Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
79 results
Cited 64 times since 2007 (3.8 per year) source: EuropePMC
European heart journal, Volume 28, Issue 18, 29 5 2007, Pages 2223-2230 Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T
Aims: Patients with atrial fibrillation (AF) present with symptoms of myocardial ischaemia despite exclusion of coronary artery disease. A small vessel disease has been suggested. We quantified myocardial perfusion, perfusion reserve, and coronary vascular resistance (CVR) in AF patients using positron emission tomography (PET). Methods and results: Twenty-five male patients (age: 58 +/- 13 years) with persistent idiopathic AF were compared with 13 age- and risk-matched male controls (age: 56 +/... Abstract
Cited 22 times since 2007 (1.3 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 34, Issue 6, 10 2 2007, Pages 900-909 Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: validation of an elastic surface model approach in comparison to cardiac magnetic resonance imaging, 4D-MSPECT and QGS. Stegger L, Lipke CS, Kies P, Nowak B, Schober O, Buell U, Schäfers M, Schaefer WM
Purpose: The segmentation algorithm ESM based on an elastic surface model was validated for the assessment of left ventricular volumes and ejection fraction from ECG-gated myocardial perfusion SPECT. Additionally, it was compared with the commercially available quantification packages 4D-MSPECT and QGS. Cardiac MRI was used as the reference method. Methods: SPECT and MRI were performed on 70 consecutive patients with suspected or proven coronary artery disease. End-diastolic (EDV) and end-systol... Abstract
Cited 4 times since 2007 (0.2 per year) source: EuropePMC
European radiology, Volume 17, Issue 6, 6 1 2007, Pages 1422-1432 Molecular cardiovascular imaging using scintigraphic methods. Stegger L, Schäfers K, Kopka K, Wagner S, Hermann S, Kies P, Law M, Schober O, Schäfers M
Molecular cardiovascular imaging plays an increasingly important role both in basic research and in clinical diagnosis. Scintigraphic methods have long been used to study pathophysiological changes on a cellular and molecular level, and they are likely to remain important molecular imaging modalities in the foreseeable future. This article provides an overview over current developments in cardiovascular molecular imaging using scintigraphic methods. The focus lies on imaging of cardiac innervati... Abstract
Cited 20 times since 2006 (1.1 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 17, Issue 6, 1 1 2006, Pages 586-593 Serial reevaluation for ARVD/C is indicated in patients presenting with left bundle branch block ventricular tachycardia and minor ECG abnormalities. Kiès P, Bootsma M, Bax JJ, Zeppenfeld K, van Erven L, Wijffels MC, van der Wall EE, Schalij MJ
Introduction: Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is based on a set of criteria proposed by the International Task Force (TF) for Cardiomyopathies in 1994. To fulfill these criteria, presence of both electrocardiographic and anatomical abnormalities must be assessed with ECG and imaging techniques, respectively. This may be difficult in patients with early/mild forms of the disease as detectable structural abnormalities may still be absent. We evaluate... Abstract
Cited 41 times since 2006 (2.3 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 33, Issue 8, 13 2 2006, Pages 866-870 Impact of sympathetic innervation on recurrent life-threatening arrhythmias in the follow-up of patients with idiopathic ventricular fibrillation. Paul M, Schäfers M, Kies P, Acil T, Schäfers K, Breithardt G, Schober O, Wichter T
Purpose: Idiopathic ventricular fibrillation (IVF) is defined as VF in the absence of any identifiable structural or functional cardiac disease. The underlying pathophysiological mechanisms are unknown. This study was performed to investigate the potential impact of sympathetic dysfunction, assessed by (123)I-meta-iodo-benzylguanidine scintigraphy ((123)I-MIBG SPECT), on the long-term prognosis of patients with IVF. Methods: (123)I-MIBG SPECT was performed in 20 patients (mean age 37+/-13 years)... Abstract
Cited 61 times since 2006 (3.3 per year) source: EuropePMC
Heart rhythm, Volume 3, Issue 2, 1 1 2006, Pages 225-234 Arrhythmogenic right ventricular dysplasia/cardiomyopathy: screening, diagnosis, and treatment. Kiès P, Bootsma M, Bax J, Schalij MJ, van der Wall EE
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a heart muscle disorder characterized pathologically by fatty or fibrofatty replacement and electrical instability of the right ventricular myocardium. Clinical manifestations include structural and functional malformations (fatty infiltration, dilatation, aneurysms) of the right ventricle, ECG abnormalities, and presentation with ventricular tachycardias with left bundle branch block pattern or sudden death. The disease often... Abstract
