Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
34 results
The international journal of cardiovascular imaging, Volume 40, Issue 3, 27 4 2023, Pages 499-508 The value of serial echocardiography in risk assessment of patients with paroxysmal atrial fibrillation. Leung M, van Rosendael PJ, van der Bijl P, Regeer MV, van Wijngaarden SE, Leung DY, Delgado V, Marsan NA, Ng ACT, Bax JJ
Progression from paroxysmal to persistent atrial fibrillation (AF) is associated with increased morbidity and mortality. We examined the association of left atrial (LA) remodeling by serial echocardiography, and AF progression over an extended follow-up period. Two-hundred ninety patients (mean age 61 ± 11 years, 73% male) who underwent transthoracic echocardiography performed at first presentation for non-valvular paroxysmal AF (PAF) and repeat echocardiogram 1-year later, were followed for p... Abstract
Cited 1 times since 2023 (1.7 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 109, Issue 20, 28 4 2023, Pages 1525-1532 Tolerability and beneficial effects of sacubitril/valsartan on systemic right ventricular failure. Nederend M, Kiès P, Regeer MV, Vliegen HW, Mertens BJ, Robbers-Visser D, Bouma BJ, Tops LF, Schalij MJ, Jongbloed MRM, Egorova AD
Objective: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for sRV failure remain poorly defined. This study aims to investigate the tolerability and effects of sacubitril/valsartan on sRV failure in adult patients with sRV. Methods: In this two-centre, prospective cohort study, all consecutive adult patients with symptomatic h... Abstract
Journal of cardiovascular development and disease, Volume 10, Issue 3, 17 3 2023, Pages 129 Contemporary Management Strategies of Baffle Leaks in Adults with a Failing Systemic Right Ventricle Late after Atrial Switch: A Case Series and Literature Overview. Neijenhuis RML, Regeer MV, van der Kley F, Vliegen HW, Jongbloed MRM, Kiès P, Schalij MJ, Jukema JW, Egorova AD
Baffle leaks are a frequently encountered and often overlooked complication after the atrial switch procedure for transposition of the great arteries. Baffle leaks are present in up to 50% of non-selected patients, and while they initially may not cause clear symptoms, they can complicate the hemodynamic course and influence the prognosis in this complex patient group. A shunt from the pulmonary venous atrium (PVA) to the systemic venous atrium (SVA) can lead to pulmonary overflow and subpulmona... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
World journal for pediatric & congenital heart surgery, Volume 13, Issue 6, 12 2 2022, Pages 807-809 Surgical Repair of a Sinus of Valsalva Aneurysm. Regeer MV, van der Zwaan HB, Schoof PH, van Aarnhem EEHL
A surgically challenging case of an unruptured Sinus of Valsalva aneurysm (SoVA) with severe aortic regurgitation (AR) due to cusp prolapse is presented. Sinus reconstruction with a patch cut out from the sinus portion of a Gelweave Valsalva graft (Terumo Vascutek) was performed. Intraoperative measurements showed insufficient effective height of the right coronary cusp; therefore, cusp plication and pericardial patch augmentation of the right coronary cusp were performed with satisfying result. Abstract
Cited 1 times since 2022 (0.5 per year) source: EuropePMC
Revista espanola de cardiologia (English ed.), Volume 76, Issue 1, 24 4 2022, Pages 2-3 Fusion imaging in congenital heart disease: just a pretty picture or a new tool to improve patient management? Regeer MV, Ajmone Marsan N
Cited 2 times since 2022 (1 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 9, 10 2 2022, Pages 870459 Atrioventricular Block Necessitating Chronic Ventricular Pacing After Tricuspid Valve Surgery in Patients With a Systemic Right Ventricle: Long-Term Follow-Up. Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Regeer MV, Koolbergen DR, Hazekamp MG, Schalij MJ, Egorova AD
Background: Patients with transposition of the great arteries (TGA) after an atrial switch or congenitally corrected TGA (ccTGA) are prone to systemic right ventricular (sRV) failure. Tricuspid valve (TV) regurgitation aggravates sRV dysfunction. Timely TV surgery stabilizes sRV function, yet the development of atrioventricular (AV)-conduction disturbances in the course of sRV failure can contribute to sRV dysfunction through pacing-induced dyssynchrony. This study aims to explore the incidence,... Abstract
The international journal of cardiovascular imaging, Volume 38, Issue 9, 16 3 2022, Pages 1951-1960 Myocardial function in COVID-19 patients after hospital discharge: a descriptive study comparing the first and second 'wave' patients. Elffers TW, de Graaf MA, Regeer MV, Omara S, Schalij MJ, Groeneveld GH, Roukens AHE, Geelhoed JJM, Antoni ML
