Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
24 results
CJC open, Volume 6, Issue 1, 23 4 2023, Pages 1-10 Blood and Imaging Biomarkers in the Long-term Follow-up of Bicuspid Aortic Valve Patients. Keuning ZA, Hendriks PM, Duijnhouwer AL, Meccanici F, Siebelink HJ, van den Hoven AT, Geenen LW, Eindhoven JA, Baggen VJM, Cuypers JAAE, Kauling RM, Roos-Hesselink JW, van den Bosch AE
Background: Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as valve stenosis and regurgitation. This study aimed to investigate sex differences in blood and imaging biomarkers and to describe the long-term prognostic value of blood and echocardiographic biomarkers. Methods: Patients were included from 2 prospective observational cohort studies; they underwent venous blood sampling and transthoracic echocardiography... Abstract
Cited 3 times since 2021 (1.3 per year) source: EuropePMC
Insights into imaging, Volume 12, Issue 1, 18 3 2021, Pages 186 The impact and challenges of implementing CTCA according to the 2019 ESC guidelines on chronic coronary syndromes: a survey and projection of CTCA services in the Netherlands. van den Boogert TPW, Claessen BEPM, Boekholdt SM, Leiner T, Vliegenthart R, Schuiling SF, Timmer JR, Bekkers SCAM, Voskuil M, Siebelink HJ, van Es W, Lamb HJ, Prokop M, Damman P, Stoker J, Willems HC, Henriques JP, Planken RN
Background: The 2019 ESC-guidelines on chronic coronary syndromes (ESC-CCS) recommend computed tomographic coronary angiography (CTCA) or non-invasive functional imaging instead of exercise ECG as initial test to diagnose obstructive coronary artery disease. Since impact and challenges of these guidelines are unknown, we studied the current utilisation of CTCA-services, status of CTCA-protocols and modeled the expected impact of these guidelines in the Netherlands. Methods and results: A survey... Abstract
Cited 10 times since 2021 (3.5 per year) source: EuropePMC
Journal of the American Heart Association, Volume 10, Issue 12, 2 1 2021, Pages e020080 Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves. Dolmaci OB, Legué J, Lindeman JHN, Driessen AHG, Klautz RJM, Van Brakel TJ, Siebelink HJ, Mertens BJA, Poelmann RE, Gittenberger-de Groot AC, Grewal N
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A... Abstract
Cited 4 times since 2021 (1.4 per year) source: EuropePMC
Lupus science & medicine, Volume 8, Issue 1, 1 1 2021, Pages e000472 Effectiveness of a multidisciplinary clinical pathway for women with systemic lupus erythematosus and/or antiphospholipid syndrome. Wind M, Hendriks M, van Brussel BTJ, Eikenboom J, Allaart CF, Lamb HJ, Siebelink HJ, Ninaber MK, van Geloven N, van Lith JMM, Huizinga TWJ, Rabelink TJ, Sueters M, Teng YKO
Objectives: SLE and/or antiphospholipid syndrome (SLE/APS) are complex and rare systemic autoimmune diseases that predominantly affect women of childbearing age. Women with SLE/APS are at high risk of developing complications during pregnancy. Therefore, clinical practice guidelines recommend that patients with SLE/APS should receive multidisciplinary counselling before getting pregnant. We investigated the clinical effectiveness of implementing a multidisciplinary clinical pathway including pre... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue Suppl 1, 16 3 2021, Pages 20-34 The effects of ACE2 expression mediating pharmacotherapy in COVID-19 patients. van Kimmenade RRJ, Belfroid E, Hoogervorst-Schilp J, Siebelink HJ, Janssen CW, Pinto Y
Background: There has been debate on the use of angiotensin-converting enzyme‑2 (ACE2) expression mediating pharmacotherapy in COVID-19 infected patients. Although it has been suggested that these drugs might lead to a higher susceptibility and severity of COVID-19 infection, experimental data suggest these agents may reduce acute lung injury via blocking angiotensin-II-mediated pulmonary permeability, inflammation and fibrosis. Methods: A systematic literature search was performed to answer the... Abstract
