Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
196 results
Respiratory research, Volume 25, Issue 1, 7 1 2024, Pages 117 MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery. van Paassen J, Hiemstra PS, van der Linden AC, de Jonge E, Zwaginga JJ, Klautz RJM, Arbous MS
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes after cardiac surgery. In this prospective cohort study in 49 adult cardiac surgery patients pr... Abstract
The Thoracic and cardiovascular surgeon, 12 2 2024 Sex Differences in the Histopathology of Acute Type A Aortic Dissections. Grewal N, Dolmaci OB, Klautz RJ, Poelmann RE
Background: Although sex-related differences in cardiovascular surgery outcomes have increasingly garnered attention in the past decades, knowledge about sex disparities in the pathophysiology of acute type A aortic dissections (ATAADs) remains sparse. In this study, we evaluate the histopathologic and atherosclerotic lesions in female and male ATAAD patients. Methods: A total of 68 patients were studied: 51 ATAAD patients (mean age: 62.5 ± 10.8 years; 49% women) and 17 control patients (mean... Abstract
Journal of cardiology, 14 2 2023, Pages S0914-5087(23)00295-2 Mitral regurgitation in atrial fibrillation: Is a simple repair enough to tackle a complex problem? Tomšič A, Meucci MC, de Jong AR, Braun J, Marsan NA, Klautz RJM, Palmen M
Background: Clinical and echocardiographic results of valve repair for mitral regurgitation in the setting of atrial fibrillation are poorly studied. Methods: Between January 2008 and December 2020, 89 patients underwent valve repair for mitral regurgitation in the setting of atrial fibrillation. Clinical and echocardiographic follow-up data were collected and studied. The primary composite endpoint consisted of all-cause mortality or hospitalization for heart failure. Results: Valve repair with... Abstract
Cited 1 times since 2023 (2.1 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 64, Issue 5, 1 1 2023, Pages ezad291 Aortic valve visualization and pressurization device: a novel device for intraoperative evaluation of aortic valve repair procedures. Arabkhani B, Sandker SC, Braun J, Hjortnaes J, van Brakel TJ, Koolbergen DR, Klautz RJM, Hazekamp MG
Objectives: Aortic valve repair procedures are technically challenging, and current intraoperative evaluation methods often fail to predict the final echocardiographic result. We have developed a novel intraoperative aortic valve visualization and pressurization (AVP) device, enabling valve inspection under physiological conditions, and measuring aortic valve insufficiency (AI) during cardioplegic arrest. Methods: The AVP device is attached to the (neo)aorta, after any type of aortic valve repai... Abstract
The American journal of cardiology, Volume 210, 13 2 2023, Pages 58-64 Oral Anticoagulation Versus Antiplatelet Treatment After Mitral Valve Repair: A Systematic Review and Meta-Analysis. Tomšič A, Zhao C, Schoones JW, Klautz RJM, Palmen M
Oral anticoagulation with vitamin K antagonists is currently advised for a period of 3 months after surgical mitral valve repair, regardless of the rhythm status. The evidence supporting this recommendation is weak and recent studies have challenged the safety and efficacy of this recommendation. A systematic review of literature was conducted by searching PubMed, Embase, Web of Science, Emcare, and Cochrane Library databases for original publications comparing the efficacy and safety of oral an... Abstract
The Annals of thoracic surgery, Volume 117, Issue 1, 14 2 2023, Pages 120-126 A Nationwide Study on Mitral Valve Repair vs Replacement for Active Endocarditis. Tomšič A, de Weger A, van der Stoel M, Klautz RJM, Palmen M, Cardiothoracic Surgery Registration Committee of the Netherlands Heart Registration
Background: Real-world evidence supporting the reproducibility and superiority of valve repair over replacement in active mitral valve infective endocarditis is lacking. Methods: Data from a prospective nationwide database, including all cardiac surgical procedures in The Netherlands, were used. Adult patients undergoing primary mitral valve intervention who had a diagnosis of active infective endocarditis and who underwent surgery between 2013 and 2020 were included. Survival analysis was perfo... Abstract
Cited 1 times since 2023 (1.5 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 64, Issue 3, 1 1 2023, Pages ezad307 The impact of annuloplasty ring or band implantation on post-repair mitral valve haemodynamic performance. Tomšič A, Sandoval E, Meucci MC, Nabeta T, Castella M, Muro A, Klautz RJM, Ajmone Marsan N, Pereda D, Palmen M