In hospitalized COVID-19 patients, myocardial injury and echocardiographic abnormalities have been described. The present study investigates cardiac function in COVID-19 patients 6 weeks post-discharge and evaluates its relation to New York Heart Association (NYHA) class. Furthermore cardiac function post-discharge between the first and second wave COVID-19 patients was compared. We evaluated 146 patients at the outpatient clinic of the Leiden University Medical Centre. NYHA class of II or highe... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 3, 2 1 2020, Pages 173-174 Broad complex tachycardia; never judge a book by its cover. Regeer MV, Tops LF, de Riva Silva M
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 3, 2 1 2020, Pages 168-171 Broad complex tachycardia; never judge a book by its cover. Regeer MV, Tops LF, de Riva Silva M
Cited 5 times since 2020 (1.2 per year) source: EuropePMC
European heart journal. Case reports, Volume 4, Issue 3, 17 3 2020, Pages 1-5 Anomalous left coronary artery from the pulmonary artery: a rare cause of an out-of-hospital cardiac arrest in an adult-a case report. Regeer MV, Bondarenko O, Zeppenfeld K, Egorova AD
Background: Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital disorder resulting in ischaemia and myocardial infarction which can act as a potential substrate for life-threatening arrhythmias and sudden cardiac death. Case summary: A 19-year-old man was admitted to the hospital after successful resuscitation from an out-of-hospital cardiac arrest (OHCA) due to ventricular fibrillation occurring during jogging. In the diagnostic work-up of the OHCA, computed t... Abstract
Cited 10 times since 2019 (2.2 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 20, Issue 10, 1 1 2019, Pages 1105-1111 Time course of left ventricular remodelling and mechanics after aortic valve surgery: aortic stenosis vs. aortic regurgitation. Vollema EM, Singh GK, Prihadi EA, Regeer MV, Ewe SH, Ng ACT, Mertens BJA, Klautz RJM, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Pressure overload in aortic stenosis (AS) and both pressure and volume overload in aortic regurgitation (AR) induce concentric and eccentric hypertrophy, respectively. These structural changes influence left ventricular (LV) mechanics, but little is known about the time course of LV remodelling and mechanics after aortic valve surgery (AVR) and its differences in AS vs. AR. The present study aimed to characterize the time course of LV mass index (LVMI) and LV mechanics [by LV global longit... Abstract
Cited 23 times since 2018 (3.9 per year) source: EuropePMC
The American journal of cardiology, Volume 122, Issue 4, 4 1 2018, Pages 584-591 Relation of Echocardiographic Markers of Left Atrial Fibrosis to Atrial Fibrillation Burden. Leung M, Abou R, van Rosendael PJ, van der Bijl P, van Wijngaarden SE, Regeer MV, Podlesnikar T, Ajmone Marsan N, Leung DY, Delgado V, Bax JJ
In patients with atrial fibrillation (AF), left atrial (LA) fibrosis is a major determinant of the progression to, and burden of AF. LA reservoir strain and total atrial conduction time (PA-TDI) reflect LA fibrotic content. We aimed to investigate the relation between LA reservoir strain and PA-TDI in AF patients and control subjects. Six-hundred two patients (mean age 56 years, 53% men) with first episode of AF and 342 controls (mean age 64 years, 71% men) without structural heart disease under... Abstract
Cited 24 times since 2018 (4 per year) source: EuropePMC
European heart journal, Volume 39, Issue 15, 1 1 2018, Pages 1308-1313 Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve. Kong WKF, Regeer MV, Poh KK, Yip JW, van Rosendael PJ, Yeo TC, Tay E, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ
Background: Transcatheter aortic valve replacement (TAVR) has been shown safe and feasible in patients with bicuspid aortic valve (BAV) morphology. Evaluation of inter-ethnic differences in valve morphology and function and aortic root dimensions in patients with BAV is important for the worldwide spread of this therapy in this subgroup of patients. Comparisons between large European and Asian cohorts of patients with BAV have not been performed, and potential differences between populations may... Abstract
Cited 13 times since 2018 (2.1 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 19, Issue 2, 1 1 2018, Pages 176-184 Three-dimensional assessment of mitral valve annulus dynamics and impact on quantification of mitral regurgitation. van Wijngaarden SE, Kamperidis V, Regeer MV, Palmen M, Schalij MJ, Klautz RJ, Bax JJ, Ajmone Marsan N, Delgado V
Aims: To assess mitral annulus dynamics in primary and secondary mitral regurgitation (MR) with 3-dimensional transesophageal echocardiography (3D TEE) and the impact on MR quantification. Methods and results: One hundred and twenty-three patients with moderate and severe MR (63 ± 11 years, 78 males) and 29 controls (59 ± 15 years, 19 males) were evaluated. Functional MR (FMR) was present in 31 patients, fibroelastic deficiency (FED) in 52 and Barlow's disease (BD) in 40. Annular geometry w... Abstract
Cited 7 times since 2018 (1.1 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 19, Issue 2, 1 1 2018, Pages 208-215 Mitral valve repair for secondary mitral regurgitation in non-ischaemic dilated cardiomyopathy is associated with left ventricular reverse remodelling and increase of forward flow. Kamperidis V, van Wijngaarden SE, van Rosendael PJ, Kong WKF, Regeer MV, van der Kley F, Sianos G, Ajmone Marsan N, Bax JJ, Delgado V