Cited 1 times since 2021 (0.3 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue Suppl 1, 16 3 2021, Pages 13-19 Impact of cardiovascular disease and cardiovascular risk factors in hospitalised COVID-19 patients. Jewbali LSD, Hoogervorst-Schilp J, Belfroid E, Jansen CW, Asselbergs FW, Siebelink HJ
Background: Hospitalised COVID-19 patients with underlying cardiovascular disease (CVD) and cardiovascular risk factors appear to be at risk of poor outcome. It is unknown if these patients should be considered a vulnerable group in healthcare delivery and healthcare recommendations during the COVID-19 pandemic. Methods: A systematic literature search was performed to answer the following question: In which hospitalised patients with proven COVID-19 and with underlying CVD and cardiovascular ris... Abstract
Cited 8 times since 2021 (2.7 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue Suppl 1, 16 3 2021, Pages 5-12 How often and to what extent do admitted COVID-19 patients have signs of cardiac injury? Habets MAW, Sturkenboom HN, Tio RA, Belfroid E, Hoogervorst-Schilp J, Siebelink HJ, Jansen CW, Smits PC
Background: COVID-19 can cause myocardial injury in a significant proportion of patients admitted to the hospital and seems to be associated with worse prognosis. The aim of this review was to study how often and to what extent COVID-19 causes myocardial injury and whether this is an important contributor to outcome with implications for management. Methods: A literature search was performed in Medline and Embase. Myocardial injury was defined as elevated cardiac troponin (cTn) levels with at le... Abstract
Cited 2 times since 2021 (0.7 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue Suppl 1, 16 3 2021, Pages 35-44 Effect of anticoagulant therapy in COVID-19 patients. Tieleman RG, Klok FA, Belfroid E, Hoogervorst-Schilp J, Schalkers I, Jansen CW, Siebelink HJ
Background: In patients hospitalised with COVID-19, an increased incidence of thromboembolic events, such as pulmonary embolism, deep vein thrombosis and stroke, has been reported. It is unknown whether anticoagulation can prevent these complications and improve outcome. Methods: A systematic literature search was performed to answer the question: What is the effect of (prophylactic and therapeutic dose) anticoagulation therapy in COVID-19 patients on cardiovascular and thromboembolic complicati... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue Suppl 1, 15 3 2021, Pages 2-4 Four guidelines on cardiovascular complications and cardiovascular disease, prognosis and treatment in COVID‑19. Siebelink HJ, Jansen CW, Belfroid E, Hoogervorst-Schilp J
Cited 2 times since 2020 (0.6 per year) source: EuropePMC
Aorta (Stamford, Conn.), Volume 8, Issue 5, 1 1 2020, Pages 121-131 Abnormal Aortic Wall Properties in Women with Turner Syndrome. Bons LR, Van Den Hoven AT, Malik M, Van Den Bosch AE, McGhie JS, Duijnhouwer AL, Siebelink HJ, Hirsch A, Devos DH, Rietzschel E, von der Thüsen JH, van de Laar IMBH, Verhagen JMA, van der Pluijm I, Budde RPJ, Roos-Hesselink JW
Background: Turner syndrome (TS) is associated with aortic dilatation and dissection, but the underlying process is unclear. The aim of this study was to investigate the elastic properties and composition of the aortic wall in women with TS. Methods: In this cross-sectional study, 52 women with TS aged 35 ± 13 years (50% monosomy, 12 with bicuspid aortic valve [BAV] and 4 with coarctation) were investigated using carotid-femoral pulse wave velocity (CF-PWV) by echocardiography and ascending ao... Abstract
Cited 1 times since 2020 (0.3 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 36, Issue 9, 25 4 2020, Pages 1771-1780 Left ventricular global longitudinal strain in bicupsid aortic valve patients: head-to-head comparison between computed tomography, 4D flow cardiovascular magnetic resonance and speckle-tracking echocardiography. van den Hoven AT, Yilmazer S, Chelu RG, van Grootel RWJ, Minderhoud SCS, Bons LR, van Berendoncks AM, Duijnhouwer AL, Siebelink HJ, van den Bosch AE, Budde RPJ, Roos-Hesselink JW, Hirsch A
