Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
138 results
Cited 6 times since 2021 (1.9 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 6, 8 2 2021, Pages 311-317 The first multicentre study on coronary anomalies in the Netherlands: MuSCAT. Koppel CJ, Driesen BW, de Winter RJ, van den Bosch AE, van Kimmenade R, Wagenaar LJ, Jukema JW, Hazekamp MG, van der Kley F, Jongbloed MRM, Kiès P, Egorova AD, Verheijen DBH, Damman P, Schoof PH, Wilschut J, Stoel M, Speekenbrink RGH, Voskuil M, Vliegen HW
Background: Current guidelines on coronary anomalies are primarily based on expert consensus and a limited number of trials. A gold standard for diagnosis and a consensus on the treatment strategy in this patient group are lacking, especially for patients with an anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) with an interarterial course. Aim: To provide evidence-substantiated recommendations for diagnostic work-up, treatment and follow-up of patients with anom... Abstract
Open heart, Volume 8, Issue 1, 1 1 2021, Pages e001252 Patient information portal for congenital aortic and pulmonary valve disease: a stepped-wedge cluster randomised trial. Etnel JRG, Bons LR, De Heer F, Robbers-Visser D, Van Beynum IM, Straver B, Jongbloed MR, Kiès P, Slieker MG, Van Dijk APJ, Kluin J, Bertels RA, Utens EMWJ, The R, Van Galen E, Mulder BJM, Blom NA, Hazekamp MG, Roos-Hesselink JW, Helbing WA, Bogers AJJC, Takkenberg JJM
Background: In response to an increased need for patient information in congenital heart disease, we previously developed an online, evidence-based information portal for patients with congenital aortic and pulmonary valve disease. To assess its effectiveness, a stepped-wedge cluster randomised trial was conducted. Methods: Adult patients and caregivers of paediatric patients with congenital aortic and/or pulmonary valve disease and/or tetralogy of Fallot who visited the outpatient clinic at any... Abstract
Cited 7 times since 2021 (2.2 per year) source: EuropePMC
Journal of cardiovascular development and disease, Volume 8, Issue 3, 26 4 2021, Pages 25 The Clinical Spectrum of Kommerell's Diverticulum in Adults with a Right-Sided Aortic Arch: A Case Series and Literature Overview. van Rosendael PJ, Stöger JL, Kiès P, Vliegen HW, Hazekamp MG, Koolbergen DR, Lamb HJ, Jongbloed MRM, Egorova AD
Background: Kommerell's diverticulum is a rare vascular anomaly characterized as an outpouch at the onset of an aberrant subclavian artery. In the variant of a right-sided aortic arch, the trachea and esophagus are enclosed dorsally by the arch. In the configuration of an aberrant left subclavian artery, a Kommerell's diverticulum and persisting ductus arteriosus or ductal ligament enclose the lateral side, forming a vascular ring which may result in (symptomatic) esophageal or trachea... Abstract
Cited 9 times since 2021 (2.8 per year) source: EuropePMC
Journal of the American Heart Association, Volume 10, Issue 5, 22 4 2021, Pages e018565 Clinical Course Long After Atrial Switch: A Novel Risk Score for Major Clinical Events. Woudstra OI, Zandstra TE, Vogel RF, van Dijk APJ, Vliegen HW, Kiès P, Jongbloed MRM, Egorova AD, Doevendans PAFM, Konings TC, Mulder BJM, Tanck MWT, Meijboom FJ, Bouma BJ
Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on the emerging risks remain scarce. We assessed the risk for events during the clinical course in adulthood, and provided a novel risk score for event-free survival. Methods and Results This multicenter study observed 167 patients with transposition of the great arteries corrected by an atrial... Abstract
European heart journal. Digital health, Volume 2, Issue 2, 22 4 2021, Pages 215-223 Potential of eHealth smart technology in optimization and monitoring of heart failure treatment in adults with systemic right ventricular failure. Nederend M, Zandstra TE, Kiès P, Jongbloed MRM, Vliegen HW, Treskes RW, Schalij MJ, Atsma DE, Egorova AD
