Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
138 results
Cited 5 times since 2014 (0.5 per year) source: EuropePMC
Fetal diagnosis and therapy, Volume 36, Issue 1, 4 1 2014, Pages 59-68 Bicuspid aortic valve morphology and associated cardiovascular abnormalities in fetal Turner syndrome: a pathomorphological study. van Engelen K, Bartelings MM, Gittenberger-de Groot AC, Baars MJ, Postma AV, Bijlsma EK, Mulder BJ, Jongbloed MR
Introduction: Bicuspid aortic valve (BAV) is common in Turner syndrome (TS). In adult TS, 82-95% of BAVs have fusion of the right and left coronary leaflets. Data in fetal stages are scarce. The purpose of this study was to gain insight into aortic valve morphology and associated cardiovascular abnormalities in a fetal TS cohort with adverse outcome early in development. Material and methods: We studied post-mortem heart specimens of 36 TS fetuses and 1 TS newborn. Results: BAV was present in 28... Abstract
Cited 5 times since 2014 (0.5 per year) source: EuropePMC
TheScientificWorldJournal, Volume 2014, 23 4 2014, Pages 531324 Echocardiographic assessment of embryonic and fetal mouse heart development: a focus on haemodynamics and morphology. Hahurij ND, Calkoen EE, Jongbloed MR, Roest AA, Gittenberger-de Groot AC, Poelmann RE, De Ruiter MC, van Munsteren CJ, Steendijk P, Blom NA
Background: Heart development is a complex process, and abnormal development may result in congenital heart disease (CHD). Currently, studies on animal models mainly focus on cardiac morphology and the availability of hemodynamic data, especially of the right heart half, is limited. Here we aimed to assess the morphological and hemodynamic parameters of normal developing mouse embryos/fetuses by using a high-frequency ultrasound system. Methods: A timed breeding program was initiated with a WT m... Abstract
Cited 23 times since 2013 (2.1 per year) source: EuropePMC
Seminars in fetal & neonatal medicine, Volume 18, Issue 5, 22 4 2013, Pages 237-244 Embryology of the heart and its impact on understanding fetal and neonatal heart disease. Gittenberger-de Groot AC, Bartelings MM, Poelmann RE, Haak MC, Jongbloed MR
Heart development is a complex process during which the heart needs to transform from a single tube towards a fully septated heart with four chambers and a separated outflow tract. Several major events contribute to this process, that largely overlap in time. Abnormal heart development results in congenital heart disease, which has an estimated incidence of 1% of liveborn children. Eighty percent of cases of congenital heart disease are considered to have a multifactoral developmental background... Abstract
Cited 9 times since 2013 (0.8 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 96, Issue 4, 16 3 2013, Pages 1390-1397 Variation in coronary anatomy in adult patients late after arterial switch operation: a computed tomography coronary angiography study. Veltman CE, Beeres SLMA, Kalkman DN, Kelder TP, Kiès P, Vliegen HW, Hazekamp MG, Delgado V, Kroft LJM, van der Wall EE, Gittenberger-de Groot AC, Scholte AJHA, Schalij MJ, Jongbloed MRM
Background: The arterial switch operation is the current treatment for transposition of the great arteries. Long-term outcome mainly depends on the patency of the transferred coronary arteries. This study assessed the presence of abnormal coronary findings and neoaortic root dilation late after arterial switch operation. Methods: In 30 adult patients after arterial switch operation (22 men, 22 ± 3 years), computed tomography angiography was performed to assess the coronary anatomy and abnormal c... Abstract
Cited 10 times since 2013 (0.9 per year) source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 45, Issue 1, 17 3 2013, Pages 83-89 Long-term tricuspid valve prosthesis-related complications in patients with congenital heart disease. van Slooten YJ, Freling HG, van Melle JP, Mulder BJ, Jongbloed MR, Ebels T, Voors AA, Pieper PG
Objectives: In patients with acquired valvar disease, morbidity and mortality rates after tricuspid valve replacement (TVR) are high. However, in adult patients with congenital heart disease, though data concerning outcome after TVR are scarce, even poorer results are suggested in patients with Ebstein anomaly. To investigate the applicability of these results to a broader array of congenital heart disease patients, we report the long-term follow-up of prosthesis-related complications, including... Abstract
Cited 5 times since 2012 (0.4 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 10, 1 1 2012, Pages 419-424 Prosthetic valves in adult patients with congenital heart disease: Rationale and design of the Dutch PROSTAVA study. Freling HG, van Slooten YJ, van Melle JP, Mulder BJ, van Dijk AP, Hillege HL, Post MC, Sieswerda GT, Jongbloed MR, Willems TP, Pieper PG, PROSTAVA investigators
Background: Data on long-term complications in adult patients with congenital heart disease (ACHD) and a prosthetic valve are scarce. Moreover, the influence of prosthetic valves on quality of life (QoL) and functional outcome in ACHD patients with prosthetic valves has not been studied. Objectives: The primary objective of the PROSTAVA study is to investigate the relation between prosthetic valve characteristics (type, size and location) and functional outcome as well as QoL in ACHD patients. T... Abstract