Left ventricular global longitudinal strain (LVGLS) analysis is a sensitive measurement of myocardial deformation most often done using speckle-tracking transthoracic echocardiography (TTE). We propose a novel approach to measure LVGLS using feature-tracking software on the magnitude dataset of 4D flow cardiovascular magnetic resonance (CMR) and compare it to dynamic computed tomography (CT) and speckle tracking TTE derived measurements. In this prospective cohort study 59 consecutive adult pati... Abstract
Cited 2 times since 2020 (0.5 per year) source: EuropePMC
Journal of cardiology, Volume 76, Issue 3, 4 1 2020, Pages 287-294 Blood biomarkers in patients with bicuspid aortic valve disease. Bons LR, Geenen LW, van den Hoven AT, Dik WA, van den Bosch AE, Duijnhouwer AL, Siebelink HJ, Budde RPJ, Boersma E, Wessels MW, van de Laar IMBH, DeRuiter MC, Goumans MJ, Loeys BL, Roos-Hesselink JW
Background: Patients with a bicuspid aortic valve (BAV) are at risk of developing valve deterioration and aortic dilatation. We aimed to investigate whether blood biomarkers are associated with disease stage in patients with BAV. Methods: Serum levels of high sensitivity C-reactive protein (hsCRP), high sensitivity troponin T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and total transforming growth factor-beta 1 (TGF-ß1) were measured in adult BAV patients with valve dysfunct... Abstract
Cited 5 times since 2019 (1.1 per year) source: EuropePMC
International journal of molecular sciences, Volume 20, Issue 13, 2 1 2019, Pages E3251 Endothelial Colony Forming Cells as an Autologous Model to Study Endothelial Dysfunction in Patients with a Bicuspid Aortic Valve. van de Pol V, Bons LR, Lodder K, Kurakula KB, Sanchez-Duffhues G, Siebelink HJ, Roos-Hesselink JW, DeRuiter MC, Goumans MJ
Bicuspid aortic valve (BAV), the most common congenital heart defect, is associated with an increased prevalence of aortic dilation, aortic rupture and aortic valve calcification. Endothelial cells (ECs) play a major role in vessel wall integrity. Little is known regarding EC function in BAV patients due to lack of patient derived primary ECs. Endothelial colony forming cells (ECFCs) have been reported to be a valid surrogate model for several cardiovascular pathologies, thereby facilitating an... Abstract
Cited 23 times since 2019 (4.5 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 5, Issue 4, 27 4 2019, Pages 480-489 Entropy as a Novel Measure of Myocardial Tissue Heterogeneity for Prediction of Ventricular Arrhythmias and Mortality in Post-Infarct Patients. Androulakis AFA, Zeppenfeld K, Paiman EHM, Piers SRD, Wijnmaalen AP, Siebelink HJ, Sramko M, Lamb HJ, van der Geest RJ, de Riva M, Tao Q
Objectives: This study proposed entropy as a new late gadolinium enhanced cardiac magnetic resonance-derived parameter to evaluate tissue inhomogeneity, independent of signal intensity thresholds. This study hypothesized that entropy within the scar is associated with ventricular arrhythmias (VAs), whereas entropy of the entire left ventricular (LV) myocardium is associated with mortality. Background: In patients after myocardial infarction, the heterogeneity of fibrosis determines the substrate... Abstract
Cited 3 times since 2018 (0.6 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 9, 27 4 2018, Pages 701-707 Coronary anatomy in Turner syndrome versus patients with isolated bicuspid aortic valves. Koenraadt WMC, Siebelink HJ, Bartelings MM, Schalij MJ, van der Vlugt MJ, van den Bosch AE, Budde RPJ, Roos-Hesselink JW, Duijnhouwer AL, van den Hoven AT, DeRuiter MC, Jongbloed MRM