Objectives: The clinical importance of optimal post-repair mitral valve diastolic performance is increasingly being recognized. The haemodynamic effect of a partial annuloplasty band implantation, in comparison to a full ring, remains insufficiently explored. Methods: Patients undergoing mitral valve repair for pure degenerative disease between 2011 and 2019 at 2 experienced heart valve centres were eligible for inclusion. Exclusion criteria were concomitant procedures other than tricuspid valve... Abstract
Echocardiography (Mount Kisco, N.Y.), Volume 40, Issue 9, 31 5 2023, Pages 892-902 Improving accuracy in diagnosing aortic stenosis severity: An in-depth analysis of echocardiographic measurement error through literature review and simulation study. Velders BJJ, Groenwold RHH, Ajmone Marsan N, Kappetein AP, Wijngaarden RAFLV, Braun J, Klautz RJM, Vriesendorp MD
Aims: The present guidelines advise replacing the aortic valve for individuals with severe aortic stenosis (AS) based on various echocardiographic parameters. Accurate measurements are essential to avoid misclassification and unnecessary interventions. The objective of this study was to evaluate the influence of measurement error on the echocardiographic evaluation of the severity of AS. Methods and results: A systematic review was performed to examine whether measurement errors are reported in... Abstract
BMC cardiovascular disorders, Volume 23, Issue 1, 19 3 2023, Pages 363 Thoracic aortic atherosclerosis in patients with a bicuspid aortic valve; a case-control study. Dolmaci OB, Klautz RJM, Poelmann RE, Lindeman JHN, Sprengers R, Kroft L, Grewal N
Introduction: Bicuspid aortic valve (BAV) patients have an increased risk to develop thoracic aortic complications. Little is known about the prevalence and severity of atherosclerosis in the BAV ascending aortic wall. This study evaluates and compares the prevalence of thoracic aortic atherosclerosis in BAV and tricuspid aortic valve (TAV) patients. Methods: Atherosclerosis was objectified using three diagnostic modalities in two separate BAV patient cohorts (with and without an aortic dilatati... Abstract
Cited 2 times since 2023 (2.4 per year) source: EuropePMC
Pathology, research and practice, Volume 248, 28 4 2023, Pages 154620 Intrinsic histological and morphological abnormalities of the pediatric thoracic aorta in bicuspid aortic valve patients are predictive for future aortopathy. Grewal N, Klautz RJM, Poelmann RE
Background: Patients with a bicuspid aortic valve (BAV) have an increased risk to develop aortic complications. Many studies are pointing towards a possible embryonic explanation for the development of both a bicuspid aortic valve as well as a defective ascending aortic wall in these patients. The fetal and newborn ascending aortic wall has however scarcely been studied in bicuspid aortic valve patients. We hypothesize that early histopathological defects might already be visible in the fetal an... Abstract
Cited 1 times since 2023 (1.1 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 6, 1 1 2023, Pages ezad114 Extensive aortic root endocarditis with extension into the intervalvular fibrous body: an updated report of a mitral valve sparing approach. Tomšič A, Palmen M, de Jong ML, Hjortnaes J, Driessen AGH, Braun J, Marsan NA, Klautz RJM
Objectives: Aortic root abscess can spread to include adjacent cardiac structures, including the central or intervalvular fibrous body and mitral valve. After radical debridement, complex surgical correction is needed. We describe the results of our mitral valve sparing approach. Methods: Between January 2004 and December 2020, 60 patients underwent operation for infective endocarditis of the aortic root with extension towards the mitral valve at 2 centres in the Netherlands. Early and late clin... Abstract
Cited 1 times since 2023 (1.1 per year) source: EuropePMC
International journal of cardiology, Volume 387, 30 5 2023, Pages 131099 Outcomes of concomitant surgical ablation in patients undergoing surgical myectomy for hypertrophic obstructive cardiomyopathy: A systematic review and meta-analysis. Kharbanda RK, Ramdat Misier NL, Van den Eynde J, El Mathari S, Tomšič A, Palmen M, Klautz RJM
