Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
482 results
Cited 4 times since 2022 (2.7 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 12, 1 1 2022, Pages 1669-1679 Left ventricular remodelling in bicuspid aortic valve disease. Butcher SC, Pio SM, Kong WKF, Singh GK, Ng ACT, Perry R, Sia CH, Poh KK, Almeida AG, González A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian Gay L, Fijałkowski M, Liang M, Tay E, Ajmone Marsan N, Selvanayagam J, Pinto F, Zamorano JL, Pibarot P, Evangelista A, Bax JJ, Delgado V
Aims: Characterization of left ventricular (LV) geometric pattern and LV mass could provide an important insight into the pathophysiological adaptations of the LV to pressure and/or volume overload in patients with bicuspid aortic valve (BAV) and significant (≥moderate) aortic valve (AV) disease. This study aimed to characterize LV remodelling and its prognostic impact in patients with BAV according to the predominant type of valvular dysfunction. Methods and results: In this international, mult... Abstract
The American journal of cardiology, Volume 186, 29 5 2022, Pages 176-180 Prognostic Value of Nonalcoholic Fatty Liver Disease in Patients With Severe Aortic Stenosis Who Underwent Transcatheter Aortic Valve Implantation. Nabeta T, Myagmardorj R, Hirasawa K, Singh GK, van der Kley F, de Weger A, Knuuti J, Bax JJ, Marsan NA, Delgado V
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. Although the association between NAFLD and aortic valve sclerosis has been described, the prevalence and prognostic implications of NAFLD among patients with severe aortic stenosis (AS) have not been described. In addition, the effect of the presence of severe tricuspid regurgitation (TR) on the prevalence of NAFLD remains unexplored. Accordingly, we investigated the prognostic implications of... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
The American journal of cardiology, Volume 185, 11 2 2022, Pages 53-62 Factors Affecting Rate of Progression of Aortic Stenosis and Its Impact on Outcomes. Amanullah MR, Pio SM, Sin KYK, Marsan NA, Ding ZP, Stassen J, Leon MB, Genereux P, Delgado V, Ewe SH, Bax JJ
The rate of aortic stenosis (AS) progression in patients with moderate AS is unclear. This study examined the risk factors of progression from moderate to severe AS and its impact on clinical outcomes. A total of 954 patients with moderate AS (valve area >1.0 and ≤1.5 cm²) and follow-up echocardiograms were included. AS progressed to severe (valve area Abstract
Cited 3 times since 2022 (1.9 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 11, 1 1 2022, Pages 1540-1551 Prognostic implications of mitral valve geometry in patients with secondary mitral regurgitation: the COAPT trial. Namazi F, Delgado V, Delgado V, Pio SM, Ajmone Marsan N, Asch FM, Medvedofsky D, Weissman NJ, Zhou Z, Redfors B, Lindenfeld J, Abraham WT, Mack MJ, Stone GW, Bax JJ
Aims: The impact of mitral valve geometry on outcomes after MitraClip treatment in secondary mitral regurgitation (MR) has not been examined. We therefore sought to evaluate the association between mitral valve geometry and outcomes of patients with heart failure (HF) and secondary MR treated with guideline-directed medical therapy (GDMT) and MitraClip. Methods and results: Mitral valve geometry was assessed from the baseline echocardiograms in 614 patients from the COAPT trial. The primary endp... Abstract
European heart journal, Volume 43, Issue 38, 1 1 2022, Pages 3599-3600 The mentorship programme: a new initiative at the European Heart Journal. Ajmone Marsan N, Cavalcante J, Bucciarelli-Ducci C
Cited 2 times since 2022 (1.3 per year) source: EuropePMC
The American journal of cardiology, Volume 184, 23 4 2022, Pages 63-71 Impact of Worsening Heart Failure on Long-Term Prognosis in Patients With Heart Failure With Reduced Ejection Fraction. Chimed S, Stassen J, Galloo X, Meucci MC, van der Bijl P, Knuuti J, Delgado V, Marsan NA, Bax JJ
Worsening heart failure (HF), defined as hospitalization for worsening signs and symptoms of HF or the need for urgent intravenous diuretics, is often considered a surrogate of poor prognosis in clinical trials. However, data on the prognostic implications of worsening HF in patients with HF and reduced ejection fraction is limited. Patients who had a first echocardiographic diagnosis of left ventricular systolic dysfunction, defined as left ventricular ejection fraction (LVEF) ≤45%, were identi... Abstract
Cited 2 times since 2022 (1.2 per year) source: EuropePMC
The American journal of cardiology, Volume 183, 14 2 2022, Pages 33-39 Effect of Bi-Atrial Size and Function in Patients With Paroxysmal or Permanent Atrial Fibrillation. Bax M, Ajmone Marsan N, Delgado V, Bax JJ, van der Bijl P