Cited 24 times since 2012 (2 per year) source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists, Volume 241, Issue 9, 30 5 2012, Pages 1413-1422 Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept. Scherptong RW, Jongbloed MR, Wisse LJ, Vicente-Steijn R, Bartelings MM, Poelmann RE, Schalij MJ, Gittenberger-De Groot AC
Background: Understanding of cardiac outflow tract (OFT) remodeling is essential to explain repositioning of the aorta and pulmonary orifice. In wild type embryos (E9.5-14.5), second heart field contribution (SHF) to the OFT was studied using expression patterns of Islet 1, Nkx2.5, MLC-2a, WT-1, and 3D-reconstructions. Abnormal remodeling was studied in VEGF120/120 embryos. Results: In wild type, Islet 1 and Nkx2.5 positive myocardial precursors formed an asymmetric elongated column almost exclu... Abstract
Cited 25 times since 2012 (2.1 per year) source: EuropePMC
Differentiation; research in biological diversity, Volume 84, Issue 1, 3 1 2012, Pages 131-148 Normal and abnormal development of the cardiac conduction system; implications for conduction and rhythm disorders in the child and adult. Jongbloed MR, Vicente Steijn R, Hahurij ND, Kelder TP, Schalij MJ, Gittenberger-de Groot AC, Blom NA
The cardiac conduction system is a specialized network that initiates and closely coordinates the heart beat. Cardiac conduction system development is intricately related to the development and maturation of the embryonic heart towards its four-chambered form, as is indicated by the fact that disturbed development of cardiac structures is often accompanied by a disturbed formation of the CCS. Electrophysiological studies have shown that selected conduction disturbances and cardiac arrhythmias do... Abstract
Cited 10 times since 2011 (0.8 per year) source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists, Volume 240, Issue 11, 1 1 2011, Pages 2561-2577 Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC
The inhibitor of differentiation Id2 is expressed in mesoderm of the second heart field, which contributes myocardial and mesenchymal cells to the primary heart tube. The role of Id2 in cardiac development is insufficiently known. Heart development was studied in sequential developmental stages in Id2 wildtype and knockout mouse embryos. Expression patterns of Id2, MLC-2a, Nkx2.5, HCN4, and WT-1 were analyzed. Id2 is expressed in myocardial progenitor cells at the inflow and outflow tract, in th... Abstract
Cited 27 times since 2011 (2.1 per year) source: EuropePMC
Heart rhythm, Volume 8, Issue 8, 21 3 2011, Pages 1254-1263 Funny current channel HCN4 delineates the developing cardiac conduction system in chicken heart. Vicente-Steijn R, Passier R, Wisse LJ, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC, Jongbloed MR
Background: Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) in the mouse is expressed in the developing cardiac conduction system (CCS). In the sinoatrial node (SAN), HCN4 is the predominant isoform responsible for the funny current. To date, no data are available on HCN4 expression during chicken CCS development. Objective: The purpose of this study was to provide the full-length sequence of Hcn4 and describe its expression pattern during development in relation to the CCS... Abstract
Cited 16 times since 2010 (1.2 per year) source: EuropePMC
Journal of cardiovascular electrophysiology, Volume 21, Issue 11, 1 1 2010, Pages 1284-1292 Electrical activation of sinus venosus myocardium and expression patterns of RhoA and Isl-1 in the chick embryo. Vicente-Steijn R, Kolditz DP, Mahtab EA, Askar SF, Bax NA, VAN DER Graaf LM, Wisse LJ, Passier R, Pijnappels DA, Schalij MJ, Poelmann RE, Gittenberger-DE Groot AC, Jongbloed MR
Unlabelled: Electrical Activity and RhoA in the Embryo. Introduction: Myocardium at the venous pole (sinus venosus) of the heart has gained clinical interest as arrhythmias can be initiated from this area. During development, sinus venosus myocardium is incorporated to the primary heart tube and expresses different markers than primary myocardium. We aimed to elucidate the development of sinus venosus myocardium, including the sinoatrial node (SAN), by studying expression patterns of RhoA in rel... Abstract
Cited 1 times since 2010 (0.1 per year) source: EuropePMC
Pacing and clinical electrophysiology : PACE, Volume 35, Issue 10, 4 1 2010, Pages e287-90 Anatomical perspective on radiofrequency ablation of AV nodal reentry tachycardia after Mustard correction for transposition of the great arteries. Jongbloed MR, Kelder TP, DEN Uijl DW, Bartelings MM, Molhoek SG, Tukkie R, Schalij MJ
A case of radiofrequency catheter ablation of atrioventricular (AV) nodal reentry tachycardia, in a patient with transposition of the great arteries after venous rerouting according to Mustard, is described. An electroanatomical map of the His and AV nodal region was created from inside the systemic venous atrium. Retrograde mapping of the pulmonary venous atrium was performed and the arterial catheter retracted to a position in close proximity to the venous catheter inside the intraatrial baffl... Abstract
Cited 47 times since 2010 (3.4 per year) source: EuropePMC
International journal of cardiology, Volume 147, Issue 1, 2 1 2010, Pages 13-24 Normal and abnormal development of pulmonary veins: state of the art and correlation with clinical entities. Douglas YL, Jongbloed MR, Deruiter MC, Gittenberger-de Groot AC