Cited 14 times since 2005 (0.8 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1049-1056 Determinants of recurrent ventricular arrhythmia or death in 300 consecutive patients with ischemic heart disease who experienced aborted sudden death: data from the Leiden out-of-hospital cardiac arrest study. Kiès P, Boersma E, Bax JJ, van der Burg AE, Bootsma M, van Erven L, van der Wall EE, Schalij MJ
Objective: Evaluation of the relation between clinical characteristics and incidence of recurrent ventricular arrhythmias (VAs) or death during long-term follow-up in a cohort of 300 consecutive ischemic heart disease (IHD) patients who had survived an episode of sudden cardiac arrest (SCA). Background: Survivors of life-threatening VA are at high risk for recurrent events. Methods: A total of 300 consecutive survivors of SCA with IHD were included in a standardized screening and evaluation prot... Abstract
Cited 37 times since 2005 (2 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 92, Issue 4, 13 2 2005, Pages 490-494 Cardiac resynchronisation therapy in chronic atrial fibrillation: impact on left atrial size and reversal to sinus rhythm. Kiès P, Leclercq C, Bleeker GB, Crocq C, Molhoek SG, Poulain C, van Erven L, Bootsma M, Zeppenfeld K, van der Wall EE, Daubert JC, Schalij MJ, Bax JJ
Objective: To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and left ventricular (LV) reverse remodelling and reversal to sinus rhythm (SR) in patients with heart failure with atrial fibrillation (AF). Patients: 74 consecutive patients (age 68 (8) years; 67 men) with advanced heart failure and AF (20 persistent and 54 permanent) were implanted with a CRT device. Main outcome measures: Patients were evaluated clinically (New York Heart Association (NYHA)... Abstract
Cited 27 times since 2005 (1.4 per year) source: EuropePMC
Heart rhythm, Volume 2, Issue 9, 1 1 2005, Pages 940-950 Identification of successful catheter ablation sites in patients with ventricular tachycardia based on electrogram characteristics during sinus rhythm. Zeppenfeld K, Kiès P, Wijffels MC, Bootsma M, van Erven L, Schalij MJ
Background: Zones of slow conduction facilitate reentry, the major mechanism of ventricular tachycardia (VT) after myocardial infarction (MI). Identification of these zones during sinus rhythm (SR) is desirable for radiofrequency (RF) catheter ablation of VT. Local conduction velocity may correlate with electrogram duration. Objectives: The purpose of this study was to revise the definition of normal electrogram characteristics and to reevaluate the significance of low-amplitude, long-duration e... Abstract
Cited 17 times since 2005 (0.9 per year) source: EuropePMC
The American journal of cardiology, Volume 96, Issue 1, 1 1 2005, Pages 108-111 Comparison of effectiveness of cardiac resynchronization therapy in patients with versus without diabetes mellitus. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Boersma E, Steendijk P, van der Wall EE, Schalij MJ
The effect of long-term cardiac resynchronization therapy (CRT) was evaluated in 32 patients with heart failure (HF) and diabetes mellitus (DM) compared with 65 patients with HF and no DM. Clinical parameters were obtained before and after 6 months of CRT. Long-term follow-up was performed Abstract
Cited 16 times since 2005 (0.8 per year) source: EuropePMC
The American journal of cardiology, Volume 95, Issue 9, 1 1 2005, Pages 1111-1114 Effect of cardiac resynchronization therapy on inducibility of ventricular tachyarrhythmias in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Zeppenfeld K, Bootsma M, van Erven L, Steendijk P, van der Wall EE, Schalij MJ
We evaluated whether long-term cardiac resynchronization therapy affects the inducibility of ventricular tachyarrhythmias in relation to reverse remodeling in cardiac arrest survivors with either ischemic or idiopathic dilated cardiomyopathy. Clinical, electrophysiologic, and echocardiographic data of 18 patients were obtained before and after 6 months of cardiac resynchronization. Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 13, Issue 4, 1 1 2005, Pages 123-125 Arrhythmogenic right ventricular dysplasia/cardiomyopathy: unresolved issues and need for registries. Kiès P, van der Wall EE
Cited 48 times since 2004 (2.5 per year) source: EuropePMC
Circulation, Volume 110, Issue 19, 1 1 2004, Pages 3017-3022 Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG
Background: Life-threatening ventricular tachyarrhythmias can occur in young patients without structural heart disease (idiopathic forms). In many patients, these are typically triggered by an increased sympathetic tone, eg, by physical or mental stress. In contrast, in Brugada syndrome, ventricular tachyarrhythmias more often occur during rest or sleep when the vagal tone is predominant. Furthermore, adrenergic agonists can reduce the level of ST-segment elevation, whereas it is increased by pa... Abstract
Cited 3 times since 2004 (0.2 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 45, Issue 10, 1 1 2004, Pages 1605-1610 Functional changes after partial left ventriculectomy and mitral valve repair assessed by gated perfusion SPECT. Schäfers M, Stypmann J, Wilhelm MJ, Stegger L, Kies P, Hermann S, Schmidt C, Breithardt G, Scheld HH, Schober O
Unlabelled: A myocardial remodeling in dilated cardiomyopathy (DCM) after partial left ventriculectomy (PLV) has been previously discussed. The aim of this study was to investigate the functional changes in the follow-up of patients with DCM undergoing PLV using electrocardiographically triggered perfusion SPECT (gated SPECT). Methods: Twelve DCM patients (10 men, 2 women; 56 +/- 9 y [mean +/- SD]), after successful PLV and mitral valve repair (PLV-MVR), were monitored by gated SPECT and echocar... Abstract
Cited 25 times since 2004 (1.3 per year) source: EuropePMC
The American journal of cardiology, Volume 94, Issue 1, 1 1 2004, Pages 130-132 Effect of left ventricular remodeling after cardiac resynchronization therapy on frequency of ventricular arrhythmias. Kiès P, Bax JJ, Molhoek SG, Bleeker GB, Zeppenfeld K, Bootsma M, St John Sutton M, van Erven L, van der Wall EE, Schalij MJ
We evaluated whether cardiac resynchronization therapy affects the prevalence of ventricular tachycardia in relation to reverse remodeling in patients with end-stage heart failure. Clinical, echocardiographic, and implantable cardioverter-defibrillator (ICD) data of 17 patients with ICDs were obtained before and after they had received an upgrade to an ICD-cardiac resynchronization therapy device. Abstract
Cited 11 times since 2003 (0.5 per year) source: EuropePMC
Nuklearmedizin. Nuclear medicine, Volume 42, Issue 6, 1 1 2003, Pages 240-243 Iodine excretion during stimulation with rhTSH in differentiated thyroid carcinoma. Löffler M, Weckesser M, Franzius C, Kies P, Schober O
Aim: Elevated iodine intake is a serious problem in the diagnostic and therapeutic application of (131)iodine in patients with differentiated thyroid cancer. Therefore, iodine avoidance is necessary 3 months in advance. Additionally, endogenous stimulation requires withdrawal of thyroid hormone substitution for 4 weeks. Exogenous stimulation using recombinant human TSH (rhTSH) enables the continuous substitution of levothyroxine, which contains 65.4% of its molecular weight in iodine. Thus, a su... Abstract
Cited 84 times since 2002 (3.8 per year) source: EuropePMC
Circulation, Volume 105, Issue 6, 1 1 2002, Pages 702-706 Cardiac autonomic dysfunction in Brugada syndrome. Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, Borggrefe M, Schober O, Breithardt G, Schäfers M
Background: Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by changes of typical ECG signs under pharmacological modulation of the myocardial autonomic tone. Methods and... Abstract
Cited 13 times since 2000 (0.5 per year) source: EuropePMC
European journal of nuclear medicine, Volume 27, Issue 3, 1 1 2000, Pages 302-307 Clinical evaluation of no-carrier-added meta-[123I]iodobenzylguanidine for myocardial scintigraphy. Knickmeier M, Matheja P, Wichter T, Schäfers KP, Kies P, Breithardt G, Schober O, Schäfers M
In clinical and research studies, images obtained using carrier-added meta-[123I]iodobenzylguanidine (c.a. [123I]MIBG) have shown quite variable quality, with varying levels of uptake in lung, liver and mediastinum; this is a significant problem for quantification of the myocardial uptake by means of region ratios. First experimental and preliminary human data in respect of no-carrier-added (n.c.a.) [123I]MIBG are indicative of improved imaging quality. The aim of the present study was to evalua... Abstract
Cited 25 times since 2000 (1 per year) source: EuropePMC
Congestive heart failure (Greenwich, Conn.), Volume 6, Issue 2, 1 1 2000, Pages 86-89 Bioimpedance monitoring: better than chest x-ray for predicting abnormal pulmonary fluid? Peacock WF, Albert NM, Kies P, White RD, Emerman CL
Bioimpedance monitoring may aid in treating heart failure. Mean thoracic electrical impedance (Zo) is inversely proportional to thoracic fluid volume and may offer greater sensitivity for detecting thoracic fluid. OBJECTIVE. Compare bioimpedance monitoring thoracic fluid detection to that of chest x-ray. METHOD. Prospective convenience sample. SETTING. 1000 bed teaching hospital. PARTICIPANTS. Patients with suspected heart failure and shortness of breath. A single blinded radiologist interpreted... Abstract