Objective: Studies investigating the efficacy of concomitant surgical atrial fibrillation (AF) ablation in hypertrophic obstructive cardiomyopathy (HOCM) patients undergoing myectomy are scarce and limited in terms of sample size. We aim to summarize current outcomes of concomitant surgical AF ablation in HOCM patients undergoing surgical myectomy. Methods: This systematic review and meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide... Abstract
Frontiers in cardiovascular medicine, Volume 10, 26 4 2023, Pages 1094969 Microinvasive mitral valve surgery: Current status and status quo. Tomšič A, Klautz RJM, Borger MA, Palmen M
Surgical mitral valve repair, performed either through median sternotomy or minimal invasive approach, presents the gold standard treatment for degenerative mitral valve disease. In dedicated centres, high repair and low complication rates have been established with excellent valve repair durability. Recently, new techniques have been introduced, that allow mitral valve repair to be performed through small surgical incisions and while avoiding cardio-pulmonary bypass. These new techniques, howev... Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 4, 1 1 2023, Pages ezad109 Anterior leaflet prolapse: does the evidence imply the need for a change in our repair strategy? Tomšič A, Palmen M, Klautz RJM
Multimedia manual of cardiothoracic surgery : MMCTS, Volume 2023, 6 1 2023 Aortic root replacement with the stentless Freestyle bioprosthesis. Velders BJJ, Arabkhani B, Schneider A, Vos RJ, Klautz RJM
In this video tutorial, the technical details for the implantation of the Freestyle stentless bioprosthesis are outlined based on the case of a 76-year-old male patient with symptomatic stenosis of a bicuspid aortic valve and aortic root dilatation. Abstract
Cited 7 times since 2023 (5.7 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 2, 1 1 2023, Pages ezac514 A multicentre, propensity score matched analysis comparing a valve-sparing approach to valve replacement in aortic root aneurysm: Insight from the AVIATOR database. Arabkhani B, Klautz RJM, de Heer F, De Kerchove L, El Khoury G, Lansac E, Schäfers HJ, El-Hamamsy I, Lenoir M, Aramendi JI, Meuris B, Verbrugghe P, Kluin J, Koolbergen DR, Bouchot O, Rudez I, Kolesar A, van Brakel TJ
Objectives: Our goal was to evaluate the outcome of valve-sparing root replacement (VSRR) and to compare the outcomes to those of patients having composite valve-graft conduit aortic root replacement (CVG-ARR) in a cohort of patients with aortic root aneurysm ± valve insufficiency, without valvular stenosis. Although valve-sparing procedures are preferable in young patients, there is a lack of comparative data in comparable patients. Methods: The VSRR procedures were performed in 2005 patients,... Abstract
Cited 1 times since 2023 (0.8 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 9, 12 2 2023, Pages 1036522 Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy. Dolmaci OB, Ayyildiz T, Poelmann RE, Driessen AHG, Koolbergen DR, Klautz RJM, Lindeman JHN, Grewal N
Objective: Patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions share many pathophysiological mechanisms leading to aortic complications. Bicuspidy is known to have a low risk for acquired coronary artery sclerosis. The aim of this study is to determine the risk of coronary sclerosis in MFS patients. Methods: Marfan syndrome patients with an aortic root dilatation, which were surgic... Abstract
Cited 2 times since 2022 (1.5 per year) source: EuropePMC
Journal of clinical medicine, Volume 12, Issue 1, 29 5 2022, Pages 272 Are Thoracic Aortic Aneurysm Patients at Increased Risk for Cardiovascular Diseases? Dolmaci OB, El Mathari S, Driessen AHG, Klautz RJM, Poelmann RE, Lindeman JHN, Grewal N
Objectives: Abdominal aortic aneurysms are associated with a sharply increased cardiovascular risk. Cardiovascular risk management is therefore recommended in prevailing guidelines for abdominal aneurysm patients. It has been hypothesized that associated risk relates to loss of aortic compliance. If this hypothesis is correct, observations for abdominal aneurysms would also apply to thoracic aortic aneurysms. The objective of this study is to test whether thoracic aneurysms are also associated w... Abstract
The Annals of thoracic surgery, Volume 116, Issue 1, 8 2 2022, Pages 200-201 Why and When Is Aortic Root Replacement in Acute Type A Dissection Preferable. Arabkhani B, Klautz RJM
Cited 2 times since 2022 (1.4 per year) source: EuropePMC
Journal of cardiac surgery, Volume 37, Issue 12, 6 1 2022, Pages 4207-4208 Can general histopathology distinguish bicuspid aortopathy? Grewal N, Driessen A, Klautz RJM, Poelmann RE