Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
195 results
Cited 19 times since 1994 (0.6 per year) source: EuropePMC
The American journal of psychiatry, Volume 151, Issue 12, 1 1 1994, Pages 1760-1766 Alprazolam withdrawal in patients with panic disorder and generalized anxiety disorder: vulnerability and effect of carbamazepine. Klein E, Colin V, Stolk J, Lenox RH
Objective: This study was designed to examine the possibility that patients with panic disorder are especially vulnerable to alprazolam withdrawal, as well as to evaluate the efficacy of carbamazepine as adjunctive treatment during alprazolam discontinuation. Method: After a 2-month open trial of alprazolam, 36 patients with panic disorder and 35 with generalized anxiety disorder entered a controlled discontinuation phase. Carbamazepine or placebo was added in a randomized, double-blind fashion,... Abstract
Cited 35 times since 1994 (1.2 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 150, Issue 6 Pt 1, 1 1 1994, Pages 1628-1631 Apocynin improves the efficacy of secretory leukocyte protease inhibitor in experimental emphysema. Stolk J, Rossie W, Dijkman JH
Secretory leukocyte protease inhibitor (SLPI) is a potent proteinase inhibitor produced in the lung. Stimulated neutrophils at sites of inflammation can inactivate SLPI by myeloperoxidase-mediated oxidation of the methionine residue in the active site of SLPI. Apocynin is a selective inhibitor of NADPH oxidase and may therefore protect SLPI against neutrophil-mediated oxidative inactivation. The aim of the present study was to determine the effect of apocynin on the efficacy of SLPI in preventin... Abstract
Cited 462 times since 1994 (15.5 per year) source: EuropePMC
American journal of respiratory cell and molecular biology, Volume 11, Issue 1, 1 1 1994, Pages 95-102 Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Stolk J, Hiltermann TJ, Dijkman JH, Verhoeven AJ
Phagocytes are able to generate reactive oxygen species by an activatable NADPH oxidase system. We investigated the inhibition of NADPH oxidase activation by a methoxy-substituted catechol, apocynin. Oxygen uptake by neutrophils incubated with 300 microM apocynin was completely inhibited at 7 min after addition of serum-treated zymosan (STZ), with a lagtime of inhibition of 2 to 3 min. The lagtime of effect of apocynin in neutrophils relatively deficient of myeloperoxidase was about 50% longer w... Abstract
Cited 3 times since 1993 (0.1 per year) source: EuropePMC
Pulmonary pharmacology, Volume 6, Issue 1, 1 1 1993, Pages 33-39 Potency of an oxidation-resistant mutant of secretory leukocyte proteinase inhibitor in lipopolysaccharide-induced emphysema in hamsters. Stolk J, Heinzel-Wieland R, Saunders D, Dijkman JH, Steffens G
Secretory leukocyte inhibitor (SLPI) is a potent inhibitor of serine proteinases, but sensitive to oxidative inactivation due to a methionine residue in the active centre of the inhibitor. We compared the potency of an oxidation-resistant mutant of recombinant SLPI with native recombinant SLPI in lipopolysaccharide (LPS)-induced emphysema in the hamster. Application of this oxidation-resistant mutant reduced the induced emphysema by 70 and 85% in two separate series of experiments. In contrast,... Abstract
Cited 21 times since 1993 (0.7 per year) source: EuropePMC
The American review of respiratory disease, Volume 147, Issue 2, 1 1 1993, Pages 442-447 Inhibition of lipopolysaccharide-induced pulmonary emphysema by intratracheally instilled recombinant secretory leukocyte proteinase inhibitor. Rudolphus A, Stolk J, Dijkman JH, Kramps JA
