Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
79 results
Cited 8 times since 2019 (1.6 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 28, Issue 2, 1 1 2019, Pages 279-283 Excellent durability of homografts in pulmonary position analysed in a predefined adult group with tetralogy of Fallot. Meijer FMM, Kies P, Jongbloed MRM, Hazekamp MG, Koolbergen DR, Blom NA, de Roos A, Schalij MJ, Vliegen HW
Objectives: In repaired tetralogy of Fallot, surgical pulmonary valve replacement (PVR) is in certain cases required. Our institution reported earlier about 26 patients who received a pulmonary homograft via PVR. To date, we have data from more than 17 years of follow-up. The aim of this retrospective study was to evaluate the late haemodynamic and clinical outcomes in this predefined patient group. Methods: Between 1993 and 2001, 26 patients underwent PVR for pulmonary regurgitation (58% men; 3... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
International journal of integrated care, Volume 18, Issue 4, 31 5 2019, Pages 15 The Integrated Dyspnea Clinic: An Evaluation of Efficiency. Rietbroek MV, Slats AM, Kiès P, de Grooth GJ, Chavannes NH, Taube C, Bonten TN
Introduction: Dyspnea is a common complaint and in 70 to 90% the origin is pulmonary or cardiovascular. However, referral to the "wrong" specialism could result in diagnostic- and treatment delay. Integrated care by a cardiologist and a pulmonologist could improve this. The aim of the present study was to evaluate whether integrated care for patients with dyspnea is more efficient and effective than regular care. Methods: Consecutive patients (n = 235) seen at our dyspnea clinic after... Abstract
Cited 13 times since 2018 (2.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 10, 10 2 2018, Pages 790-796 Long-term outcome after atrial correction for transposition of the great arteries. Couperus LE, Vliegen HW, Zandstra TE, Kiès P, Jongbloed MRM, Holman ER, Zeppenfeld K, Hazekamp MG, Schalij MJ, Scherptong RWC
Objective: This study assessed adult survival and morbidity patterns in patients who underwent atrial correction according to Mustard or Senning for transposition of the great arteries (TGA). Methods: In 76 adult patients with TGA (59% male) after atrial correction, long-term survival and morbidity were investigated in three periods: early (30 years postoperatively). Results: The Mustard technique was performed in 41 (54%) patients, and the Senning technique was performed in 35 (46%) patients ag... Abstract
Cited 2 times since 2018 (0.4 per year) source: EuropePMC
International journal of cardiology, Volume 273, 24 4 2018, Pages 203-206 ECG derived ventricular gradient exceeds echocardiography in the early detection of pulmonary hypertension in scleroderma patients. Meijer FMM, Kies P, Jongbloed MRM, van Wijngaarden SE, Swenne CA, Man S, Schalij MJ, de Vries-Bouwstra JK, Vliegen HW
Background: Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension (PH) which is a major cause of death in this population. Echocardiographic (TTE) derived pulmonary arterial pressure (PAP) can be unreliable for the early detection of PH. Previous studies demonstrate that the ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) can detect PH in a heterogeneous population suspected of PH. The aim of this study is to assess... Abstract
Heart (British Cardiac Society), Volume 104, Issue 4, 1 1 2017, Pages 332-339 Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography. Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E
Objective: We investigated the impact of cardiac presynaptic norepinephrine recycling in patients with long-QT syndrome (LQTS) using positron emission tomography (PET) with 11C-meta-hydroxyephedrine ([11C]mHED-PET). Methods: [11C]mHED-PET was performed in 25 patients with LQTS (LQT1: n=14; LQT2: n=11) and 20 healthy controls and correlated with clinical parameters. [11C]mHED-PET images were analysed for global and regional retention indices (RI) and washout rates (WO) reflecting dynamic paramete... Abstract
Cited 27 times since 2017 (4.1 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 104, Issue 7, 28 4 2017, Pages 574-580 Factors associated with coronary artery disease and stroke in adults with congenital heart disease. Bokma JP, Zegstroo I, Kuijpers JM, Konings TC, van Kimmenade RRJ, van Melle JP, Kiès P, Mulder BJM, Bouma BJ
Objective: To determine factors associated with coronary artery disease (CAD) and ischaemic stroke in ageing adult congenital heart disease (ACHD) patients. Methods: We performed a multicentre case-control study, using data from the national CONgenital CORvitia (CONCOR) registry to identify ACHD patients within five participating centres. Patients with CAD were matched (1:2 ratio) with ACHD patients without CAD on age, CHD defect group and gender. Patients with ischaemic stroke (or transient isc... Abstract
Cited 3 times since 2017 (0.4 per year) source: EuropePMC