Aims: It remains unclear whether surgical or transcatheter mitral valve repair for secondary mitral regurgitation (MR) in patients with non-ischaemic cardiomyopathy reverse the underlying left ventricular (LV) pathophysiology. We hypothesized that mitral valve repair improves LV systolic function and forward flow and induces LV reverse remodelling in this group of patients. Methods and results: Seventy-six patients (65 ± 14 years old, 43% male) with non-ischaemic cardiomyopathy and moderate to s... Abstract
Cited 4 times since 2017 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 18, Issue 9, 1 1 2017, Pages 1041-1048 Three-dimensional transoesophageal echocardiography of the aortic valve and root: changes in aortic root dilation and aortic regurgitation. Regeer MV, Kamperidis V, Versteegh MIM, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Aims: It has been hypothesized that in response to dilation of the aortic root, the aortic valve cusps may remodel to prevent aortic regurgitation (AR). The aim of the present study was to evaluate the association between aortic cusp dimensions and aortic root geometry. Methods and results: Three-dimensional transoesophageal echocardiography was performed in 40 patients with aortic root dilation (mean age 57 ± 12 years, 75% men, 35% bicuspid aortic valve) and 20 controls with a normal aortic roo... Abstract
Cited 29 times since 2017 (4.1 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 10, Issue 3, 1 1 2017, Pages e005155 Sex Differences in Phenotypes of Bicuspid Aortic Valve and Aortopathy: Insights From a Large Multicenter, International Registry. Kong WK, Regeer MV, Ng AC, McCormack L, Poh KK, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Yip JW, Ma L, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ
Background: This large multicenter, international bicuspid aortic valve (BAV) registry aimed to define the sex differences in prevalence, valve morphology, dysfunction (aortic stenosis/regurgitation), aortopathy, and complications (endocarditis and aortic dissection). Methods and results: Demographic, clinical, and echocardiographic data at first presentation of 1992 patients with BAV (71.5% men) were retrospectively analyzed. BAV morphology and valve function were assessed; aortopathy configura... Abstract
Cited 42 times since 2017 (5.9 per year) source: EuropePMC
JAMA cardiology, Volume 2, Issue 3, 1 1 2017, Pages 285-292 Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy. Kong WK, Delgado V, Poh KK, Regeer MV, Ng AC, McCormack L, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Liang M, Yip JW, Ma LC, Kamperidis V, van Rosendael PJ, van der Velde ET, Ajmone Marsan N, Bax JJ
Importance: Little is known about the association between bicuspid aortic valve (BAV) morphologic findings and the degree of valvular dysfunction, presence of aortopathy, and complications, including aortic valve surgery, aortic dissection, and all-cause mortality. Objective: To investigate the association between BAV morphologic findings (raphe vs nonraphe) and the degree of valve dysfunction, presence of aortopathy, and prognosis (including need for aortic valve surgery, aortic dissection, and... Abstract
Cited 7 times since 2017 (1 per year) source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 12, Issue 13, 1 1 2017, Pages 1660-1666 Left bundle branch block after sutureless, transcatheter, and stented biological aortic valve replacement for aortic stenosis. Regeer MV, Merkestein LR, de Weger A, Kamperidis V, van der Kley F, van Rosendael PJ, Marsan NA, Klautz RJ, Schalij MJ, Bax JJ, Delgado V
Aims: Conventional aortic valve replacement (AVR), sutureless AVR (su-AVR) and transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) are associated with conduction abnormalities. The aim of the present study was to assess the incidence of left bundle branch block (LBBB) after su-AVR and TAVI, in comparison to conventional AVR. Methods and results: A total of 501 patients (mean age 74±8 years, 53% male) without preoperative cardiac conduction disturbances who underwent AV... Abstract
Cited 9 times since 2016 (1.2 per year) source: Scopus
Journal of cardiovascular computed tomography, Volume 11, Issue 1, 25 4 2016, Pages 1-7 Prognostic implications of descending thoracic aorta dilation after surgery for aortic dissection. Regeer MV, Martina B, Versteegh MI, de Weger A, Klautz RJ, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Background: The present study assessed whether descending thoracic aorta growth can be measured reliably by volumetric analysis using multi-detector row computed tomography (MDCT) and whether growth influences the need for future aortic interventions in survivors of acute type A aortic dissection. Methods: A total of 51 patients (58 ± 11 years, 61% male) who underwent surgery for type A aortic dissection with ≥2 postoperative MDCT scans ≥5 months apart were included. Volumetric analysis of the d... Abstract