Experiments were performed to test whether recombinant secretory leukocyte proteinase inhibitor (rSLPI) was able to prevent the development of lipopolysaccharide (LPS)-mediated pulmonary emphysema, hemorrhage, and secretory cell metaplasia (SCM) in hamsters. Several groups of eight animals were intratracheally treated for four weeks, twice a week with 0.5 mg Escherichia coli LPS or with saline. In the first experiment, an additional group of eight hamsters was treated with 0.5 mg LPS mixed with... Abstract
Cited 1 times since 1993 (0 per year) source: EuropePMC
Agents and actions. Supplements, Volume 42, 1 1 1993, Pages 111-121 Oxidation resistant muteins of antileukoproteinase as potential therapeutic agents. Steffens GJ, Heinzel-Wieland R, Saunders D, Wolf B, Rudolphus A, Stolk J, Krarnps JA, Dijkman JA
Native antileukoproteinase (ALP) and two oxidant resistant mutants ALP 242 and ALP 231 were synthesized by means of recombinant DNA technology. In the ALP 242 molecule the methionine residue located in the reactive centre of the binding loop is replaced by a leucine residue. In ALP 231 all four methionine residues of the second domain were substituted by leucine residues. The native inhibitor and the two oxidant resistant molecules show comparable inhibitory capacities towards human neutrophil e... Abstract
Cited 13 times since 1992 (0.4 per year) source: EuropePMC
The American journal of pathology, Volume 141, Issue 1, 1 1 1992, Pages 153-160 Detection of extracellular neutrophil elastase in hamster lungs after intratracheal instillation of E. coli lipopolysaccharide using a fluorogenic, elastase-specific, synthetic substrate. Rudolphus A, Stolk J, van Twisk C, van Noorden CJ, Dijkman JH, Kramps JA
Repeated intratracheal instillations of E. coli lipopolysaccharide (LPS) in hamster lungs cause an influx of polymorphonuclear leukocytes (PMNs) into the alveolar walls, with concomitant development of severe emphysema. It has been suggested that elastase, released by these PMNs, is involved in the development of emphysema. This study demonstrates the release of elastase from recruited PMNs in cryostat sections of hamster lungs, after being treated once, twice, or thrice with LPS, intratracheall... Abstract
Cited 43 times since 1992 (1.4 per year) source: EuropePMC
The Journal of pathology, Volume 167, Issue 3, 1 1 1992, Pages 349-356 Induction of emphysema and bronchial mucus cell hyperplasia by intratracheal instillation of lipopolysaccharide in the hamster. Stolk J, Rudolphus A, Davies P, Osinga D, Dijkman JH, Agarwal L, Keenan KP, Fletcher D, Kramps JA
The aim of this study was to determine whether lipopolysaccharide-induced elastase release from recruited neutrophils in the hamster lung would induce emphysema, measured by mean linear intercept (Lm) and bronchial mucus cell hyperplasia (BMCH), scored in tissue sections stained with periodic acid-Schiff. Lipopolysaccharide (LPS) was instilled transorally twice a week for up to 5 weeks in hamsters. At 4 weeks after seven LPS instillations, Lm amounted to 87.6 +/- 1.2 microns, while it was 68.3 +... Abstract
Cited 6 times since 1992 (0.2 per year) source: EuropePMC
American journal of respiratory cell and molecular biology, Volume 6, Issue 5, 1 1 1992, Pages 521-526 Potency of antileukoprotease and alpha 1-antitrypsin to inhibit degradation of fibrinogen by adherent polymorphonuclear leukocytes from normal subjects and patients with chronic granulomatous disease. Stolk J, Davies P, Kramps JA, Dijkman JH, Humes JJ, Knight WB, Green BG, Mumford R, Bonney RJ, Hanlon WA
We have studied the relative efficacy of antileukoprotease (ALP) and alpha 1-antitrypsin (alpha 1AT) to inhibit the degradation of substrate by polymorphonuclear leukocytes (PMN) attached onto a fibrinogen matrix. PMN elastase activity was assayed by radioimmunoassay of a specific 21-residue cleavage product from the amino terminus of the A alpha chain, A alpha (1-21), of fibrinogen. The adherence of PMN (1.0 x 10(6)) to a fibrinogen matrix was facilitated by incubation with recombinant tumor ne... Abstract