Atrial fibrillation (AF) remains the most common arrhythmia in clinical practice. The choice between a rate-control and rhythm-control strategy depends on various factors, including the anatomical and functional substrate. This study investigates the anatomical and functional characteristics of both atria in patients with AF and explores the potential therapeutic implications. From an ongoing registry of patients with paroxysmal or permanent AF, those who underwent cardiac computed tomography (C... Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 36, Issue 2, 13 2 2022, Pages 252-254 Left Ventricular Myocardial Work to Differentiate Cardiac Amyloidosis From Hypertrophic Cardiomyopathy. Stassen J, Tjahjadi C, Adam R, Debonnaire P, Claeys M, Popescu BA, Jurcut R, Delgado V, Bax JJ, Marsan NA
Cited 3 times since 2022 (1.8 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 24, Issue 8, 1 1 2022, Pages 1291-1299 Tricuspid regurgitation after cardiac resynchronization therapy: evolution and prognostic significance. Stassen J, Galloo X, Hirasawa K, Marsan NA, van der Bijl P, Delgado V, Bax JJ
Aims: Tricuspid regurgitation (TR) is common in patients with heart failure (HF) and is associated with worse outcome. This study investigated the effect of cardiac resynchronization therapy (CRT) on TR severity and long-term outcome. Methods and results: Tricuspid regurgitation severity was assessed at baseline and 6 months after CRT implantation, using a multiparametric approach. Patients were divided into four groups: (i) no or mild TR without progression; (ii) no or mild TR with progression... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 10, 1 1 2022, Pages 1326-1335 Left ventricular remodelling patterns in patients with moderate aortic stenosis. Stassen J, Ewe SH, Hirasawa K, Butcher SC, Singh GK, Amanullah MR, Sin KYK, Ding ZP, Pio SM, Chew NWS, Sia CH, Kong WKF, Poh KK, Cohen DJ, Généreux P, Leon MB, Marsan NA, Delgado V, Bax JJ
Aims: Moderate aortic stenosis (AS) is associated with an increased risk of adverse events. Because outcomes in patients with AS are ultimately driven by the condition of the left ventricle (LV) and not by the valve, assessment of LV remodelling seems important for risk stratification. This study evaluated the association between different LV remodelling patterns and outcomes in patients with moderate AS. Methods and results: Patients with moderate AS (aortic valve area 1.0-1.5 cm2) were identif... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 80, Issue 11, 1 1 2022, Pages 1071-1084 Impact of Left Ventricular Ejection Fraction on Clinical Outcomes in Bicuspid Aortic Valve Disease. Hecht S, Butcher SC, Pio SM, Kong WKF, Singh GK, Ng ACT, Perry R, Poh KK, Almeida AG, González A, Shen M, Yeo TC, Shanks M, Popescu BA, Gay LG, Fijałkowski M, Liang M, Tay E, Marsan NA, Selvanayagam J, Pinto F, Zamorano JL, Evangelista A, Delgado V, Bax JJ, Pibarot P
Background: The prognostic impact of left ventricular ejection fraction (LVEF) in patients with bicuspid aortic valve (BAV) disease has not been previously studied. Objectives: The purpose of this study was to determine the prognostic impact of LVEF in BAV patients according to the type of aortic valve dysfunction. Methods: We retrospectively analyzed the data collected in 2,672 patients included in an international registry of patients with BAV. Patients were classified according to the type of... Abstract
Cited 2 times since 2022 (1.2 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 10, 1 1 2022, Pages 1273-1276 How to assess severe tricuspid regurgitation by echocardiography? Sade LE, Muraru D, Marsan NA, Agricola E, Stankovic I, Stankovic I, Donal E
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
The American journal of cardiology, Volume 182, 30 5 2022, Pages 83-88 Comparison of the Quantity of Calcium in the Aortic Valve and the Coronary Arteries in Men Versus Women Who Underwent Transcatheter Aortic Valve Implantation. Singh GK, Vollema EM, Stassen J, van Rosendael A, Gegenava T, van der Kley F, Knuuti J, Marsan NA, Delgado V, Bax JJ
Several studies have shown an association between aortic stenosis (AS) and coronary atherosclerosis. This study aimed to evaluate the gender differences in aortic valve calcium (AVC) and coronary artery calcium (CAC) and the association between CAC and all-cause mortality in patients with severe AS. A total of 260 patients (80 ± 7 years, 39% men) with severe AS who were scheduled for transcatheter aortic valve implantation (TAVI) were included. AVC and CAC before TAVI were assessed by noncontras... Abstract
Cited 5 times since 2022 (3 per year) source: EuropePMC
Hepatology communications, Volume 6, Issue 11, 27 4 2022, Pages 3163-3174 Left atrial dysfunction is an independent predictor of mortality in patients with cirrhosis treated by transjugular intrahepatic portosystemic shunt. Meucci MC, Hoogerduijn Strating MM, Butcher SC, van Rijswijk CSP, Van Hoek B, Delgado V, Bax JJ, Tushuizen ME, Marsan NA
