-marketing studies conducted by expert reference cen... Abstract
Cited 6 times since 2015 (0.7 per year) source: EuropePMC
Rheumatology (Oxford, England), Volume 55, Issue 3, 15 3 2015, Pages 504-512 Impact of pulmonary fibrosis and elevated pulmonary pressures on right ventricular function in patients with systemic sclerosis. Yiu KH, Ninaber MK, Kroft LJ, Schouffoer AA, Stolk J, Scherer HU, Meijs J, de Vries-Bouwstra J, Tse HF, Delgado V, Bax JJ, Huizinga TW, Marsan NA
Objectives: Right ventricular (RV) dysfunction is of great prognostic value in patients with SSc. The aim of the present study was to assess in these patients the relationship between pulmonary fibrosis and elevated pulmonary pressure (PHT) with RV function. Methods: A total of 102 SSc patients who underwent thoracic CT and transthoracic echocardiography were included. Speckle tracking-derived RV free wall strain was used to assess RV function. Results: A total of 51 (50%) SSc patients did not h... Abstract
Cited 11 times since 2015 (1.3 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 192, Issue 1, 1 1 2015, Pages 114-116 Relationship between Change in Lung Density and Long-Term Progression of Lung Function. Stolk J, Stockley RA, Piitulainen E, Stoel BC
PloS one, Volume 10, Issue 6, 12 2 2015, Pages e0129426 Association of Lung Inflammatory Cells with Small Airways Function and Exhaled Breath Markers in Smokers - Is There a Specific Role for Mast Cells? Nussbaumer-Ochsner Y, Stolk J, Ferraz da Silva LF, van Schadewijk A, de Jeu RC, Prins FA, Mauad T, Rabe KF, Hiemstra PS
Background: Smoking is associated with a mixed inflammatory infiltrate in the airways. We evaluated whether airway inflammation in smokers is related to lung function parameters and inflammatory markers in exhaled breath. Methods: Thirty-seven smokers undergoing lung resection for primary lung cancer were assessed pre-operatively by lung function testing including single-breath-nitrogen washout test (sb-N2-test), measurement of fractional exhaled nitric oxide (FeNO) and pH/8-isoprostane in exhal... Abstract
Cited 1 times since 2015 (0.1 per year) source: EuropePMC
COPD, Volume 12 Suppl 1, 1 1 2015, Pages 32-35 Conductivity in Exhaled Breath Condensate from Subjects with Emphysema and Type ZZ alpha-1-Antitrypsin Deficiency. Stolk J, Fumagalli M, Viglio S, Iadarola P
The assessment of biomarkers in biological samples from the lung has long been employed. Upon cooling water vapor present in exhaled breath, variable amounts of droplets of condensate (EBC) containing volatile and non-volatile compounds may be easily and non-invasively obtained from patients of any age.Objective of the present study was to compare the level of EBC conductivity determined for cohorts of individuals with different inflammatory lung disorders with that of healthy never-smoking indi... Abstract
Cited 9 times since 2015 (1 per year) source: EuropePMC
European journal of radiology, Volume 84, Issue 5, 22 4 2015, Pages 975-979 Lung structure and function relation in systemic sclerosis: application of lung densitometry. Ninaber MK, Stolk J, Smit J, Le Roy EJ, Kroft LJ, Bakker ME, de Vries Bouwstra JK, Schouffoer AA, Staring M, Stoel BC
Introduction: Interstitial lung disease occurs frequently in patients with systemic sclerosis (SSc). Quantitative computed tomography (CT) densitometry using the percentile density method may provide a sensitive assessment of lung structure for monitoring parenchymal damage. Therefore, we aimed to evaluate the optimal percentile density score in SSc by quantitative CT densitometry, against pulmonary function. Material and methods: We investigated 41 SSc patients by chest CT scan, spirometry and... Abstract
Cited 7 times since 2014 (0.7 per year) source: EuropePMC
The European respiratory journal, Volume 45, Issue 2, 16 3 2014, Pages 365-376 Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency. Van't Wout EF, van Schadewijk A, Lomas DA, Stolk J, Marciniak SJ, Hiemstra PS
α1-antitrypsin deficiency is the most widely recognised genetic disorder causing chronic obstructive pulmonary disease (COPD). Mutant Z α1-antitrypsin expression has previously been linked to intracellular accumulation and polymerisation of this proteinase inhibitor. Subsequently, this has been described to underlie an exaggerated endoplasmic reticulum stress response and enhanced nuclear factor-κB signalling. However, whether monocyte-derived macrophages display the same features remains unknow... Abstract
Clinical and experimental rheumatology, Volume 32, Issue 6 Suppl 86, 17 3 2014, Pages S-60-7 Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures. Ninaber MK, Hamersma WB, Schouffoer AA, Kovacs G, Olschewski H, Holman ER, Ajmone Marsan N, Stolk J
Objectives: During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates to systolic PAP at rest. Methods: In a prospective design we evaluated V'O₂/HR slopes for breakpoints. To understand its physiologi... Abstract
QJM : monthly journal of the Association of Physicians, Volume 108, Issue 1, 13 2 2014, Pages 33-38 The global peripheral chemoreflex drive in patients with systemic sclerosis: a rebreathing and exercise study. Ninaber MK, Hamersma WB, Schouffoer AA, van 't Wout EF, Stolk J
