Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
170 results
Cited 32 times since 2020 (9.4 per year) source: EuropePMC
European heart journal, Volume 41, Issue 43, 1 1 2020, Pages 4181-4187 Long-term clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COMPARE trial. van Andel MM, Indrakusuma R, Jalalzadeh H, Balm R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJM, de Waard V, Groenink M
Aims: The COMPARE trial showed a small but significant beneficial effect of 3-year losartan treatment on aortic root dilatation rate in adults with Marfan syndrome (MFS). However, no significant effect was found on clinical endpoints, possibly due to a short follow-up period. The aim of the current study was therefore to investigate the long-term clinical outcomes after losartan treatment. Methods and results: In the original COMPARE study (inclusion 2008-2009), adult patients with MFS (n = 233)... Abstract
Cited 7 times since 2020 (1.9 per year) source: EuropePMC
BioMed research international, Volume 2020, 27 4 2020, Pages 8748934 Blood Monocyte Phenotype Fingerprint of Stable Coronary Artery Disease: A Cross-Sectional Substudy of SMARTool Clinical Trial. Sbrana S, Campolo J, Clemente A, Bastiani L, Cecchettini A, Ceccherini E, Caselli C, Neglia D, Parodi O, Chiappino D, Smit JM, Scholte AJ, Pelosi G, Rocchiccioli S
Background and aims: Atherosclerosis is an inflammatory disease with long-lasting activation of innate immunity and monocytes are the main blood cellular effectors. We aimed to investigate monocyte phenotype (subset fraction and marker expression) at different stages of coronary atherosclerosis in stable coronary artery disease (CAD) patients. Methods: 73 patients with chronic coronary syndrome were evaluated by CT coronary angiography (CTCA) and classified by maximal diameter stenosis of major... Abstract
Cited 4 times since 2020 (1 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 6, Issue 9, 12 2 2020, Pages 1073-1085 RV Tissue Heterogeneity on CT: A Novel Tool to Identify the VT Substrate in ARVC. Venlet J, Tao Q, de Graaf MA, Glashan CA, de Riva Silva M, van der Geest RJ, Scholte AJ, Piers SRD, Zeppenfeld K
Objectives: This study sought to evaluate whether right ventricular (RV) tissue heterogeneity on computed tomography (CT): 1) is associated with conduction delay in arrhythmogenic right ventricular cardiomyopathy (ARVC); and 2) distinguishes patients with ARVC from those with exercise-induced arrhythmogenic remodeling (EIAR) and control individuals. Background: ARVC is characterized by fibrofatty replacement, related to conduction delay and ventricular tachycardias. Distinguishing ARVC from acqu... Abstract
Cited 7 times since 2020 (1.8 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 52, Issue 4, 6 1 2020, Pages 971-977 How to Measure the Aorta Using MRI: A Practical Guide. van Hout MJ, Scholte AJ, Juffermans JF, Westenberg JJ, Zhong L, Zhou X, Schalla SM, Hope MD, Bremerich J, Kramer CM, Dewey M, Ordovas KG, Bluemke DA, Lamb HJ
Cited 24 times since 2020 (5.9 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 13, Issue 3, 12 2 2020, Pages e009750 Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography. Smit JM, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Rocchiccioli S, Parodi O, Pelosi G, Scholte AJ
Background Progression of coronary artery disease using serial coronary computed tomography angiography (CTA) is of clinical interest. Our primary aim was to prospectively assess the impact of clinical characteristics and statin use on quantitatively assessed coronary plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent coronary CTA for suspected coronary artery disease were prospectively included to undergo follow-up coronary CT... Abstract
Cited 12 times since 2020 (2.9 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 21, Issue 3, 1 1 2020, Pages 273-281 The impact of visceral and general obesity on vascular and left ventricular function and geometry: a cross-sectional magnetic resonance imaging study of the UK Biobank. van Hout MJP, Dekkers IA, Westenberg JJM, Schalij MJ, Scholte AJHA, Lamb HJ