International journal of cardiology, Volume 243, 2 1 2017, Pages 191-193 Clinical course of tricuspid regurgitation in repaired tetralogy of Fallot. Woudstra OI, Bokma JP, Winter MM, Kiès P, Jongbloed MRM, Vliegen HW, Groenink M, Meijboom FJ, Mulder BJM, Bouma BJ
Background: Little is known on the clinical course of tricuspid regurgitation (TR) in patients with repaired tetralogy of Fallot (rTOF) and which patients are at particular risk. This study aims to determine TR course, characteristics associated with TR progression, and the prognostic relevance of TR in rTOF patients. Methods: In this dualcenter cohort study, rTOF patients from a prospective national registry with ≥1 cardiac magnetic resonance imaging study and ≥2 echocardiograms available were... Abstract
Cited 2 times since 2016 (0.3 per year) source: EuropePMC
Nuklearmedizin. Nuclear medicine, Volume 55, Issue 5, 20 3 2016, Pages 196-202 Sex differences in absolute myocardial perfusion. Non-invasive H2(15)O-PET in young healthy adults. Range FT, Kies P, Schäfers KP, Breithardt G, Schober O, Wichter T, Schäfers MA
Aim: To investigate sex differences in myocardial perfusion especially in healthy individuals since former studies are rare and findings are controversial. Participants, methods: 26 subjects were enrolled: 16 healthy women (age: 34 ±7 years) were compared with 10 healthy men (age: 34 ± 3 years; p = ns). Myocardial blood flow (MBF) and coronary vascular resistance (CVR) were quantified at rest, during adenosine infusion and cold-pressor-testing, using positron emission tomography and radioactive-... Abstract
Cited 1 times since 2013 (0.1 per year) source: EuropePMC
Heart rhythm, Volume 11, Issue 8, 22 4 2013, Pages 1490-1491 Cardiac sympathetic innervation in a patient with catecholaminergic polymorphic ventricular tachycardia. Paul M, Kies P, Schäfers M, Schulze-Bahr E
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 96, Issue 4, 16 3 2013, Pages 1390-1397 Variation in coronary anatomy in adult patients late after arterial switch operation: a computed tomography coronary angiography study. Veltman CE, Beeres SLMA, Kalkman DN, Kelder TP, Kiès P, Vliegen HW, Hazekamp MG, Delgado V, Kroft LJM, van der Wall EE, Gittenberger-de Groot AC, Scholte AJHA, Schalij MJ, Jongbloed MRM
Background: The arterial switch operation is the current treatment for transposition of the great arteries. Long-term outcome mainly depends on the patency of the transferred coronary arteries. This study assessed the presence of abnormal coronary findings and neoaortic root dilation late after arterial switch operation. Methods: In 30 adult patients after arterial switch operation (22 men, 22 ± 3 years), computed tomography angiography was performed to assess the coronary anatomy and abnormal c... Abstract
Cited 6 times since 2011 (0.5 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 416-420 Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M
Purpose: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a nonischaemic cardiomyopathy and leading cause of sudden death in the young. It has been shown that microvascular dysfunction reflected by an impaired myocardial blood flow (MBF) response to stress is present in patients with other forms of nonischaemic cardiomyopathy, e.g. dilated cardiomyopathy, and that the reduced MBF may be related to a poor prognosis. Therefore, we quantified MBF, coronary flow reserve and coronary vascula... Abstract
Cited 23 times since 2011 (1.8 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 52, Issue 10, 9 2 2011, Pages 1559-1565 Cardiac sympathetic dysfunction in genotyped patients with arrhythmogenic right ventricular cardiomyopathy and risk of recurrent ventricular tachyarrhythmias. Paul M, Wichter T, Kies P, Gerss J, Wollmann C, Rahbar K, Eckardt L, Breithardt G, Schober O, Schulze-Bahr E, Schäfers M
Unlabelled: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) typically present with ventricular tachyarrhythmias preferentially triggered by an elevated sympathetic tone. Previous studies demonstrated an impairment of the presynaptic catecholamine reuptake as assessed by (123)I-labeled norepinephrine analog on metaiodobenzylguanidine ((123)I-MIBG) SPECT. Mutations in the gene encoding for plakophilin-2 (PKP-2) are the most common cause of autosomal dominant ARVC (ARVC-9). In... Abstract
Cited 9 times since 2011 (0.7 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 38, Issue 10, 21 3 2011, Pages 1899-1907 Impaired cardiac sympathetic innervation in symptomatic patients with long QT syndrome. Kies P, Paul M, Gerss J, Stegger L, Mönnig G, Schober O, Wichter T, Schäfers M, Schulze-Bahr E