Background: Exercise intolerance (EI) in systemic sclerosis (SSc) is difficult to manage by the clinician. The peripheral chemoreflex drive compensates for metabolic acidosis during exercise and may be related to EI. Aim: To assess the global peripheral chemoreflex drive (GPCD) in patients with SSc at rest and during exercise. Methods: Consecutively tested SSc patients (n = 49) were evaluated by pulmonary function tests, carbon dioxide (CO2) rebreathing studies and non-invasive cardiopulmonary e... Abstract
Cited 1 times since 2014 (0.1 per year) source: EuropePMC
BMC pulmonary medicine, Volume 14, 4 1 2014, Pages 57 Increased respiratory drive relates to severity of dyspnea in systemic sclerosis. Ninaber MK, Hamersma WB, Schuerwegh AJ, Stolk J
Background: Dyspnea may be a presenting symptom in progressive systemic sclerosis (SSc). Respiratory drive (mouth occlusion pressure, MOP, at rest and during CO2 rebreathing, 7% CO2, 93% O2) is a major determinant of dyspnea and may relate to the magnitude of dyspnea. Methods: In a prospective design, MOP at 0.1 sec (P0.1) was measured in 73 SSc patients while breathing room air and during CO2 rebreathing. An abnormal V'E/P0.1 is defined as < 8 L/min/cm H2O. Dyspnea scores were assessed... Abstract
Cited 23 times since 2014 (2.3 per year) source: EuropePMC
Medical physics, Volume 41, Issue 2, 1 1 2014, Pages 021905 Towards local progression estimation of pulmonary emphysema using CT. Staring M, Bakker ME, Stolk J, Shamonin DP, Reiber JH, Stoel BC
Purpose: Whole lung densitometry on chest CT images is an accepted method for measuring tissue destruction in patients with pulmonary emphysema in clinical trials. Progression measurement is required for evaluation of change in health condition and the effect of drug treatment. Information about the location of emphysema progression within the lung may be important for the correct interpretation of drug efficacy, or for determining a treatment plan. The purpose of this study is therefore to deve... Abstract
Proteomes, Volume 2, Issue 1, 22 4 2014, Pages 18-52 Respiratory Proteomics Today: Are Technological Advances for the Identification of Biomarker Signatures Catching up with Their Promise? A Critical Review of the Literature in the Decade 2004-2013. Viglio S, Stolk J, Iadarola P, Giuliano S, Luisetti M, Salvini R, Fumagalli M, Bardoni A
To improve the knowledge on a variety of severe disorders, research has moved from the analysis of individual proteins to the investigation of all proteins expressed by a tissue/organism. This global proteomic approach could prove very useful: (i) for investigating the biochemical pathways involved in disease; (ii) for generating hypotheses; or (iii) as a tool for the identification of proteins differentially expressed in response to the disease state. Proteomics has not been used yet in the fie... Abstract
Cited 4 times since 2013 (0.4 per year) source: EuropePMC
Electrophoresis, Volume 35, Issue 1, 23 4 2013, Pages 109-118 From micellar electrokinetic chromatography to liquid chromatography-mass spectrometry: revisiting the way of analyzing human fluids for the search of desmosines, putative biomarkers of chronic obstructive pulmonary disease. Viglio S, Stolk J, Luisetti M, Ferrari F, Piccinini P, Iadarola P
Desmosine (DES) and isodesmosine are two isomer amino acids unique-to-mature, cross-linked elastin. Based on this feature, they have been discussed as surrogate markers of chronic obstructive pulmonary disease, a disorder characterized by progressive degradation of lung elastin. Despite the development of numerous protocols, detection of DESs in body fluids is still considered to be technically challenging. In fact, owing to the minute concentration of these circulating cross-links, their accura... Abstract
Cited 17 times since 2013 (1.6 per year) source: EuropePMC
Human molecular genetics, Volume 23, Issue 4, 4 1 2013, Pages 929-941 Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin. van 't Wout EF, Dickens JA, van Schadewijk A, Haq I, Kwok HF, Ordóñez A, Murphy G, Stolk J, Lomas DA, Hiemstra PS, Marciniak SJ
Overexpression of Z α1-antitrypsin is known to induce polymer formation, prime the cells for endoplasmic reticulum stress and initiate nuclear factor kappa B (NF-κB) signalling. However, whether endogenous expression in primary bronchial epithelial cells has similar consequences remains unclear. Moreover, the mechanism of NF-κB activation has not yet been elucidated. Here, we report excessive NF-κB signalling in resting primary bronchial epithelial cells from ZZ patients compared with wild-type... Abstract
Cited 14 times since 2013 (1.3 per year) source: EuropePMC
COPD, Volume 10 Suppl 1, 1 1 2013, Pages 50-53 Alpha-1 antitrypsin deficiency: the European experience. Stockley RA, Dirksen A, Stolk J
AATD is a European genetic condition that has disseminated along human migration routes. The discovery, function, phenotyping methodologies and biochemical mechanisms have been led by several European countries. The variable availability of augmentation therapy has permitted a better understanding of the natural history and the ability to deliver controlled clinical trials. The establishment of a worldwide registry remains central to the future of understanding and managing AATD. Abstract