Aims: We aimed to evaluate the associations of body fat distribution with cardiovascular function and geometry in the middle-aged general population. Methods and results: Four thousand five hundred and ninety participants of the UK Biobank (54% female, mean age 61.1 ± 7.2 years) underwent cardiac magnetic resonance for assessment of left ventricular (LV) parameters [end-diastolic volume (EDV), ejection fraction (EF), cardiac output (CO), and index (CI)] and magnetic resonance imaging for body co... Abstract
Cited 7 times since 2019 (1.6 per year) source: EuropePMC
Journal of cardiovascular computed tomography, Volume 14, Issue 3, 5 1 2019, Pages 251-257 Coronary atherosclerosis scoring with semiquantitative CCTA risk scores for prediction of major adverse cardiac events: Propensity score-based analysis of diabetic and non-diabetic patients. van den Hoogen IJ, van Rosendael AR, Lin FY, Lu Y, Dimitriu-Leen AC, Smit JM, Scholte AJHA, Achenbach S, Al-Mallah MH, Andreini D, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Raff GL, Rubinshtein R, Villines TC, Gransar H, Jones EC, Peña JM, Shaw LJ, Min JK, Bax JJ
Aims: We aimed to compare semiquantitative coronary computed tomography angiography (CCTA) risk scores - which score presence, extent, composition, stenosis and/or location of coronary artery disease (CAD) - and their prognostic value between patients with and without diabetes mellitus (DM). Risk scores derived from general chest-pain populations are often challenging to apply in DM patients, because of numerous confounders. Methods: Out of a combined cohort from the Leiden University Medical Ce... Abstract
European journal of hybrid imaging, Volume 3, Issue 1, 28 4 2019, Pages 19 Correction to: Characterization of the left ventricular arrhythmogenic substrate with multimodality imaging: role of innervation imaging and left ventricular global longitudinal strain. El Mahdiui M, Smit JM, van Rosendael AR, Delgado V, Marsan NA, Jukema JW, Scholte AJHA, Bax JJ
Cited 7 times since 2019 (1.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 20, Issue 11, 1 1 2019, Pages 1231-1238 Referral of patients for fractional flow reserve using quantitative flow ratio. Smit JM, Koning G, van Rosendael AR, El Mahdiui M, Mertens BJ, Schalij MJ, Jukema JW, Delgado V, Reiber JHC, Bax JJ, Scholte AJ
Aims: Quantitative flow ratio (QFR) is a recently developed technique to calculate fractional flow reserve (FFR) based on 3D quantitative coronary angiography and computational fluid dynamics, obviating the need for a pressure-wire and hyperaemia induction. QFR might be used to guide patient selection for FFR and subsequent percutaneous coronary intervention (PCI) referral in hospitals not capable to perform FFR and PCI. We aimed to investigate the feasibility to use QFR to appropriately select... Abstract
Cited 1 times since 2019 (0.2 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 28, Issue 4, 16 3 2019, Pages 1707-1714 Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain. El Mahdiui M, Smit JM, van Rosendael AR, Jukema JW, Bax JJ, Scholte AJHA
Background: Coronary artery calcium (CAC) score has shown to provide incremental prognostic information when added to the Framingham risk score. Although the relation between CAC and myocardial ischemia has been evaluated, there has been little evaluation of the relationship between CAC score and inducible myocardial ischemia on computed tomography myocardial perfusion (CTP). Methods and results: Patients who were referred with stable chest pain from the outpatient clinic and who underwent non-c... Abstract
European journal of hybrid imaging, Volume 3, Issue 1, 2 1 2019, Pages 14 Characterization of the left ventricular arrhythmogenic substrate with multimodality imaging: role of innervation imaging and left ventricular global longitudinal strain. El Mahdiui M, Smit JM, van Rosendael AR, Delgado V, Ajmone Marsan N, Jukema JW, Scholte AJHA, Bax JJ
Background: Even though implantable cardioverter defibrillator (ICD) implantation for primary prevention has shown to reduce the risk of sudden cardiac death in chronic heart failure patients with reduced left ventricular ejection fraction (LVEF), a significant portion of these patients will never receive appropriate ICD therapy. We aimed to functionally characterize the arrhythmogenic substrate using left ventricular (LV) global longitudinal strain (GLS) and heart-to-mediastinum (H/M) ratio on... Abstract