The present study aimed to investigate (1) the association between left ventricular diastolic dysfunction (LVDD), graded according to the algorithm proposed by the Cirrhotic Cardiomyopathy Consortium, and long-term survival in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS) and (2) the additive prognostic value of left atrial (LA) function, as assessed by LA reservoir strain, using two-dimensional speckle-tracking echocardiography (2D-STE). A total of 129... Abstract
Cited 3 times since 2022 (1.8 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 38, Issue 12, 24 4 2022, Pages 2781-2789 Vessel and sex differences in pericoronary adipose tissue attenuation obtained with coronary CT in individuals without coronary atherosclerosis. van Rosendael SE, Kuneman JH, van den Hoogen IJ, Kitslaar PH, van Rosendael AR, van der Bijl P, Reiber JHC, Ajmone Marsan N, Jukema JW, Knuuti J, Bax JJ
Pericoronary adipose tissue (PCAT) attenuation, derived from coronary computed tomography angiography (CCTA), is associated with coronary artery inflammation. Values for PCAT attenuation in men and women without atherosclerosis on CCTA are lacking. The aim of the current study was to assess the mean PCAT attenuation in individuals without coronary artery atherosclerosis on CCTA. Data on PCAT attenuation in men and women without coronary artery atherosclerosis on CCTA were included in this retros... Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 36, Issue 2, 14 2 2022, Pages 163-171 Effects of Atrial Ischemia on Left Atrial Remodeling in Patients with ST-Segment Elevation Myocardial Infarction. Montero-Cabezas JM, Abou R, Chimed S, Fortuni F, Goedemans L, Ajmone Marsan N, Bax JJ, Delgado V
Background: Adverse left atrial (LA) remodeling after ST-segment elevation myocardial infarction (STEMI) has been associated with poor prognosis. Flow impairment in the dominant coronary atrial branch (CAB) may affect large areas of LA myocardium, potentially leading to adverse LA remodeling during follow-up. The aim of this study was to assess echocardiographic LA remodeling in patients with STEMI with impaired coronary flow in the dominant CAB. Methods: Of 897 patients with STEMI, 69 patients... Abstract
Cited 4 times since 2022 (2.3 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 108, Issue 17, 11 2 2022, Pages 1401-1407 Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis. Stassen J, Ewe SH, Butcher SC, Amanullah MR, Mertens BJ, Hirasawa K, Singh GK, Sin KY, Ding ZP, Pio SM, Sia CH, Chew N, Kong W, Poh KK, Cohen D, Généreux P, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ
Objective: To investigate the prognostic impact of left ventricular (LV) diastolic dysfunction in patients with moderate aortic stenosis (AS) and preserved LV systolic function. Methods: Patients with a first diagnosis of moderate AS (aortic valve area >1.0 and ≤1.5 cm2) and preserved LV systolic function (LV ejection fraction ≥50%) were identified. LV diastolic function was evaluated using echocardiographic criteria according to the 2016 American Society of Echocardiography/European Associat... Abstract
The international journal of cardiovascular imaging, Volume 38, Issue 10, 8 2 2022, Pages 2141-2142 Progression of moderate to severe aortic stenosis: new insights into cardiac remodeling. Stassen J, Singh GK, Butcher SC, Hirasawa K, Marsan NA, Delgado V, Bax JJ
Cited 6 times since 2022 (3.5 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 80, Issue 7, 1 1 2022, Pages 666-676 Prevalence and Prognostic Implications of Discordant Grading and Flow-Gradient Patterns in Moderate Aortic Stenosis. Stassen J, Ewe SH, Singh GK, Butcher SC, Hirasawa K, Amanullah MR, Pio SM, Sin KYK, Ding ZP, Sia CH, Chew NWS, Kong WKF, Poh KK, Leon MB, Pibarot P, Delgado V, Marsan NA, Bax JJ
Background: The prognostic implications of discordant grading in severe aortic stenosis (AS) are well known. However, the prevalence of different flow-gradient patterns and their prognostic implications in moderate AS are unknown. Objectives: The purpose of this study was to investigate the occurrence and prognostic implications of different flow-gradient patterns in patients with moderate AS. Methods: Patients with moderate AS (aortic valve area >1.0 and ≤1.5 cm2) were identified and divided... Abstract
Cited 1 times since 2022 (0.6 per year) source: EuropePMC
The international journal of cardiovascular imaging, Volume 38, Issue 12, 18 3 2022, Pages 2687-2693 Prognostic value of left atrial volume index in degenerative mitral stenosis. Yedidya I, Butcher SC, Stassen J, van der Bijl P, Ngiam JN, Chew NWS, Sia CH, Leow R, Li TY, Kong WKF, Poh KK, Kornowski R, Marsan NA, Delgado V, Bax JJ
Purpose: Degenerative mitral stenosis (DMS) is associated with a poor prognosis. Although mean transmitral gradient (TMG) has shown a good correlation with outcome, little is known about the association between other echocardiographic parameters and prognosis in patients with DMS. The current study aimed to evaluate the prognostic value of left atrial volume index (LAVI) in patients with DMS. Methods: A total of 155 patients with DMS (72[63-80] years, 67% female) were included. The population wa... Abstract