Aims: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA are prone to heart failure and arrhythmias. This study evaluated feasibility, patient adherence, and satisfaction of a smart technology-based care pathway for heart failure treatment optimization in these patients. Methods and results: Patients with symptomatic sRV failure eligible for initiation of sacubitril/valsartan were provided w... Abstract
Pediatric cardiology, Volume 42, Issue 4, 1 1 2021, Pages 866-874 Oxygen Uptake Efficiency Slope is Strongly Correlated to VO<sub>2peak</sub> Long-Term After Arterial Switch Operation. Terol Espinosa de Los Monteros C, Van der Palen RLF, Hazekamp MG, Rammeloo L, Jongbloed MRM, Blom NA, Harkel ADJT
After the arterial switch operation (ASO) for transposition of the great arteries (TGA), many patients have an impaired exercise tolerance. Exercise tolerance is determined with cardiopulmonary exercise testing by peak oxygen uptake (VO2peak). Unlike VO2peak, the oxygen uptake efficiency slope (OUES) does not require a maximal effort for interpretation. The value of OUES has not been assessed in a large group of patients after ASO. The purpose of this study was to determine OUES and VO2peak, eva... Abstract
Cited 16 times since 2021 (4.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 107, Issue 21, 15 3 2021, Pages 1725-1730 Sacubitril/valsartan in the treatment of systemic right ventricular failure. Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD
Objective: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients. Methods: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circ... Abstract
Cited 3 times since 2021 (0.9 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 32, Issue 1, 1 1 2021, Pages 122-129 The significance of symptoms before and after surgery for anomalous aortic origin of coronary arteries in adolescents and adults. Meijer FMM, Egorova AD, Jongbloed MRM, Koppel C, Habib G, Hazekamp MG, Vliegen HW, Kies P
Objectives: The aim of this study is to describe the significance of symptoms preoperatively and at medium-term follow-up in adolescent and adult patients who underwent surgery of anomalous aortic origin of a coronary artery (AAOCA). Methods: Consecutive patients who underwent surgery for AAOCA in our tertiary referral centre between 2001 and 2018 were included. Clinical characteristics and symptoms were evaluated and medium-term outcomes were recorded. Symptoms were classified according to the... Abstract
Journal of electrocardiology, Volume 61, 5 1 2020, Pages 141-146 Lack of diagnostic utility of the ECG-derived ventricular gradient in patients with suspected acute pulmonary embolism. Meijer FMM, Hendriks SV, Huisman MV, van der Hulle T, Swenne CA, Kies P, Jongbloed MRM, Egorova AD, Vliegen HW, Klok FA
Introduction: The YEARS algorithm was successfully developed to reduce the number of computed tomography pulmonary angiography (CTPA) investigations in the diagnostic management of patients with suspected pulmonary embolism (PE), although half of patients still needed to be referred for CTPA. We hypothesized that ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO), an easy to use tool for detecting PE-induced pulmonary hypertension (PH), may further impro... Abstract
Cited 5 times since 2020 (1.3 per year) source: EuropePMC
PloS one, Volume 15, Issue 5, 15 3 2020, Pages e0228478 Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development. Gittenberger-de Groot AC, Peterson JC, Wisse LJ, Roest AAW, Poelmann RE, Bökenkamp R, Elzenga NJ, Hazekamp M, Bartelings MM, Jongbloed MRM, DeRuiter MC
Objectives: In congenital heart malformations with pulmonary stenosis to atresia an abnormal lateral ductus arteriosus to left pulmonary artery connection can lead to a localised narrowing (pulmonary ductal coarctation) or even interruption We investigated embryonic remodelling and pathogenesis of this area. Material and methods: Normal development was studied in WntCre reporter mice (E10.0-12.5) for neural crest cells and Nkx2.5 immunostaining for second heart field cells. Data were compared to... Abstract
Cited 6 times since 2020 (1.5 per year) source: EuropePMC