Cited 14 times since 2019 (2.8 per year) source: EuropePMC
Journal of the American Heart Association, Volume 8, Issue 6, 1 1 2019, Pages e007201 Coronary Calcium Characteristics as Predictors of Major Adverse Cardiac Events in Symptomatic Patients: Insights From the CORE 320 Multinational Study. Lo-Kioeng-Shioe MS, Vavere AL, Arbab-Zadeh A, Schuijf JD, Rochitte CE, Chen MY, Rief M, Kofoed KF, Clouse ME, Scholte AJ, Miller JM, Betoko A, Blaha MJ, Cox C, Deckers JW, Lima JAC
Background The predictive value of coronary artery calcium ( CAC ) has been widely studied; however, little is known about specific characteristics of CAC that are most predictive. We aimed to determine the independent associations of Agatston score, CAC volume, CAC area, CAC mass, and CAC density score with major adverse cardiac events in patients with suspected coronary artery disease. Methods and Results A total of 379 symptomatic participants, aged 45 to 85 years, referred for invasive coron... Abstract
Cited 4 times since 2019 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 123, Issue 10, 22 4 2019, Pages 1722-1728 Comparison of Diagnostic Performance of Quantitative Flow Ratio in Patients With Versus Without Diabetes Mellitus. Smit JM, El Mahdiui M, van Rosendael AR, Jukema JW, Koning G, Reiber JHC, Bax JJ, Scholte AJ
Quantitative flow ratio (QFR) is a novel technique to calculate fractional flow reserve (FFR), without hyperemia induction or a pressure wire, and has not yet been validated in patients with diabetes mellitus (DM), who are at increased risk of coronary microvascular dysfunction. The purpose of our study was to compare the diagnostic performance of QFR in diabetic and nondiabetic patients. Patients who underwent invasive coronary angiography and subsequent invasive FFR measurement within 6 months... Abstract
Cited 37 times since 2019 (7.1 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 12, Issue 10, 16 3 2019, Pages 1987-1997 Superior Risk Stratification With Coronary Computed Tomography Angiography Using a Comprehensive Atherosclerotic Risk Score. van Rosendael AR, Shaw LJ, Xie JX, Dimitriu-Leen AC, Smit JM, Scholte AJ, van Werkhoven JM, Callister TQ, DeLago A, Berman DS, Hadamitzky M, Hausleiter J, Al-Mallah MH, Budoff MJ, Kaufmann PA, Raff G, Chinnaiyan K, Cademartiri F, Maffei E, Villines TC, Kim YJ, Feuchtner G, Lin FY, Jones EC, Pontone G, Andreini D, Marques H, Rubinshtein R, Achenbach S, Dunning A, Gomez M, Hindoyan N, Gransar H, Leipsic J, Narula J, Min JK, Bax JJ
Objectives: This study was designed to assess the prognostic value of a new comprehensive coronary computed tomography angiography (CTA) score compared with the stenosis severity component of the Coronary Artery Disease-Reporting and Data System (CAD-RADS). Background: Current risk assessment with coronary CTA is mainly focused on maximal stenosis severity. Integration of plaque extent, location, and composition in a comprehensive model may improve risk stratification. Methods: A total of 2,134... Abstract
Cited 4 times since 2019 (0.8 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 42, Issue 2, 9 2 2019, Pages 208-215 Impact of left atrial box surface ratio on the recurrence after ablation for persistent atrial fibrillation. Keçe F, Scholte AJ, de Riva M, Naruse Y, Watanabe M, Alizadeh Dehnavi R, Schalij MJ, Zeppenfeld K, Trines SA
Background: The posterior wall of the left atrium (LA) is a well-known substrate for atrial fibrillation (AF) maintenance. Isolation of the posterior wall between the pulmonary veins (box lesion) may improve ablation success. Box lesion surface area size varies depending on the individual anatomy. This retrospective study evaluates the influence of box lesion surface area as a ratio of total LA surface area (box surface ratio) on arrhythmia recurrence. Methods: Seventy consecutive patients with... Abstract
Cited 3 times since 2018 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 19, Issue 11, 1 1 2018, Pages 1287-1293 Long-term prognostic value of single-photon emission computed tomography myocardial perfusion imaging after primary PCI for STEMI. Smit JM, Hermans MP, Dimitriu-Leen AC, van Rosendael AR, Dibbets-Schneider P, de Geus-Oei LF, Mertens BJ, Schalij MJ, Bax JJ, Scholte AJ