Interest for the pulmonary veins has increased in the past decade after the potential arrhythmogenicity of the myocardial sleeve surrounding these structures has been recognized. Furthermore, there are several clinical entities, such as anomalous connection pattern and pulmonary vein stenosis, that are related to abnormal pulmonary vein development. In this review, we will describe current literature and aim to elucidate and reorganize current opinions on normal and abnormal pulmonary vein devel... Abstract
The American journal of the medical sciences, Volume 339, Issue 1, 1 1 2010, Pages 89-91 Do not put money where your mouth is! de Groot NM, Scholte AJ, Jongbloed MR, Schuijf JD, DeRuiter MC, Bax JJ, Schalij MJ
A 60-year-old woman presented with repolarization disorders on the electrocardiogram after a generalized seizure, which immediately disappeared after vomiting up a 20-eurocent coin. We did not find any evidence of coronary artery disease. Multislice computed tomography demonstrated no coronary atherosclerotic stenosis but a close relationship of the esophagus with the coronary arteries. This relation was further studied in detail in a human cadaver. From our findings, it is most likely that the... Abstract
Cited 21 times since 2009 (1.4 per year) source: EuropePMC
Pediatric research, Volume 65, Issue 1, 1 1 2009, Pages 27-32 Pulmonary vein, dorsal atrial wall and atrial septum abnormalities in podoplanin knockout mice with disturbed posterior heart field contribution. Douglas YL, Mahtab EA, Jongbloed MR, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Deruiter MC, Gittenberger-de Groot AC
The developing sinus venosus myocardium, derived from the posterior heart field, contributes to the atrial septum, the posterior atrial wall, the sino-atrial node, and myocardium lining the pulmonary and cardinal veins, all expressing podoplanin, a coelomic and myocardial marker. We compared development and differentiation of the myocardium and vascular wall of the pulmonary veins (PV), left atrial dorsal wall, and atrial septum in wild type with podoplanin knockout mouse embryos (E10.5-E18.5) b... Abstract
Cited 36 times since 2009 (2.3 per year) source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists, Volume 238, Issue 1, 1 1 2009, Pages 183-193 Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, DeRuiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC
We investigated the role of podoplanin in development of the sinus venosus myocardium comprising the sinoatrial node, dorsal atrial wall, and primary atrial septum as well as the myocardium of the cardinal and pulmonary veins. We analyzed podoplanin wild-type and knockout mouse embryos between embryonic day 9.5-15.5 using immunohistochemical marker podoplanin; sinoatrial-node marker HCN4; myocardial markers MLC-2a, Nkx2.5, as well as Cx43; coelomic marker WT-1; and epithelial-to-mesenchymal tran... Abstract
Cited 19 times since 2008 (1.2 per year) source: EuropePMC
International journal of cardiology, Volume 134, Issue 3, 30 5 2009, Pages 302-312 Pulmonary vein and atrial wall pathology in human total anomalous pulmonary venous connection. Douglas YL, Jongbloed MR, den Hartog WC, Bartelings MM, Bogers AJ, Ebels T, DeRuiter MC, Gittenberger-de Groot AC
Background: Normally, the inside of the left atrial (LA) body and pulmonary veins (PVs) is lined by vessel wall tissue covered by myocardium. In total anomalous pulmonary venous connection (TAPVC), no connection of the PVs with the LA body exists. These veins have an increased incidence of PV stenosis. We describe the consequences of the absent connection for the histopathology of the wall of the LA body and the PVs, and hypothesize on a mechanism predisposing to PV stenosis. Methods and results... Abstract
Cited 7 times since 2008 (0.4 per year) source: EuropePMC
Circulation research, Volume 102, Issue 7, 1 1 2008, Pages 749-751 Pitx2: a challenging teenager. Poelmann RE, Jongbloed MR, Gittenberger-de Groot AC
Cited 32 times since 2008 (2 per year) source: EuropePMC
TheScientificWorldJournal, Volume 8, 3 1 2008, Pages 239-269 Development of the cardiac conduction system and the possible relation to predilection sites of arrhythmogenesis. Jongbloed MR, Mahtab EA, Blom NA, Schalij MJ, Gittenberger-de Groot AC
The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties than the surrounding working myocardium, which can be observed on a histological level, as well as by the expression patterns of several immunohistological and molecular markers. In recent years, many markers have been studied that have helped to el... Abstract
Cited 9 times since 2007 (0.5 per year) source: EuropePMC
Genesis (New York, N.Y. : 2000), Volume 45, Issue 2, 1 1 2007, Pages 76-82 Complex genomic rearrangement in CCS-LacZ transgenic mice. Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI
The cardiac conduction system (CCS)-lacZ insertional mouse mutant strain genetically labels the developing and mature CCS. This pattern of expression is presumed to reflect the site of transgene integration rather than regulatory elements within the transgene proper. We sought to characterize the genomic structure of the integration locus and identify nearby gene(s) that might potentially confer the observed CCS-specific transcription. We found rearrangement of chromosome 7 between regions D1 an... Abstract