Cited 22 times since 1991 (0.7 per year) source: EuropePMC
Journal of leukocyte biology, Volume 50, Issue 1, 1 1 1991, Pages 43-48 rTNF alpha facilitates human polymorphonuclear leukocyte adherence to fibrinogen matrices with mobilization of specific and tertiary but not azurophilic granule markers. Hanlon WA, Stolk J, Davies P, Humes JL, Mumford R, Bonney RJ
rTNF alpha facilitates highly reproducible adherence of polymorphonuclear leukocyte (PMN) to fibrinogen-coated surfaces in a concentration- and time-dependent manner. The adhesion was maximal with 1.0 nM rTNF alpha within 40-50 min at 37 degrees C. A monoclonal antibody (1B4) directed toward the beta 2-chain of the integrin receptor for fibrinogen (CD11b, CD18) completely inhibited the rTNF alpha induced adhesion. TNF alpha caused a time-dependent secretion of the granule markers gelatinase and... Abstract
Cited 15 times since 1991 (0.4 per year) source: EuropePMC
Annals of the New York Academy of Sciences, Volume 624, 1 1 1991, Pages 97-108 Role of antileukoprotease in the human lung. Kramps JA, Rudolphus A, Stolk J, Willems LN, Dijkman JH
Cited 3 times since 1991 (0.1 per year) source: EuropePMC
Annals of the New York Academy of Sciences, Volume 624, 1 1 1991, Pages 350-352 Lipopolysaccharide-induced alveolar wall destruction in the hamster is inhibited by intratracheal treatment with r-secretory leukocyte protease inhibitor. Stolk J, Rudolphus A, Kramps JA
Cited 10 times since 1987 (0.3 per year) source: EuropePMC
Radiographics : a review publication of the Radiological Society of North America, Inc, Volume 7, Issue 3, 1 1 1987, Pages 425-445 Magnetic resonance imaging of primary malignant bone tumors. Bloem JL, Bluemm RG, Taminiau AH, van Oosterom AT, Stolk J, Doornbos J
The authors find that MRI yields more useful information in a single study than CT, Tc scanning or angiography; they use it as the primary local staging procedure in malignant bone tumors. Abstract
Cited 2 times since 1986 (0.1 per year) source: EuropePMC
Thorax, Volume 41, Issue 11, 1 1 1986, Pages 840-845 In vitro effect of a mucolytic thiol agent on the activity of polymorphonuclear leucocyte elastase and antileucoprotease. Stolk J, Kramps JA, Dijkman JH
We have studied the effects of the mucolytic thiol agent mercapto-ethanesulphonate (mesna) on the activity of both polymorphonuclear leucocyte (PMN) elastase and antileucoprotease in vitro. In all tests a specific synthetic substrate was used to measure elastase activity, which was then related to enzyme activity in the absence of mesna. The relative elastase activity decreased to 67.5% of control values after the enzyme had been incubated in a 120 mmol/l mesna solution. In the sol phase of puru... Abstract
Cited 14 times since 1985 (0.4 per year) source: EuropePMC
Archives of internal medicine, Volume 145, Issue 8, 1 1 1985, Pages 1513-1515 A case of carbimazole-induced intrahepatic cholestasis. An immune-mediated reaction? Blom H, Stolk J, Schreuder HB, von Blomberg-van der Flier M
A patient is described with cholestatic hepatitis following the use of carbimazole. A liver biopsy specimen showed intracanalicular cholestasis and some mononuclear cell infiltrate in the portal triades, consistent with drug toxicity; indications of an autoimmune or viral pathogenesis were absent. Rechallenge with the drug precipitated jaundice and disturbed liver function once more. Carbimazole induced a blastogenic response of patient lymphocytes in vitro. Both may suggest the involvement of a... Abstract