Purpose: Increased sympathetic activation is a key modifier for arrhythmogenesis in patients with long QT syndrome (LQTS), a congenital channelopathy. Therefore, we investigated cardiac sympathetic function using 123I-metaiodobenzylguanidine (MIBG) single photon emission computed tomography (SPECT) in a cohort of symptomatic LQTS patients and correlated these findings with the underlying genotype. Methods: [123I]MIBG SPECT was performed in 28 LQTS patients. Among these, 18 patients (64%) had a p... Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 18, Issue 2, 1 1 2011, Pages 368-370 Subvalvular hypertrophic calcification of the mitral annulus: [(18)F]FDG-PET-CT, MRI, and echocardiography findings. Persigehl T, Maintz D, Kies P, Heindel W, Schober O, Tiemann K, Rahbar K
Cited 13 times since 2009 (0.9 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 20, Issue 10, 26 4 2009, Pages 1119-1127 Patients with scar-related right ventricular tachycardia: determinants of long-term outcome. Wijnmaalen AP, Schalij MJ, Bootsma M, Kies P, DE Roos A, Putter H, Bax JJ, Zeppenfeld K
Introduction: Patients with established arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) based on task force (TF) criteria and ventricular tachycardia (VT) are at risk of VT recurrence and sudden death. Data on patients with VT due to right ventricular (RV) scar not fulfilling TF criteria are lacking. The purpose of this study was to assess the long-term arrhythmia recurrence rate and outcome in patients with scar-related right VT with and without a diagnosis of ARVC/D. Methods... Abstract
Cited 27 times since 2009 (1.8 per year) source: EuropePMC
European heart journal, Volume 30, Issue 13, 2 1 2009, Pages 1621-1626 Recurrence of ventricular arrhythmias in ischaemic secondary prevention implantable cardioverter defibrillator recipients: long-term follow-up of the Leiden out-of-hospital cardiac arrest study (LOHCAT). Borleffs CJ, van Erven L, Schotman M, Boersma E, Kiès P, van der Burg AE, Zeppenfeld K, Bootsma M, van der Wall EE, Bax JJ, Schalij MJ
Aims: To assess the long-term rate of mortality and the recurrence of potentially life-threatening ventricular arrhythmias in secondary prevention implantable cardioverter defibrillator (ICD) patients and to construct a model for baseline risk stratification. Methods and results: Since 1996, all patients with ischaemic heart disease, receiving ICD therapy for secondary prevention of sudden death, were included in the current study. Patients were evaluated at implantation and during long-term fol... Abstract
Cited 37 times since 2009 (2.5 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 36, Issue 10, 9 2 2009, Pages 1622-1628 Evaluation and comparison of 11C-choline uptake and calcification in aortic and common carotid arterial walls with combined PET/CT. Kato K, Schober O, Ikeda M, Schäfers M, Ishigaki T, Kies P, Naganawa S, Stegger L
Purpose: Inflamed atherosclerotic plaques may rupture and cause acute myocardial infarction, stroke and other thrombotic events. Early detection of these unstable plaques could, in many cases, prevent such potentially fatal events. 11C-choline or 18F-labelled choline derivatives for visualizing the synthesis of phospholipids, are promising markers of plaque inflammation with potential advantages over 18F-FDG. Their potential for plaque characterization in humans is, however, unclear. In this stu... Abstract
Cited 12 times since 2009 (0.8 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 50, Issue 3, 17 3 2009, Pages 390-396 Myocardial perfusion in nonischemic dilated cardiomyopathy with and without atrial fibrillation. Range FT, Paul M, Schäfers KP, Acil T, Kies P, Hermann S, Schober O, Breithardt G, Wichter T, Schäfers MA
Unlabelled: Recent studies have shown that idiopathic atrial fibrillation (AF) is associated with diminished myocardial perfusion and perfusion reserve, which are also impaired in various forms of cardiomyopathies. In many cases, AF develops during progression of dilated cardiomyopathy (DCM) and may aggravate heart failure. This study compared myocardial perfusion between patients with nonischemic DCM with and without AF. Methods: Twelve men (age +/- SD, 55 +/- 12 y) who had DCM and persistent A... Abstract
Cited 3 times since 2009 (0.2 per year) source: EuropePMC
Nuklearmedizin. Nuclear medicine, Volume 48, Issue 2, 14 2 2009, Pages 71-78 [Position paper nuclear cardiology: update 2008]. Schäfers M, Bengel F, Büll U, Burchert W, Kies P, Kluge R, Krause BJ, Lindner O, Nienaber C, Nowak B, Schäfer W, Schober O, Schwaiger M, Silber S, Vom Dahl J, Zimmermann R
Nuclear cardiology is well established in clinical diagnostic algorithms for many years. This is an update 2008 of the first common position paper of the German Association of Nuclear Medicine and the German Association of Cardiology, Heart and Circulation Research published in 2001 aiming at an overview of state-of-the-art scintigraphic methods. Abstract
Cited 2 times since 2007 (0.1 per year) source: EuropePMC
European journal of nuclear medicine and molecular imaging, Volume 35, Issue 3, 18 3 2007, Pages 687 Discrepancy between glucose metabolism and sympathetic nerve terminals in a patient with metastatic paraganglioma. Rahbar K, Kies P, Stegger L, Juergens KU, Weckesser M