Journal of molecular and cellular cardiology, Volume 143, 8 2 2020, Pages 26-37 Human epicardium-derived cells reinforce cardiac sympathetic innervation. Ge Y, Smits AM, van Munsteren JC, Gittenberger-de Groot AC, Poelmann RE, van Brakel TJ, Schalij MJ, Goumans MJ, DeRuiter MC, Jongbloed MRM
Rationale: After cardiac damage, excessive neurite outgrowth (sympathetic hyperinnervation) can occur, which is related to ventricular arrhythmias/sudden cardiac death. Post-damage reactivation of epicardium causes epicardium-derived cells (EPDCs) to acquire a mesenchymal character, contributing to cardiac regeneration. Whether EPDCs also contribute to cardiac re/hyperinnervation, is unknown. Aim: To investigate whether mesenchymal EPDCs influence cardiac sympathetic innervation. Methods and res... Abstract
Cited 1 times since 2020 (0.2 per year) source: EuropePMC
European journal of obstetrics, gynecology, and reproductive biology, Volume 248, 6 1 2020, Pages 150-155 Evaluation of mode of birth in pregnant women with heart disease. Petrus AHJ, Jongert BL, Kiès P, Sueters M, Jongbloed MRM, Vliegen HW, Schalij MJ, van Lith J, van den Akker T
Objective: Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluate mode of birth and pregnancy outcomes in women with HD in a tertiary care hospital in the Netherlands. Study design: The study population consisted of 128 consecutive pregnancies in 99 women with HD,... Abstract
Cited 11 times since 2020 (2.6 per year) source: EuropePMC
International journal of cardiology, Volume 306, 17 3 2020, Pages 78-85 Coronary anomalies in tetralogy of Fallot - A meta-analysis. Koppel CJ, Jongbloed MRM, Kiès P, Hazekamp MG, Mertens BJA, Schalij MJ, Vliegen HW
Background: An anomalous coronary artery is reported in 2% to 23% of patients with tetralogy of Fallot (TOF). Knowledge of coronary anatomy prior to corrective surgery is vital to avoid damage to vessels crossing the right ventricular outflow tract (RVOT). A meta-analysis on the prevalence of anomalous coronary arteries in TOF is lacking to date. Here, an overview of coronary anomalies in TOF is provided and implications for patient management are discussed. Methods: PubMed, Embase and Web of Sc... Abstract
Cited 7 times since 2019 (1.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 27, Issue 12, 1 1 2019, Pages 590-593 Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. Zandstra TE, Palmen M, Hazekamp MG, Meyns B, Beeres SLMA, Holman ER, Kiès P, Jongbloed MRM, Vliegen HW, Egorova AD, Schalij MJ, Tops LF
Ventricular assist device (VAD) implantation is an established treatment modality for patients with end-stage heart failure, and improves symptoms and survival. In the Netherlands, it is not yet routinely considered in patients with congenital heart disease and failing systemic right ventricle (SRV). Recently, a VAD was implanted in 2 SRV patients, one who underwent a Mustard procedure during infancy for transposition of the great arteries (male, 47 years old) and one with a congenitally correct... Abstract
Cited 5 times since 2019 (1.1 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 29, Issue 3, 1 1 2019, Pages 461-468 A 45-year experience with the Fontan procedure: tachyarrhythmia, an important sign for adverse outcome. Rijnberg FM, Blom NA, Sojak V, Bruggemans EF, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Bouma BJ, Hazekamp MG
Objectives: This study aims to evaluate our 45-year experience with the Fontan procedure and to identify risk factors for late mortality and morbidity. Methods: Demographic, preoperative, perioperative and postoperative characteristics were retrospectively collected for all patients who underwent a Fontan procedure in a single centre between 1972 and 2016. Results: The study included 277 Fontan procedures (44 atriopulmonary connections, 28 Fontan-Björk, 42 lateral tunnels and 163 extracardiac co... Abstract
Cited 8 times since 2019 (1.7 per year) source: EuropePMC
JACC. Clinical electrophysiology, Volume 5, Issue 10, 31 5 2019, Pages 1130-1140 Multisize Electrodes for Substrate Identification in Ischemic Cardiomyopathy: Validation by Integration of Whole Heart Histology. Glashan CA, Tofig BJ, Tao Q, Blom SA, Jongbloed MRM, Nielsen JC, Lukac P, Kristiansen SB, Zeppenfeld K