Objective: Variations in coronary anatomy, like absent left main stem and left dominant coronary system, have been described in patients with Turner syndrome (TS) and in patients with bicuspid aortic valves (BAV). It is unknown whether coronary variations in TS are related to BAV and to specific BAV subtypes. Aim: To compare coronary anatomy in patients with TS with/without BAV versus isolated BAV and to study BAV morphology subtypes in these groups. Methods: Coronary anatomy and BAV morphology... Abstract
Cited 13 times since 2018 (2.3 per year) source: EuropePMC
International journal of cardiology, Volume 276, 24 4 2018, Pages 230-235 Intermodality variation of aortic dimensions: How, where and when to measure the ascending aorta. Bons LR, Duijnhouwer AL, Boccalini S, van den Hoven AT, van der Vlugt MJ, Chelu RG, McGhie JS, Kardys I, van den Bosch AE, Siebelink HJ, Nieman K, Hirsch A, Broberg CS, Budde RPJ, Roos-Hesselink JW
Background: No established reference-standard technique is available for ascending aortic diameter measurements. The aim of this study was to determine agreement between modalities and techniques. Methods: In patients with aortic pathology transthoracic echocardiography, computed tomography angiography (CTA) and magnetic resonance angiography (MRA) were performed. Aortic diameters were measured at the sinus of Valsalva (SoV), sinotubular junction (STJ) and tubular ascending aorta (TAA) during mi... Abstract
Cited 11 times since 2018 (1.8 per year) source: EuropePMC
European radiology, Volume 28, Issue 9, 6 1 2018, Pages 4027-4035 High spatial resolution free-breathing 3D late gadolinium enhancement cardiac magnetic resonance imaging in ischaemic and non-ischaemic cardiomyopathy: quantitative assessment of scar mass and image quality. Bizino MB, Tao Q, Amersfoort J, Siebelink HJ, van den Bogaard PJ, van der Geest RJ, Lamb HJ
Purpose: To compare breath-hold (BH) with navigated free-breathing (FB) 3D late gadolinium enhancement cardiac MRI (LGE-CMR) MATERIALS AND METHODS: Fifty-one patients were retrospectively included (34 ischaemic cardiomyopathy, 14 non-ischaemic cardiomyopathy, three discarded). BH and FB 3D phase sensitive inversion recovery sequences were performed at 3T. FB datasets were reformatted into normal resolution (FB-NR, 1.46x1.46x10mm) and high resolution (FB-HR, isotropic 0.91-mm voxels). Scar mass,... Abstract
Cited 1 times since 2016 (0.1 per year) source: EuropePMC
The Canadian journal of cardiology, Volume 32, Issue 12, 19 3 2016, Pages 1576.e7-1576.e9 Prosthesis Dislocation After Transapical Valve-In-Valve Mitral Valve Implantation. Tomšič A, Palmen M, Versteegh MI, van der Kley F, Siebelink HJ, Berendsen RR, Schalij MJ
Transapical valve-in-valve mitral valve implantation (TA-MVI) has been described as an alternative treatment option in patients with degenerated bioprostheses in the mitral position. We report the first case of prosthesis dislocation and migration into the left atrium after TA-MVI. A new prosthesis was implanted using the same approach. The dislocated prosthesis was successfully removed through the left atrial appendage through an extended anterolateral thoracotomy without the use of cardiopulmo... Abstract
Cited 7 times since 2012 (0.6 per year) source: EuropePMC
European journal of radiology, Volume 82, Issue 4, 14 2 2012, Pages 680-685 High field carotid vessel wall imaging: a study on reproducibility. Kröner ES, Westenberg JJ, van der Geest RJ, Brouwer NJ, Doornbos J, Kooi ME, van der Wall EE, Lamb HJ, Siebelink HJ
Purpose: Currently, a multi-contrast protocol, including a combination of five MR-sequences is used as reference standard for morphologic imaging and quantitative measurements of the carotid artery vessel wall. The purpose of this study is to investigate the scan-rescan reproducibility together with intra- and inter-observer reproducibility of each of the five MR-sequences. Methods: Twenty healthy volunteers (55% male, mean age=26 years) underwent repeated MR-examinations (3T-Philips-MRI) of the... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 7-8, 1 1 2008, Pages 270-271 Atrial fibrillation: an unusual cause. Siebelink HJ, Willems TP, Götte MJ