Aims: The aim of this study was to determine the long-term prognostic value of infarct size and myocardial ischaemia on single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: In total, 1092 STEMI patients who underwent primary PCI and SPECT MPI within 1-6 months were included (median follow-up time of 6.9 years). In the entire cohort, SP... Abstract
Cited 2 times since 2018 (0.3 per year) source: EuropePMC
Journal of cardiovascular computed tomography, Volume 12, Issue 3, 3 1 2018, Pages 212-219 Diagnostic accuracy of semi-automatic quantitative metrics as an alternative to expert reading of CT myocardial perfusion in the CORE320 study. Ostovaneh MR, Vavere AL, Mehra VC, Kofoed KF, Matheson MB, Arbab-Zadeh A, Fujisawa Y, Schuijf JD, Rochitte CE, Scholte AJ, Kitagawa K, Dewey M, Cox C, DiCarli MF, George RT, Lima JAC
Aims: To determine the diagnostic accuracy of semi-automatic quantitative metrics compared to expert reading for interpretation of computed tomography perfusion (CTP) imaging. Methods: The CORE320 multicenter diagnostic accuracy clinical study enrolled patients between 45 and 85 years of age who were clinically referred for invasive coronary angiography (ICA). Computed tomography angiography (CTA), CTP, single photon emission computed tomography (SPECT), and ICA images were interpreted manually... Abstract
Cited 1 times since 2017 (0.2 per year) source: EuropePMC
The American journal of cardiology, Volume 121, Issue 5, 11 2 2017, Pages 537-543 Gender-Specific Differences in All-Cause Mortality Between Incomplete and Complete Revascularization in Patients With ST-Elevation Myocardial Infarction and Multi-Vessel Coronary Artery Disease. Dimitriu-Leen AC, Hermans MPJ, van Rosendael AR, van Zwet EW, van der Hoeven BL, Bax JJ, Scholte AJHA
The best revascularization strategy (complete vs incomplete revascularization) in patients with ST-elevation myocardial infarction (STEMI) is still debated. The interaction between gender and revascularization strategy in patients with STEMI on all-cause mortality is uncertain. The aim of the present study was to evaluate gender-specific difference in all-cause mortality between incomplete and complete revascularization in patients with STEMI and multi-vessel coronary artery disease. The study p... Abstract
Cited 14 times since 2017 (2.2 per year) source: EuropePMC
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Volume 125, Issue 1, 4 1 2017, Pages 55-61 Different manifestation of irradiation induced coronary artery disease detected with coronary computed tomography compared with matched non-irradiated controls. van Rosendael AR, Daniëls LA, Dimitriu-Leen AC, Smit JM, van Rosendael PJ, Schalij MJ, Bax JJ, Scholte AJHA
Background and purpose: Patients who received chest irradiation for treatment of a malignancy are at increased risk for the development of coronary artery atherosclerosis. Little is known about the anatomical coronary artery plaque characteristics of irradiation induced coronary artery disease (CAD). This study aimed to evaluate potential differences in the presence, extent, severity, composition and location of CAD in patients treated with mediastinal irradiation compared with non-irradiated co... Abstract
Cited 10 times since 2017 (1.5 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 18, Issue 9, 1 1 2017, Pages 969-977 Impact of computed tomography myocardial perfusion following computed tomography coronary angiography on downstream referral for invasive coronary angiography, revascularization and, outcome at 12 months. van Rosendael AR, Dimitriu-Leen AC, de Graaf MA, van Zwet EW, Jukema JW, Bax JJ, Kroft LJ, Scholte AJ
Aims: The aim of this study was to assess the impact of adding stress computed tomography (CT) myocardial perfusion (CTP) to coronary CT angiography (CTA) on downstream referral for invasive coronary angiography (ICA), revascularization, and outcome in patients presenting with new-onset chest pain. Methods and results: Three hundred and eighty-four patients were referred for cardiac CT. Patients with lesions ≥50% stenosis underwent subsequently stress CTP. Perfusion scans were considered abnorma... Abstract