Objectives: This study sought to evaluate the value of combined electrogram (EGM) information provided by simultaneous mapping using micro- and conventional electrodes in the identification of post-myocardial infarction ventricular tachycardia substrate. Background: Ventricular tachycardias after myocardial infarction are related to scars with complex geometry. Scar delineation and ventricular tachycardia substrate identification relies on bipolar voltages (BV) and EGM characteristics. Early rep... Abstract
Cited 10 times since 2019 (2.1 per year) source: EuropePMC
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 21, Issue 1, 25 4 2019, Pages 43 Stress increases intracardiac 4D flow cardiovascular magnetic resonance -derived energetics and vorticity and relates to VO<sub>2</sub>max in Fontan patients. Kamphuis VP, Elbaz MSM, van den Boogaard PJ, Kroft LJM, Lamb HJ, Hazekamp MG, Jongbloed MRM, Blom NA, Helbing WA, Roest AAW, Westenberg JJM
Background: We hypothesize that dobutamine-induced stress impacts intracardiac hemodynamic parameters and that this may be linked to decreased exercise capacity in Fontan patients. Therefore, the purpose of this study was to assess the effect of pharmacologic stress on intraventricular kinetic energy (KE), viscous energy loss (EL) and vorticity from four-dimensional (4D) Flow cardiovascular magnetic resonance (CMR) imaging in Fontan patients and to study the association between stress response a... Abstract
Cited 14 times since 2019 (2.9 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 22, 10 2 2019, Pages 1732-1740 Progression of aortic root dilatation and aortic valve regurgitation after the arterial switch operation. van der Palen RLF, van der Bom T, Dekker A, Tsonaka R, van Geloven N, Kuipers IM, Konings TC, Rammeloo LAJ, Ten Harkel ADJ, Jongbloed MRM, Koolbergen DR, Mulder BJM, Hazekamp MG, Blom NA
Objective: To study neo-aortic growth and the evolution of neo-aortic valve regurgitation (AR) in patients with transposition of the great arteries (TGA) after arterial switch operation (ASO) from newborn to adulthood and to identify patients at risk. Methods: Neo-aortic dimensions (annulus/root/sinotubular junction) and neo-aortic valve regurgitation were assessed serially in 345 patients with TGA who underwent ASO between 1977 and 2015. Linear mixed-effect models were used to assess increase o... Abstract
Cited 8 times since 2019 (1.5 per year) source: EuropePMC
Interactive cardiovascular and thoracic surgery, Volume 28, Issue 2, 1 1 2019, Pages 279-283 Excellent durability of homografts in pulmonary position analysed in a predefined adult group with tetralogy of Fallot. Meijer FMM, Kies P, Jongbloed MRM, Hazekamp MG, Koolbergen DR, Blom NA, de Roos A, Schalij MJ, Vliegen HW
Objectives: In repaired tetralogy of Fallot, surgical pulmonary valve replacement (PVR) is in certain cases required. Our institution reported earlier about 26 patients who received a pulmonary homograft via PVR. To date, we have data from more than 17 years of follow-up. The aim of this retrospective study was to evaluate the late haemodynamic and clinical outcomes in this predefined patient group. Methods: Between 1993 and 2001, 26 patients underwent PVR for pulmonary regurgitation (58% men; 3... Abstract
Cited 13 times since 2018 (2.4 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 105, Issue 10, 10 2 2018, Pages 790-796 Long-term outcome after atrial correction for transposition of the great arteries. Couperus LE, Vliegen HW, Zandstra TE, Kiès P, Jongbloed MRM, Holman ER, Zeppenfeld K, Hazekamp MG, Schalij MJ, Scherptong RWC
Objective: This study assessed adult survival and morbidity patterns in patients who underwent atrial correction according to Mustard or Senning for transposition of the great arteries (TGA). Methods: In 76 adult patients with TGA (59% male) after atrial correction, long-term survival and morbidity were investigated in three periods: early (30 years postoperatively). Results: The Mustard technique was performed in 41 (54%) patients, and the Senning technique was performed in 35 (46%) patients ag... Abstract